Suchergebnisse - "transcriptional repression"

Chromatin folding by the Polycomb group proteins and its elusive role in epigenetic repression

Autoren: Lizana, Ludvig Schwartz, Yuri B.

Quelle: The FEBS Journal.

Schlagwörter: chromatin, computational modelling, epigenetics, genome architecture, Polycomb, transcriptional repression

Dateibeschreibung: electronic

Zugangs-URL: https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-242757
https://doi.org/10.1111/febs.70199

Structure and Methyl-lysine Binding Selectivity of the HUSH Complex Subunit MPP8

Autoren: Nikolopoulos, Nikos Oda, Shun-Ichiro Prigozhin, Daniil M et al.

Quelle: Journal of Molecular Biology. 437(2)

Schlagwörter: Biochemistry and Cell Biology, Biological Sciences, Genetics, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Cancer, Generic health relevance, Humans, Protein Binding, Models, Molecular, Crystallography, X-Ray, Lysine, Histone-Lysine N-Methyltransferase, Protein Conformation, Protein Domains, Nuclear Proteins, Retroelements, Amino Acid Sequence, Phosphoproteins, H3K9 methyltransferase, LINE-1 retrotransposon, epigenetic silencing, histone H3 lysine 9 methylation, transcriptional repression, Medicinal and Biomolecular Chemistry, Microbiology, Biochemistry & Molecular Biology, Biochemistry and cell biology

Zugangs-URL: https://escholarship.org/uc/item/37f979c3

Functional characterization of four soybean C2H2 zinc-finger genes in Phytophthora resistance

Autoren: Yuting Chen Xinyue Liu Yanyan Zhou et al.

Quelle: Plant Signaling & Behavior, Vol 20, Iss 1 (2025)

Schlagwörter: soybean, phytophthora root rot, c2h2 zinc finger protein (c2h2-zfp), gmzfp2, transcriptional repression, Plant ecology, QK900-989, Biology (General), QH301-705.5

Dateibeschreibung: electronic resource

Relation: https://doaj.org/toc/1559-2316; https://doaj.org/toc/1559-2324

Zugangs-URL: https://doaj.org/article/1b0f1e84153d433ca2d064768eed612d

Citrus WRKY28 acts as a transcription repressor to modulate cuticular long-chain alkanes accumulation in response to water loss stress

Autoren: Mingfei Zhang Jiahuan Liu Xiangyi Li et al.

Quelle: Industrial Crops and Products, Vol 236, Iss , Pp 121922- (2025)

Schlagwörter: Alkanes, Postharvest, Transcriptional repression, Wax metabolism, WRKY, Plant culture, SB1-1110

Dateibeschreibung: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0926669025014682; https://doaj.org/toc/1872-633X

Zugangs-URL: https://doaj.org/article/7c811b079e594ad386a767d31073e521

Transcriptional changes impact hepatic proteome in autophagy‐impaired liver

Autoren: Kamal Baral Spandan Joshi Adriana Lopez et al.

Quelle: FEBS Open Bio
FEBS Open Bio, Vol 14, Iss 11, Pp 1851-1863 (2024)

Schlagwörter: Male, autophagy, Proteome, QH301-705.5, NF-E2-Related Factor 2, non‐degradative, liver, Nrf2, hepatic proteome, Mice, Liver, transcriptional repression, Autophagy, Animals, Humans, Biology (General), Research Article

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39284785
https://doaj.org/article/22a957af6fd64d09bc842ccbc286b605

Genome-Wide Identification, Drought-Responsive Expression, and EAR-Mediated Regulatory Network Construction of TOPLESS Genes in Populus ussuriensis Kom.

Autoren: Wanxin Li Qianqian Liu Jingru Ren et al.

Quelle: Plants, Vol 14, Iss 20, p 3213 (2025)

Schlagwörter: Populus ussuriensis, Topless gene family, drought stress, transcriptional repression, EAR motif, Botany, QK1-989

Dateibeschreibung: electronic resource

Relation: https://www.mdpi.com/2223-7747/14/20/3213; https://doaj.org/toc/2223-7747

Zugangs-URL: https://doaj.org/article/834e815f75ac4c92959c71d8e94d8747

BCL6 coordinates muscle mass homeostasis with nutritional states

Autoren: Hui J. Wang Weiwei Fan Sihao Liu et al.

Quelle: Proc Natl Acad Sci U S A

Schlagwörter: MECHANISM, Male, GROWTH-HORMONE SECRETAGOGUE, BCL6, Nutritional Status, SARCOPENIA, Mice, SUPPRESSOR, transcriptional repression, STAT5 Transcription Factor, Animals, Homeostasis, SOCS2, GHRELIN, Muscle, Skeletal, GENE-EXPRESSION, Janus Kinases, Mice, Knockout, Biological Sciences, HYPERTROPHY, DEFICIENCY, Mice, Inbred C57BL, muscle mass, Growth Hormone, growth hormone, Proto-Oncogene Proteins c-bcl-6, SKELETAL-MUSCLE, SENSITIVITY, Signal Transduction

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39841144

Involvement of HDAC2-mediated kcnq2/kcnq3 genes transcription repression activated by EREG/EGFR-ERK-Runx1 signaling in bone cancer pain

Autoren: Zi-Xian Zhang Yue Tian Song Li et al.

Quelle: Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-31 (2024)

Schlagwörter: Bone cancer pain, Kv7(KCNQ)/M potassium channels, Transcriptional repression, Histone deacetylase 2, Methyl CpG binding protein 2, Epiregulin, Medicine, Cytology, QH573-671

Dateibeschreibung: electronic resource

Relation: https://doaj.org/toc/1478-811X

Zugangs-URL: https://doaj.org/article/86cac846465f4ff0a6ecb161acf7ae22

Impacts of perR on oxygen sensitivity, gene expression, and murine infection in Clostridioides difficile 630∆erm

Autoren: Anna L. Gregory Hailey E. Bussan Madeline A. Topf et al.

Quelle: Journal of Bacteriology, Vol 207, Iss 2 (2025)

Schlagwörter: Clostridium difficile, oxidative stress, anaerobes, transcriptional repression, Medicine

Dateibeschreibung: electronic resource

Relation: https://doaj.org/toc/0021-9193; https://doaj.org/toc/1098-5530

Zugangs-URL: https://doaj.org/article/a8d8be04a8e94bd2a508c0e2a6620531

Identification of Indoquinazoline Derivatives as Novel NR4A1 Agonists by Suppressing Adipocyte Lipogenesis for Treatment of Obesity

Autoren: Yu-Tao Hu Jia-Chun Luo Shu-Min Xu et al.

Schlagwörter: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, thereby inhibiting triglyceride, targeting antiobesity agents, suppressing adipocyte lipogenesis, previous research identified, mediated transcriptional repression, mechanistic studies showed, l1 cell model, effective antiobesity therapies, direct molecular target, promising therapeutic strategy, based protein profiling, nr4a1 binding affinity, suppressed lipid anabolism, r17 , obesity developing safe, novel nr4a1 agonists, promising lead, based compound, novel class, novel agonist, nr4a1 activation, significant lipid

Relation: https://figshare.com/articles/journal_contribution/Identification_of_Indoquinazoline_Derivatives_as_Novel_NR4A1_Agonists_by_Suppressing_Adipocyte_Lipogenesis_for_Treatment_of_Obesity/29920665

Verfügbarkeit: https://doi.org/10.1021/acs.jmedchem.5c00895.s003
https://figshare.com/articles/journal_contribution/Identification_of_Indoquinazoline_Derivatives_as_Novel_NR4A1_Agonists_by_Suppressing_Adipocyte_Lipogenesis_for_Treatment_of_Obesity/29920665

The ERVK3‑1 Microprotein Interacts with the HUSH Complex

Autoren: Ayodya Jayatissa Nadiya Jaunbocus Betel Erkalo et al.

Schlagwörter: Biochemistry, Medicine, Microbiology, Genetics, Molecular Biology, Developmental Biology, Marine Biology, Cancer, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, target gene expression, noninfectious molecular remnants, currently unknown whether, ancient exogenous retroviruses, ubiquitously expressed human, 1 microprotein interacts, 1 microprotein, endogenous retroviruses, human genome, human cells, 1 <, transcriptional repression, thus suggest, less genes, hush complex

Relation: https://figshare.com/articles/journal_contribution/The_ERVK3_1_Microprotein_Interacts_with_the_HUSH_Complex/29626986

Verfügbarkeit: https://doi.org/10.1021/acs.biochem.5c00023.s001
https://figshare.com/articles/journal_contribution/The_ERVK3_1_Microprotein_Interacts_with_the_HUSH_Complex/29626986

Figure Source Data Files

Autoren: Antoine Peters

Schlagwörter: Cell development, proliferation and death, Genomics and transcriptomics, Developmental genetics (incl. sex determination), Epigenetics (incl. genome methylation and epigenomics), Gene expression (incl. microarray and other genome-wide approaches), Genomics, Epigenetics, Spermatogenesis, Spermatogonia Stem Cells, Meiosis, Fertility, Histone Modifications, Histone Methylation, Histone Demethylation, KDM2A, H3K4me3, H3K27me3, H3K36me2, Polycomb Repressive Complex, Transcriptional Regulation, Transcriptional Repression, Meiotic Sex Chromosome Inactivation (MSCI)

Relation: https://figshare.com/articles/journal_contribution/Figure_Source_Data_Files/29256725

Verfügbarkeit: https://doi.org/10.6084/m9.figshare.29256725.v1
https://figshare.com/articles/journal_contribution/Figure_Source_Data_Files/29256725

Shortened CRISPR-Cas9 arrays enable multiplexed gene targeting in bacteria from a smaller DNA footprint

Autoren: Gawlitt, Sandra Liao, Chunyu Achmedov, Tatjana et al.

Quelle: RNA Biol
RNA Biology, Vol 20, Iss 1, Pp 666-680 (2023)
RNA Biology

Schlagwörter: Bacteria, crispr arrays, DNA Footprinting, QH426-470, Endonucleases, crispr-cas9, transcriptional repression, Gene Targeting, Genetics, Escherichia coli, Clustered Regularly Interspaced Short Palindromic Repeats, CRISPR-Cas Systems, multiplexed targeting, rna structure prediction, Research Paper

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/37654098
https://doaj.org/article/fde7e1846cdc41ca814ee8c762767e35

Building Silence at Scale: A CRISPRi-Based Analysis of Kaposi’s Sarcoma-Associated Herpesvirus

Autoren: Brackett, Kevin Lammert

Schlagwörter: Virology, Bioengineering, Molecular biology, CRISPRi, Genetic Manipulation, KSHV, Transcriptional Repression, Viral-Host Interactions

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/73j574g5
https://escholarship.org/content/qt73j574g5/qt73j574g5.pdf

Using the Allen Brain Cell Atlas of the Human Brain to Gain Insights into C-Terminal-Binding Protein 1 (CtBP1)’s Potential Function

Autoren: Suhjin Lee Uthayashanker R. Ezekiel

Quelle: Biologics, Vol 5, Iss 2, p 14 (2025)

Schlagwörter: CtBP1, HADDTS, Allen’s ABC atlas, transcriptional repression, Biology (General), QH301-705.5

Dateibeschreibung: electronic resource

Relation: https://www.mdpi.com/2673-8449/5/2/14; https://doaj.org/toc/2673-8449

Zugangs-URL: https://doaj.org/article/b2991d09a2ac48ed8ebd2334d852e8a9

Regulation of jasmonate signaling by reversible acetylation of TOPLESS in Arabidopsis

Autoren: Chunpeng An Lei Deng Huawei Zhai et al.

Quelle: MOLECULAR PLANT

Schlagwörter: jasmonate signaling, 0301 basic medicine, deacetylation, MEDIATOR SUBUNIT MED25, Arabidopsis, PROTEIN, Cyclopentanes, Histone Deacetylases, 03 medical and health sciences, Gene Expression Regulation, Plant, transcriptional repression, MYC TRANSCRIPTION FACTORS, Oxylipins, acetylation, TOPLESS corepressor, 0303 health sciences, Arabidopsis Proteins, REPRESSION, histone acetylation, Biology and Life Sciences, HDA6, Acetylation, PLANT IMMUNITY, STEM-CELL NICHE, Repressor Proteins, EAR MOTIF, HISTONE ACETYLATION, COREPRESSOR, DEFENSE RESPONSES, Co-Repressor Proteins, GCN5

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/35780296
https://biblio.ugent.be/publication/8760737/file/8760739
https://biblio.ugent.be/publication/8760737
http://hdl.handle.net/1854/LU-8760737
http://doi.org/10.1016/j.molp.2022.06.014

ATM‐Dependent Recruitment of BRD7 is required for Transcriptional Repression and DNA Repair at DNA Breaks Flanking Transcriptional Active Regions

Autoren: Hu, Kaishun Li, Yu Wu, Wenjing et al.

Quelle: Advanced Science. 7(20)

Schlagwörter: Biochemistry and Cell Biology, Biological Sciences, Rare Diseases, Genetics, Cancer, Neurodegenerative, 1.1 Normal biological development and functioning, Underpinning research, ATM, BRD7, NuRD, PRC2, transcriptional repression

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/8w3843dz
https://escholarship.org/content/qt8w3843dz/qt8w3843dz.pdf

The SUMO Ligase Su(var)2-10 Controls Hetero- and Euchromatic Gene Expression via Establishing H3K9 Trimethylation and Negative Feedback Regulation

Autoren: Ninova, Maria Godneeva, Baira Chen, Yung-Chia Ariel et al.

Quelle: Molecular Cell. 77(3)

Schlagwörter: Biochemistry and Cell Biology, Bioinformatics and Computational Biology, Genetics, Biological Sciences, Human Genome, Underpinning research, 1.1 Normal biological development and functioning, Animals, Chromosomal Proteins, Non-Histone, DNA Methylation, Drosophila Proteins, Drosophila melanogaster, Euchromatin, Feedback, Physiological, Gene Expression, Gene Expression Regulation, Gene Silencing, Heterochromatin, Histone-Lysine N-Methyltransferase, Histones, Ligases, Methyltransferases, Protein Inhibitors of Activated STAT, Repressor Proteins, Small Ubiquitin-Related Modifier Proteins, H3K9me3, SUMO, cell fate maintenance, chromatin, epigenetics, gene regulation, germline, heterochromatin, transcriptional repression, transposons, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences, Health sciences

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/5g22s8sf
https://escholarship.org/content/qt5g22s8sf/qt5g22s8sf.pdf

Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis

Autoren: Hong, Suk-Hyun Fang, Sungsoon Lu, Benson C. et al.

Quelle: Proceedings of the National Academy of Sciences of the United States of America, 2018 Oct 01. 115(41), 10381-10386.

Zugangs-URL: https://www.jstor.org/stable/26532187

Krüppel homolog 1 represses insect ecdysone biosynthesis by directly inhibiting the transcription of steroidogenic enzymes

Autoren: Zhang, Tianlei Song, Wei Li, Zheng et al.

Quelle: Proceedings of the National Academy of Sciences of the United States of America, 2018 Apr 01. 115(15), 3960-3965.

Zugangs-URL: https://www.jstor.org/stable/26508492