Search Results - "type"

Early insulin degludec with continuous intravenous insulin infusion in the management of diabetic ketoacidosis: A randomized controlled trial.

Authors: Thammakosol K Jantarapootirat M Traiwanatham S et al.

Source: Diabetes, obesity & metabolism [Diabetes Obes Metab] 2025 Dec; Vol. 27 (12), pp. 7020-7029. Date of Electronic Publication: 2025 Sep 03.

Publication Type: Journal Article; Randomized Controlled Trial

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 100883645 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1463-1326 (Electronic) Linking ISSN: 14628902 NLM ISO Abbreviation: Diabetes Obes Metab Subsets: MEDLINE

MeSH Terms: Insulin, Long-Acting*/administration & dosage , Insulin, Long-Acting*/adverse effects , Insulin, Long-Acting*/therapeutic use , Diabetic Ketoacidosis*/drug therapy , Diabetic Ketoacidosis*/blood , Hypoglycemic Agents*/administration & dosage , Hypoglycemic Agents*/adverse effects , Hypoglycemic Agents*/therapeutic use , Diabetes Mellitus, Type 2*/complications , Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/blood, Humans ; Male ; Female ; Middle Aged ; Adult ; Infusions, Intravenous ; Prospective Studies ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Treatment Outcome ; Hypoglycemia/chemically induced ; Hypoglycemia/prevention & control ; Drug Therapy, Combination ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/drug therapy ; Length of Stay

A systematic survey of type I secretion systems and their substrate proteins in Salmonella .

Authors: Yu M Chen Y Cao X et al.

Source: Virulence [Virulence] 2025 Dec; Vol. 16 (1), pp. 2533414. Date of Electronic Publication: 2025 Jul 15.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101531386 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-5608 (Electronic) Linking ISSN: 21505594 NLM ISO Abbreviation: Virulence Subsets: MEDLINE

MeSH Terms: Bacterial Proteins*/genetics , Bacterial Proteins*/metabolism , Salmonella*/genetics , Salmonella*/metabolism , Salmonella*/pathogenicity , Type I Secretion Systems*/genetics , Type I Secretion Systems*/metabolism, Multigene Family ; Gene Expression Regulation, Bacterial ; Evolution, Molecular ; Genome, Bacterial ; Type III Secretion Systems/genetics ; Genomic Islands ; Virulence Factors/genetics

Stimulation of angiotensin II type 2 receptor recruit skeletal and cardiac muscle microvasculature in humans.

Authors: Tan WKA Jahn LA Hartline L et al.

Source: American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2025 Nov 01; Vol. 329 (5), pp. E755-E763. Date of Electronic Publication: 2025 Oct 13.

Publication Type: Journal Article

Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1555 (Electronic) Linking ISSN: 01931849 NLM ISO Abbreviation: Am J Physiol Endocrinol Metab Subsets: MEDLINE

MeSH Terms: Receptor, Angiotensin, Type 2*/metabolism , Receptor, Angiotensin, Type 2*/agonists , Muscle, Skeletal*/blood supply , Muscle, Skeletal*/drug effects , Muscle, Skeletal*/metabolism , Angiotensin II*/pharmacology , Microvessels*/drug effects , Microvessels*/metabolism, Humans ; Male ; Adult ; Female ; Angiotensin II Type 1 Receptor Blockers/pharmacology ; Benzimidazoles/pharmacology ; Biphenyl Compounds ; Glucose Clamp Technique ; Insulin/pharmacology ; Young Adult ; Tetrazoles/pharmacology ; Myocardium/metabolism ; Hemodynamics/drug effects ; Microcirculation/drug effects ; Brachial Artery/drug effects ; Regional Blood Flow/drug effects ; Receptor, Angiotensin, Type 1

Adult-onset type 1 diabetes: predictors of major cardiovascular events and mortality.

Authors: Wei Y Andersson T Tuomi T et al.

Source: European heart journal [Eur Heart J] 2025 Oct 07; Vol. 46 (38), pp. 3776-3786.

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 8006263 Publication Model: Print Cited Medium: Internet ISSN: 1522-9645 (Electronic) Linking ISSN: 0195668X NLM ISO Abbreviation: Eur Heart J Subsets: MEDLINE

MeSH Terms: Diabetes Mellitus, Type 1*/complications , Diabetes Mellitus, Type 1*/mortality , Diabetes Mellitus, Type 1*/epidemiology , Cardiovascular Diseases*/mortality , Cardiovascular Diseases*/epidemiology , Cardiovascular Diseases*/etiology, Humans ; Male ; Female ; Adult ; Middle Aged ; Sweden/epidemiology ; Prognosis ; Diabetes Mellitus, Type 2/mortality ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Age of Onset ; Risk Factors ; Incidence ; Glycated Hemoglobin/metabolism ; Registries ; Aged

6-Nitrodopamine Release From Mouse Seminal Vesicles Is Dependent on Endothelial Nitric Oxide Synthase (eNOS) Activation.

Authors: Britto-Júnior J Godoy PRC Lima DO et al.

Source: Pharmacology research & perspectives [Pharmacol Res Perspect] 2025 Oct; Vol. 13 (5), pp. e70167.

Publication Type: Journal Article

Journal Info: Publisher: John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 101626369 Publication Model: Print Cited Medium: Internet ISSN: 2052-1707 (Electronic) Linking ISSN: 20521707 NLM ISO Abbreviation: Pharmacol Res Perspect Subsets: MEDLINE

MeSH Terms: Nitric Oxide Synthase Type III*/metabolism , Nitric Oxide Synthase Type III*/genetics , Seminal Vesicles*/metabolism , Seminal Vesicles*/drug effects , Dopamine*/analogs & derivatives , Dopamine*/metabolism, Animals ; Male ; Mice ; Mice, Knockout ; Nitric Oxide Synthase Type I/genetics ; Nitric Oxide Synthase Type I/metabolism ; Nitric Oxide Synthase Type II/genetics ; Nitric Oxide Synthase Type II/metabolism ; Mice, Inbred C57BL ; Electric Stimulation

Salacia Reticulata Extract Improves Insulin Sensitivity and Glucose Homeostasis by Activating Insulin Signaling and Glucagon-like Peptide-1 Modulation.

Authors: Jung J Park SH Cho W et al.

Source: Journal of medicinal food [J Med Food] 2025 Oct; Vol. 28 (10), pp. 1060-1068. Date of Electronic Publication: 2025 Jun 16.

Publication Type: Journal Article

Journal Info: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 9812512 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-7600 (Electronic) Linking ISSN: 1096620X NLM ISO Abbreviation: J Med Food Subsets: MEDLINE

MeSH Terms: Insulin Resistance* , Insulin*/metabolism , Diabetes Mellitus, Type 2*/metabolism , Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/genetics , Plant Extracts*/administration & dosage , Glucagon-Like Peptide 1*/metabolism , Glucagon-Like Peptide 1*/blood , Glucagon-Like Peptide 1*/genetics , Salacia*/chemistry , Glucose*/metabolism, Animals ; Signal Transduction/drug effects ; Male ; Rats ; Blood Glucose/metabolism ; Homeostasis/drug effects ; Humans ; Glucose Transporter Type 4/metabolism ; Glucose Transporter Type 4/genetics ; Rats, Inbred OLETF ; Mice ; Hypoglycemic Agents/administration & dosage ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/drug effects ; Insulin Receptor Substrate Proteins/metabolism ; Insulin Receptor Substrate Proteins/genetics ; Adiponectin/blood ; Adiponectin/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; Cell Line

Neuronal PAC1 deletion impairs structural plasticity.

Authors: Jansen MI Hrncir H MacKenzie-Graham A et al.

Source: Life sciences [Life Sci] 2025 Oct 01; Vol. 378, pp. 123843. Date of Electronic Publication: 2025 Jul 06.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE

MeSH Terms: Neuronal Plasticity*/physiology , Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I*/genetics , Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I*/metabolism , Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I*/deficiency , Pyramidal Cells*/metabolism , Neurons*/metabolism, Animals ; Mice ; Mice, Knockout ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Male ; Hippocampus/metabolism ; Mice, Inbred C57BL ; Nitric Oxide Synthase Type I/metabolism ; Dendritic Spines/metabolism ; Spatial Memory

A new BMP type 1 receptor kinase inhibitor for safe and efficient oral treatment to prevent genetically induced heterotopic ossification in mice.

Authors: Yang J Pan H Sekimata K et al.

Source: Bone [Bone] 2025 Oct; Vol. 199, pp. 117565. Date of Electronic Publication: 2025 Jun 18.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8504048 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2763 (Electronic) Linking ISSN: 18732763 NLM ISO Abbreviation: Bone Subsets: MEDLINE

MeSH Terms: Ossification, Heterotopic*/prevention & control , Ossification, Heterotopic*/genetics , Ossification, Heterotopic*/drug therapy , Ossification, Heterotopic*/pathology , Protein Kinase Inhibitors*/therapeutic use , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/administration & dosage , Bone Morphogenetic Protein Receptors, Type I*/antagonists & inhibitors , Bone Morphogenetic Protein Receptors, Type I*/metabolism, Animals ; Administration, Oral ; Mice ; Myositis Ossificans/drug therapy ; Myositis Ossificans/genetics ; Mice, Transgenic ; Activin Receptors, Type I/metabolism ; Activin Receptors, Type I/genetics ; Signal Transduction/drug effects ; Humans

Understanding the Increasing Prevalence of Obesity in Patients With Type 1 Diabetes: Strategies for Improving Clinical Care.

Authors: Ruddiman KR Bartfield JK Hirsch IB

Source: Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2025 Dec; Vol. 33 (12), pp. 2246-2263. Date of Electronic Publication: 2025 Oct 07.

Publication Type: Journal Article; Review

Journal Info: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101264860 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1930-739X (Electronic) Linking ISSN: 19307381 NLM ISO Abbreviation: Obesity (Silver Spring) Subsets: MEDLINE

MeSH Terms: Diabetes Mellitus, Type 1*/complications , Diabetes Mellitus, Type 1*/epidemiology , Obesity*/epidemiology , Obesity*/therapy , Obesity*/complications, Humans ; Prevalence ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Bariatric Surgery ; Life Style

Bni5 regulates and coordinates septin architecture and myosin-II functions at the cell division site.

Authors: Okada H Chen X Marquardt J et al.

Source: The Journal of cell biology [J Cell Biol] 2025 Dec 01; Vol. 224 (12). Date of Electronic Publication: 2025 Nov 06.

Publication Type: Journal Article

Journal Info: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 0375356 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-8140 (Electronic) Linking ISSN: 00219525 NLM ISO Abbreviation: J Cell Biol Subsets: MEDLINE

MeSH Terms: Saccharomyces cerevisiae Proteins*/metabolism , Saccharomyces cerevisiae Proteins*/genetics , Saccharomyces cerevisiae*/metabolism , Saccharomyces cerevisiae*/genetics , Saccharomyces cerevisiae*/cytology , Myosin Heavy Chains*/metabolism , Myosin Heavy Chains*/genetics , Septins*/metabolism , Septins*/genetics , Myosin Type II*/metabolism , Myosin Type II*/genetics , Cell Division*, Cytokinesis ; Phosphorylation ; Myosin Type I/metabolism ; Myosin Type I/genetics ; Protein Binding

Emerging insights into the type I secretion system: a key player in Salmonella virulence and host-pathogen interactions.

Authors: Li S Liu H Qiu J

Source: MBio [mBio] 2025 Nov 12; Vol. 16 (11), pp. e0165525. Date of Electronic Publication: 2025 Sep 22.

Publication Type: Journal Article; Review

Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE

MeSH Terms: Host-Pathogen Interactions* , Salmonella*/pathogenicity , Salmonella*/genetics , Type I Secretion Systems*/metabolism , Type I Secretion Systems*/genetics, Humans ; Virulence ; Animals ; Bacterial Proteins/metabolism ; Bacterial Proteins/genetics ; Salmonella Infections/microbiology ; Type III Secretion Systems/metabolism ; Virulence Factors/metabolism ; Virulence Factors/genetics

Global Burden of Diabetic Ketoacidosis.

Authors: Mohan V Lee K

Source: Diabetes technology & therapeutics [Diabetes Technol Ther] 2025 Nov; Vol. 27 (S4), pp. S6-S13.

Publication Type: Journal Article; Review

Journal Info: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 100889084 Publication Model: Print Cited Medium: Internet ISSN: 1557-8593 (Electronic) Linking ISSN: 15209156 NLM ISO Abbreviation: Diabetes Technol Ther Subsets: MEDLINE

MeSH Terms: Diabetic Ketoacidosis*/epidemiology , Diabetic Ketoacidosis*/etiology , Diabetes Mellitus, Type 1*/complications , Diabetes Mellitus, Type 1*/epidemiology , Diabetes Mellitus, Type 1*/drug therapy, Humans ; Sodium-Glucose Transporter 2 Inhibitors/adverse effects ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Global Health ; Pregnancy ; Female ; Incidence ; Child ; Blood Glucose/analysis ; Adolescent ; Adult

Human Adipose Tissue 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition Without Tachyphylaxis by Clofutriben, a Pseudo-Irreversible Enzyme Inhibitor.

Authors: An G Gutierrez JA Abad-Zapatero C et al.

Source: Clinical and translational science [Clin Transl Sci] 2025 Nov; Vol. 18 (11), pp. e70398.

Publication Type: Journal Article

Journal Info: Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE

MeSH Terms: 11-beta-Hydroxysteroid Dehydrogenase Type 1*/antagonists & inhibitors , 11-beta-Hydroxysteroid Dehydrogenase Type 1*/metabolism , 11-beta-Hydroxysteroid Dehydrogenase Type 1*/chemistry , Adipose Tissue*/enzymology , Adipose Tissue*/drug effects , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/administration & dosage , Enzyme Inhibitors*/pharmacokinetics , Pyridines*/administration & dosage , Pyridines*/pharmacology , Pyridines*/pharmacokinetics, Humans ; Middle Aged ; Male ; Female ; Obesity/drug therapy ; Obesity/enzymology ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/enzymology ; Hydrocortisone/metabolism ; Molecular Docking Simulation ; Adult ; Dose-Response Relationship, Drug ; Cortisone/metabolism

Development of a genetically encoded melanocortin sensor for high sensitivity in vivo imaging.

Authors: Namkung Y Slutzki T Pedroso J et al.

Source: Molecular metabolism [Mol Metab] 2025 Nov; Vol. 101, pp. 102254. Date of Electronic Publication: 2025 Sep 18.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE

MeSH Terms: Receptor, Melanocortin, Type 1*/metabolism , Receptor, Melanocortin, Type 1*/genetics , Melanocortins*/metabolism, Animals ; Mice ; Agouti-Related Protein/metabolism ; alpha-MSH/metabolism ; Receptor, Melanocortin, Type 4/metabolism ; Receptor, Melanocortin, Type 4/genetics ; Humans ; Green Fluorescent Proteins/metabolism ; Green Fluorescent Proteins/genetics ; HEK293 Cells ; Male ; Mice, Inbred C57BL

Synergistic target network construction and dynamic simulation analysis based on a prospective systems pharmacology strategy.

Authors: Li H Zheng Z Zhen G et al.

Source: Medicine [Medicine (Baltimore)] 2025 Oct 24; Vol. 104 (43), pp. e45369.

Publication Type: Journal Article

Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE

MeSH Terms: Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/metabolism , Network Pharmacology*/methods , Estradiol*/analogs & derivatives , Estradiol*/pharmacology , Hypoglycemic Agents*/pharmacology, Molecular Docking Simulation ; Molecular Dynamics Simulation ; Humans ; Signal Transduction/drug effects ; Insulin Resistance ; Phosphatidylinositol 3-Kinases/metabolism ; Glucose Transporter Type 4/metabolism ; Proto-Oncogene Proteins c-akt/metabolism

Stressed β-cells contribute to loss of peri-islet extracellular matrix in type 1 diabetes.

Authors: Johansen CG Lam K Farnsworth NL

Source: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2025 Oct 10; Vol. 16, pp. 1675043. Date of Electronic Publication: 2025 Oct 10 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE

MeSH Terms: Diabetes Mellitus, Type 1*/pathology , Diabetes Mellitus, Type 1*/metabolism , Extracellular Matrix*/metabolism , Extracellular Matrix*/pathology , Insulin-Secreting Cells*/pathology , Insulin-Secreting Cells*/metabolism , Islets of Langerhans*/metabolism , Islets of Langerhans*/pathology, Animals ; Mice ; Mice, Inbred NOD ; Humans ; Matrix Metalloproteinase 3/metabolism ; Matrix Metalloproteinase 3/genetics ; Female ; Male ; Hyperglycemia/metabolism ; Hyperglycemia/pathology ; Collagen Type IV/metabolism

Effect of short-term intensive insulin pump therapy on serum endotrophin levels in patients with newly diagnosed type 2 diabetes.

Authors: Li Y Gui X Weng Y et al.

Source: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2025 Oct 08; Vol. 16, pp. 1658272. Date of Electronic Publication: 2025 Oct 08 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE

MeSH Terms: Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/blood , Diabetes Mellitus, Type 2*/diagnosis , Insulin*/administration & dosage , Insulin Infusion Systems* , Peptide Fragments*/blood , Hypoglycemic Agents*/administration & dosage, Humans ; Male ; Female ; Middle Aged ; Insulin Resistance ; Aged ; Biomarkers/blood ; Adult ; Case-Control Studies ; Blood Glucose ; Collagen Type VI

Simultaneous Pancreas and Kidney Transplantation in Patients With Type 2 Diabetes Mellitus.

Authors: Owen R Reynard J Thompson E et al.

Source: Transplant international : official journal of the European Society for Organ Transplantation [Transpl Int] 2025 Oct 07; Vol. 38, pp. 14772. Date of Electronic Publication: 2025 Oct 07 (Print Publication: 2025).

Publication Type: Journal Article; Review

Journal Info: Publisher: Frontiers Media S. A Country of Publication: Switzerland NLM ID: 8908516 Publication Model: eCollection Cited Medium: Internet ISSN: 1432-2277 (Electronic) Linking ISSN: 09340874 NLM ISO Abbreviation: Transpl Int Subsets: MEDLINE

MeSH Terms: Kidney Transplantation*/methods , Diabetes Mellitus, Type 2*/surgery , Diabetes Mellitus, Type 2*/complications , Pancreas Transplantation*/methods, Humans ; Graft Survival ; Insulin Resistance ; Treatment Outcome ; Diabetes Mellitus, Type 1/surgery ; Diabetes Mellitus, Type 1/complications ; Diabetic Nephropathies/surgery

Optimizing Diabetes-in-Pregnancy Outcomes Requires a Care Continuum.

Authors: Huang AM Miodovnik M Reece EA

Source: American journal of perinatology [Am J Perinatol] 2025 Oct; Vol. 42 (13), pp. 1704-1713. Date of Electronic Publication: 2025 Jan 28.

Publication Type: Journal Article; Review

Journal Info: Publisher: Thieme-Stratton Country of Publication: United States NLM ID: 8405212 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-8785 (Electronic) Linking ISSN: 07351631 NLM ISO Abbreviation: Am J Perinatol Subsets: MEDLINE

MeSH Terms: Pregnancy in Diabetics*/therapy , Pregnancy in Diabetics*/epidemiology , Diabetes Mellitus, Type 1*/therapy , Diabetes Mellitus, Type 1*/epidemiology , Diabetes Mellitus, Type 1*/complications , Diabetes Mellitus, Type 1*/drug therapy , Diabetes, Gestational*/therapy , Diabetes, Gestational*/epidemiology , Continuity of Patient Care*, Humans ; Female ; Pregnancy ; Pregnancy Outcome ; Preconception Care ; Insulin/therapeutic use ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/therapy ; Obesity/epidemiology ; Maternal Mortality ; Infant, Newborn ; Hypoglycemic Agents/therapeutic use

AT 1 receptors play a role in sepsis-induced vasoplegia by increasing iNOS expression in the perivascular adipose tissue.

Authors: Awata WMC Pimenta GF Dourado TMH et al.

Source: Pflugers Archiv : European journal of physiology [Pflugers Arch] 2025 Oct; Vol. 477 (10), pp. 1259-1271. Date of Electronic Publication: 2025 Aug 30.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: Germany NLM ID: 0154720 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2013 (Electronic) Linking ISSN: 00316768 NLM ISO Abbreviation: Pflugers Arch Subsets: MEDLINE

MeSH Terms: Sepsis*/metabolism , Sepsis*/complications , Nitric Oxide Synthase Type II*/metabolism , Adipose Tissue*/metabolism , Adipose Tissue*/drug effects , Receptor, Angiotensin, Type 1*/metabolism , Vasoplegia*/metabolism , Vasoplegia*/etiology, Animals ; Male ; Rats ; Rats, Wistar ; Losartan/pharmacology ; Angiotensin II Type 1 Receptor Blockers/pharmacology ; Nitric Oxide/metabolism ; Angiotensin II/blood ; Angiotensin II/metabolism