Suchergebnisse - "monocytes"

Association of intermediate monocytes with dengue severity among the pediatric population of Odisha, India.

Autoren: Dash MK Samal S Rout S et al.

Quelle: Scientific reports [Sci Rep] 2025 Oct 23; Vol. 15 (1), pp. 37116. Date of Electronic Publication: 2025 Oct 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Monocytes*/immunology , Monocytes*/metabolism , Dengue*/immunology , Dengue*/epidemiology , Dengue*/pathology , Dengue*/virology , Dengue Virus*/immunology, Humans ; India/epidemiology ; Child ; Male ; Female ; Child, Preschool ; Lipopolysaccharide Receptors/metabolism ; Receptors, IgG/metabolism ; Severity of Illness Index ; Adolescent ; Molecular Docking Simulation ; Infant ; Immunophenotyping ; Severe Dengue ; Capsid Proteins/metabolism ; Capsid Proteins/chemistry ; GPI-Linked Proteins

Myeloid GPSM1 regulates atherosclerosis progression by governing monocyte and macrophage activation and chemotaxis.

Autoren: Zhang Y Cao Y Sun Y et al.

Quelle: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Dec 02; Vol. 122 (48), pp. e2517531122. Date of Electronic Publication: 2025 Nov 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH-Schlagworte: Atherosclerosis*/metabolism , Atherosclerosis*/pathology , Atherosclerosis*/genetics , Monocytes*/metabolism , Monocytes*/immunology , Macrophage Activation* , Macrophages*/metabolism , Chemotaxis*, Animals ; Mice ; Humans ; Kruppel-Like Factor 4 ; Disease Progression ; Mice, Inbred C57BL ; Male ; Mice, Knockout, ApoE

Monocyte iron load correlates with immune suppression and sepsis severity: A longitudinal analysis.

Autoren: Mertens C Reuter D Agarvas AR et al.

Quelle: The Journal of infection [J Infect] 2025 Dec; Vol. 91 (6), pp. 106660. Date of Electronic Publication: 2025 Nov 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: W.B. Saunders Country of Publication: England NLM ID: 7908424 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2742 (Electronic) Linking ISSN: 01634453 NLM ISO Abbreviation: J Infect Subsets: MEDLINE

MeSH-Schlagworte: Sepsis*/immunology , Sepsis*/pathology , Sepsis*/blood , Monocytes*/metabolism , Monocytes*/immunology , Monocytes*/chemistry , Iron*/blood , Iron*/metabolism , Immune Tolerance*, Humans ; Longitudinal Studies ; Male ; Female ; Middle Aged ; Aged ; Biomarkers/blood ; Severity of Illness Index ; Adult ; HLA-DR Antigens

Detection of S1 spike protein in CD16+ monocytes up to 245 days in SARS-CoV-2-negative post-COVID-19 vaccine syndrome (PCVS) individuals.

Autoren: Patterson BK Yogendra R Francisco EB et al.

Quelle: Human vaccines & immunotherapeutics [Hum Vaccin Immunother] 2025 Dec; Vol. 21 (1), pp. 2494934. Date of Electronic Publication: 2025 May 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101572652 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2164-554X (Electronic) Linking ISSN: 21645515 NLM ISO Abbreviation: Hum Vaccin Immunother Subsets: MEDLINE

MeSH-Schlagworte: Spike Glycoprotein, Coronavirus*/immunology , Spike Glycoprotein, Coronavirus*/analysis , Monocytes*/immunology , Monocytes*/metabolism , Receptors, IgG*/immunology , Receptors, IgG*/metabolism , COVID-19*/immunology , COVID-19*/prevention & control , COVID-19 Vaccines*/immunology , COVID-19 Vaccines*/adverse effects , COVID-19 Vaccines*/administration & dosage , SARS-CoV-2*/immunology, Humans ; Male ; Female ; Middle Aged ; Adult ; Aged ; Cytokines ; GPI-Linked Proteins

Human cytomegalovirus-triggered necroptosis is suppressed by sequestration of MLKL in the nucleus of infected monocytes.

Autoren: Geiler BW Moradpour S Chauder BB et al.

Quelle: Journal of virology [J Virol] 2025 Nov 25; Vol. 99 (11), pp. e0102025. Date of Electronic Publication: 2025 Nov 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE

MeSH-Schlagworte: Monocytes*/virology , Monocytes*/metabolism , Necroptosis* , Cytomegalovirus*/physiology , Protein Kinases*/metabolism , Protein Kinases*/genetics , Cytomegalovirus Infections*/virology , Cytomegalovirus Infections*/metabolism , Cell Nucleus*/metabolism , Cell Nucleus*/virology, Humans ; Caspase 8/metabolism ; Apoptosis ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism

Monocytes at the crossroads of aortic stenosis and myocardial damage.

Autoren: Issa N Candellier A Boudot C et al.

Quelle: Cardiovascular research [Cardiovasc Res] 2025 Nov 22; Vol. 121 (14), pp. 2157-2176.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Oxford Journals Country of Publication: England NLM ID: 0077427 Publication Model: Print Cited Medium: Internet ISSN: 1755-3245 (Electronic) Linking ISSN: 00086363 NLM ISO Abbreviation: Cardiovasc Res Subsets: MEDLINE

MeSH-Schlagworte: Aortic Valve Stenosis*/pathology , Aortic Valve Stenosis*/physiopathology , Aortic Valve Stenosis*/metabolism , Aortic Valve Stenosis*/surgery , Aortic Valve Stenosis*/immunology , Aortic Valve Stenosis*/therapy , Monocytes*/metabolism , Monocytes*/pathology , Monocytes*/drug effects , Monocytes*/immunology , Aortic Valve*/pathology , Aortic Valve*/metabolism , Aortic Valve*/physiopathology , Aortic Valve*/surgery , Aortic Valve*/immunology , Myocardium*/pathology , Myocardium*/metabolism , Myocardium*/immunology , Calcinosis*/pathology , Calcinosis*/physiopathology , Calcinosis*/metabolism, Humans ; Animals ; Disease Progression ; Inflammation Mediators/metabolism ; Ventricular Remodeling ; Heart Valve Prosthesis Implantation/adverse effects ; Fibrosis ; Signal Transduction ; Transcatheter Aortic Valve Replacement/adverse effects ; Risk Factors

SCR Disease Name: Aortic Valve, Calcification of

Monocytes/Macrophages and Atherogenesis.

Autoren: Kozlov S Riazantseva T Melnikov I et al.

Quelle: International journal of molecular sciences [Int J Mol Sci] 2025 Nov 12; Vol. 26 (22). Date of Electronic Publication: 2025 Nov 12.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: Atherosclerosis*/pathology , Atherosclerosis*/metabolism , Atherosclerosis*/immunology , Atherosclerosis*/etiology , Macrophages*/metabolism , Macrophages*/pathology , Macrophages*/immunology , Monocytes*/metabolism , Monocytes*/pathology , Monocytes*/immunology, Humans ; Animals ; Plaque, Atherosclerotic/pathology ; Plaque, Atherosclerotic/metabolism ; Inflammation/pathology

Alpha-toxin-elicited CX 3 CL1 release in Staphylococcus aureus pneumonia impairs bactericidal function of human monocytes.

Autoren: Mairpady Shambat S Chen P Barilla RM et al.

Quelle: MBio [mBio] 2025 Nov 12; Vol. 16 (11), pp. e0268925. Date of Electronic Publication: 2025 Oct 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE

MeSH-Schlagworte: Bacterial Toxins*/metabolism , Bacterial Toxins*/toxicity , Monocytes*/immunology , Monocytes*/drug effects , Monocytes*/microbiology , Staphylococcus aureus*/pathogenicity , Staphylococcus aureus*/immunology , Chemokine CX3CL1*/metabolism , Hemolysin Proteins*/metabolism , Pneumonia, Staphylococcal*/microbiology , Pneumonia, Staphylococcal*/immunology , Pneumonia, Staphylococcal*/metabolism, Humans ; Lung/microbiology ; Phagocytosis ; ADAM10 Protein/metabolism ; ADAM10 Protein/antagonists & inhibitors ; Membrane Proteins ; Amyloid Precursor Protein Secretases

A TLR4-dependent fibroblast-monocyte axis in tumor-draining lymph nodes contributes to metastasis in triple-negative breast cancer.

Autoren: Mattavelli G Helal M Cetkovic A et al.

Quelle: Immunity [Immunity] 2025 Nov 11; Vol. 58 (11), pp. 2830-2846.e15. Date of Electronic Publication: 2025 Sep 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE

MeSH-Schlagworte: Triple Negative Breast Neoplasms*/pathology , Triple Negative Breast Neoplasms*/immunology , Triple Negative Breast Neoplasms*/metabolism , Toll-Like Receptor 4*/metabolism , Toll-Like Receptor 4*/immunology , Monocytes*/immunology , Monocytes*/metabolism , Lymph Nodes*/immunology , Lymph Nodes*/pathology , Lymph Nodes*/metabolism , Fibroblasts*/immunology , Fibroblasts*/metabolism, Animals ; Female ; Mice ; Humans ; B7-H1 Antigen/metabolism ; Cell Line, Tumor ; Lymphatic Metastasis ; Tumor Microenvironment/immunology ; Chemokine CCL2/metabolism ; T-Lymphocytes/immunology

Temporary effects of random positioning on the function and plasticity of proliferating monocytes.

Autoren: Marchal S Dittrich A Becker N et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 10; Vol. 15 (1), pp. 39360. Date of Electronic Publication: 2025 Nov 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Monocytes*/cytology , Monocytes*/physiology , Monocytes*/drug effects , Monocytes*/metabolism , Cell Proliferation* , Cell Plasticity*, Humans ; Cell Differentiation ; Lipopolysaccharides/pharmacology ; Phagocytosis ; THP-1 Cells ; Macrophages/cytology ; Cell Culture Techniques/methods

A contemporary strain of RSV activates primary human monocytes after abortive infection.

Autoren: Agac A Ludlow M Knittler MC et al.

Quelle: Frontiers in immunology [Front Immunol] 2025 Nov 07; Vol. 16, pp. 1699818. Date of Electronic Publication: 2025 Nov 07 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH-Schlagworte: Monocytes*/immunology , Monocytes*/virology , Monocytes*/metabolism , Respiratory Syncytial Virus Infections*/immunology , Respiratory Syncytial Virus Infections*/virology , Respiratory Syncytial Virus, Human*/immunology , Respiratory Syncytial Virus, Human*/physiology, Humans ; Cytokines/metabolism ; THP-1 Cells ; Cells, Cultured ; HLA-DR Antigens ; Chemokines/metabolism

Transcriptome analysis of classical blood cells reveals downregulation of pro-inflammatory genes in the classical monocytes of long COVID patients.

Autoren: Fricke F Mai F Wossidlo C et al.

Quelle: Frontiers in immunology [Front Immunol] 2025 Nov 07; Vol. 16, pp. 1710783. Date of Electronic Publication: 2025 Nov 07 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH-Schlagworte: COVID-19*/immunology , COVID-19*/genetics , COVID-19*/blood , Monocytes*/immunology , Monocytes*/metabolism , SARS-CoV-2*/immunology , Transcriptome*, Humans ; Male ; Female ; Gene Expression Profiling ; Middle Aged ; Down-Regulation ; Adult ; Inflammation/genetics ; Inflammation/immunology ; Single-Cell Analysis ; Cytokines/blood ; Aged ; Leukocytes, Mononuclear/immunology

Unveiling the Role of Sdc4⁺ Monocytes in NASH: A Single-Cell RNA Sequencing Study.

Autoren: Li JZ Mao T Gao YX et al.

Quelle: Immunological investigations [Immunol Invest] 2025 Nov; Vol. 54 (8), pp. 1445-1460. Date of Electronic Publication: 2025 Aug 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8504629 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-4311 (Electronic) Linking ISSN: 08820139 NLM ISO Abbreviation: Immunol Invest Subsets: MEDLINE

MeSH-Schlagworte: Monocytes*/immunology , Monocytes*/metabolism , Non-alcoholic Fatty Liver Disease*/immunology , Non-alcoholic Fatty Liver Disease*/genetics , Non-alcoholic Fatty Liver Disease*/metabolism , Syndecan-4*/metabolism , Syndecan-4*/genetics, Animals ; Humans ; Mice ; Single-Cell Analysis ; Sequence Analysis, RNA ; Hep G2 Cells ; Male ; Liver/pathology ; Liver/immunology ; Mice, Inbred C57BL ; Interleukin-10/genetics ; Interleukin-10/metabolism ; Macrophages/immunology ; Disease Models, Animal ; Female

Butyrate suppresses mucosal inflammation in inflammatory bowel disease primarily through HDAC3 inhibition in monocytes and macrophages.

Autoren: Parada-Venegas D De la Fuente López M Dubois-Camacho K et al.

Quelle: The FEBS journal [FEBS J] 2025 Nov; Vol. 292 (22), pp. 6134-6157. Date of Electronic Publication: 2025 Oct 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 101229646 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-4658 (Electronic) Linking ISSN: 1742464X NLM ISO Abbreviation: FEBS J Subsets: MEDLINE

MeSH-Schlagworte: Histone Deacetylases*/metabolism , Histone Deacetylases*/genetics , Inflammatory Bowel Diseases*/drug therapy , Inflammatory Bowel Diseases*/pathology , Inflammatory Bowel Diseases*/genetics , Inflammatory Bowel Diseases*/metabolism , Macrophages*/drug effects , Macrophages*/metabolism , Macrophages*/pathology , Butyrates*/pharmacology , Monocytes*/drug effects , Monocytes*/metabolism , Monocytes*/pathology , Intestinal Mucosa*/drug effects , Intestinal Mucosa*/pathology , Intestinal Mucosa*/metabolism, Humans ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Receptors, G-Protein-Coupled/antagonists & inhibitors ; Histone Deacetylase Inhibitors/pharmacology ; Monocarboxylic Acid Transporters/genetics ; Monocarboxylic Acid Transporters/metabolism ; Inflammation/drug therapy ; Inflammation/pathology ; Organoids/drug effects ; Organoids/metabolism ; Phagocytosis/drug effects ; THP-1 Cells ; Symporters

The effects of interleukin-6-receptor inhibition on monocytes in STEMI: a substudy of the ASSAIL-MI trial.

Autoren: Huse C Murphy SL Yang K et al.

Quelle: EBioMedicine [EBioMedicine] 2025 Nov; Vol. 121, pp. 105960. Date of Electronic Publication: 2025 Oct 11.

Publikationsart: Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE

MeSH-Schlagworte: Monocytes*/metabolism , Monocytes*/drug effects , ST Elevation Myocardial Infarction*/drug therapy , ST Elevation Myocardial Infarction*/metabolism , ST Elevation Myocardial Infarction*/blood , Receptors, Interleukin-6*/antagonists & inhibitors , Receptors, Interleukin-6*/metabolism , Antibodies, Monoclonal, Humanized*/therapeutic use , Antibodies, Monoclonal, Humanized*/pharmacology, Humans ; Male ; Female ; Middle Aged ; Apoptosis/drug effects ; Aged ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/drug effects ; Transcriptome ; Suppressor of Cytokine Signaling 3 Protein/metabolism ; Suppressor of Cytokine Signaling 3 Protein/genetics

Systems approach identifies monocyte imbalance in symptomatic and asymptomatic P. vivax malaria.

Autoren: Studniberg SI Bafit M Ioannidis LJ et al.

Quelle: Molecular systems biology [Mol Syst Biol] 2025 Nov; Vol. 21 (11), pp. 1434-1465. Date of Electronic Publication: 2025 Aug 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101235389 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-4292 (Electronic) Linking ISSN: 17444292 NLM ISO Abbreviation: Mol Syst Biol Subsets: MEDLINE

MeSH-Schlagworte: Malaria, Vivax*/immunology , Malaria, Vivax*/parasitology , Malaria, Vivax*/genetics , Monocytes*/immunology , Monocytes*/metabolism , Monocytes*/parasitology , Plasmodium vivax*/immunology , Systems Biology*/methods, Humans ; Gene Expression Profiling ; Asymptomatic Infections ; Male ; Adult ; Female ; Gene Expression Regulation

SARS-CoV-2 Nucleocapsid Protein Does Not Induce Inflammation in Endothelial Cells or Monocytes.

Autoren: Tufail M Lu X Barr SD et al.

Quelle: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2025 Oct 31; Vol. 39 (20), pp. e71142.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

MeSH-Schlagworte: Monocytes*/metabolism , Monocytes*/immunology , Monocytes*/drug effects , Monocytes*/pathology , Endothelial Cells*/metabolism , Endothelial Cells*/drug effects , Endothelial Cells*/immunology , Endothelial Cells*/pathology , Endothelial Cells*/virology , Inflammation*/metabolism , Coronavirus Nucleocapsid Proteins*/pharmacology , SARS-CoV-2*/metabolism , COVID-19*/virology , Phosphoproteins*, Humans ; Animals ; Mice ; Lipopolysaccharides/pharmacology ; THP-1 Cells ; Cell Adhesion/drug effects

Multi-Omics Dissection of TIMP1 in Monocytes/Macrophages Reveals Pathogenic Mechanisms and Therapeutic Opportunities in Ankylosing Spondylitis.

Autoren: Chen J Huang C Xue J et al.

Quelle: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2025 Oct 31; Vol. 39 (20), pp. e71086.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

MeSH-Schlagworte: Tissue Inhibitor of Metalloproteinase-1*/genetics , Tissue Inhibitor of Metalloproteinase-1*/metabolism , Monocytes*/metabolism , Monocytes*/pathology , Spondylitis, Ankylosing*/metabolism , Spondylitis, Ankylosing*/drug therapy , Spondylitis, Ankylosing*/genetics , Spondylitis, Ankylosing*/pathology , Macrophages*/metabolism , Macrophages*/pathology, Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Animals ; Proteomics/methods ; Male ; STAT1 Transcription Factor/metabolism ; STAT1 Transcription Factor/genetics ; Multiomics

Monocyte-driven IFN and TNF programs orchestrate inflammatory networks in antisynthetase syndrome-associated interstitial lung disease.

Autoren: Fan Y Zhang W Su M et al.

Quelle: Frontiers in immunology [Front Immunol] 2025 Oct 23; Vol. 16, pp. 1652999. Date of Electronic Publication: 2025 Oct 23 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH-Schlagworte: Lung Diseases, Interstitial*/immunology , Lung Diseases, Interstitial*/etiology , Lung Diseases, Interstitial*/metabolism , Myositis*/immunology , Myositis*/complications , Monocytes*/immunology , Monocytes*/metabolism , Tumor Necrosis Factor-alpha*/metabolism , Tumor Necrosis Factor-alpha*/immunology , Tumor Necrosis Factor-alpha*/genetics , Interferon-gamma*/metabolism , Interferon-gamma*/immunology, Humans ; Male ; Female ; Middle Aged ; Gene Regulatory Networks ; Single-Cell Analysis ; Signal Transduction ; Aged ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/metabolism

SCR Disease Name: Antisynthetase syndrome

Paroxetine suppresses 27-hydroxycholesterol-induced responses in THP-1 human monocytic cells by regulating the AKT/mTORC1 pathway.

Autoren: Park D Son Y Lee D et al.

Quelle: Scientific reports [Sci Rep] 2025 Oct 21; Vol. 15 (1), pp. 36797. Date of Electronic Publication: 2025 Oct 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Proto-Oncogene Proteins c-akt*/metabolism , Hydroxycholesterols*/pharmacology , Monocytes*/drug effects , Monocytes*/metabolism , Mechanistic Target of Rapamycin Complex 1*/metabolism , Signal Transduction*/drug effects, Humans ; THP-1 Cells ; Phosphorylation/drug effects ; Chemokine CCL2/metabolism ; Chemokine CCL2/genetics