Výsledky vyhľadávania - "p38 Mitogen-Activated Protein Kinases metabolism"

A p38 MAPK-ROS axis fuels proliferation stress and DNA damage during CRISPR-Cas9 gene editing in hematopoietic stem and progenitor cells.

Autori: Della Volpe, L. Midena, F. Vacca, R. a ďalší

Zdroj: Cell reports. Medicine, vol. 5, no. 11, pp. 101823

Predmety: Hematopoietic Stem Cells/metabolism, CRISPR-Cas Systems/genetics, p38 Mitogen-Activated Protein Kinases/metabolism, p38 Mitogen-Activated Protein Kinases/genetics, Gene Editing/methods, DNA Damage/genetics, Animals, Cell Proliferation/genetics, Reactive Oxygen Species/metabolism, Mice, Humans, Inbred C57BL, Cell Differentiation/genetics, Tumor Suppressor Protein p53/metabolism, Tumor Suppressor Protein p53/genetics, CRISPR-Cas9, DNA damage, DNA damage response, cell cycle, clonal output, differentiation, gene editing, hematopoietic stem cells, p38 MAPK-ROS, proliferative stress, single-cell analyses

Popis súboru: application/pdf

Relation: info:eu-repo/semantics/altIdentifier/pmid/39536752; info:eu-repo/semantics/altIdentifier/eissn/2666-3791; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_4C0238456CA75; https://serval.unil.ch/notice/serval:BIB_4C0238456CA7; https://serval.unil.ch/resource/serval:BIB_4C0238456CA7.P001/REF.pdf

Dostupnosť: https://serval.unil.ch/notice/serval:BIB_4C0238456CA7
https://doi.org/10.1016/j.xcrm.2024.101823
https://serval.unil.ch/resource/serval:BIB_4C0238456CA7.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_4C0238456CA75

Cytotoxic effect caspase activation dependent of a genetically engineered fusion protein with a CD154 peptide mimetic (OmpC-CD154p) on B-NHL cell lines is mediated by the inhibition of bcl-6 and YY1 through MAPK p38 activation.

Autori: Pantoja-Escobar, Gerardo Morales-Martínez, Mario Vega, Gabriel G a ďalší

Zdroj: Leukemia & lymphoma. 60(4)

Predmety: Antineoplastic Agents: chemistry, pharmacology, Apoptosis: drug effects, CD40 Antigens: metabolism, CD40 Ligand: chemistry, Caspases: metabolism, Cell Cycle: drug effects, Cell Line, Tumor, Cell Survival: drug effects, Humans, Molecular Mimicry, Peptides: chemistry, pharmacology, Porins: chemistry, Proto-Oncogene Proteins c-bcl-6: metabolism, YY1 Transcription Factor: metabolism, p38 Mitogen-Activated Protein Kinases: metabolism

Popis súboru: application/pdf

Prístupová URL adresa: https://escholarship.org/uc/item/3nj9g30m
https://escholarship.org/content/qt3nj9g30m/qt3nj9g30m.pdf

Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis

Autori: Edlund, Sofia Lee, So Young Grimsby, Susanne a ďalší

Zdroj: Molecular and Cellular Biology. 25(4):1475-1488

Predmety: Animals, Apoptosis/drug effects/*physiology, COS Cells, Cell Fractionation, Cercopithecus aethiops, Cytoskeletal Proteins/*metabolism, DNA-Binding Proteins/*metabolism, Glycogen Synthase Kinase 3/metabolism, Humans, Male, Mice, Phosphorylation/drug effects, Prostatic Neoplasms/metabolism, Protein Binding/drug effects, Protein-Serine-Threonine Kinases/metabolism, Proto-Oncogene Proteins/metabolism, RNA, Small Interfering/metabolism, Research Support, Non-U.S. Gov't, Serine/metabolism, Trans-Activators/*metabolism, Transcription Factors/*metabolism, Transforming Growth Factor beta/*pharmacology, Tumor Cells, Cultured, p38 Mitogen-Activated Protein Kinases/metabolism

Popis súboru: print

Prístupová URL adresa: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-72728
https://doi.org/10.1128/MCB.25.4.1475-1488.2005

Myostatin regulates the production of fibroblast growth factor 23 (FGF23) in UMR106 osteoblast–like cells

Autori: Franz Ewendt Martina Feger Michael Föller

Zdroj: Pflugers Arch

Predmety: 0301 basic medicine, Signaling and Cell Physiology, Pyridines, Activin Receptors, Dioxoles, p38 Mitogen-Activated Protein Kinases, Cell Line, Mice, 03 medical and health sciences, Cell Line, Tumor [MeSH], Activin Receptors/metabolism [MeSH], Cell Line [MeSH], Fibroblast Growth Factor-23/genetics [MeSH], Osteoblasts/metabolism [MeSH], Signaling and cell physiology, Withanolides/pharmacology [MeSH], TGF-β, Phosphate, p38 Mitogen-Activated Protein Kinases/antagonists, Vitamin D, Imidazoles/pharmacology [MeSH], Benzamides/pharmacology [MeSH], Pyridines/pharmacology [MeSH], Calcium/metabolism [MeSH], Protein Kinase Inhibitors/pharmacology [MeSH], NF-kappa B/antagonists, Fibroblast Growth Factor-23/metabolism [MeSH], Rats [MeSH], Animals [MeSH], Mice [MeSH], NF-kappa B/metabolism [MeSH], Ca, Myostatin/pharmacology [MeSH], p38 Mitogen-Activated Protein Kinases/metabolism [MeSH], p38MAPK, Dioxoles/pharmacology [MeSH], Osteoblasts/drug effects [MeSH], Cell Line, Tumor, Animals, Protein Kinase Inhibitors, Withanolides, 0303 health sciences, Osteoblasts, Imidazoles, NF-kappa B, Myostatin, Rats, Fibroblast Growth Factor-23, Benzamides, Calcium, ddc:570

Popis súboru: 1 Online-Ressource; application/pdf

Prístupová URL adresa: https://link.springer.com/content/pdf/10.1007/s00424-021-02561-y.pdf
https://pubmed.ncbi.nlm.nih.gov/33895875
https://link.springer.com/content/pdf/10.1007/s00424-021-02561-y.pdf
https://www.ncbi.nlm.nih.gov/pubmed/33895875
https://link.springer.com/article/10.1007/s00424-021-02561-y
https://pubmed.ncbi.nlm.nih.gov/33895875/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164604
https://europepmc.org/article/MED/33895875
https://repository.publisso.de/resource/frl:6446960

B55α/PP2A Limits Endothelial Cell Apoptosis During Vascular Remodeling: A Complementary Approach To Disrupt Pathological Vessels?

Autori: Elizabeth A. V. Jones Donatella Ponti Massimiliano Mazzone a ďalší

Zdroj: Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Dipòsit Digital de la UB
instname

Predmety: Male, 0301 basic medicine, Cardiac & Cardiovascular Systems, p38 Mitogen-Activated Protein Kinases/metabolism, Oncologia, B55/PP2A-phosphatase, tumor progression, Angiogenesis Inhibitors, Apoptosis, Human Umbilical Vein Endothelial Cells/drug effects, Inbred C57BL, p38 Mitogen-Activated Protein Kinases, ANGIOGENESIS, ACTIVATION, Mice, Carcinoma, Lewis Lung, Protein Phosphatase 2/antagonists & inhibitors, Protein Phosphatase 2, Enzyme Inhibitors, Phosphorylation, 1102 Cardiorespiratory Medicine and Haematology, Endothelial Cells/drug effects, Enzyme Inhibitors/pharmacology, Mice, Knockout, Hypoxia-Inducible Factor-Proline Dioxygenases/genetics, 0303 health sciences, Tumor, vascular endothelial growth factor, Neovascularization, Pathologic, apoptosis, P38, PROTEIN PHOSPHATASE 2A, Hematology, VEGF, endothelial cells, PP2A, 3. Good health, Oncology, oncology, Female, Biologia del desenvolupament, 3201 Cardiovascular medicine and haematology, Life Sciences & Biomedicine, Signal Transduction, Lewis Lung/drug therapy, Knockout, INHIBITION, Breast Neoplasms, Vascular Remodeling, perfusion, Cell Line, MECHANISMS, Hypoxia-Inducible Factor-Proline Dioxygenases, Angiogenesis Inhibitors/pharmacology, blood vessels, developmental biology, 03 medical and health sciences, Breast Neoplasms/drug therapy, Cell Line, Tumor, Developmental biology, KINASE, Human Umbilical Vein Endothelial Cells, Animals, Humans, Neovascularization, Pathologic, Science & Technology, Carcinoma, 3202 Clinical sciences, Endothelial Cells, 1103 Clinical Sciences, Mice, Inbred C57BL, Peripheral Vascular Disease, Cardiovascular System & Hematology, METASTASIS, Cardiovascular System & Cardiology

Popis súboru: application/pdf

Prístupová URL adresa: https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.119.316071
https://pubmed.ncbi.nlm.nih.gov/32527198
https://hdl.handle.net/2445/199448
https://cris.maastrichtuniversity.nl/en/publications/d96637ad-1fdd-4778-a8d9-ff88a0197f22
https://doi.org/10.1161/CIRCRESAHA.119.316071
https://pubmed.ncbi.nlm.nih.gov/32527198/
https://iris.unito.it/handle/2318/1782133
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.119.316071
https://www.ncbi.nlm.nih.gov/pubmed/32527198
https://www.narcis.nl/publication/RecordID/oai%3Acris.maastrichtuniversity.nl%3Apublications%2Fd96637ad-1fdd-4778-a8d9-ff88a0197f22
https://www.scilit.net/article/90dc76a9603b09c6a249ba2b51c4ae9b
http://hdl.handle.net/2445/199448
https://hdl.handle.net/2318/1782133
https://doi.org/10.1161/CIRCRESAHA.119.316071

Microglial-specific depletion of TAK1 is neuroprotective in the acute phase after ischemic stroke

Autori: Thomas Zeyen Rozina Noristani Shahin Habib a ďalší

Zdroj: J Mol Med (Berl)
Journal of molecular medicine 98(6), 833-847 (2020). doi:10.1007/s00109-020-01916-9

Predmety: Blood Glucose, Brain Infarction, 0301 basic medicine, Genotype, Cell Survival, MAP Kinase Kinase 4, Mice, Transgenic, Brain Ischemia, Mice, 03 medical and health sciences, Oxygen Consumption, Animals, Cells, Cultured, Mice, Knockout, 0303 health sciences, MAP Kinase Kinase Kinases, Neuroprotection, 3. Good health, Disease Models, Animal, MAP Kinase Kinase Kinases/metabolism [MeSH], Phosphorylation [MeSH], Brain Ischemia/etiology [MeSH], Cell Survival [MeSH], Brain Infarction/pathology [MeSH], Neuroinflammation, Brain Ischemia/metabolism [MeSH], Reperfusion Injury/metabolism [MeSH], Inflammation Mediators/metabolism [MeSH], Oxygen Consumption [MeSH], Cytokines/metabolism [MeSH], Brain Infarction/metabolism [MeSH], Brain Ischemia/diagnosis [MeSH], Original Article, Mice, Transgenic [MeSH], Microglia/metabolism [MeSH], Stroke, Blood Glucose [MeSH], TAK1, Reperfusion Injury/pathology [MeSH], Disease Models, Animal [MeSH], Neuroprotection/genetics [MeSH], Stroke/metabolism [MeSH], Microglia, MAP Kinase Kinase 4/metabolism [MeSH], Animals [MeSH], Disease Susceptibility [MeSH], Mice, Knockout [MeSH], Reperfusion Injury/etiology [MeSH], Mice [MeSH], Stroke/diagnosis [MeSH], Ischemia-reperfusion injury, MAP Kinase Kinase Kinases/genetics [MeSH], p38 Mitogen-Activated Protein Kinases/metabolism [MeSH], Brain Infarction/etiology [MeSH], Genotype [MeSH], Cells, Cultured [MeSH], Biomarkers [MeSH], Stroke/etiology [MeSH], Cytokines, Disease Susceptibility, Inflammation Mediators, Biomarkers

Prístupová URL adresa: https://link.springer.com/content/pdf/10.1007/s00109-020-01916-9.pdf
https://pubmed.ncbi.nlm.nih.gov/32382778
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297861
https://link.springer.com/content/pdf/10.1007/s00109-020-01916-9.pdf
https://link.springer.com/article/10.1007/s00109-020-01916-9
https://pubmed.ncbi.nlm.nih.gov/32382778/
https://repository.publisso.de/resource/frl:6441531
https://publications.rwth-aachen.de/record/811441

Increased Release of Proinflammatory Proteins in Primary Human Adipocytes and Activation of the Inflammatory NFĸB, p38, and ERK Pathways upon Omentin Treatment

Autori: Corinna Niersmann Karin Röhrig Matthias Blüher a ďalší

Zdroj: Obesity Facts, Vol 13, Iss 2, Pp 221-236 (2020)

Predmety: 0301 basic medicine, RC620-627, Omentin, Adipokine, Primary human adipocytes, Proinflammatory action, NFĸB signaling, MAP Kinase Signaling System, Primary Cell Culture, primary human adipocytes, nfĸb signaling, GPI-Linked Proteins, p38 Mitogen-Activated Protein Kinases, 03 medical and health sciences, 0302 clinical medicine, Lectins, Adipocytes, Humans, TX341-641, Nutritional diseases. Deficiency diseases, Cells, Cultured, omentin, ddc:610, adipokine, Dose-Response Relationship, Drug, Nutrition. Foods and food supply, Dose-Response Relationship, Drug [MeSH], Adipokine, Adipocytes/drug effects [MeSH], Proinflammatory action, Humans [MeSH], MAP Kinase Signaling System/drug effects [MeSH], Inflammation Mediators/metabolism [MeSH], Lectins/pharmacology [MeSH], Cytokines/metabolism [MeSH], NFĸB signaling, Omentin, NF-kappa B/metabolism [MeSH], Primary human adipocytes, Adipocytes/cytology [MeSH], p38 Mitogen-Activated Protein Kinases/metabolism [MeSH], Signal Transduction/drug effects [MeSH], Adipocytes/metabolism [MeSH], Cells, Cultured [MeSH], Cytokines/pharmacology [MeSH], Primary Cell Culture [MeSH], Research Article, GPI-Linked Proteins/pharmacology [MeSH], NF-kappa B, proinflammatory action, 3. Good health, Cytokines, Inflammation Mediators, Signal Transduction

Prístupová URL adresa: https://www.karger.com/Article/Pdf/506405
https://pubmed.ncbi.nlm.nih.gov/32252061
https://doaj.org/article/f954334cb4c847c88482e73ddf589dd4
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250360
https://europepmc.org/article/MED/32252061
https://pubmed.ncbi.nlm.nih.gov/32252061/
https://repository.publisso.de/resource/frl:6476773
https://ul.qucosa.de/api/qucosa:83650/attachment/ATT-0/
https://ul.qucosa.de/id/qucosa:83650

Involvement of the p38/MK2 Pathway in MCLR Hepatotoxicity Revealed through MAPK Pharmacological Inhibition and Phosphoproteomics in HepaRG Cells

Autori: Lynch, Katherine D Iverson, Dayne T Bachhav, Namrata K a ďalší

Predmety: Phosphorylation, Chemical and Drug Induced Liver Injury - metabolism, Cytoskeleton - metabolism, Humans, Microcystins - toxicity, Mitogen-Activated Protein Kinases - metabolism, p38 Mitogen-Activated Protein Kinases - metabolism, Phosphoprotein Phosphatases - metabolism

Popis súboru: pdf

Relation: ispartof: International journal of molecular sciences spage 11168 issue 13 vol 24; WOS:001031179700001; https://doi.org/10.3390/ijms241311168; 99901181236801842; https://rex.libraries.wsu.edu/view/delivery/01ALLIANCE_WSU/12420986960001842/13420986950001842; alma:01ALLIANCE_WSU/bibs/99901181236801842

Dostupnosť: https://doi.org/10.3390/ijms241311168
https://rex.libraries.wsu.edu/esploro/outputs/journalArticle/Involvement-of-the-p38MK2-Pathway-in/99901181236801842
https://rex.libraries.wsu.edu/view/delivery/01ALLIANCE_WSU/12420986960001842/13420986950001842

MAP kinase pathways in UV-induced apoptosis of retinal pigment epithelium ARPE19 cells.

Autori: Roduit, R. Schorderet, D.F.

Predmety: Apoptosis/physiology, Apoptosis/radiation effects, Cell Line, Humans, MAP Kinase Kinase 4/metabolism, MAP Kinase Signaling System/physiology, Mitogen-Activated Protein Kinase 1/metabolism, Mitogen-Activated Protein Kinase 8/antagonists & inhibitors, Mitogen-Activated Protein Kinase 8/metabolism, Mitogen-Activated Protein Kinase 9/antagonists & inhibitors, Mitogen-Activated Protein Kinase 9/metabolism, Pigment Epithelium of Eye/cytology, Pigment Epithelium of Eye/physiopathology, Proto-Oncogene Proteins c-fos/metabolism, Retina/enzymology, Retina/radiation effects, Transcription Factor AP-1/metabolism, Ultraviolet Rays, p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors, p38 Mitogen-Activated Protein Kinases/metabolism

Popis súboru: application/pdf

Relation: Apoptosis; 1573-675X[electronic]; https://iris.unil.ch/handle/iris/83112; serval:BIB_1FF6934DDA79; 000253574000002

Dostupnosť: https://iris.unil.ch/handle/iris/83112
https://doi.org/10.1007/s10495-008-0179-8

Delayed-onset of procoagulant signalling revealed by kinetic analysis of COAT platelet formation.

Autori: Alberio, L. Ravanat, C. Hechler, B. a ďalší

Predmety: Blood Coagulation, Blood Platelets/metabolism, Calcium/metabolism, Cell Separation, Cells, Cultured, Collagen/metabolism, Crotalid Venoms/metabolism, Dual Specificity Phosphatase 2/metabolism, Flow Cytometry, Humans, Lectins, C-Type/metabolism, Mitochondria/metabolism, Platelet Activation, Platelet Glycoprotein GPIIb-IIIa Complex/metabolism, Protein Binding, Protein Kinase C/metabolism, Signal Transduction, Thrombin/metabolism, p38 Mitogen-Activated Protein Kinases/metabolism, von Willebrand Factor/metabolism, COAT, Platelets, apoptosis, calcium, intracellular signalling, phosphorylation, procoagulant, surface

Relation: Thrombosis and haemostasis; https://iris.unil.ch/handle/iris/259328; serval:BIB_FB7ADCDA152B; 000402591300010

Dostupnosť: https://iris.unil.ch/handle/iris/259328
https://doi.org/10.1160/TH16-09-0711

Peroxynitrite activates ERK via Raf-1 and MEK, independently from EGF receptor and p21Ras in H9C2 cardiomyocytes

Autori: Pesse, B. Levrand, S. Feihl, F. a ďalší

Predmety: Animals Cell Line Enzyme Activation/drug effects Extracellular Signal-Regulated MAP Kinases/*metabolism JNK Mitogen-Activated Protein Kinases/metabolism MAP Kinase Signaling System/drug effects Mitogen-Activated Protein Kinase Kinases/*metabolism Myocytes, Cardiac/*drug effects/*metabolism Oxidants/toxicity Peroxynitrous Acid/*toxicity Proto-Oncogene Proteins c-raf/*metabolism Proto-Oncogene Proteins p21(ras)/metabolism Rats Receptor, Epidermal Growth Factor/metabolism p38 Mitogen-Activated Protein Kinases/metabolism

Popis súboru: application/pdf

Relation: Journal of Molecular and Cellular Cardiology; https://iris.unil.ch/handle/iris/221318; serval:BIB_84752A80AD1A; 000229052500007

Dostupnosť: https://iris.unil.ch/handle/iris/221318
https://doi.org/10.1016/j.yjmcc.2005.02.020

Tubular Cytoplasmic Expression of Zinc Finger Protein SNAI1 in Renal Transplant Biopsies: A Sign of Diseased Epithelial Phenotype?

Autori: Prunotto, M. Chaykovska, L. Bongiovanni, M. a ďalší

Predmety: Allografts/drug effects, Animals, Biopsy, Calcineurin Inhibitors/pharmacology, Chronic Disease, Cytoplasm/metabolism, Dogs, Epithelial Cells/metabolism, Epithelial-Mesenchymal Transition/drug effects, Female, Fibrosis, Glycogen Synthase Kinase 3 beta/metabolism, HSP27 Heat-Shock Proteins/metabolism, Kidney Transplantation/adverse effects, Kidney Tubules/drug effects, Kidney Tubules/metabolism, Kidney Tubules/pathology, Madin Darby Canine Kidney Cells, Male, Mice, Knockout, Phenotype, Phosphorylation/drug effects, Proteasome Endopeptidase Complex/metabolism, Snail Family Transcription Factors/metabolism, Up-Regulation/drug effects, Ureteral Obstruction/pathology, Zinc Fingers, p38 Mitogen-Activated Protein Kinases/metabolism

Relation: The American Journal of Pathology; https://iris.unil.ch/handle/iris/204161; serval:BIB_D7AA443A9F92; 000390829300008

Dostupnosť: https://iris.unil.ch/handle/iris/204161
https://doi.org/10.1016/j.ajpath.2016.09.017

Regulation of glucose transporter expression in cardiac myocytes: p38 MAPK is a strong inducer of GLUT4.

Autori: Montessuit, C. Rosenblatt-Velin, N. Papageorgiou, I. a ďalší

Predmety: Animals, Newborn, Cells, Cultured, Electrophoretic Mobility Shift Assay, Enzyme Activation, Fibroblast Growth Factor 2/analysis, Fibroblast Growth Factor 2/metabolism, Fluorescent Antibody Technique, Genetic Engineering, Glucose Transporter Type 1, Glucose Transporter Type 4, Immunoblotting/methods, Insulin-Like Growth Factor I/analysis, Insulin-Like Growth Factor I/metabolism, Luciferases/genetics, MAP Kinase Signaling System/physiology, Male, Mitogen-Activated Protein Kinases/metabolism, Monosaccharide Transport Proteins/analysis, Monosaccharide Transport Proteins/genetics, Muscle Proteins/analysis, Muscle Proteins/genetics, Myocytes, Cardiac/metabolism, Rats, Sprague-Dawley, Reverse Transcriptase Polymerase Chain Reaction, p38 Mitogen-Activated Protein Kinases/metabolism

Relation: Cardiovascular Research; https://iris.unil.ch/handle/iris/145675; serval:BIB_94F16730230B; 000224241900013

Dostupnosť: https://iris.unil.ch/handle/iris/145675
https://doi.org/10.1016/j.cardiores.2004.06.005

Specific transcriptional programs differentiate ICOS from CD28 costimulatory signaling in human Naïve CD4+ T cells

Autori: Casimiro Luca Gigliotti Elena Boggio Francesco Favero a ďalší

Prispievatelia: Casimiro Luca Gigliotti Elena Boggio Francesco Favero a ďalší

Zdroj: Front Immunol
Digital.CSIC. Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
instname
Frontiers in Immunology, Vol 13 (2022)

Predmety: CD4-Positive T-Lymphocytes, 0301 basic medicine, CD28, p38 Mitogen-Activated Protein Kinases/metabolism, Transcription, Genetic, Immunology, Receptors, Antigen, T-Cell, p38 Mitogen-Activated Protein Kinases, Inducible T-Cell Co-Stimulator Protein, Cholesterol/metabolism, 03 medical and health sciences, 0302 clinical medicine, Genetic, CD28 Antigens, Receptors, Humans, Glycosaminoglycans/metabolism, T-cell receptor, CD28 Antigen, Glycosaminoglycans, human CD4+ T cell, p38 Mitogen-Activated Protein Kinase, RNA sequencing, RC581-607, T-Cell, 3. Good health, T-Cell/metabolism, Cholesterol, Glycosaminoglycan, ICOS, Antigen, Inducible T-Cell Co-Stimulator Protein/metabolism, human CD4+ T cells, Immunologic diseases. Allergy, Transcription, Human

Popis súboru: ELETTRONICO

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/36131938
http://hdl.handle.net/10261/280405
https://doaj.org/article/55eb914dee7e467a8a6a4d3d915b6074
https://hdl.handle.net/11370/36b15861-1084-4b5e-9d17-3eefc7304761
https://research.rug.nl/en/publications/36b15861-1084-4b5e-9d17-3eefc7304761
https://doi.org/10.3389/fimmu.2022.915963

Humanin Attenuates NMDA-Induced Excitotoxicity by Inhibiting ROS-dependent JNK/p38 MAPK Pathway

Autori: Yang, Xiaorong Zhang, Hongmei Wu, Jinzi a ďalší

Zdroj: International Journal of Molecular Sciences

Predmety: Hn, MAPKs, Nmda, Ros, excitotoxicity, neuroprotection, Animals, Intracellular Signaling Peptides and Proteins / pharmacology, MAP Kinase Signaling System / drug effects, Mitogen-Activated Protein Kinases / metabolism, N-Methylaspartate / toxicity, Rats, Wistar, Reactive Oxygen Species / metabolism, Signal Transduction / drug effects, p38 Mitogen-Activated Protein Kinases / metabolism

Popis súboru: application/pdf

Relation: https://doi.org/10.3390/ijms19102982; https://hdl.handle.net/20.500.12503/31564; 19; 10

Dostupnosť: https://hdl.handle.net/20.500.12503/31564

Cytotoxic effect caspase activation dependent of a genetically engineered fusion protein with a CD154 peptide mimetic (OmpC-CD154p) on B-NHL cell lines is mediated by the inhibition of bcl-6 and YY1 through MAPK p38 activation

Autori: Mario Morales-Martinez Gerardo Pantoja-Escobar Graciela Castro-Escarpulli a ďalší

Zdroj: Leukemia & lymphoma, vol 60, iss 4

Predmety: 0301 basic medicine, Cell Survival, Apoptosis: drug effects, CD40 Ligand, Proto-Oncogene Proteins c-bcl-6: metabolism, Cell Survival: drug effects, Porins, Antineoplastic Agents, Apoptosis, Peptides: chemistry, YY1 Transcription Factor: metabolism, p38 Mitogen-Activated Protein Kinases, Cell Line, 03 medical and health sciences, CD40 Antigens: metabolism, 0302 clinical medicine, Porins: chemistry, Cell Line, Tumor, p38 Mitogen-Activated Protein Kinases: metabolism, Cell Cycle: drug effects, Humans, CD40 Antigens, YY1 Transcription Factor, Antineoplastic Agents: chemistry, 0303 health sciences, Tumor, Cell Cycle, Molecular Mimicry, Caspases: metabolism, 3. Good health, Caspases, Proto-Oncogene Proteins c-bcl-6, pharmacology, CD40 Ligand: chemistry, Peptides

Popis súboru: application/pdf

Prístupová URL adresa: https://escholarship.org/content/qt3nj9g30m/qt3nj9g30m.pdf?t=qlc247
https://pubmed.ncbi.nlm.nih.gov/30277117
https://escholarship.org/content/qt3nj9g30m/qt3nj9g30m.pdf?t=qlc247
https://www.ncbi.nlm.nih.gov/pubmed/30277117
https://pubmed.ncbi.nlm.nih.gov/30277117/
https://www.tandfonline.com/doi/full/10.1080/10428194.2018.1516286
https://escholarship.org/uc/item/3nj9g30m
https://europepmc.org/article/MED/30277117
https://escholarship.org/uc/item/3nj9g30m

Inhibition of fucosylation in human invasive ductal carcinoma reduces E‐selectin ligand expression, cell proliferation, and ERK1/2 and p38 MAPK activation

Autori: Paula A. Videira Isabel Serrano Mylène A. Carrascal a ďalší

Prispievatelia: Paula A. Videira Isabel Serrano Mylène A. Carrascal a ďalší

Zdroj: Mol Oncol
Molecular Oncology, Vol 12, Iss 5, Pp 579-593 (2018)

Predmety: 0301 basic medicine, cell migration, sialyl‐Lewis X/A, Oligosaccharides, Ligands, p38 Mitogen-Activated Protein Kinases, MAP Kinase Signaling System / drug effects, E-Selectin / metabolismo, Fucose / analogs & derivatives, Carcinoma, Ductal, Breast / enzymology, RC254-282, Research Articles, Fucose / pharmacology, Carcinoma, Ductal, Breast, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Middle Aged, Fucosyltransferases, 3. Good health, Carcinoma, Ductal, Breast / pathology, Breast Neoplasms / pathology, p38 Mitogen-Activated Protein Kinases / genetics, Female, Breast Neoplasms / enzymology, E-Selectin, Fucosyltransferases / antagonists & inhibitors, Oligosaccharides / metabolismo, Adult, MAP Kinase Signaling System, proliferation, Primary Cell Culture, Breast Neoplasms, E-Selectin / metabolism, Cell Adhesion / drug effects, 03 medical and health sciences, breast cancer, p38 Mitogen-Activated Protein Kinases / metabolism, E-Selectin / genetics, Cell Line, Tumor, Cell Adhesion, Humans, HSJ ANPAT, Neoplasm Invasiveness, Sialyl Lewis X Antigen, Aged, Cell Proliferation, Fucose, fucosylation, Oligosaccharides / metabolism, Cell Proliferation / drug effects

Popis súboru: application/pdf

Prístupová URL adresa: https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1878-0261.12163
https://pubmed.ncbi.nlm.nih.gov/29215790
https://doaj.org/article/aa487eb10376413e99bc71ac96aa6fff
https://repositorio-aberto.up.pt/bitstream/10216/127061/1/10.1002-1878-0261.12163.pdf
http://europepmc.org/articles/PMC5928367
https://www.ncbi.nlm.nih.gov/pubmed/29215790
https://novaresearch.unl.pt/en/publications/inhibition-of-fucosylation-in-human-invasive-ductal-carcinoma-red
https://febs.onlinelibrary.wiley.com/doi/pdf/10.1002/1878-0261.12163
https://core.ac.uk/display/159166726
https://hdl.handle.net/10216/127061
http://hdl.handle.net/10400.17/3949

GCK is essential to systemic inflammation and pattern recognition receptor signaling to JNK and p38.

Autori: Zhong, Jian Gavrilescu, L Cristina Molnár, Arpád a ďalší

Zdroj: Proceedings of the National Academy of Sciences of the United States of America. 106(11)

Predmety: Adrenomedullin: pharmacology, Animals, Bone Marrow Transplantation, Cytokines: metabolism, Extracellular Signal-Regulated MAP Kinases, Hematopoietic Stem Cells: metabolism, Inflammation: etiology, JNK Mitogen-Activated Protein Kinases: metabolism, Macrophages: metabolism, Mice, Mice, Knockout, NF-kappa B, Protein-Serine-Threonine Kinases: deficiency, physiology, Receptors, Pattern Recognition: metabolism, p38 Mitogen-Activated Protein Kinases: metabolism

Popis súboru: application/pdf

Prístupová URL adresa: https://escholarship.org/uc/item/6bt8z08s
https://escholarship.org/content/qt6bt8z08s/qt6bt8z08s.pdf

Club cell-specific role of programmed cell death 5 in pulmonary fibrosis

Autori: Soo-Yeon Park Jung Yeon Hong Soo Yeon Lee a ďalší

Prispievatelia: Soo-Yeon Park Jung Yeon Hong Soo Yeon Lee a ďalší

Zdroj: Nat Commun
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Predmety: Apoptosis Regulatory Proteins / deficiency, Male, 0301 basic medicine, Bronchioles / metabolism, Gene Expression, Inbred C57BL, Respiratory Mucosa / metabolism, Transgenic, Mice, Apoptosis Regulatory Proteins / metabolism, Transforming Growth Factor beta / metabolism, Idiopathic Pulmonary Fibrosis / pathology, Lung, Mice, Knockout, 0303 health sciences, Apoptosis Regulatory Proteins / genetics, Middle Aged, Neoplasm Proteins, 3. Good health, Neoplasm Proteins / deficiency, Gene Knockdown Techniques, Female, Epithelial Cells / metabolism, Signal Transduction, Knockout, Science, Mice, Transgenic, Epithelial Cells / pathology, Article, Respiratory Mucosa / pathology, Cell Line, 03 medical and health sciences, Lung / pathology, Animals, Humans, p38 Mitogen-Activated Protein Kinases / metabolism, Bronchioles, Aged, Animal, Smad3 Protein / metabolism, Neoplasm Proteins / genetics, Epithelial Cells, Idiopathic Pulmonary Fibrosis, Mice, Inbred C57BL, Bronchioles / pathology, Disease Models, Animal, Idiopathic Pulmonary Fibrosis / genetics, Disease Models, Lung / metabolism, Apoptosis Regulatory Proteins, Neoplasm Proteins / metabolism

Prístupová URL adresa: https://www.nature.com/articles/s41467-021-23277-8.pdf
https://pubmed.ncbi.nlm.nih.gov/34011956
https://doaj.org/article/3d4d03ec3ef149fe84412d2547f541c9
https://www.nature.com/articles/s41467-021-23277-8.pdf
https://pubmed.ncbi.nlm.nih.gov/34011956/
http://ui.adsabs.harvard.edu/abs/2021NatCo..12.2923P/abstract
https://ir.ymlib.yonsei.ac.kr/bitstream/22282913/184522/1/T202103111.pdf
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184522
https://europepmc.org/articles/PMC8134485/

4-hydroxytamoxifen does not deteriorate cardiac function in cardiomyocyte-specific MerCreMer transgenic mice

Autori: Andre Heinen Stefanie Gödecke Ulrich Flögel a ďalší

Zdroj: Basic Res Cardiol

Predmety: Male, 0301 basic medicine, Time Factors, Mice, Transgenic, p38 Mitogen-Activated Protein Kinases, Ventricular Function, Left, Mice, 03 medical and health sciences, Animals, Cardiac energetics, Cardiac function, Mice, Inbred C57BL [MeSH], Glycogen Synthase Kinase 3 beta/genetics [MeSH], Original Contribution, Tamoxifen/pharmacology [MeSH], Mice, Transgenic [MeSH], Proto-Oncogene Proteins c-akt/genetics [MeSH], Gene Expression Regulation/drug effects [MeSH], Male [MeSH], Myocytes, Cardiac/metabolism [MeSH], Tamoxifen/toxicity [MeSH], Energy Metabolism/drug effects [MeSH], Cardiomyopathy, Integrases/genetics [MeSH], Myocytes, Cardiac/drug effects [MeSH], Myosin Heavy Chains/genetics [MeSH], p38 Mitogen-Activated Protein Kinases/genetics [MeSH], Tamoxifen/analogs, aMHC-MerCreMer/loxP system, Gene Editing [MeSH], Fibrosis [MeSH], Ventricular Remodeling/drug effects [MeSH], Animals [MeSH], Myocytes, Cardiac/pathology [MeSH], Time Factors [MeSH], Proto-Oncogene Proteins c-akt/metabolism [MeSH], p38 Mitogen-Activated Protein Kinases/metabolism [MeSH], Ventricular Function, Left/drug effects [MeSH], 4-hydroxytamoxifen, Glycogen Synthase Kinase 3 beta/metabolism [MeSH], Myocytes, Cardiac, Gene Editing, 2. Zero hunger, 0303 health sciences, Glycogen Synthase Kinase 3 beta, Integrases, Myosin Heavy Chains, Ventricular Remodeling, Fibrosis, 3. Good health, Mice, Inbred C57BL, Tamoxifen, Gene Expression Regulation, Energy Metabolism, Proto-Oncogene Proteins c-akt

Prístupová URL adresa: https://link.springer.com/content/pdf/10.1007/s00395-020-00841-9.pdf
https://pubmed.ncbi.nlm.nih.gov/33544211
https://link.springer.com/content/pdf/10.1007/s00395-020-00841-9.pdf
https://link.springer.com/article/10.1007/s00395-020-00841-9
https://pubmed.ncbi.nlm.nih.gov/33544211/
https://europepmc.org/article/MED/33544211
https://khepri-node.dev.meta-infra.org/papers/4-hydroxytamoxifen-does-not-deteriorate-cardiac/33544211
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864833
https://repository.publisso.de/resource/frl:6450770