Suchergebnisse - "traps"

Macrophage extracellular traps promote peritoneal fibrosis through the ROS/TGF-β/Smad pathway under high-glucose dialysis conditions.

Autoren: Wang J Yu C Lyu H et al.

Quelle: International immunopharmacology [Int Immunopharmacol] 2025 Dec 10; Vol. 167, pp. 115748. Date of Electronic Publication: 2025 Oct 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

MeSH-Schlagworte: Peritoneal Fibrosis*/immunology , Peritoneal Fibrosis*/pathology , Peritoneal Fibrosis*/metabolism , Peritoneal Dialysis*/adverse effects , Macrophages*/immunology , Macrophages*/metabolism , Extracellular Traps*/metabolism , Extracellular Traps*/immunology, Animals ; Mice ; Reactive Oxygen Species/metabolism ; Transforming Growth Factor beta/metabolism ; Glucose ; RAW 264.7 Cells ; Signal Transduction ; Male ; Humans ; Mice, Inbred C57BL ; Smad2 Protein/metabolism ; Disease Models, Animal ; Coculture Techniques ; Peritoneum/pathology ; Dialysis Solutions/adverse effects ; Epithelial-Mesenchymal Transition ; Smad Proteins/metabolism

Phellodendrine alleviates acute pancreatitis by inhibiting p38 MAPK-p47 ^phox pathway-mediated neutrophil extracellular traps formation and ROS production.

Autoren: Zhang J Li P Xu X et al.

Quelle: International immunopharmacology [Int Immunopharmacol] 2025 Dec 10; Vol. 167, pp. 115658. Date of Electronic Publication: 2025 Oct 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

MeSH-Schlagworte: Extracellular Traps*/drug effects , Extracellular Traps*/metabolism , Extracellular Traps*/immunology , p38 Mitogen-Activated Protein Kinases*/metabolism , Neutrophils*/drug effects , Neutrophils*/immunology , Pancreatitis*/drug therapy , Pancreatitis*/chemically induced , Pancreatitis*/immunology , Quinolizines*/therapeutic use , Quinolizines*/pharmacology, Animals ; Reactive Oxygen Species/metabolism ; Mice ; NADPH Oxidases/metabolism ; Mice, Inbred C57BL ; Male ; Disease Models, Animal ; Ceruletide ; Signal Transduction/drug effects ; Humans

Neutrophil extracellular traps promote bone loss in type 1 diabetes via suppression of the FN1-PI3K/Akt signaling axis.

Autoren: Liu X Xiao D Zhang D et al.

Quelle: International immunopharmacology [Int Immunopharmacol] 2025 Dec 03; Vol. 166, pp. 115629. Date of Electronic Publication: 2025 Oct 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

MeSH-Schlagworte: Extracellular Traps*/metabolism , Extracellular Traps*/immunology , Diabetes Mellitus, Type 1*/immunology , Diabetes Mellitus, Type 1*/complications , Diabetes Mellitus, Type 1*/metabolism , Diabetes Mellitus, Experimental*/immunology , Diabetes Mellitus, Experimental*/complications , Fibronectins*/metabolism , Fibronectins*/genetics , Osteoporosis*/immunology , Osteoporosis*/etiology , Osteoporosis*/metabolism , Neutrophils*/immunology, Animals ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Mice ; Phosphatidylinositol 3-Kinases/metabolism ; Male ; Osteogenesis ; Mice, Inbred C57BL ; Humans ; Osteoblasts ; Cell Line ; Deoxyribonuclease I/metabolism

High Dose of Antithrombin Suppresses Neutrophil Extracellular Trap Formation in Human Neutrophils In Vitro Following Lipopolysaccharide- and Platelet-Induced Stimulation.

Autoren: Aoyama-Ishikawa M Higashi H Murakami H et al.

Quelle: Surgical infections [Surg Infect (Larchmt)] 2025 Dec; Vol. 26 (10), pp. 762-769. Date of Electronic Publication: 2025 Sep 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 9815642 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8674 (Electronic) Linking ISSN: 10962964 NLM ISO Abbreviation: Surg Infect (Larchmt) Subsets: MEDLINE

MeSH-Schlagworte: Extracellular Traps*/drug effects , Extracellular Traps*/metabolism , Lipopolysaccharides*/pharmacology , Neutrophils*/drug effects , Neutrophils*/immunology , Antithrombins*/pharmacology , Antithrombins*/administration & dosage , Blood Platelets*/drug effects , Blood Platelets*/immunology, Humans ; Protein-Arginine Deiminase Type 4 ; Male ; Adult ; Female ; Cells, Cultured

Exploring the role of neutrophil extracellular traps in leukemia: a comprehensive review.

Autoren: Abbasi-Shahkouh A Rashidan K Azadmehr A et al.

Quelle: Leukemia & lymphoma [Leuk Lymphoma] 2025 Dec; Vol. 66 (13), pp. 2369-2379. Date of Electronic Publication: 2025 Sep 01.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 9007422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1029-2403 (Electronic) Linking ISSN: 10268022 NLM ISO Abbreviation: Leuk Lymphoma Subsets: MEDLINE

MeSH-Schlagworte: Extracellular Traps*/metabolism , Extracellular Traps*/immunology , Leukemia*/metabolism , Leukemia*/pathology , Leukemia*/etiology , Leukemia*/immunology , Neutrophils*/metabolism , Neutrophils*/immunology , Neutrophils*/pathology, Humans ; Animals

Significance of neutrophil extracellular traps and low-density granulocytes in advanced chronic kidney disease (stage 5D) cases with COVID-19.

Autoren: Chancharoenthana W Kamolratanakul S Ariyanon W et al.

Quelle: Renal failure [Ren Fail] 2025 Dec; Vol. 47 (1), pp. 2559093. Date of Electronic Publication: 2025 Sep 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE

MeSH-Schlagworte: Extracellular Traps*/metabolism , Extracellular Traps*/immunology , COVID-19*/blood , COVID-19*/complications , COVID-19*/immunology , Renal Insufficiency, Chronic*/blood , Renal Insufficiency, Chronic*/complications , Renal Insufficiency, Chronic*/immunology , Granulocytes*/metabolism , Granulocytes*/immunology, Humans ; Male ; Female ; Middle Aged ; Prospective Studies ; Aged ; SARS-CoV-2 ; Histones/blood ; Adult ; Severity of Illness Index

Da-Yuan-Yin decoction suppresses NETs formation, inhibits the IL-23/JAK2/STAT3 signalling pathway, and modulates metabolic profiles and gut microbiota composition in damp-heat syndrome.

Autoren: Yang Y Guo L Yu J et al.

Quelle: Annals of medicine [Ann Med] 2025 Dec; Vol. 57 (1), pp. 2519684. Date of Electronic Publication: 2025 Jun 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8906388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2060 (Electronic) Linking ISSN: 07853890 NLM ISO Abbreviation: Ann Med Subsets: MEDLINE

MeSH-Schlagworte: Hot Temperature*/adverse effects , Humidity*/adverse effects , Heat Exhaustion*/drug therapy , Heat Exhaustion*/etiology , Heat Exhaustion*/metabolism , Drugs, Chinese Herbal*/pharmacology , Drugs, Chinese Herbal*/therapeutic use , Extracellular Traps*/drug effects , Extracellular Traps*/immunology , Extracellular Traps*/metabolism, Syndrome ; Animals ; Rats ; Disease Models, Animal ; Lipopolysaccharides/administration & dosage ; Lipopolysaccharides/immunology ; Diet, High-Fat/adverse effects ; Dietary Sugars/administration & dosage ; Dietary Sugars/adverse effects ; Signal Transduction/drug effects ; Signal Transduction/immunology ; Gastrointestinal Microbiome/drug effects ; Gastrointestinal Microbiome/immunology ; Interleukin-23/metabolism ; Janus Kinase 2/metabolism ; STAT3 Transcription Factor/metabolism ; Male ; Specific Pathogen-Free Organisms ; Rats, Sprague-Dawley

The methyl-CpG binding domain 2 regulates peptidylarginine deiminase 4 expression and promotes neutrophil extracellular trap formation via the Janus kinase 2 signaling pathway in experimental severe asthma.

Autoren: Peng B Yan MY Chen YR et al.

Quelle: Annals of medicine [Ann Med] 2025 Dec; Vol. 57 (1), pp. 2458207. Date of Electronic Publication: 2025 Jan 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8906388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2060 (Electronic) Linking ISSN: 07853890 NLM ISO Abbreviation: Ann Med Subsets: MEDLINE

MeSH-Schlagworte: Extracellular Traps*/metabolism , Extracellular Traps*/immunology , Asthma*/immunology , Asthma*/pathology , Asthma*/metabolism , Protein-Arginine Deiminase Type 4*/metabolism , Protein-Arginine Deiminase Type 4*/genetics , DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/genetics , Janus Kinase 2*/metabolism, Animals ; Mice ; Signal Transduction/immunology ; Mice, Inbred C57BL ; Disease Models, Animal ; Neutrophils/immunology ; Neutrophils/metabolism ; Lung/pathology ; Lung/immunology ; Female ; Humans ; Male ; Lipopolysaccharides

Neutrophil extracellular trap-borne C3-driven endothelial dysfunction in Klebsiella pneumoniae liver abscess.

Autoren: Wang H Chen L Wang C et al.

Quelle: Virulence [Virulence] 2025 Dec; Vol. 16 (1), pp. 2580104. Date of Electronic Publication: 2025 Oct 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101531386 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-5608 (Electronic) Linking ISSN: 21505594 NLM ISO Abbreviation: Virulence Subsets: MEDLINE

MeSH-Schlagworte: Extracellular Traps*/metabolism , Extracellular Traps*/immunology , Klebsiella pneumoniae*/pathogenicity , Klebsiella Infections*/microbiology , Klebsiella Infections*/immunology , Klebsiella Infections*/pathology , Liver Abscess*/microbiology , Liver Abscess*/immunology , Liver Abscess*/pathology , Complement C3*/metabolism , Complement C3*/immunology, Animals ; Humans ; Mice ; Male ; Mice, Inbred C57BL ; Disease Models, Animal ; Female ; Neutrophils/immunology ; Signal Transduction ; Liver/pathology ; Liver/microbiology ; Middle Aged

Initial Insights into the NET-Associated ceRNA Network in Pulpitis: Transcriptomic and Functional Exploration.

Autoren: Guo X Wu K Dang L et al.

Quelle: International dental journal [Int Dent J] 2025 Dec; Vol. 75 (6), pp. 100958. Date of Electronic Publication: 2025 Sep 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: England NLM ID: 0374714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-595X (Electronic) Linking ISSN: 00206539 NLM ISO Abbreviation: Int Dent J Subsets: MEDLINE

MeSH-Schlagworte: Pulpitis*/genetics , Pulpitis*/metabolism , Gene Regulatory Networks* , Extracellular Traps*/genetics , Extracellular Traps*/metabolism , Transcriptome*, Humans ; Animals ; Mice ; RNA, Long Noncoding/genetics ; RNA, Messenger/genetics ; Disease Models, Animal ; Computational Biology ; Male ; Protein Interaction Maps ; MicroRNAs ; RNA, Competitive Endogenous

Ovulation releases G-CSF to induce peritoneal neutrophil influx and netosis, facilitating peritoneal seeding of high-grade serous carcinoma.

Autoren: Chu TY Chen PC Khine AA et al.

Quelle: Neoplasia (New York, N.Y.) [Neoplasia] 2025 Dec; Vol. 70, pp. 101236. Date of Electronic Publication: 2025 Oct 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 100886622 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5586 (Electronic) Linking ISSN: 14765586 NLM ISO Abbreviation: Neoplasia Subsets: MEDLINE

MeSH-Schlagworte: Extracellular Traps*/metabolism , Extracellular Traps*/immunology , Neutrophils*/metabolism , Neutrophils*/immunology , Ovarian Neoplasms*/pathology , Ovarian Neoplasms*/metabolism , Granulocyte Colony-Stimulating Factor*/metabolism , Cystadenocarcinoma, Serous*/pathology , Cystadenocarcinoma, Serous*/metabolism , Ovulation*/metabolism , Peritoneal Neoplasms*/secondary , Peritoneal Neoplasms*/metabolism , Neutrophil Infiltration*, Female ; Humans ; Animals ; Mice ; Neoplasm Seeding ; Cell Line, Tumor ; Tumor Microenvironment ; Neoplasm Grading

Neutrophil extracellular traps and neuropsychiatric lupus: Signaling pathways involved in NET formation and mechanisms affecting the central nervous system.

Autoren: Guan X He X Liu L

Quelle: Autoimmunity reviews [Autoimmun Rev] 2025 Nov 28; Vol. 24 (11), pp. 103897. Date of Electronic Publication: 2025 Jul 31.

Publikationsart: Journal Article; Review; Systematic Review

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101128967 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-0183 (Electronic) Linking ISSN: 15689972 NLM ISO Abbreviation: Autoimmun Rev Subsets: MEDLINE

MeSH-Schlagworte: Extracellular Traps*/immunology , Extracellular Traps*/metabolism , Lupus Vasculitis, Central Nervous System*/immunology , Lupus Vasculitis, Central Nervous System*/metabolism , Neutrophils*/immunology , Neutrophils*/metabolism , Signal Transduction*/immunology , Central Nervous System*/immunology , Central Nervous System*/metabolism , Central Nervous System*/pathology, Humans ; Blood-Brain Barrier/immunology ; Blood-Brain Barrier/pathology ; Blood-Brain Barrier/metabolism ; Animals

Polyethylene glycol loxenatide reduces NETosis and immunofluorescence hyperactivation in Behçet's disease.

Autoren: Jia F Wu X Sheng H

Quelle: European journal of medical research [Eur J Med Res] 2025 Nov 26; Vol. 30 (1), pp. 1187. Date of Electronic Publication: 2025 Nov 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 9517857 Publication Model: Electronic Cited Medium: Internet ISSN: 2047-783X (Electronic) Linking ISSN: 09492321 NLM ISO Abbreviation: Eur J Med Res Subsets: MEDLINE

MeSH-Schlagworte: Behcet Syndrome*/drug therapy , Behcet Syndrome*/immunology , Behcet Syndrome*/pathology , Behcet Syndrome*/metabolism , Extracellular Traps*/drug effects , Extracellular Traps*/metabolism , Extracellular Traps*/immunology , Polyethylene Glycols*/pharmacology , Neutrophils*/drug effects , Neutrophils*/metabolism , Neutrophils*/immunology , Neutrophil Activation*/drug effects, Humans ; Animals ; Mice ; Reactive Oxygen Species/metabolism ; Male ; Female ; Pyroptosis/drug effects ; Adult

It's a Trap!-Potential of Cathepsins in NET Formation.

Autoren: Pruchniak P Niedzielska A Nejfeld R et al.

Quelle: International journal of molecular sciences [Int J Mol Sci] 2025 Nov 20; Vol. 26 (22). Date of Electronic Publication: 2025 Nov 20.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: Cathepsins*/metabolism , Extracellular Traps*/metabolism , Extracellular Traps*/immunology , Neutrophils*/immunology , Neutrophils*/metabolism, Humans ; Animals ; Immunity, Innate ; Phagocytosis ; Inflammation/immunology ; Inflammation/metabolism

Exposure to bacterial lipopolysaccharide aggravates H1N1-mediated lung immunopathology via neutrophil extracellular trap formation.

Autoren: Yan G Hu Z Peng Y et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 18; Vol. 15 (1), pp. 40541. Date of Electronic Publication: 2025 Nov 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Influenza A Virus, H1N1 Subtype*/immunology , Influenza A Virus, H1N1 Subtype*/pathogenicity , Extracellular Traps*/immunology , Extracellular Traps*/metabolism , Lipopolysaccharides* , Lung*/immunology , Lung*/pathology , Lung*/virology , Orthomyxoviridae Infections*/immunology , Orthomyxoviridae Infections*/pathology , Orthomyxoviridae Infections*/virology, Animals ; Neutrophils/immunology ; Mice ; Humans ; Cytokines/metabolism ; Disease Models, Animal

NETosis-specific cell death: a novel mechanism in the pathogenesis of gouty arthritis.

Autoren: Liu K Ma S Li D et al.

Quelle: European journal of medical research [Eur J Med Res] 2025 Nov 18; Vol. 30 (1), pp. 1134. Date of Electronic Publication: 2025 Nov 18.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 9517857 Publication Model: Electronic Cited Medium: Internet ISSN: 2047-783X (Electronic) Linking ISSN: 09492321 NLM ISO Abbreviation: Eur J Med Res Subsets: MEDLINE

MeSH-Schlagworte: Extracellular Traps*/metabolism , Extracellular Traps*/immunology , Arthritis, Gouty*/pathology , Arthritis, Gouty*/immunology , Arthritis, Gouty*/metabolism , Arthritis, Gouty*/etiology , Arthritis, Gouty*/drug therapy, Humans ; Neutrophils/metabolism ; Cell Death ; Uric Acid/metabolism ; Animals

Eosinophil extracellular traps formation is correlated with cancer prognosis by tumor microenvironment remodeling.

Autoren: Zhang J Qiu Y Liu Y et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 17; Vol. 15 (1), pp. 40209. Date of Electronic Publication: 2025 Nov 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Tumor Microenvironment*/immunology , Neoplasms*/pathology , Neoplasms*/immunology , Neoplasms*/genetics , Neoplasms*/mortality , Neoplasms*/metabolism , Extracellular Traps*/metabolism , Extracellular Traps*/immunology , Eosinophils*/immunology , Eosinophils*/metabolism, Humans ; Prognosis ; Macrophages/immunology ; Gene Expression Regulation, Neoplastic

Neutrophil extracellular traps mediate macrophage polarization and pyroptosis through the TLR9-NF-κB/AIM2 pathway exacerbating myositis-associated interstitial lung disease.

Autoren: Cui X Zhao L Su Q et al.

Quelle: International immunopharmacology [Int Immunopharmacol] 2025 Nov 14; Vol. 165, pp. 115431. Date of Electronic Publication: 2025 Sep 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

MeSH-Schlagworte: Extracellular Traps*/immunology , Extracellular Traps*/metabolism , Lung Diseases, Interstitial*/immunology , Lung Diseases, Interstitial*/pathology , Lung Diseases, Interstitial*/metabolism , Macrophages*/immunology , Myositis*/immunology, Animals ; Pyroptosis/immunology ; Humans ; Toll-Like Receptor 9/metabolism ; Mice ; NF-kappa B/metabolism ; Signal Transduction ; Male ; THP-1 Cells ; Lung/pathology ; Lung/immunology ; Female ; Mice, Inbred C57BL ; Disease Models, Animal

Sars-Cov-2 spike protein and plasma from COVID-19 patients induce extracellular traps by myeloid-derived suppressor cells.

Autoren: Grassi G Gili S Casetti R et al.

Quelle: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2025 Nov 13; Vol. 15, pp. 1612198. Date of Electronic Publication: 2025 Nov 13 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN: 2235-2988 (Electronic) Linking ISSN: 22352988 NLM ISO Abbreviation: Front Cell Infect Microbiol Subsets: MEDLINE

MeSH-Schlagworte: COVID-19*/immunology , COVID-19*/blood , Spike Glycoprotein, Coronavirus*/immunology , Spike Glycoprotein, Coronavirus*/blood , Spike Glycoprotein, Coronavirus*/metabolism , Extracellular Traps*/immunology , Extracellular Traps*/metabolism , SARS-CoV-2*/immunology , Myeloid-Derived Suppressor Cells*/immunology , Myeloid-Derived Suppressor Cells*/metabolism, Humans ; Male ; Female ; Middle Aged ; Toll-Like Receptor 4/metabolism ; Aged ; Apoptosis ; Endothelial Cells ; Adult

Desloratadine as the selective 5HT 2A R antagonist suppresses neutrophil extracellular traps formation to ameliorate diabetic peripheral neuropathy pathology.

Autoren: Lu D Ruan Y Zhou F et al.

Quelle: Journal of neuroinflammation [J Neuroinflammation] 2025 Nov 05; Vol. 22 (1), pp. 261. Date of Electronic Publication: 2025 Nov 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094 (Electronic) Linking ISSN: 17422094 NLM ISO Abbreviation: J Neuroinflammation Subsets: MEDLINE

MeSH-Schlagworte: Diabetic Neuropathies*/drug therapy , Diabetic Neuropathies*/pathology , Diabetic Neuropathies*/metabolism , Loratadine*/analogs & derivatives , Loratadine*/pharmacology , Loratadine*/therapeutic use , Extracellular Traps*/drug effects , Extracellular Traps*/metabolism , Serotonin 5-HT2 Receptor Antagonists*/pharmacology , Serotonin 5-HT2 Receptor Antagonists*/therapeutic use , Neutrophils*/drug effects , Neutrophils*/metabolism, Animals ; Mice ; Male ; Humans ; Mice, Inbred C57BL ; Female ; Receptor, Serotonin, 5-HT2A/metabolism ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/pathology ; Ganglia, Spinal/drug effects ; Ganglia, Spinal/metabolism ; Ganglia, Spinal/pathology ; Middle Aged ; Disease Models, Animal