Výsledky vyhľadávania - "requirement"

Molecular dynamics simulation-driven focused virtual screening and experimental validation of Fisetin as an inhibitor of Helicobacter pylori HtrA protease.

Autori: Gao L Jiang X Duan H a ďalší

Zdroj: Molecular diversity [Mol Divers] 2025 Dec; Vol. 29 (6), pp. 6243-6258. Date of Electronic Publication: 2025 Feb 23.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE

Výrazy zo slovníka MeSH: Helicobacter pylori*/enzymology , Helicobacter pylori*/drug effects , Molecular Dynamics Simulation* , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Flavonoids*/pharmacology , Flavonoids*/chemistry , Bacterial Proteins*/antagonists & inhibitors , Bacterial Proteins*/chemistry , Bacterial Proteins*/metabolism , Serine Proteinase Inhibitors*/pharmacology , Serine Proteinase Inhibitors*/chemistry , High-Temperature Requirement A Serine Peptidase 1*/antagonists & inhibitors , High-Temperature Requirement A Serine Peptidase 1*/chemistry, Flavonols ; Molecular Docking Simulation ; Humans ; Caseins/metabolism ; Drug Evaluation, Preclinical

Heterologous Expression, Purification, and Characterization of a High-Temperature Requirement A (HtrA) Protease Homologue from Leptospira.

Autori: Kumari P Singh G Singh SK a ďalší

Zdroj: Applied biochemistry and biotechnology [Appl Biochem Biotechnol] 2025 Nov; Vol. 197 (11), pp. 7215-7235. Date of Electronic Publication: 2025 Sep 06.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Humana Press Country of Publication: United States NLM ID: 8208561 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0291 (Electronic) Linking ISSN: 02732289 NLM ISO Abbreviation: Appl Biochem Biotechnol Subsets: MEDLINE

Výrazy zo slovníka MeSH: High-Temperature Requirement A Serine Peptidase 1*/chemistry , High-Temperature Requirement A Serine Peptidase 1*/genetics , High-Temperature Requirement A Serine Peptidase 1*/isolation & purification , Leptospira*/enzymology , Bacterial Proteins*/chemistry , Bacterial Proteins*/genetics , Bacterial Proteins*/isolation & purification, Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification ; Amino Acid Sequence ; Cloning, Molecular ; Hydrogen-Ion Concentration ; Temperature ; Protein Binding ; Humans ; Cell Line, Tumor

The serine protease HTRA1 targets tau fibrils and provides a proteolytic barrier against pathogenic protein conformations.

Autori: Hagemeier B Ripkens K Schulze N a ďalší

Zdroj: The Journal of biological chemistry [J Biol Chem] 2025 Oct; Vol. 301 (10), pp. 110729. Date of Electronic Publication: 2025 Sep 16.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: High-Temperature Requirement A Serine Peptidase 1*/metabolism , High-Temperature Requirement A Serine Peptidase 1*/genetics , tau Proteins*/metabolism , tau Proteins*/chemistry , tau Proteins*/genetics , Proteolysis* , Amyloid*/metabolism , Amyloid*/chemistry , Amyloid*/genetics, Humans ; Protein Conformation ; HEK293 Cells ; Animals

The serine protease HtrA regulates Group B Streptococcus virulence and affects the host response to infection.

Autori: Brokaw A Wallen G Orvis A a ďalší

Zdroj: PLoS pathogens [PLoS Pathog] 2025 Oct 06; Vol. 21 (10), pp. e1013562. Date of Electronic Publication: 2025 Oct 06 (Print Publication: 2025).

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE

Výrazy zo slovníka MeSH: Streptococcus agalactiae*/pathogenicity , Streptococcus agalactiae*/enzymology , Streptococcus agalactiae*/genetics , Streptococcal Infections*/microbiology , Streptococcal Infections*/immunology , Streptococcal Infections*/pathology , Bacterial Proteins*/metabolism , Bacterial Proteins*/genetics , Pregnancy Complications, Infectious*/microbiology , High-Temperature Requirement A Serine Peptidase 1*/metabolism, Female ; Pregnancy ; Animals ; Mice ; Virulence ; Humans ; Virulence Factors/metabolism

Typical "brainstem chocolate chip sign" in heterozygous HTRA1-related cerebral small vessel disease.

Autori: Guo Y Peng Q Ling C

Zdroj: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2025 Oct; Vol. 46 (10), pp. 5581-5584. Date of Electronic Publication: 2025 Jul 09.

Spôsob vydávania: Case Reports; Journal Article

Informácie o časopise: Publisher: Springer-Verlag Italia Country of Publication: Italy NLM ID: 100959175 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1590-3478 (Electronic) Linking ISSN: 15901874 NLM ISO Abbreviation: Neurol Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: High-Temperature Requirement A Serine Peptidase 1*/genetics , Cerebral Small Vessel Diseases*/genetics , Cerebral Small Vessel Diseases*/diagnostic imaging , Cerebral Small Vessel Diseases*/pathology , Cerebral Small Vessel Diseases*/complications , Brain Stem*/diagnostic imaging , Brain Stem*/pathology, Humans ; Male ; Middle Aged ; Magnetic Resonance Imaging ; Heterozygote

Human papillomavirus E7 inhibits immune responses in keratinocytes by activating HTRA1‑mediated mitophagy.

Autori: Zhang B Kong D Chen S a ďalší

Zdroj: International journal of molecular medicine [Int J Mol Med] 2026 Jan; Vol. 57 (1). Date of Electronic Publication: 2025 Nov 14.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9810955 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-244X (Electronic) Linking ISSN: 11073756 NLM ISO Abbreviation: Int J Mol Med Subsets: MEDLINE

Výrazy zo slovníka MeSH: Keratinocytes*/immunology , Keratinocytes*/virology , Keratinocytes*/metabolism , Mitophagy*/immunology , Mitophagy*/genetics , Papillomavirus E7 Proteins*/metabolism , Papillomavirus E7 Proteins*/genetics , Papillomavirus E7 Proteins*/immunology , High-Temperature Requirement A Serine Peptidase 1*/metabolism , High-Temperature Requirement A Serine Peptidase 1*/genetics , Human papillomavirus 16*/immunology, Humans ; Papillomavirus Infections/immunology ; Papillomavirus Infections/virology ; Interferon Type I/metabolism ; Protein Kinases/metabolism ; Signal Transduction ; Cell Line, Tumor ; Ubiquitin-Protein Ligases/metabolism ; Human Papillomavirus Viruses

KLF13 promotes breast cancer progression through the HTRA1 and the Hedgehog signaling pathway.

Autori: Huang M Zhang J Yan C a ďalší

Zdroj: Breast cancer (Tokyo, Japan) [Breast Cancer] 2025 Sep; Vol. 32 (5), pp. 1088-1101. Date of Electronic Publication: 2025 Jun 24.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Maruzen Co Country of Publication: Japan NLM ID: 100888201 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1880-4233 (Electronic) Linking ISSN: 13406868 NLM ISO Abbreviation: Breast Cancer Subsets: MEDLINE

Výrazy zo slovníka MeSH: Breast Neoplasms*/pathology , Breast Neoplasms*/genetics , Breast Neoplasms*/immunology , Breast Neoplasms*/metabolism , Hedgehog Proteins*/metabolism , High-Temperature Requirement A Serine Peptidase 1*/metabolism , High-Temperature Requirement A Serine Peptidase 1*/genetics , Kruppel-Like Transcription Factors*/metabolism , Kruppel-Like Transcription Factors*/genetics , Repressor Proteins*/metabolism , Repressor Proteins*/genetics, Humans ; Female ; Signal Transduction ; Animals ; Mice ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Disease Progression ; Cell Line, Tumor ; Cell Movement/genetics ; Tumor Escape/genetics ; Xenograft Model Antitumor Assays

BASP1/HTRA2 axis, targeted by miR-7a-5p, exerted a pro-apoptosis role in myocardial ischemia/reperfusion injury.

Autori: Zi C Zhu Y Ma X a ďalší

Zdroj: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2025 Sep; Vol. 502, pp. 117437. Date of Electronic Publication: 2025 Jun 06.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0333 (Electronic) Linking ISSN: 0041008X NLM ISO Abbreviation: Toxicol Appl Pharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: MicroRNAs*/genetics , MicroRNAs*/metabolism , Apoptosis*/physiology , High-Temperature Requirement A Serine Peptidase 2*/metabolism , High-Temperature Requirement A Serine Peptidase 2*/genetics , Myocardial Reperfusion Injury*/pathology , Myocardial Reperfusion Injury*/genetics , Myocardial Reperfusion Injury*/metabolism , Membrane Proteins*/genetics , Membrane Proteins*/metabolism , Nerve Tissue Proteins*/genetics , Nerve Tissue Proteins*/metabolism, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Myocytes, Cardiac/pathology ; Myocytes, Cardiac/metabolism ; Disease Models, Animal ; Cell Line ; Signal Transduction ; Myocardial Infarction/pathology ; Myocardial Infarction/genetics ; Intracellular Signaling Peptides and Proteins

Select Azo Compounds Post-translationally Modulate HTRA1 Abundance and Activity Potentially through Interactions at the Trimer Interface.

Autori: Hulleman JD Jeon S Bali S a ďalší

Zdroj: ACS chemical biology [ACS Chem Biol] 2025 Aug 15; Vol. 20 (8), pp. 1849-1862. Date of Electronic Publication: 2025 Jul 30.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

Výrazy zo slovníka MeSH: High-Temperature Requirement A Serine Peptidase 1*/metabolism , High-Temperature Requirement A Serine Peptidase 1*/genetics , High-Temperature Requirement A Serine Peptidase 1*/chemistry , Azo Compounds*/pharmacology , Azo Compounds*/chemistry , Protein Processing, Post-Translational*/drug effects, Humans ; Macular Degeneration/genetics ; Retinal Pigment Epithelium/metabolism ; CRISPR-Cas Systems

Downregulation of HTRA1 Promotes EMT and Anoikis Resistance in Colorectal Cancer via Activation of Hippo/YAP1 Pathway by Facilitating LATS2 Degradation.

Autori: Jiang Z Li X Liu F a ďalší

Zdroj: Molecular carcinogenesis [Mol Carcinog] 2025 Aug; Vol. 64 (8), pp. 1330-1346. Date of Electronic Publication: 2025 May 26.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8811105 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-2744 (Electronic) Linking ISSN: 08991987 NLM ISO Abbreviation: Mol Carcinog Subsets: MEDLINE

Výrazy zo slovníka MeSH: Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/metabolism , Epithelial-Mesenchymal Transition*/genetics , Protein Serine-Threonine Kinases*/metabolism , Protein Serine-Threonine Kinases*/genetics , Anoikis*/genetics , Tumor Suppressor Proteins*/metabolism , Tumor Suppressor Proteins*/genetics , Transcription Factors*/metabolism , Transcription Factors*/genetics , Adaptor Proteins, Signal Transducing*/metabolism , Adaptor Proteins, Signal Transducing*/genetics , High-Temperature Requirement A Serine Peptidase 1*/genetics , High-Temperature Requirement A Serine Peptidase 1*/metabolism, Humans ; YAP-Signaling Proteins ; Hippo Signaling Pathway ; Mice ; Animals ; Gene Expression Regulation, Neoplastic ; Signal Transduction ; Down-Regulation ; Female ; Male ; Prognosis ; Cell Line, Tumor ; Middle Aged ; Mice, Nude ; Proteolysis

Cerebral small vessel disease related to a heterozygous missense mutation in HTRA1: A case report.

Autori: Gao Y Zheng Y Lian J a ďalší

Zdroj: Medicine [Medicine (Baltimore)] 2025 Aug 29; Vol. 104 (35), pp. e44128.

Spôsob vydávania: Journal Article; Case Reports

Informácie o časopise: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE

Výrazy zo slovníka MeSH: Cerebral Small Vessel Diseases*/genetics , Cerebral Small Vessel Diseases*/drug therapy , High-Temperature Requirement A Serine Peptidase 1*/genetics , Mutation, Missense*, Female ; Humans ; Heterozygote ; Leukoencephalopathies/genetics ; Magnetic Resonance Imaging ; Alopecia ; Cerebral Infarction ; Spinal Diseases

SCR Disease Name: Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy

Diagnostic performance of "pons chocolate chip sign" in heterozygous HTRA1-related cerebral small vessel disease.

Autori: Guo Y Peng Q Yang Y a ďalší

Zdroj: BMC neurology [BMC Neurol] 2025 Aug 27; Vol. 25 (1), pp. 360. Date of Electronic Publication: 2025 Aug 27.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 100968555 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2377 (Electronic) Linking ISSN: 14712377 NLM ISO Abbreviation: BMC Neurol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Cerebral Small Vessel Diseases*/genetics , Cerebral Small Vessel Diseases*/diagnostic imaging , High-Temperature Requirement A Serine Peptidase 1*/genetics , CADASIL*/diagnostic imaging , CADASIL*/genetics , Pons*/diagnostic imaging, Humans ; Male ; Female ; Cross-Sectional Studies ; Middle Aged ; Magnetic Resonance Imaging ; Adult ; Aged ; Heterozygote ; Sensitivity and Specificity

Widening the Spectrum of Fusion Events in Schwannoma: Identification of a Novel TANC1::HTRA1 Fusion.

Autori: Watkins JA Tarpey P O'Donovan M a ďalší

Zdroj: Genes, chromosomes & cancer [Genes Chromosomes Cancer] 2025 Aug; Vol. 64 (8), pp. e70072.

Spôsob vydávania: Case Reports; Journal Article

Informácie o časopise: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 9007329 Publication Model: Print Cited Medium: Internet ISSN: 1098-2264 (Electronic) Linking ISSN: 10452257 NLM ISO Abbreviation: Genes Chromosomes Cancer Subsets: MEDLINE

Výrazy zo slovníka MeSH: High-Temperature Requirement A Serine Peptidase 1*/genetics , Neurilemmoma*/genetics , Neurilemmoma*/pathology , Oncogene Proteins, Fusion*/genetics, Female ; Humans ; Middle Aged

Phase 2 Study of the Anti-High Temperature Requirement A1 (HtrA1) Fab Galegenimab (FHTR2163) in Geographic Atrophy Secondary to Age-Related Macular Degeneration.

Autori: Eichenbaum DA Holekamp N Khanani AM a ďalší

Zdroj: American journal of ophthalmology [Am J Ophthalmol] 2025 Jul; Vol. 275, pp. 14-26. Date of Electronic Publication: 2025 Mar 13.

Spôsob vydávania: Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial; Multicenter Study

Informácie o časopise: Publisher: Elsevier Science Country of Publication: United States NLM ID: 0370500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1891 (Electronic) Linking ISSN: 00029394 NLM ISO Abbreviation: Am J Ophthalmol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Geographic Atrophy*/drug therapy , Geographic Atrophy*/etiology , Geographic Atrophy*/diagnosis , Geographic Atrophy*/physiopathology , High-Temperature Requirement A Serine Peptidase 1*/antagonists & inhibitors , Antibodies, Monoclonal, Humanized*/therapeutic use , Antibodies, Monoclonal, Humanized*/administration & dosage , Immunoglobulin Fab Fragments*/therapeutic use , Macular Degeneration*/complications , Macular Degeneration*/drug therapy, Humans ; Male ; Female ; Intravitreal Injections ; Aged ; Visual Acuity/physiology ; Single-Blind Method ; Fluorescein Angiography ; Aged, 80 and over ; Tomography, Optical Coherence ; Treatment Outcome ; Middle Aged

HTRA1 and complement activation in neovascular age-related macular degeneration.

Autori: Tanaka K Omori T Oguchi Y a ďalší

Zdroj: Japanese journal of ophthalmology [Jpn J Ophthalmol] 2025 May; Vol. 69 (3), pp. 453-459. Date of Electronic Publication: 2025 Feb 12.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Springer Tokyo Country of Publication: Japan NLM ID: 0044652 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1613-2246 (Electronic) Linking ISSN: 00215155 NLM ISO Abbreviation: Jpn J Ophthalmol Subsets: MEDLINE

Výrazy zo slovníka MeSH: High-Temperature Requirement A Serine Peptidase 1*/metabolism , High-Temperature Requirement A Serine Peptidase 1*/genetics , Wet Macular Degeneration*/metabolism , Wet Macular Degeneration*/genetics , Wet Macular Degeneration*/diagnosis , Aqueous Humor*/metabolism , Complement Activation*/physiology, Humans ; Male ; Female ; Cross-Sectional Studies ; Aged ; Genotype ; Aged, 80 and over ; Vascular Endothelial Growth Factor A/metabolism ; Middle Aged ; Tomography, Optical Coherence ; Fluorescein Angiography ; Proteins

Unraveling the genetic underpinnings of mitochondrial traits and associated circulating inflammatory proteins in Alzheimer's disease: Mitochondrial HtrA2-T cell CD5 negative axis.

Autori: Wang Y Wu Z Zheng Y a ďalší

Zdroj: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2025 May; Vol. 105 (2), pp. 505-518. Date of Electronic Publication: 2025 Apr 01.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: SAGE Publications Country of Publication: United States NLM ID: 9814863 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-8908 (Electronic) Linking ISSN: 13872877 NLM ISO Abbreviation: J Alzheimers Dis Subsets: MEDLINE

Výrazy zo slovníka MeSH: Alzheimer Disease*/genetics , Mitochondria*/genetics , Mitochondria*/metabolism , High-Temperature Requirement A Serine Peptidase 2*/genetics, Humans ; Genome-Wide Association Study ; Mendelian Randomization Analysis

Single-cell transcriptomic analysis and luteolin treatment reveal three adipogenic genes, including Aspn, Htra1 and Efemp1.

Autori: Tao T Xu Y Zhang CH a ďalší

Zdroj: Biochimica et biophysica acta. Molecular and cell biology of lipids [Biochim Biophys Acta Mol Cell Biol Lipids] 2025 Mar; Vol. 1870 (2), pp. 159585. Date of Electronic Publication: 2024 Dec 09.

Spôsob vydávania: Journal Article; Research Support, Non-U.S. Gov't

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731727 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2618 (Electronic) Linking ISSN: 13881981 NLM ISO Abbreviation: Biochim Biophys Acta Mol Cell Biol Lipids Subsets: MEDLINE

Výrazy zo slovníka MeSH: Luteolin*/pharmacology , Adipogenesis*/genetics , Adipogenesis*/drug effects , High-Temperature Requirement A Serine Peptidase 1*/genetics , High-Temperature Requirement A Serine Peptidase 1*/metabolism , Transcriptome*/drug effects , Extracellular Matrix Proteins*/genetics , Extracellular Matrix Proteins*/metabolism, Animals ; Mice ; 3T3-L1 Cells ; Single-Cell Analysis/methods ; Mice, Inbred C57BL ; Male ; Gene Expression Profiling ; Diet, High-Fat/adverse effects ; Obesity/genetics ; Obesity/metabolism

Ablation of Htra1 leads to sub-RPE deposits and photoreceptor abnormalities.

Autori: Biswas P Woodard DR Hollingsworth TJ a ďalší

Zdroj: JCI insight [JCI Insight] 2025 Feb 10; Vol. 10 (3). Date of Electronic Publication: 2025 Feb 10.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE

Výrazy zo slovníka MeSH: High-Temperature Requirement A Serine Peptidase 1*/genetics , High-Temperature Requirement A Serine Peptidase 1*/metabolism , Retinal Pigment Epithelium*/pathology , Retinal Pigment Epithelium*/metabolism , Retinal Pigment Epithelium*/ultrastructure , Macular Degeneration*/pathology , Macular Degeneration*/genetics , Macular Degeneration*/metabolism, Animals ; Mice ; Mice, Knockout ; Disease Models, Animal ; Bruch Membrane/pathology ; Bruch Membrane/metabolism ; Retina/pathology ; Retina/metabolism ; Mice, Inbred C57BL

Electrophysiology-based screening identifies neuronal HtrA serine peptidase 2 (HTRA2) as a synaptic plasticity regulator participating in tauopathy.

Autori: Zheng N Li K Cao J a ďalší

Zdroj: Translational psychiatry [Transl Psychiatry] 2025 Jan 10; Vol. 15 (1), pp. 5. Date of Electronic Publication: 2025 Jan 10.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE

Výrazy zo slovníka MeSH: High-Temperature Requirement A Serine Peptidase 2*/metabolism , High-Temperature Requirement A Serine Peptidase 2*/genetics , Neuronal Plasticity*/physiology , Neurons*/metabolism , Long-Term Potentiation*/physiology , Tauopathies*/metabolism , Tauopathies*/physiopathology, Animals ; Mice ; Mice, Inbred C57BL ; Humans ; Hippocampus/metabolism ; Male ; Alzheimer Disease/metabolism ; Alzheimer Disease/physiopathology ; Disease Models, Animal ; Proteomics ; Female ; Long-Term Synaptic Depression/physiology

Association of polymorphisms in the HTRA1 gene with myopia.

Autori: Chen SY Xu YM Tam POS a ďalší

Zdroj: The British journal of ophthalmology [Br J Ophthalmol] 2025 Mar 20; Vol. 109 (4), pp. 456-462. Date of Electronic Publication: 2025 Mar 20.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 0421041 Publication Model: Electronic Cited Medium: Internet ISSN: 1468-2079 (Electronic) Linking ISSN: 00071161 NLM ISO Abbreviation: Br J Ophthalmol Subsets: MEDLINE

Výrazy zo slovníka MeSH: High-Temperature Requirement A Serine Peptidase 1*/genetics , Myopia*/genetics , Polymorphism, Single Nucleotide*, Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Genotype ; Genotyping Techniques ; Haplotypes ; Hong Kong/epidemiology ; East Asian People/genetics