Suchergebnisse - "nAChR"

Assessing species-specific neonicotinoid toxicity using cross-species chimeric nicotinic acetylcholine receptors in a Drosophila model

Autoren: Anna Lassota James J. L. Hodge Matthias Soller

Quelle: Scientific Reports, Vol 15, Iss 1, Pp 1-12 (2025)

Schlagwörter: nAChR, Neonicotinoids, Apis mellifera, Drosophila, CRISPR-Cas9 genome engineering, Pesticides, Medicine, Science

Dateibeschreibung: electronic resource

Relation: https://doaj.org/toc/2045-2322

Zugangs-URL: https://doaj.org/article/2e0dc0c841db42f0bbdef6ee765435bb

Synthesis and in silico studies of new thiophene-isoquinolinone hybrids as potential larvicides against Culex pipiens

Autoren: Mahmoud Kamal Mohamed H. Hekal Fatma S. M. Abu El-Azm et al.

Quelle: Scientific Reports, Vol 15, Iss 1, Pp 1-24 (2025)

Schlagwörter: Thiophene-isoquinolinone hybrids, Culex pipiens, Larvicidal activity, Acetylcholinesterase (AChE), Nicotinic acetylcholine receptor (nAChR), Molecular docking, Medicine, Science

Dateibeschreibung: electronic resource

Relation: https://doaj.org/toc/2045-2322

Zugangs-URL: https://doaj.org/article/8010ee3e0329409285d7e87415c73406

Correction: Nicotine-mediated effects in neuronal and mouse models of synucleinopathy

Autoren: Mohamed Bilal Fares Omar Alijevic Stephanie Johne et al.

Quelle: Frontiers in Neuroscience, Vol 19 (2025)

Schlagwörter: induced pluripotent stem cell (iPSC), nicotinic acetylcholine receptors (nAChR), neuroprotection, Neurosciences. Biological psychiatry. Neuropsychiatry, synucleinopathy, transgenic mice, nicotine, RC321-571

Zugangs-URL: https://doaj.org/article/5d4653c3e939432696012b88a395f918

α7 nicotinic acetylcholine receptor and depression: Mechanistic insights and therapeutic prospects

Autoren: Canmao Wang Danna Gan Zixi Hong et al.

Quelle: Neurobiology of Disease, Vol 216, Iss , Pp 107122- (2025)

Schlagwörter: α7 nAChR, Depression, Neuroinflammation, Monoaminergic neurotransmission, BDNF, Gut-brain axis, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

Dateibeschreibung: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996125003390; https://doaj.org/toc/1095-953X

Zugangs-URL: https://doaj.org/article/93495d9e5db2436ea8ac1def1da94dba

Uncovering a novel role of nAChRs in oxidative stress-mediated vascular dysfunction in COPD

Autoren: Rosa Andreu-Martínez Onofre Munar-Rubert Jorge Rodríguez-Pérez et al.

Quelle: Redox Biology, Vol 86, Iss , Pp 103838- (2025)

Schlagwörter: Vascular dysfunction, Human pulmonary artery smooth muscle cells, COPD, Oxidative stress, Calcium dysregulation, nAChR, Medicine (General), R5-920, Biology (General), QH301-705.5

Dateibeschreibung: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231725003519; https://doaj.org/toc/2213-2317

Zugangs-URL: https://doaj.org/article/f8e17f7141bf4582882a99c5f89f2d49

An N‐Terminally Elongated Peptide From Conus rolani Defines a New Class of Ribbon α‐Conotoxins Targeting Muscle nAChRs

Autoren: Matías L. Giglio Paula Flórez‐Salcedo Layla Azam et al.

Quelle: FASEB J
Giglio, M L, Flórez-Salcedo, P, Azam, L, Watkins, M, Koch, T L, Basgall-De la Rosa, E, Douglass, A D, McIntosh, J M, Olivera, B M & Gajewiak, J 2025, ' An N-Terminally Elongated Peptide From Conus rolani Defines a New Class of Ribbon α-Conotoxins Targeting Muscle nAChRs ', FASEB Journal, vol. 39, no. 12, e70698 . https://doi.org/10.1096/fj.202500721RR

Schlagwörter: α-Conotoxin, bioassay, venom, nAChR, electrophysiology, peptide stability, disulfide connectivity, Research Article

Dateibeschreibung: application/pdf

Zugangs-URL: https://curis.ku.dk/ws/files/455898673/An_N-Terminally_Elongated_Peptide.pdf

Long-term muscarinic inhibition increases intrinsic excitability through the upregulation of A-type potassium currents in cortical neurons

Autoren: Denise Riquelme Patricia Romo-Toledo Paula Leyton et al.

Quelle: Front Cell Dev Biol
Frontiers in Cell and Developmental Biology, Vol 13 (2025)

Schlagwörter: Cell and Developmental Biology, cortical neurons, QH301-705.5, A-type potassium currents, intrinsic excitability, homeostatic regulation of excitability, Biology (General), nicotinic acetylcholine receptor (nAChR), muscarinic acetylcholine receptor (mAChR)

Zugangs-URL: https://doaj.org/article/09641e07725a4dfc92659a6536d8c943

Abnormal response to chronic social defeat stress and fear extinction in a mouse model of Lynx2-based cholinergic dysregulation

Autoren: Kristin R. Anderson Peter J. Rogu Talulla B. Palumbo et al.

Quelle: Front Neurosci
Frontiers in Neuroscience, Vol 19 (2025)

Schlagwörter: LYPD1, Lynx2, social interaction, nicotinic acetylcholine receptors, Neurosciences. Biological psychiatry. Neuropsychiatry, nAChR, anxiety behavior, RC321-571, Neuroscience

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/40236946
https://doaj.org/article/362e3ad0078f457b815c3a70a2c080ba

Synthesis and Evaluation of Compound Targeting α7 and β2 Subunits in Nicotinic Acetylcholinergic Receptor.

Autoren: Singh, Karanveer Ngo, Allyson Keerthisinghe, Oshini et al.

Quelle: Molecules. 28(24)

Schlagwörter: PET, [125I]α-bungarotoxin, [18F]nifene, amyloid plaques, autoradiography, mice, rat, α7β2 nAChR, Rats, Mice, Animals, Receptors, Nicotinic, alpha7 Nicotinic Acetylcholine Receptor, Brain, Hippocampus, Positron-Emission Tomography

Dateibeschreibung: application/pdf

Zugangs-URL: https://escholarship.org/uc/item/9g30r680
https://escholarship.org/content/qt9g30r680/qt9g30r680.pdf

Teucrium Polium ameliorates amyloid β-induced brain network disorders in rats: electrophysiological and behavioral studies

Autoren: Karen Simonyan Lilit Darbinyan Lilia Hambardzumyan et al.

Quelle: BMC Complementary Medicine and Therapies, Vol 25, Iss 1, Pp 1-17 (2025)

Schlagwörter: Amyloid β(25–35), Teucrium Polium, nAChR, Spike activity, Nucleus basalis magnocellularis, Other systems of medicine, RZ201-999

Dateibeschreibung: electronic resource

Relation: https://doaj.org/toc/2662-7671

Zugangs-URL: https://doaj.org/article/15c69e090e9f431f80a746cff4092d93

Using insecticidal compounds to elucidate the potential role of neurotransmitters in Lepidoptera pupal ecdysis

Autoren: Niranjana Krishnan Cassandra Gorman Jillian Stewart et al.

Quelle: Scientific Reports, Vol 15, Iss 1, Pp 1-15 (2025)

Schlagwörter: Lepidoptera, Acetylcholine, Nicotinic acetylcholine receptor (nAChR), Insecticide, Ecdysis, Crustacean cardioactive peptide (CCAP) neurons, Medicine, Science

Dateibeschreibung: electronic resource

Relation: https://doaj.org/toc/2045-2322

Zugangs-URL: https://doaj.org/article/029424a5717148ebb3966dba0180bf6e

HIV, smoking, and the brain: a convergence of neurotoxicities

Autoren: Benjamin L. Orlinick Shelli F. Farhadian

Quelle: AIDS Research and Therapy, Vol 22, Iss 1, Pp 1-9 (2025)

Schlagwörter: HIV, Tobacco smoking, Neurocognitive impairment, nAChR, Neuroinflammation, Nicotine, Immunologic diseases. Allergy, RC581-607

Dateibeschreibung: electronic resource

Relation: https://doaj.org/toc/1742-6405

Zugangs-URL: https://doaj.org/article/ee1c7201e6604916968f57d6904488de

Editorial: Mechanisms of cholinergic transmission in motivation and cognition

Autoren: T. Chase Francis Anna M. Klawonn

Quelle: Front Mol Neurosci
Frontiers in Molecular Neuroscience, Vol 18 (2025)
Francis, T C & Klawonn, A M 2025, 'Editorial : Mechanisms of cholinergic transmission in motivation and cognition', Frontiers in Molecular Neuroscience, vol. 18, 1586940. https://doi.org/10.3389/fnmol.2025.1586940

Schlagwörter: cognition, muscarinic receptor, motivation, nicotinic receptor (nAChR), Neurosciences. Biological psychiatry. Neuropsychiatry, addiction, Molecular Neuroscience, acetylcholine, reward, RC321-571

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/40206189
https://doaj.org/article/be7bd41c7b1d4fef98a46d58ed851257
http://www.scopus.com/inward/record.url?scp=105002174289&partnerID=8YFLogxK
https://pure.au.dk/portal/en/publications/f30b1806-b92f-4f92-9b8c-89ebca2bf936
https://doi.org/10.3389/fnmol.2025.1586940

Supplementary Methods: Computational Model Experiment.

Autoren: Aman Ullah Karen Therrien John R. Cressman et al.

Schlagwörter: Biochemistry, Medicine, Cell Biology, Genetics, Neuroscience, Science Policy, Mental Health, Biological Sciences not elsewhere classified, thalamic reticular nucleus, significant neurodevelopmental impairments, modulate neuronal firing, genetic disorder caused, brain region critical, 7 nachr expression, 7 nachr activity, 7 nachr ), 3 microdeletion syndrome, trn neuron embedded, produce distinct wake, developed computational models, compartment kinetic model, computational model, wake states, trn ), regulating thalamocortical, oscillations involved, multiple genes, like states, increased risk, heterozygous deletion

Relation: https://figshare.com/articles/journal_contribution/Supplementary_Methods_Computational_Model_Experiment_/30011886

Verfügbarkeit: https://doi.org/10.1371/journal.pone.0330635.s001
https://figshare.com/articles/journal_contribution/Supplementary_Methods_Computational_Model_Experiment_/30011886

Oleic Acid Could Act as a Channel Blocker in the Inhibition of nAChR: Insights from Molecular Dynamics Simulations

Autoren: Diego J. Obiol María J. Amundarain Fernando Zamarreño et al.

Quelle: The Journal of Physical Chemistry B. 128:2398-2411

Schlagwörter: 0301 basic medicine, 0303 health sciences, Binding Sites, MOLECULAR DYNAMICS SIMULATIONS, Cell Membrane, INHIBITION, nAChR, Receptors, Nicotinic, Molecular Dynamics Simulation, Torpedo, 03 medical and health sciences, ACID OLEIC, Animals, Oleic Acid

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38445598
http://hdl.handle.net/11336/232539

Histone Methyltransferase G9a Plays an Essential Role on Nicotine Preference in Zebrafish

Autoren: Maria Paula Faillace Joaquin Ortiz Leandro Rocco et al.

Quelle: Molecular Neurobiology. 61:6245-6263

Schlagwörter: Male, Nicotine, G9a/GLP complex, Histone-Lysine N-Methyltransferase, Azepines, Receptors, Nicotinic, Zebrafish Proteins, Conditioned place preference, Epigenetic regulation, BIX-01294, Histones, Reward, Quinazolines, Animals, nAchR α-subunits, Histone lysine methylation, Zebrafish

Dateibeschreibung: application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38289455
http://hdl.handle.net/11336/241479

Modulation of Ca2+ oscillation following ischemia and nicotinic acetylcholine receptors in primary cortical neurons by high-throughput analysis

Autoren: Tsutomu Sasaki Sunao Hisada Hideaki Kanki et al.

Quelle: Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)

Schlagwörter: Ca2+ oscillations, High-throughput screening, Ischemia, nAChR, PAM, Medicine, Science

Dateibeschreibung: electronic resource

Relation: https://doaj.org/toc/2045-2322

Zugangs-URL: https://doaj.org/article/9b6e3447e8e248359c5367162194bbbc

Pro-Inflammatory Protein PSCA Is Upregulated in Neurological Diseases and Targets β2-Subunit-Containing nAChRs

Autoren: Mikhail A. Shulepko Yuqi Che Alexander S. Paramonov et al.

Quelle: Biomolecules, Vol 15, Iss 10, p 1381 (2025)

Schlagwörter: prostate stem cell antigen, PSCA, Ly6/uPAR, nAChR, Alzheimer disease, aging, Microbiology, QR1-502

Dateibeschreibung: electronic resource

Relation: https://www.mdpi.com/2218-273X/15/10/1381; https://doaj.org/toc/2218-273X

Zugangs-URL: https://doaj.org/article/c74d9df46c404af386879afd14b08cf1

Neuromuscular System of Nematodes Is a Target of Synergistic Pharmacological Effects of Carvacrol and Geraniol

Autoren: Maja Stojković Djordje S. Marjanović Dragana Medić et al.

Quelle: Pharmaceuticals, Vol 18, Iss 8, p 1232 (2025)

Schlagwörter: geraniol, carvacrol, nAChR, Asu-ACR-16, Caenorhabditis elegans, Ascaris suum, Medicine, Pharmacy and materia medica, RS1-441

Dateibeschreibung: electronic resource

Relation: https://www.mdpi.com/1424-8247/18/8/1232; https://doaj.org/toc/1424-8247

Zugangs-URL: https://doaj.org/article/e56f503d699944678ce9614f40b35841

Variations in 'Functional Site' Residues and Classification of Three-Finger Neurotoxins in Snake Venoms

Autoren: R. Manjunatha Kini Cho Yeow Koh

Quelle: Toxins, Vol 17, Iss 8, p 364 (2025)

Schlagwörter: nicotinic acetylcholine receptor (nAChR), ligand-gated ion channels, molecular evolution, phylogenic analysis, sequence alignment, structure–function relationships, Medicine

Dateibeschreibung: electronic resource

Relation: https://www.mdpi.com/2072-6651/17/8/364; https://doaj.org/toc/2072-6651

Zugangs-URL: https://doaj.org/article/a53a1660290c4d46b185d64107918c7a