Search Results - "plasma half life"

Long-Acting Human PASylated Leptin Reaches the Murine Central Nervous System and Offers Potential for Optimized Replacement Therapy

Authors: Volker Morath Stefanie Maurer Annette Feuchtinger et al.

Source: Mol Pharm

Subject Terms: Article, adipokine, blood-brain barrier, light sheetfluorescence microscopy, obesity, PASylation, plasma half-life, ddc

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/40335095
https://mediatum.ub.tum.de/1785036

Real-World Assessment of Pharmacokinetics, Clinical Outcomes, and Costs After Switching from Standard Half-Life to Extended Half-Life FVIII in Well-Controlled Hemophilia A Patients

Authors: Maria Choví-Trull Juan Eduardo Megías-Vericat Santiago Bonanad-Boix et al.

Source: Hematology Reports, Vol 17, Iss 5, p 53 (2025)

Subject Terms: hemophilia A, pharmacokinetics, factor VIII, plasma half-life, polyethylene glycols, turoctocog alfa pegol, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://www.mdpi.com/2038-8330/17/5/53; https://doaj.org/toc/2038-8330

Access URL: https://doaj.org/article/7d7e637890b64f9ea63eb78122c57b25

A Chaos-Driven Fractional ψ–Hamzah Model for Targeted Elimination of Pancreatic Cancer Stem Cells (CSCs) via Nano-Liposomal Drug–Vaccine Conjugates

Authors: JALALI, SEYED RASOUL

Subject Terms: ψ–Hamzah model, pancreatic ductal adenocarcinoma, PDAC therapy, pancreatic cancer stem cells, CSC targeting, tumor microenvironment modeling, KRAS G12D mutation therapy, TP53 mutation pathways, TGF-β signaling alteration, fibroblast-rich stroma resistance, tumor heterogeneity, metastasis modeling, fractional calculus in oncology, Caputo derivative in tumor modeling, fractional-order pharmacokinetics, fractal tumor geometry, chaotic immune–tumor interaction, non-linear cancer dynamics, Gompertz model limitations, logistic tumor model, immune suppression modeling, tumor–immune tensor field, stromal–vascular microenvironment, cancer stem cell relapse, tumor recurrence prevention, drug resistance modeling, nanovaccine design, MUC1-Tn glycopeptide antigen, KRAS^G12D mutant epitope vaccine, mesothelin peptide vaccine, CpG ODN adjuvant, MPLA adjuvant durability, PLGA nanoparticle carriers, w/o/w double emulsion method, nanoparticle encapsulation efficiency, nanoparticle zeta potential, DLS particle size analysis, immune durability T-cell response, IgG antibody formation, systemic immunological memory, vaccine stability, injection-site inflammation, absence of anaphylaxis, apoptosis induction in CSCs, tumor inhibition percentages, long-term immune durability, nano-liposomal drug delivery, Hamzah-CSC Inhibitor (HCI-1), Wnt/β-catenin pathway inhibition, GAPDH metabolic blocking, glucose depletion therapy, NAD⁺ metabolism suppression, nicotinamide mononucleotide (NMN), PEGylated liposomal carriers, liposomal encapsulation process, liposomal pharmacokinetics, plasma half-life measurement, ECM penetration efficiency, CD133+ CSC marker targeting, biliary clearance safety, liposomal drug stability, lyophilization preservation, CSC apoptosis assays, Panc-1 CSC+ experimental validation, Annexin-V apoptosis measurement, IFN-γ secretion, IL-2 immune stimulation, cytokine release safety, multi-compartment PK models, fractional pharmacodynamics, Grünwald–Letnikov derivative, variable-order fractional calculus, chaotic tumor modeling, non-deterministic drug distribution, receptor binding kinetics, Michaelis–Menten clearance pathways, immune checkpoint resistance, immune feedback oscillations, tumor hypoxia modeling, fibrotic pressure dynamics, angiogenesis suppression, metastatic pattern remapping, fractal immune simulation, tensorial tumor analysis, fractional fractal immune stimulation, computational oncology, systems pharmacology, bioinformatics integration, pharmacogenomic modeling, in silico cancer modeling, mathematical oncology frameworks, tumor–drug–immunity integration, adaptive CSC modeling, chaos-stability tumor modeling, immune escape prevention, apoptosis without recurrence, nano-vaccine industrial synthesis, multiphase microfluidic bioreactors, PDMS anti-adhesive coating, laminar–chaotic convection control, precision nitrogen/oxygen gas flow, thermal loop heating, fractal-chaotic order ψ parameterization, CSC protein fractional derivative modeling, nanoparticle antigen conjugation, gold nanoparticle vaccines, maleimide–thiol chemical conjugation, antigen attachment conditions, storage stability in low RH, ultrafiltration nanoparticle purification, industrial scale-up protocols, pharmacological safety standards, EMA/FDA fast-track potential, WHO therapeutic guidelines, legal intellectual property protection, Creative Commons licensing, Zenodo registration, ScienceOpen registration, ORCID author profile, patient-specific tumor modeling, personalized oncology approaches, computational immunology, nanomedicine engineering, regenerative oncology, mathematical immune system modeling, chaos-driven tumor suppression, fractional memory-driven pharmacology, spatiotemporal tumor simulations, computational biophysics, immune checkpoint integration, advanced drug design, targeted immunotherapy, bioengineering cancer therapies, nanobiological oncology, therapeutic innovation pathways, oncological chaos modeling, CSC eradication without relapse, systemic immune activation, integrated therapy frameworks, vaccine–drug dual therapy, resistant PDAC solutions, multi-scale therapeutic optimization, quantum-inspired cancer modeling, fractal nanomedicine design, adaptive therapeutic dynamics, clinical translation of fractional models, chaos-based drug design, tumor eradication predictions, resistant pancreatic cancer cure strategies, apoptosis-driven remission, mathematical proof-of-concept oncology, high-fidelity simulation frameworks, long-term CSC suppression, translational oncology research, precision medicine in PDAC, computational chaos-based pharmacology, CSC relapse prevention, nanocarrier engineering, immune cell infiltration modeling, lymphocyte activation mapping, macrophage modulation, Treg suppression modeling, fractal dimension tumor pathways, CSC metabolic adaptability, apoptosis probability modeling, CSC niche targeting, fibroblast suppression, matrix remodeling therapy, tumor vascular normalization, PDAC drug synergy, pharmacological fractal engineering, experimental nanomedicine validation, chaotic immune response synchronization, CSC elimination strategies, biocompatible therapeutic systems, advanced oncology simulation, fractional systems biology, CSC resilience dismantling, universal ψ–Hamzah cancer framework

Complexing amphotericin B with gold nanoparticles improves fungal clearance from the brains of mice infected with Cryptococcal neoformans

Authors: Koteswara R Chintalacharuvu Zlatko A Matolek Benny Pacheco et al.

Source: Medical Mycology. 59:1085-1091

Subject Terms: 0301 basic medicine, Brain Diseases, 0303 health sciences, Antifungal Agents, Erythrocytes, Cryptococcosis, 3. Good health, plasma half-life, Disease Models, Animal, Mice, 03 medical and health sciences, Amphotericin B, Cryptococcus neoformans, Animals, Humans, Gold nanoparticles, human red blood cell toxicity, Gold, Cryptococcal meningoencephalitis

Access URL: https://academic.oup.com/mmy/article-pdf/59/11/1085/40811084/myab042.pdf
https://pubmed.ncbi.nlm.nih.gov/34332505
https://academic.oup.com/mmy/article/59/11/1085/6333233

Half-life of Fructosyl-valine in the Plasma of Chicks

Authors: Ryosuke Makino Natsuki Takahashi Kazumi Kita

Source: J Poult Sci
The Journal of Poultry Science, Vol 57, Iss 1, Pp 63-66 (2020)

Subject Terms: plasma half-life, 0301 basic medicine, Research Note, 03 medical and health sciences, amadori product, gastrointestinal absorption, 0402 animal and dairy science, fructosyl-valine, 04 agricultural and veterinary sciences, SF1-1100, Animal culture

Access URL: https://www.jstage.jst.go.jp/article/jpsa/57/1/57_0180150/_pdf
https://pubmed.ncbi.nlm.nih.gov/32174766
https://doaj.org/article/f92465272aea4c7f8fd28d8f613314ce
https://ci.nii.ac.jp/naid/130007792234
http://altmetrics.ceek.jp/article/www.jstage.jst.go.jp/article/jpsa/57/1/57_0180150/_article/-char/ja/
https://www.jstage.jst.go.jp/article/jpsa/57/1/57_0180150/_article/-char/ja/
https://pubmed.ncbi.nlm.nih.gov/32174766/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063081

Growing weapons to fight hemophilia

Authors: Pier Mannuccio Mannucci

Source: Bleeding, Thrombosis and Vascular Biology, Vol 2, Iss 1 (2023)

Subject Terms: plasma half-life, 03 medical and health sciences, rFVIII, 0302 clinical medicine, hemophilia, RC666-701, recombinant prophylactic therapy, efanesoctocog, Diseases of the circulatory (Cardiovascular) system, 3. Good health

Access URL: https://doaj.org/article/f396f7ea1aaa44e0a71ccd63bf1ca6c1

Accumulation and clearance of perfluorooctanoic acid (PFOA) in current and former residents of an exposed community.

Authors: Seals, Ryan Bartell, Scott M Steenland, Kyle

Source: Environmental health perspectives. 119(1)

Subject Terms: Adult, Aged, Caprylates: analysis, blood, Environmental Exposure: analysis, statistics & numerical data, Environmental Monitoring, Female, Fluorocarbons: analysis, blood, Half-Life, Humans, Male, Middle Aged, Models, Biological, Ohio, Questionnaires, Residence Characteristics: statistics & numerical data, Water Pollutants, Chemical: analysis, blood, Water Supply: analysis, West Virginia, Young Adult, C8, Half-life, Pfa, Pfoa, Serum levels, Water contaminationperfluorooctanoic acid, adult, article, bioaccumulation, blood level, concentration (parameters), environmental exposure, female, human, male, plasma clearance, plasma half life, pollution monitoring, priority journal, residential area, United States, water contamination, Adult, Aged, Environmental Exposure, Environmental Monitoring, Female, Fluorocarbons, Half-Life, Humans, Male, Middle Aged, Models, Biological, Octanoic Acids, Ohio, Questionnaires, Residence Characteristics, Water Pollutants, Chemical, Water Supply, West Virginia, Young Adult, Adult, Aged, Caprylates: analysis, blood, Environmental Exposure: analysis, statistics & numerical data, Environmental Monitoring, Female, Fluorocarbons: analysis, blood, Half-Life, Humans, Male, Middle Aged, Models, Biological, Ohio, Questionnaires, Residence Characteristics: statistics & numerical data, Water Pollutants, Chemical: analysis, blood, Water Supply: analysis, West Virginia, Young Adult, C8, Half-life, Pfa, Pfoa, Serum levels, Water contaminationperfluorooctanoic acid, adult, article, bioaccumulation, blood level, concentration (parameters), environmental exposure, female, human, male, plasma clearance, plasma half life, pollution monitoring, priority journal, residential area, United States, water contamination, Adult, Aged, Environmental Exposure, Environmental Monitoring, Female, Fluorocarbons, Half-Life, Humans, Male, Middle Aged, Models, Biological, Octanoic Acids, Ohio, Questionnaires, Residence Characteristics, Water Pollutants, Chemical, Water Supply, West Virginia, Young Adult

File Description: application/pdf

Access URL: https://escholarship.org/uc/item/79j411dt
https://escholarship.org/content/qt79j411dt/qt79j411dt.pdf

Surface protein engineering increases the circulation time of a cell membrane-based nanotherapeutic

Authors: Krishnamurthy, Sangeetha Muthukumaran, Padmalosini Jayakumar, Muthu Kumara Gnanasammandhan et al.

Contributors: Krishnamurthy, Sangeetha Muthukumaran, Padmalosini Jayakumar, Muthu Kumara Gnanasammandhan et al.

Source: Nanomedicine: Nanotechnology, Biology and Medicine. 18:169-178

Subject Terms: 0301 basic medicine, Surface Properties, CARRIER, Research & Experimental Medicine, Protein Engineering, THERAPY, DELIVERY, 03 medical and health sciences, Polylactic Acid-Polyglycolic Acid Copolymer, POLYETHYLENE-GLYCOL, NANOPARTICLES, Animals, Humans, Cell ghosts, Medicine [Science], Tissue Distribution, Nanoscience & Nanotechnology, Synthetic biology, PLASMA HALF-LIFE, Mice, Inbred BALB C, 0303 health sciences, Science & Technology, Research & Experimental, Cell Membrane, Blood Proteins, Nanoghosts, Dynamic Light Scattering, PROSTATE-CANCER, Rats, Nanomedicine, PASylation, HEK293 Cells, PEGYLATION, Drug delivery, Medicine, Science & Technology - Other Topics, Lipid polymer hybrid nanoparticles, Nanoparticles, Adsorption, Life Sciences & Biomedicine

Access URL: https://pubmed.ncbi.nlm.nih.gov/30853651
https://www.ncbi.nlm.nih.gov/pubmed/30853651
https://dr.ntu.edu.sg/handle/10356/150808
https://www.sciencedirect.com/science/article/pii/S1549963419300577
https://pubmed.ncbi.nlm.nih.gov/30853651/
https://hdl.handle.net/10356/150808

Site-Specific Introduction of Negative Charges on the Protein Surface for Improving Global Functions of Recombinant Fetal Hemoglobin

Authors: Karin Kettisen Cedric Dicko Emanuel Smeds et al.

Source: Frontiers in Molecular Biosciences, Vol 8 (2021)

Subject Terms: protein engineering, fetal hemoglobin, protein surface charge, DNA cleavage, small-angle X-ray scattering, plasma half-life, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmolb.2021.649007/full; https://doaj.org/toc/2296-889X

Access URL: https://doaj.org/article/5f6e14cddf714e8db7ae475fa6387fba

Complexing amphotericin B with gold nanoparticles improves fungal clearance from the brains of mice infected with Cryptococcal neoformans

Authors: Chintalacharuvu, Koteswara R. Matolek, Zlatko A. Pacheco, Benny et al.

Source: Medical Mycology, 59 (11)

Subject Terms: Cryptococcal meningoencephalitis, Amphotericin B, Gold nanoparticles, human red blood cell toxicity, plasma half-life

File Description: application/application/pdf

Relation: info:eu-repo/semantics/altIdentifier/wos/000720750400004; https://hdl.handle.net/20.500.11850/519144

Availability: https://hdl.handle.net/20.500.11850/519144
https://doi.org/10.3929/ethz-c-000519144

Effect of C-terminus Conjugation via Different Conjugation Chemistries on In Vivo Activity of Albumin-Conjugated Recombinant GLP-1

Authors: Junyong Park Mijeong Bak Kiyoon Min et al.

Source: Pharmaceutics, Vol 13, Iss 2, p 263 (2021)

Subject Terms: plasma half-life extension, albumin conjugation, in vivo glucose-lowering activity, glucagon-like peptide-1, Pharmacy and materia medica, RS1-441

Relation: https://www.mdpi.com/1999-4923/13/2/263; https://doaj.org/toc/1999-4923; https://doaj.org/article/c69c61edea3b48d9ab3e7c537a1c0278

Availability: https://doi.org/10.3390/pharmaceutics13020263
https://doaj.org/article/c69c61edea3b48d9ab3e7c537a1c0278

Molecular Design, Expression and Evaluation of PASylated Human Recombinant Erythropoietin with Enhanced Functional Properties

Authors: Hedayati, Mohammad Hossein Norouzian, Dariush Aminian, Mahdi et al.

Source: The Protein Journal. 36:36-48

Subject Terms: 0301 basic medicine, Molecular dynamic, Pharmacokinetic properties, 0303 health sciences, Biological activity, Gene Expression, Molecular Dynamics Simulation, Recombinant Proteins, Alcohol Oxidoreductases, Mice, 03 medical and health sciences, PASylation, 13. Climate action, Cricetinae, Plasma half-life, Animals, Humans, Erythropoietin

Access URL: https://pubmed.ncbi.nlm.nih.gov/28168382
https://europepmc.org/article/MED/28168382
https://www.ncbi.nlm.nih.gov/pubmed/28168382
https://link.springer.com/article/10.1007/s10930-017-9699-9
https://pubmed.ncbi.nlm.nih.gov/28168382/

Drug Delivery Strategies for Enhancing the Therapeutic Efficacy of Toxin-Derived Anti-Diabetic Peptides

Authors: Reeju Amatya Taehoon Park Seungmi Hwang et al.

Source: Toxins, Vol 12, Iss 313, p 313 (2020)

Subject Terms: toxin, diabetes, anti-diabetic peptide, drug delivery, plasma half-life, cell-penetrating peptide, Medicine

Relation: https://www.mdpi.com/2072-6651/12/5/313; https://doaj.org/toc/2072-6651; https://doaj.org/article/141e8f99b20146a0bb5bf5cbb8300263

Availability: https://doi.org/10.3390/toxins12050313
https://doaj.org/article/141e8f99b20146a0bb5bf5cbb8300263

Highly Variable Pharmacokinetics of Tyramine in Humans and Polymorphisms in OCT1, CYP2D6, and MAO-A

Authors: Rafehi, Muhammad Faltraco, Frank Matthaei, Johannes et al.

Contributors: Rafehi, Muhammad Faltraco, Frank Matthaei, Johannes et al.

Source: Front Pharmacol
Frontiers in Pharmacology, Vol 10 (2019)

Subject Terms: 0301 basic medicine, systolic blood pressure, genotype, Pressor response, OCT1, tyramine, oxidative deamination, human experiment, biogenic amine, genetic polymorphism, monoamine oxidase, organic cation transporter 1, plasma clearance, pharmacogenetics, 2. Zero hunger, ddc:610, 0303 health sciences, CYP2D6, adult, OCT1 gene, protein function, pressor response, 3. Good health, female, MAO, drug exposure, area under the curve, Tyramine, RM1-950, urine level, volunteer, Article, 4 hydroxyphenylacetic acid, in vivo study, 03 medical and health sciences, male, human, normal human, SLC22A1, cytochrome P450 2D6, Pharmacology, Monoamine oxidase, amine oxidase (flavin containing) isoenzyme A, Biogenic amine, drug metabolism, plasma half life, CYP2D6 gene, drug blood level, genetic variation, MAO A gene, drug metabolite, Therapeutics. Pharmacology, Dewey Decimal Classification::600 | Technik::610 | Medizin, Gesundheit, deamination

File Description: application/pdf

Access URL: https://www.frontiersin.org/articles/10.3389/fphar.2019.01297/pdf
https://pubmed.ncbi.nlm.nih.gov/31736764
https://doaj.org/article/f55790e222414a8e9795d76df9fa1ea9
https://www.frontiersin.org/article/10.3389/fphar.2019.01297/full
https://www.frontiersin.org/articles/10.3389/fphar.2019.01297/full
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831736/
https://pubmed.ncbi.nlm.nih.gov/31736764/
https://europepmc.org/article/MED/31736764
https://resolver.sub.uni-goettingen.de/purl?gs-1/16579
https://resolver.sub.uni-goettingen.de/purl?gro-2/68027
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/109314
https://opus.bibliothek.uni-augsburg.de/opus4/files/109314/fphar-10-01297.pdf
https://doi.org/10.3389/fphar.2019.01297
https://nbn-resolving.org/urn:nbn:de:bvb:384-opus4-1093147

Half-life of Glycated Tryptophan in the Plasma of Chickens

Authors: Ryosuke Makino Kazumi Kita

Source: The Journal of Poultry Science, Vol 55, Iss 2, Pp 117-119 (2018)

Subject Terms: chicken, glycation, php-thβc, plasma half-life, tryptophan, Animal culture, SF1-1100

File Description: electronic resource

Relation: https://www.jstage.jst.go.jp/article/jpsa/55/2/55_0170158/_html/-char/en; https://doaj.org/toc/1346-7395; https://doaj.org/toc/1349-0486

Access URL: https://doaj.org/article/5125a856c3df4355b876eb3b640507d5

In Vitro and In Vivo Evaluation of PEGylated Starch-Coated Iron Oxide Nanoparticles for Enhanced Photothermal Cancer Therapy

Authors: Reeju Amatya Seungmi Hwang Taehoon Park et al.

Source: Pharmaceutics, Vol 13, Iss 6, p 871 (2021)

Subject Terms: iron oxide nanoparticle, polyethylene glycol, plasma half-life, photothermal therapy, cancer, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/13/6/871; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/3fc6c040f8b4435c8eafa5f4a9fe1409

Pharmacokinetics, Safety, and Tolerability of Oxfendazole in Healthy Volunteers: a Randomized, Placebo-Controlled First-in-Human Single-Dose Escalation Study

Authors: An, G. Murry, D.J. Gajurel, K. et al.

Source: Antimicrobial Agents and Chemotherapy. 63

Subject Terms: Male, double blind procedure, drug safety, ultra performance liquid chromatography, limit of quantitation, phase 1 clinical trial, Clinical pharmacokinetics, diarrhea, Administration, Oral, volume of distribution, 0302 clinical medicine, aspartate aminotransferase, Anthelmintic agent, drug dose regimen, adult, single drug dose, Middle Aged, Healthy Volunteers, sore throat, unclassified drug, 3. Good health, female, leukocytosis, priority journal, oxfendazole glucuronide, Female, First-in-human study, eosinophilia, bicarbonate blood level, Half-Life, Adult, oxfendazole, drug exposure, pharmacokinetic parameters, side effect, Adolescent, area under the curve, Biological Availability, bicarbonate, urinary excretion, oxfendazole sulfate, Article, Young Adult, 03 medical and health sciences, male, Double-Blind Method, first in human study, activated partial thromboplastin time, neutropenia, no-observed-adverse-effect level, Humans, controlled study, human, normal human, arthralgia, Oxfendazole, fenbendazole, liquid chromatography-mass spectrometry, elimination half-life, viral gastroenteritis, Dose-Response Relationship, Drug, Cysticercosis, maximum plasma concentration, oxfendazole sulfone, leukopenia, drug bioavailability, renal clearance, major clinical study, drug metabolism, flatulence, plasma half life, intestine absorption, time to maximum plasma concentration, elimination rate constant, randomized controlled trial, drug solubility, PR interval, drug metabolite, Benzimidazoles, drug dose escalation, drug tolerability, plasma concentration-time curve

Access URL: https://aac.asm.org/content/aac/63/4/e02255-18.full.pdf
https://pubmed.ncbi.nlm.nih.gov/30745383
https://www.ncbi.nlm.nih.gov/pubmed/30745383
https://pubmed.ncbi.nlm.nih.gov/30745383/
https://siis.unmsm.edu.pe/en/publications/pharmacokinetics-safety-and-tolerability-of-oxfendazole-in-health-4
https://europepmc.org/article/PMC/PMC6437481
https://jhu.pure.elsevier.com/en/publications/pharmacokinetics-safety-and-tolerability-of-oxfendazole-in-health
https://repositorio.upch.edu.pe/handle/20.500.12866/7396

Influence of protein properties and protein modification on biodistribution and tumor uptake of anticancer antibodies, antibody derivatives, and non-Ig scaffolds

Authors: Warnders, Frank-Jan Lub-de Hooge, Marjolijn N de Vries, Elisabeth G E et al.

Source: Warnders, F-J, Lub-de Hooge, M N, de Vries, E G E & Kosterink, J G W 2018, 'Influence of protein properties and protein modification on biodistribution and tumor uptake of anticancer antibodies, antibody derivatives, and non-Ig scaffolds', Medicinal research reviews, vol. 38, no. 6, pp. 1837-1873. https://doi.org/10.1002/med.21498

Subject Terms: biodistribution, drug, modification, molecular imaging, protein, POSITRON-EMISSION-TOMOGRAPHY, PLASMA HALF-LIFE, HER2/NEU-OVEREXPRESSING METASTATIC BREAST, NEAR-INFRARED PHOTOIMMUNOTHERAPY, DEPENDENT CELLULAR CYTOTOXICITY, HUMANIZED MONOCLONAL-ANTIBODY, ANTI-HER2 AFFIBODY MOLECULES, ACUTE LYMPHOBLASTIC-LEUKEMIA, PROSTATE-CANCER XENOGRAFTS, MEDIATED DRUG DISPOSITION

File Description: application/pdf

Availability: https://hdl.handle.net/11370/4de253e6-fe86-44da-a9f9-af5c72f0d3f6
https://research.rug.nl/en/publications/4de253e6-fe86-44da-a9f9-af5c72f0d3f6
https://doi.org/10.1002/med.21498
https://pure.rug.nl/ws/files/85463006/Warnders_et_al_2018_Medicinal_Research_Reviews.pdf

A single compartment simulation model of pharmacokinetics

Authors: Salankar, Harsh V. Rode, Sonali B. Bhavsar, Vinayak H.

Source: International Journal of Basic & Clinical Pharmacology; Vol. 7 No. 10 (2018): October 2018; 2065-2069 ; 2279-0780 ; 2319-2003

Subject Terms: Elimination kinetics, Plasma half-life, Pharmacokinetics, Simulation model, Single compartment

File Description: application/pdf

Relation: https://www.ijbcp.com/index.php/ijbcp/article/view/2800/2122; https://www.ijbcp.com/index.php/ijbcp/article/view/2800

Availability: https://www.ijbcp.com/index.php/ijbcp/article/view/2800
https://doi.org/10.18203/2319-2003.ijbcp20183949

Multiplexed Evaluation of Serum and CSF Pharmacokinetics of Brain-Targeting Single-Domain Antibodies Using a NanoLC–SRM-ILIS Method

Authors: Haqqani, A.S. Caram-Salas, N. Ding, W. et al.

Source: Molecular Pharmaceutics. 10:1542-1556

Subject Terms: Male, 0301 basic medicine, microvascular endothelial cell, limit of quantitation, blood brain barrier, animal cell, blood cerebrospinal fluid barrier, Mass Spectrometry, Drug Delivery Systems, binding affinity, Nanotechnology, Tissue Distribution, endothelium cell, isotope labeling, Cells, Cultured, Chromatography, High Pressure Liquid, Immunoassay, 0303 health sciences, limit of detection, Brain, drug cerebrospinal fluid level, unclassified drug, brain endothelial cell, Protein Transport, Blood-Brain Barrier, FC44 antibody, phage display, FC5 antibody, in vitro study, animal experiment, peptides and proteins, cerebrospinal fluid, animal tissue, 03 medical and health sciences, fluorescence imaging, male, Animals, Humans, Rats, Wistar, outcome assessment, treatment duration, human cell, Endothelial Cells, molecular weight, nucleotide sequence, Single-Domain Antibodies, brain cell, plasma half life, Rats, nanobody

Access URL: https://pubmed.ncbi.nlm.nih.gov/23150993
https://pubs.acs.org/doi/abs/10.1021/mp3004995
https://pubs.acs.org/doi/10.1021/mp3004995
https://www.ncbi.nlm.nih.gov/pubmed/23150993
https://europepmc.org/article/MED/23150993