Search Results - "structures"

Spatial characterization of tertiary lymphoid structures as predictive biomarkers for immune checkpoint blockade in head and neck squamous cell carcinoma.

Authors: Ruiz-Torres DA Bryan ME Hirayama S et al.

Source: Oncoimmunology [Oncoimmunology] 2025 Dec; Vol. 14 (1), pp. 2466308. Date of Electronic Publication: 2025 Feb 18.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101570526 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2162-402X (Electronic) Linking ISSN: 21624011 NLM ISO Abbreviation: Oncoimmunology Subsets: MEDLINE

MeSH Terms: Squamous Cell Carcinoma of Head and Neck*/drug therapy , Squamous Cell Carcinoma of Head and Neck*/pathology , Squamous Cell Carcinoma of Head and Neck*/immunology , Immune Checkpoint Inhibitors*/therapeutic use , Immune Checkpoint Inhibitors*/pharmacology , Tertiary Lymphoid Structures*/pathology , Tertiary Lymphoid Structures*/immunology , Head and Neck Neoplasms*/drug therapy , Head and Neck Neoplasms*/pathology , Head and Neck Neoplasms*/immunology , Biomarkers, Tumor*/metabolism, Humans ; Male ; Female ; Middle Aged ; Aged ; Tumor Microenvironment

Tertiary lymphoid structures in cancer: spatiotemporal heterogeneity, immune orchestration, and translational opportunities​​.

Authors: Deng S Chen Y Song B et al.

Source: Journal of hematology & oncology [J Hematol Oncol] 2025 Nov 11; Vol. 18 (1), pp. 97. Date of Electronic Publication: 2025 Nov 11.

Publication Type: Journal Article; Review

Journal Info: Publisher: Biomed Central Country of Publication: England NLM ID: 101468937 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-8722 (Electronic) Linking ISSN: 17568722 NLM ISO Abbreviation: J Hematol Oncol Subsets: MEDLINE

MeSH Terms: Tertiary Lymphoid Structures*/immunology , Tertiary Lymphoid Structures*/pathology , Neoplasms*/immunology , Neoplasms*/pathology , Neoplasms*/therapy, Humans ; Tumor Microenvironment/immunology ; Immunotherapy/methods ; Animals

Chemokine/cytokine-releasing biomaterials induce in situ tertiary lymphoid-like structures and enhance antitumor immunity.

Authors: Falahat R Mulé JJ

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Nov 11; Vol. 122 (45), pp. e2409560122. Date of Electronic Publication: 2025 Nov 03.

Publication Type: Journal Article

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH Terms: Tertiary Lymphoid Structures*/immunology , Tertiary Lymphoid Structures*/pathology , Chemokines*/administration & dosage , Chemokines*/pharmacology , Cytokines*/administration & dosage , Cytokines*/immunology , Biocompatible Materials*/pharmacology, Animals ; Mice ; Mice, Inbred C57BL ; Hydrogels ; Female ; T-Lymphocytes/immunology ; B-Lymphocytes/immunology ; Cell Line, Tumor

Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures.

Authors: Cakmak P Lun JH Singh A et al.

Source: Immunity [Immunity] 2025 Nov 11; Vol. 58 (11), pp. 2847-2863.e8. Date of Electronic Publication: 2025 Oct 21.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE

MeSH Terms: Glioma*/immunology , Glioma*/pathology , Glioma*/genetics , Glioma*/mortality , Tertiary Lymphoid Structures*/immunology , Tertiary Lymphoid Structures*/pathology , Tertiary Lymphoid Structures*/genetics , Brain Neoplasms*/immunology , Brain Neoplasms*/pathology , Brain Neoplasms*/genetics , Brain Neoplasms*/mortality, Humans ; Male ; Female ; Middle Aged ; Adult ; Gene Expression Profiling ; Transcriptome ; B-Lymphocytes/immunology ; Aged ; T-Lymphocytes/immunology ; Tumor Microenvironment/immunology ; Dendritic Cells/immunology ; Lymphocytes, Tumor-Infiltrating/immunology ; Proteome

Characteristics of tertiary lymphoid structures in prostate cancer and the impact of neoadjuvant therapy on their formation and maturation.

Authors: Liu S Yu Y Zhou J et al.

Source: Frontiers in immunology [Front Immunol] 2025 Nov 04; Vol. 16, pp. 1663396. Date of Electronic Publication: 2025 Nov 04 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH Terms: Prostatic Neoplasms*/immunology , Prostatic Neoplasms*/pathology , Prostatic Neoplasms*/drug therapy , Prostatic Neoplasms*/therapy , Tertiary Lymphoid Structures*/immunology , Tertiary Lymphoid Structures*/pathology, Male ; Humans ; Neoadjuvant Therapy ; Animals ; Mice ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/drug effects ; Tumor Microenvironment/immunology ; Tumor Microenvironment/drug effects ; Prognosis

B lymphocytes and tertiary lymphoid structures have a prognostic impact on penile squamous cell carcinoma.

Authors: Zavillová N Waldauf P Kendall Bártů M et al.

Source: The journal of pathology. Clinical research [J Pathol Clin Res] 2025 Nov; Vol. 11 (6), pp. e70059.

Publication Type: Journal Article

Journal Info: Publisher: Wiley Blackwell Country of Publication: England NLM ID: 101658534 Publication Model: Print Cited Medium: Internet ISSN: 2056-4538 (Electronic) Linking ISSN: 20564538 NLM ISO Abbreviation: J Pathol Clin Res Subsets: MEDLINE

MeSH Terms: Penile Neoplasms*/pathology , Penile Neoplasms*/immunology , Penile Neoplasms*/mortality , Penile Neoplasms*/genetics , Tertiary Lymphoid Structures*/pathology , Tertiary Lymphoid Structures*/immunology , Carcinoma, Squamous Cell*/pathology , Carcinoma, Squamous Cell*/immunology , Carcinoma, Squamous Cell*/mortality , Carcinoma, Squamous Cell*/genetics , B-Lymphocytes*/immunology , B-Lymphocytes*/pathology , Lymphocytes, Tumor-Infiltrating*/immunology , Lymphocytes, Tumor-Infiltrating*/pathology, Humans ; Male ; Middle Aged ; Aged ; Prognosis ; Antigens, CD20/analysis ; Biomarkers, Tumor/analysis ; Immunohistochemistry ; Tumor Suppressor Protein p53/genetics ; Aged, 80 and over ; Mutation ; Adult

Spatial Transcriptional Dynamics of CD74⁺ B Cells in Tertiary Lymphoid Structures Drive Immune Evolution in Penile Squamous Cell Carcinoma.

Authors: Xue T Deng C Liu J et al.

Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Nov; Vol. 12 (44), pp. e09742. Date of Electronic Publication: 2025 Oct 20.

Publication Type: Journal Article

Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

MeSH Terms: Penile Neoplasms*/immunology , Penile Neoplasms*/genetics , Penile Neoplasms*/pathology , Tertiary Lymphoid Structures*/immunology , Tertiary Lymphoid Structures*/genetics , Tertiary Lymphoid Structures*/pathology , Carcinoma, Squamous Cell*/immunology , Carcinoma, Squamous Cell*/genetics , Carcinoma, Squamous Cell*/pathology , B-Lymphocytes*/immunology , B-Lymphocytes*/metabolism , Antigens, Differentiation, B-Lymphocyte*/metabolism , Antigens, Differentiation, B-Lymphocyte*/genetics , Antigens, Differentiation, B-Lymphocyte*/immunology, Male ; Humans ; Histocompatibility Antigens Class II

The Dichotomous Role of Tertiary Lymphoid Structures in Hepatocellular Carcinoma: From Spatial Location to Clinical Implications.

Authors: Xu J Cheng Y Feng Y et al.

Source: Immunological investigations [Immunol Invest] 2025 Nov; Vol. 54 (8), pp. 1326-1363. Date of Electronic Publication: 2025 Aug 31.

Publication Type: Journal Article; Review

Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8504629 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-4311 (Electronic) Linking ISSN: 08820139 NLM ISO Abbreviation: Immunol Invest Subsets: MEDLINE

MeSH Terms: Carcinoma, Hepatocellular*/immunology , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/therapy , Liver Neoplasms*/immunology , Liver Neoplasms*/pathology , Liver Neoplasms*/therapy , Tertiary Lymphoid Structures*/immunology , Tertiary Lymphoid Structures*/pathology , Tertiary Lymphoid Structures*/metabolism, Humans ; Tumor Microenvironment/immunology ; Immunotherapy/methods ; Animals ; Cancer-Associated Fibroblasts/immunology ; Lymphocytes, Tumor-Infiltrating/immunology

Microorganisms in cancer tertiary lymphoid structure formation.

Authors: Li H Chen FY Wang Q et al.

Source: Seminars in cancer biology [Semin Cancer Biol] 2025 Nov; Vol. 116, pp. 69-83. Date of Electronic Publication: 2025 Sep 19.

Publication Type: Journal Article; Review

Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 9010218 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-3650 (Electronic) Linking ISSN: 1044579X NLM ISO Abbreviation: Semin Cancer Biol Subsets: MEDLINE

MeSH Terms: Neoplasms*/microbiology , Neoplasms*/immunology , Neoplasms*/pathology , Neoplasms*/therapy , Tertiary Lymphoid Structures*/microbiology , Tertiary Lymphoid Structures*/immunology , Tertiary Lymphoid Structures*/pathology, Humans ; Tumor Microenvironment/immunology ; Animals ; Signal Transduction ; Immunotherapy/methods

Assessment of tertiary lymphoid structures via ¹⁸ F-FDG PET/CT scan in patients with pancreatic adenocarcinoma.

Authors: Yan Y Zou X Lin X et al.

Source: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2025 Oct 23; Vol. 74 (11), pp. 345. Date of Electronic Publication: 2025 Oct 23.

Publication Type: Journal Article

Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8605732 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0851 (Electronic) Linking ISSN: 03407004 NLM ISO Abbreviation: Cancer Immunol Immunother Subsets: MEDLINE

MeSH Terms: Positron Emission Tomography Computed Tomography*/methods , Pancreatic Neoplasms*/diagnostic imaging , Pancreatic Neoplasms*/immunology , Pancreatic Neoplasms*/pathology , Pancreatic Neoplasms*/mortality , Fluorodeoxyglucose F18* , Tertiary Lymphoid Structures*/diagnostic imaging , Tertiary Lymphoid Structures*/immunology , Tertiary Lymphoid Structures*/pathology , Adenocarcinoma*/diagnostic imaging , Adenocarcinoma*/immunology , Adenocarcinoma*/pathology, Humans ; Male ; Female ; Middle Aged ; Aged ; Prognosis ; Adult ; Aged, 80 and over ; Lymphocytes, Tumor-Infiltrating/immunology

Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immunity in metastatic cancer.

Authors: Osorio JC Knorr DA Weitzenfeld P et al.

Source: Cancer cell [Cancer Cell] 2025 Oct 13; Vol. 43 (10), pp. 1902-1916.e9. Date of Electronic Publication: 2025 Aug 14.

Publication Type: Journal Article; Clinical Trial, Phase I

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE

MeSH Terms: CD40 Antigens*/agonists , CD40 Antigens*/immunology , Tertiary Lymphoid Structures*/immunology , Tertiary Lymphoid Structures*/pathology , Antibodies, Monoclonal* , Immunoglobulin Fc Fragments*/immunology, Animals ; Humans ; Mice ; Female ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/drug effects ; Tumor Microenvironment/immunology ; Tumor Microenvironment/drug effects ; Male ; Middle Aged ; Xenograft Model Antitumor Assays ; Aged ; Neoplasm Metastasis ; Receptors, IgG/metabolism

Prognostic and clinicopathological significance of tertiary lymphoid structure in esophageal squamous cell carcinoma: a systematic review and meta-analysis review.

Authors: Yu CT Gao Y Liu RY et al.

Source: BMC cancer [BMC Cancer] 2025 Oct 09; Vol. 25 (1), pp. 1544. Date of Electronic Publication: 2025 Oct 09.

Publication Type: Journal Article; Systematic Review; Meta-Analysis

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE

MeSH Terms: Esophageal Squamous Cell Carcinoma*/pathology , Esophageal Squamous Cell Carcinoma*/mortality , Esophageal Squamous Cell Carcinoma*/immunology , Esophageal Neoplasms*/pathology , Esophageal Neoplasms*/mortality , Esophageal Neoplasms*/immunology , Tertiary Lymphoid Structures*/pathology , Tertiary Lymphoid Structures*/immunology, Humans ; Prognosis ; Neoplasm Staging

Tertiary Lymphoid Structures Across Organs: Context, Composition, and Clinical Levers.

Authors: Guillaume SM Beccaria CG Iannacone M et al.

Source: Immunological reviews [Immunol Rev] 2025 Oct; Vol. 335 (1), pp. e70063.

Publication Type: Journal Article; Review

Journal Info: Publisher: Blackwell Country of Publication: England NLM ID: 7702118 Publication Model: Print Cited Medium: Internet ISSN: 1600-065X (Electronic) Linking ISSN: 01052896 NLM ISO Abbreviation: Immunol Rev Subsets: MEDLINE

MeSH Terms: Tertiary Lymphoid Structures*/immunology , Tertiary Lymphoid Structures*/metabolism , Lymphoid Tissue*/immunology, Humans ; Animals ; Neoplasms/immunology ; Organ Specificity ; Autoimmunity ; Germinal Center/immunology

Prognostic Value of Tertiary Lymphoid Structures in Epithelial Ovarian Carcinoma.

Authors: Nakao T Harano K Wakabayashi M et al.

Source: Anticancer research [Anticancer Res] 2025 Dec; Vol. 45 (12), pp. 5543-5555.

Publication Type: Journal Article

Journal Info: Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 8102988 Publication Model: Print Cited Medium: Internet ISSN: 1791-7530 (Electronic) Linking ISSN: 02507005 NLM ISO Abbreviation: Anticancer Res Subsets: MEDLINE

MeSH Terms: Carcinoma, Ovarian Epithelial*/pathology , Carcinoma, Ovarian Epithelial*/surgery , Carcinoma, Ovarian Epithelial*/immunology , Carcinoma, Ovarian Epithelial*/mortality , Tertiary Lymphoid Structures*/pathology , Tertiary Lymphoid Structures*/immunology , Ovarian Neoplasms*/pathology , Ovarian Neoplasms*/surgery , Ovarian Neoplasms*/immunology , Ovarian Neoplasms*/mortality, Humans ; Female ; Prognosis ; Middle Aged ; Aged ; B7-H1 Antigen/metabolism ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/pathology ; Adult ; Cytoreduction Surgical Procedures ; Aged, 80 and over

From PD-1/PD-L1 to tertiary lymphoid structures: Paving the way for precision immunotherapy in cholangiocarcinoma treatment.

Authors: Huang FJ Fang YY Wen JY et al.

Source: Human vaccines & immunotherapeutics [Hum Vaccin Immunother] 2025 Dec; Vol. 21 (1), pp. 2444697. Date of Electronic Publication: 2025 Jan 06.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101572652 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2164-554X (Electronic) Linking ISSN: 21645515 NLM ISO Abbreviation: Hum Vaccin Immunother Subsets: MEDLINE

MeSH Terms: B7-H1 Antigen*/immunology , B7-H1 Antigen*/antagonists & inhibitors , Bile Duct Neoplasms*/immunology , Bile Duct Neoplasms*/mortality , Bile Duct Neoplasms*/therapy , Cholangiocarcinoma*/immunology , Cholangiocarcinoma*/mortality , Cholangiocarcinoma*/therapy , Immunotherapy*/methods , Programmed Cell Death 1 Receptor*/immunology , Programmed Cell Death 1 Receptor*/antagonists & inhibitors , Tertiary Lymphoid Structures*/immunology , Bibliometrics*, Humans ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Precision Medicine/methods ; Tumor Microenvironment/immunology

Spatial immunoprofiling of retroperitoneal leiomyosarcomas reveals intratumoral heterogeneity in immune cell infiltration, checkpoint molecule expression, and tertiary lymphoid structures.

Authors: Benesova I Balko J Tovazhnianska V et al.

Source: Annals of medicine [Ann Med] 2025 Dec; Vol. 57 (1), pp. 2568725. Date of Electronic Publication: 2025 Oct 13.

Publication Type: Journal Article

Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8906388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2060 (Electronic) Linking ISSN: 07853890 NLM ISO Abbreviation: Ann Med Subsets: MEDLINE

MeSH Terms: Leiomyosarcoma*/immunology , Leiomyosarcoma*/pathology , Retroperitoneal Neoplasms*/immunology , Retroperitoneal Neoplasms*/pathology , Tertiary Lymphoid Structures*/immunology , Tertiary Lymphoid Structures*/pathology, Humans ; B7-H1 Antigen/metabolism ; B7-H1 Antigen/immunology ; Programmed Cell Death 1 Receptor/metabolism ; Programmed Cell Death 1 Receptor/immunology ; Immune Checkpoint Inhibitors/therapeutic use ; Lymphocyte Activation Gene 3 Protein ; Male ; Female ; Lymphocytes, Tumor-Infiltrating/immunology ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Middle Aged ; Antigens, CD/metabolism ; Aged ; Tumor Microenvironment/immunology

Mature tertiary lymphoid structures linked to HPV status and anti-PD-1 based chemoimmunotherapy response in head and neck squamous cell carcinoma.

Authors: Zhang L Ren S Lan T et al.

Source: Oncoimmunology [Oncoimmunology] 2025 Dec; Vol. 14 (1), pp. 2528109. Date of Electronic Publication: 2025 Jul 07.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101570526 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2162-402X (Electronic) Linking ISSN: 21624011 NLM ISO Abbreviation: Oncoimmunology Subsets: MEDLINE

MeSH Terms: Squamous Cell Carcinoma of Head and Neck*/immunology , Squamous Cell Carcinoma of Head and Neck*/virology , Squamous Cell Carcinoma of Head and Neck*/drug therapy , Squamous Cell Carcinoma of Head and Neck*/pathology , Head and Neck Neoplasms*/immunology , Head and Neck Neoplasms*/virology , Head and Neck Neoplasms*/drug therapy , Head and Neck Neoplasms*/pathology , Tertiary Lymphoid Structures*/immunology , Tertiary Lymphoid Structures*/pathology , Tertiary Lymphoid Structures*/virology , Papillomavirus Infections*/virology , Papillomavirus Infections*/complications , Papillomavirus Infections*/immunology , Immune Checkpoint Inhibitors*/therapeutic use , Immune Checkpoint Inhibitors*/pharmacology, Humans ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Immunotherapy/methods ; Male ; Lymphocytes, Tumor-Infiltrating/immunology ; Papillomaviridae

Identifying the potential therapeutic targets of tertiary lymphoid structure in IgA nephropathy based on bioinformatics.

Authors: Zou M Yang D Xu H et al.

Source: Autoimmunity [Autoimmunity] 2025 Dec; Vol. 58 (1), pp. 2519285. Date of Electronic Publication: 2025 Jun 23.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 8900070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1607-842X (Electronic) Linking ISSN: 08916934 NLM ISO Abbreviation: Autoimmunity Subsets: MEDLINE

MeSH Terms: Glomerulonephritis, IGA*/genetics , Glomerulonephritis, IGA*/immunology , Glomerulonephritis, IGA*/therapy , Glomerulonephritis, IGA*/pathology , Glomerulonephritis, IGA*/metabolism , Computational Biology*/methods , Tertiary Lymphoid Structures*/genetics , Tertiary Lymphoid Structures*/immunology , Tertiary Lymphoid Structures*/pathology, Humans ; Protein Interaction Maps ; Gene Expression Profiling ; Databases, Genetic ; Gene Regulatory Networks ; Gene Ontology

Single-cell and spatial transcriptomics implicate a prognostic function of tertiary lymphoid structures in gastric cancer.

Authors: Wang Y Zhang G Zhang X et al.

Source: Nature communications [Nat Commun] 2025 Nov 25; Vol. 16 (1), pp. 10435. Date of Electronic Publication: 2025 Nov 25.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH Terms: Stomach Neoplasms*/genetics , Stomach Neoplasms*/pathology , Stomach Neoplasms*/immunology , Stomach Neoplasms*/metabolism , Tertiary Lymphoid Structures*/pathology , Tertiary Lymphoid Structures*/immunology , Tertiary Lymphoid Structures*/genetics , Tertiary Lymphoid Structures*/metabolism , Transcriptome*, Humans ; Chemokine CXCL13/metabolism ; Chemokine CXCL13/genetics ; Single-Cell Analysis/methods ; Prognosis ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Receptors, CXCR5/metabolism ; Receptors, CXCR5/genetics ; Intercellular Adhesion Molecule-1/metabolism ; Gene Expression Profiling ; Tumor Microenvironment/immunology ; Female ; Male ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Gene Expression Regulation, Neoplastic ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Vascular Cell Adhesion Molecule-1/metabolism ; Lymphocytes, Tumor-Infiltrating/immunology ; Germinal Center/immunology ; Middle Aged

Mapping B cells and the immune landscape of tertiary lymphoid structures reveals their clinical impact in neuroblastoma.

Authors: Melaiu O Chierici M Gragera P et al.

Source: Journal for immunotherapy of cancer [J Immunother Cancer] 2025 Nov 11; Vol. 13 (11). Date of Electronic Publication: 2025 Nov 11.

Publication Type: Journal Article

Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE

MeSH Terms: Neuroblastoma*/immunology , Neuroblastoma*/pathology , Neuroblastoma*/genetics , Tertiary Lymphoid Structures*/immunology , Tertiary Lymphoid Structures*/pathology , B-Lymphocytes*/immunology , B-Lymphocytes*/metabolism, Humans ; Male ; Female ; Child ; Prognosis ; Child, Preschool ; Tumor Microenvironment/immunology ; Infant ; Lymphocytes, Tumor-Infiltrating/immunology