Suchergebnisse - "translocator protein"

Inflammation of central nervous system fiber tracts is active in patients over six months post-intracerebral hemorrhage

Autoren: Zhuyu Gao Kunbin Lian Fuxin Lin et al.

Quelle: Acta Neuropathologica Communications, Vol 13, Iss 1, Pp 1-11 (2025)

Schlagwörter: Hemorrhagic stroke, Chronic phase, Translocator protein, 18F-DPA714, Positron emission tomographic imaging, Neurology. Diseases of the nervous system, RC346-429

Dateibeschreibung: electronic resource

Relation: https://doaj.org/toc/2051-5960

Zugangs-URL: https://doaj.org/article/f13c4202d57e4456941b3f05b6f9b18c

Development and evaluation of [11C]DPA-813 and [18F]DPA-814: novel TSPO PET tracers insensitive to human single nucleotide polymorphism rs6971: novel TSPO PET tracers insensitive to human single nucleotide polymorphism rs6971

Autoren: Wissam Beaino Esther JM Kooijman Eryn L. Werry et al.

Quelle: Eur J Nucl Med Mol Imaging

Schlagwörter: Positron emission tomography, Experimental autoimmune encephalomyelitis, Neuroinflammation, Translocator protein 18 kDa, Autoradiography, Original Article, Polymorphism

Zugangs-URL: https://pure.amsterdamumc.nl/en/publications/d7587c45-75ef-4b9c-93bf-4ad9d3ebf9a8
https://doi.org/10.1007/s00259-025-07109-1

Expression of mitochondrial TSPO and FAM173B is associated with inflammation and symptoms in patients with painful knee osteoarthritis

Autoren: Palada, Vinko Siddiqah Ahmed, Aisha Hugo, Anders et al.

Quelle: Rheumatology. 60(4):1724-1733

Schlagwörter: family with sequence similarity 173B (FAM173B), joint pain, mitochondrial dysfunction, osteoarthritis (OA), synovial inflammation, translocator protein (TSPO)

Dateibeschreibung: electronic

Zugangs-URL: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-441391
https://doi.org/10.1093/rheumatology/keaa565

Discovery of the First-in-Class Dual TSPO/Carbonic Anhydrase Modulators with Promising Neurotrophic Activity

Autoren: Valeria Poggetti Elisa Angeloni Lorenzo Germelli et al.

Quelle: ACS Chemical Neuroscience. 16:1-15

Schlagwörter: Receptors, GABA, Drug Discovery, Humans, Microglia, 2-phenylindole, carbonic anhydrases, multitarget-directed ligands, neurodegenerative diseases, neuroprotection, translocator protein, Carbonic Anhydrases, Cell Line

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39545683

Microglial responses partially mediate the effect of Aβ on cognition in Alzheimer's disease

Autoren: Lasse S. Madsen Rola Ismail Peter Parbo et al.

Quelle: Alzheimers Dement
Madsen, L S, Ismail, R, Parbo, P, Kjeldsen, P L, Schaldemose, J L, Hansen, K V, Gottrup, H, Aanerud, J, Eskildsen, S F & Brooks, D J 2024, 'Microglial responses partially mediate the effect of Aβ on cognition in Alzheimer's disease', Alzheimer's & Dementia, vol. 20, no. 11, pp. 8028-8037. https://doi.org/10.1002/alz.14298

Schlagwörter: cognition, Male, Alzheimer Disease/diagnostic imaging, Aniline Compounds/pharmacology, Cognitive Dysfunction/metabolism, Neuropsychological Tests, Isoquinolines/pharmacology, position emission tomography, Microglia/metabolism, mild cognitive impairment, Cognition, Alzheimer Disease, Neuropsychological Tests/statistics & numerical data, Humans, Cognitive Dysfunction, Longitudinal Studies, Amyloid beta-Peptides/metabolism, Cognition/physiology, Aged, PK11195, Amyloid beta-Peptides, Aniline Compounds, translocator protein, Brain, Alzheimer's disease, Brain/diagnostic imaging, Isoquinolines, Magnetic Resonance Imaging, amyloid beta, Thiazoles, Positron-Emission Tomography, Female, Microglia, Research Article

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39392185
https://pure.au.dk/portal/en/publications/387f4b8c-3327-467d-b3fa-0a6de53d98c6
https://doi.org/10.1002/alz.14298
http://www.scopus.com/inward/record.url?scp=85205963623&partnerID=8YFLogxK

History of Tspo deletion and induction in vivo: Phenotypic outcomes under physiological and pathological situations

Autoren: Bréhat, Juliette Issop, Leeyah Morin, Didier et al.

Weitere Verfasser: Bréhat, Juliette Issop, Leeyah Morin, Didier et al.

Quelle: Biochimie. 224:80-90

Schlagwörter: [SDV] Life Sciences [q-bio], Mice, Phenotype, Receptors, GABA, translocator protein, tissue specific deletion, global deletion, Animals, Humans, tissue specific induction, animal models, Gene Deletion, 3. Good health

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38432291
https://hal.science/hal-04539609v1/document
https://hal.science/hal-04539609v1
https://doi.org/10.1016/j.biochi.2024.03.001

Enhanced structure/function of mTSPO translocator in lipid:surfactant mixed micelles

Autoren: Saade, Christelle Pozza, Alexandre Bonneté, Françoise et al.

Weitere Verfasser: Saade, Christelle Pozza, Alexandre Bonneté, Françoise et al.

Quelle: 'Biochimie ', vol: 224, pages: 3-15 (2024)

Schlagwörter: dodecyl phosphocholine, multi-angle laser light scattering MST, SLD, Trp, Mice, DM, mTSPO, mouse TSPO circular dichroism DDM, multi-angle laser light scattering, membrane protein, decyl maltoside DMPC, size-exclusion chromatography SLD, SDS, 2 DPC, Micelles, sodium dodecyl sulfate SEC, small-angle X-ray scattering SDS, microscale thermophoresis mTSPO, mouse TSPO, DPC, SAXS, SEC, mouse TSPO circular dichroism, Lipids, dodecyl maltoside, size-exclusion chromatography, [SDV] Life Sciences [q-bio], sodium dodecyl sulfate, DMPC, Dimyristoylphosphatidylcholine, scattering length density Trp, TSPO, smallangle neutron scattering, DDM, dodecyl maltoside DM, scattering length density, Surface-Active Agents, Structure-Activity Relationship, dodecyl phosphocholine MALLS, Receptors, GABA, Animals, tryptophan, MALLS, MST, translocator protein, SANS, tryptophan TSPO, microscale thermophoresis, mouse TSPO SANS, smallangle neutron scattering SAXS, small-angle X-ray scattering, decyl maltoside, small-angle scattering (SAXS/SANS)

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38663457
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:66469

Translocator protein (TSPO) in glioma: implications for diagnosis, disease progression monitoring, and targeted therapies

Autoren: Julius Mulumba Bo Luo Jiang Wu et al.

Quelle: Exploration of Neuroscience, Vol 4, p 100681 (2025)

Schlagwörter: disease progression monitoring, translocator protein, diagnosis, glioma, Neurosciences. Biological psychiatry. Neuropsychiatry, molecular imaging, targeted therapy, RC321-571

Zugangs-URL: https://doaj.org/article/8e78bd0cbcd344d69f5b841fdca5a712

Identification of a mechanism promoting mitochondrial sterol accumulation during myocardial ischemia–reperfusion: role of TSPO and STAR

Autoren: Bréhat, Juliette Leick, Shirin Musman, Julien et al.

Weitere Verfasser: Bréhat, Juliette Leick, Shirin Musman, Julien et al.

Quelle: Basic Research in Cardiology. 119:481-503

Schlagwörter: Benzodiazepinones, translocator protein, cytochrome P450, Steroidogenic Acute Regulatory Protein, Myocardial Reperfusion Injury, Phosphoproteins, Receptors, GABA-A, Mitochondria, Heart, Mitochondria, Myocardial ischemia–reperfusion, Steroidogenic acute regulatory protein, Translocator protein, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Rats, 3. Good health, mitochondria, Disease Models, Animal, Cholesterol, myocardial ischemia-reperfusion, Receptors, GABA, steroidogenic acute regulatory protein, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Animals, Rats, Wistar

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38517482
https://hal.science/hal-04539472v1
https://doi.org/10.1007/s00395-024-01043-3
https://hal.science/hal-04539472v1/document
https://hdl.handle.net/10281/494401
https://doi.org/10.1007/s00395-024-01043-3

Translocator protein deficiency blocks the ferroptosis of malignant peripheral nerve sheath tumors through glutathione peroxidase 4

Autoren: Xiaoli Zhang Zhuonan Pu Chun Ran et al.

Quelle: Frontiers in Cellular Neuroscience, Vol 19 (2025)

Schlagwörter: malignant peripheral nerve sheath tumor, translocator protein, ferroptosis, lipid peroxidation, glutathione peroxidase 4, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

Dateibeschreibung: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fncel.2025.1624817/full; https://doaj.org/toc/1662-5102

Zugangs-URL: https://doaj.org/article/a8859437ac2b439a87452a300b27051b

The soluble epoxide hydrolase inhibitor TPPU improves comorbidity of chronic pain and depression via the AHR and TSPO signaling

Autoren: Luo, Ailin Wu, Zifeng Li, Shan et al.

Quelle: Journal of Translational Medicine. 21(1)

Schlagwörter: 32 Biomedical and Clinical Sciences (for-2020), 3209 Neurosciences (for-2020), 3202 Clinical Sciences (for-2020), Mental Health (rcdc), Neurosciences (rcdc), Depression (rcdc), Brain Disorders (rcdc), Pain Research (rcdc), Mental Illness (rcdc), Chronic Pain (rcdc), Behavioral and Social Science (rcdc), 2.1 Biological and endogenous factors (hrcs-rac), 5.1 Pharmaceuticals (hrcs-rac), Animals (mesh), Mice (mesh), Anhedonia (mesh), Antidepressive Agents (mesh), Chronic Pain (mesh), Comorbidity (mesh), Cytochrome P-450 CYP1A1 (mesh), Cytokines (mesh), Depression (mesh), Epoxide Hydrolases (mesh), Phenylurea Compounds (mesh), Receptors, Aryl Hydrocarbon (mesh), Receptors, Cytoplasmic and Nuclear (mesh), Chronic pain, Depression, Soluble epoxide hydrolase, TPPU, Translocator protein, Aryl hydrocarbon receptor, Animals (mesh), Mice (mesh), Phenylurea Compounds (mesh), Cytochrome P-450 CYP1A1 (mesh), Epoxide Hydrolases (mesh), Receptors, Cytoplasmic and Nuclear (mesh), Receptors, Aryl Hydrocarbon (mesh), Antidepressive Agents (mesh), Cytokines (mesh), Depression (mesh), Comorbidity (mesh), Chronic Pain (mesh), Anhedonia (mesh), Aryl hydrocarbon receptor, Chronic pain, Depression, Soluble epoxide hydrolase, TPPU, Translocator protein, Animals (mesh), Mice (mesh), Anhedonia (mesh), Antidepressive Agents (mesh), Chronic Pain (mesh), Comorbidity (mesh), Cytochrome P-450 CYP1A1 (mesh), Cytokines (mesh), Depression (mesh), Epoxide Hydrolases (mesh), Phenylurea Compounds (mesh), Receptors, Aryl Hydrocarbon (mesh), Receptors, Cytoplasmic and Nuclear (mesh), 11 Medical and Health Sciences (for), Immunology (science-metrix), 32 Biomedical and clinical sciences (for-2020), 42 Health sciences (for-2020)

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/5qn3r2wt
https://escholarship.org/content/qt5qn3r2wt/qt5qn3r2wt.pdf

18 kDa TSPO targeting drives polarized human microglia towards a protective and restorative neurosteroidome profile

Autoren: Lorenzo Germelli Elisa Angeloni Eleonora Da Pozzo et al.

Quelle: Cell Mol Life Sci

Schlagwörter: Receptors, GABA, Humans, Original Article, Microglia, Pregnanolone, Cholesterol Side-Chain Cleavage Enzyme, 18 kDa Translocator Protein (TSPO), Neuroinflammation, Neurosteroidome, TSPO ligand, Neurosteroids

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39757281
https://hdl.handle.net/11568/1312487
https://doi.org/10.1007/s00018-024-05544-1

Comparing and combining TSPO-PET tracers in tauopathies

Autoren: Crook, Harry Franzmeier, Nicolai Rahmouni, Nesrine et al.

Quelle: European Journal of Nuclear Medicine and Molecular Imaging.

Schlagwörter: Radiology and Medical Imaging, Radiologi och bildbehandling, Alzheimer’s disease, Neuroinflammation, Positron emission tomography, Progressive supranuclear palsy, Translocator protein

Zugangs-URL: https://gup.ub.gu.se/publication/355066

Translocator Protein TSPO (Peripheral Benzodiazepine Receptor): The Modern Story of the Ancient Preserved Protein with Ambiguous Functions

Autoren: Yassir Mustafa Kamal Al Mulla Hummadi

Quelle: Iraqi Journal of Pharmaceutical Sciences, Vol 33, Iss 1 (2024)

Schlagwörter: RS1-441, Pharmacy and materia medica, Keywords: peripheral benzodiazepine receptors, translocator protein TSPO, steroidogenic acute regulatory protein StAR, cholesterol, mitochondria, central benzodiazepine receptor CBR, peripheral benzodiazepine receptor PBR, 3. Good health

Zugangs-URL: https://doaj.org/article/1ae1fe2325b3436993a03105bde43656

Extra-axial inflammatory signal and its relation to peripheral and central immunity in depression

Autoren: Brandi Eiff Edward T. Bullmore Menna R. Clatworthy et al.

Quelle: Brain
Eiff, B, Bullmore, E T, Clatworthy, M, Fryer, T, Pariante, C, Mondelli, V, Maccioni, L, Hadjikhani, N, Loggia, M L, Moskowitz, M A, Bruner, E, Veronese, M, Turkheimer, F & Schubert, J 2024, ' Extra-axial inflammatory signal and its relation to peripheral and central immunity in depression ', Brain . https://doi.org/10.1093/brain/awae343

Schlagwörter: 0301 basic medicine, skull, 0303 health sciences, 03 medical and health sciences, positron emission tomography, inflammation, translocator protein, microglia, parameninges, Original Article

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39657983
https://kclpure.kcl.ac.uk/ws/files/309902649/BIODEP_ExtraAxialImmuneInteractions_SkullStudy_finalSubmitted.pdf

Characterization of cortico-meningeal translocator protein expression in multiple sclerosis

Autoren: Elena Herranz Constantina A Treaba Valeria T Barletta et al.

Quelle: Brain. 147:2566-2578

Schlagwörter: Male, Adult, Cerebral Cortex, 0301 basic medicine, positron emission tomography, Multiple Sclerosis, translocator protein, Pyridines, Middle Aged, Multiple Sclerosis, Chronic Progressive, multiple sclerosis, Magnetic Resonance Imaging, 03 medical and health sciences, cortex, Meninges, Multiple Sclerosis, Relapsing-Remitting, 0302 clinical medicine, Receptors, GABA, meninges, Positron-Emission Tomography, Acetamides, Humans, Female, Aged

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38289855

Positron Emission Tomography Studies of the Glial Cell Marker Translocator Protein in Patients With Psychosis: A Meta-analysis Using Individual Participant Data

Autoren: Plaven-Sigray, Pontus Matheson, Granville J. Collste, Karin et al.

Quelle: Biological Psychiatry. 84(6):433-442

Schlagwörter: Immune activation, Meta-analysis, Microglia, Positron emission tomography, Psychosis, Schizophrenia, Translocator protein

Dateibeschreibung: electronic

Zugangs-URL: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-440722
https://doi.org/10.1016/j.biopsych.2018.02.1171

Translocator protein (TSPO) expression in neoplastic cells and tumor-associated macrophages in meningiomas

Autoren: Nadja Blum Christian Mirian Andrea Daniela Maier et al.

Quelle: Journal of Neuropathology & Experimental Neurology. 82:1020-1032

Schlagwörter: Tumor-associated macrophage, Receptors, GABA, Brain Neoplasms, TAMs, Macrophages, Tumor-Associated Macrophages, Meningeal Neoplasms, Humans, Microglia, Meningioma, Translocator protein, TSPO

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/37952221

Usefulness of Serum Translocator Protein as a Potential Predictive Biochemical Marker of Three-Month Cognitive Impairment After Acute Intracerebral Hemorrhage: A Prospective Observational Cohort Study

Autoren: Zhou,Jing Yang,Chunsong Xv,Qichen et al.

Quelle: Int J Gen Med
International Journal of General Medicine, Vol Volume 16, Pp 5389-5403 (2023)

Schlagwörter: Medicine (General), R5-920, translocator protein, biomarkers, International Journal of General Medicine, intracerebral hemorrhage, 3. Good health, cognitive impairment, Original Research

Dateibeschreibung: text/html

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38021045
https://doaj.org/article/76567d0ebb554b80bb5094e38313bb4d
https://www.dovepress.com/usefulness-of-serum-translocator-protein-as-a-potential-predictive-bio-peer-reviewed-fulltext-article-IJGM

Glial activation among individuals with neurological post-acute sequelae of coronavirus disease 2019: A positron emission tomography study of brain fog using [18F]-FEPPA

Autoren: Sean A.P. Clouston Paul Vaska Tesleem Babalola et al.

Quelle: Brain, Behavior, & Immunity - Health, Vol 44, Iss , Pp 100945- (2025)

Schlagwörter: Post-acute sequelae of COVID-19, Respiratory infection, Glial activation, Translocator protein, Essential Workers, Positron emission tomography, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

Dateibeschreibung: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666354625000031; https://doaj.org/toc/2666-3546

Zugangs-URL: https://doaj.org/article/a2f653c9dcb64c30a99d3b23a4db25ea