Výsledky vyhledávání - "minimizing side effects"

Tumor size in mice with KRAS-Ink tumors following systemic treatment with MMAF or iRGD-MMAF.

Autoři: Norio Miyamura Chisato M. Yamazaki Yasuaki Anami a další

Témata: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Cancer, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, mmaf homed selectively, minimizing side effects, mmaf conjugate internalized, specific delivery scaffold, specific cytotoxic agent, extravascular tumor tissue, specific delivery, mmaf ), tumor effects, specific entry, drug conjugate, cytotoxic peptide, %22">xlink ">, v integrin, tumor tissues, results indicate, penetrating capacity, injected systemically

Dostupnost: https://doi.org/10.1371/journal.pone.0331564.s002
https://figshare.com/articles/journal_contribution/Tumor_size_in_mice_with_KRAS-Ink_tumors_following_systemic_treatment_with_MMAF_or_iRGD-MMAF_/30034403

Information for detailed synthesis procedures and characterization data for compounds.

Autoři: Norio Miyamura Chisato M. Yamazaki Yasuaki Anami a další

Témata: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Cancer, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, mmaf homed selectively, minimizing side effects, mmaf conjugate internalized, specific delivery scaffold, specific cytotoxic agent, extravascular tumor tissue, specific delivery, mmaf ), tumor effects, specific entry, drug conjugate, cytotoxic peptide, %22">xlink ">, v integrin, tumor tissues, results indicate, penetrating capacity, injected systemically

Relation: https://figshare.com/articles/journal_contribution/Information_for_detailed_synthesis_procedures_and_characterization_data_for_compounds_/30034400

Dostupnost: https://doi.org/10.1371/journal.pone.0331564.s001
https://figshare.com/articles/journal_contribution/Information_for_detailed_synthesis_procedures_and_characterization_data_for_compounds_/30034400

Fig A: Box plot showing the Normalized Sensitivity Indices (SI) Across Parameters and Scaling Ranges.

Autoři: Aryan Golzaryan Mohammad Souri Farshad M. Kashkooli a další

Témata: Biophysics, Medicine, Physiology, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, local sensitivity analysis, interstitial fluid pressure, gamma camera imaging, calculated absorbed doses, injected activity amount, 7 %), resulting, statistical analysis using, multiscale modeling framework, minimizing side effects, increase clearance rate, aai proved beneficial, tumor absorbed dose, standalone pbpk model, absorbed dose, tumor heterogeneity, administered activity, without aai, wilcoxon signed, selected radiation, salivary glands, salivary gland

Relation: https://figshare.com/articles/journal_contribution/Fig_A_Box_plot_showing_the_Normalized_Sensitivity_Indices_SI_Across_Parameters_and_Scaling_Ranges_/29585701

Dostupnost: https://doi.org/10.1371/journal.pcbi.1013247.s003
https://figshare.com/articles/journal_contribution/Fig_A_Box_plot_showing_the_Normalized_Sensitivity_Indices_SI_Across_Parameters_and_Scaling_Ranges_/29585701

Fig A: Classification of compartments and their sub-compartments.

Autoři: Aryan Golzaryan Mohammad Souri Farshad M. Kashkooli a další

Témata: Biophysics, Medicine, Physiology, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, local sensitivity analysis, interstitial fluid pressure, gamma camera imaging, calculated absorbed doses, injected activity amount, 7 %), resulting, statistical analysis using, multiscale modeling framework, minimizing side effects, increase clearance rate, aai proved beneficial, tumor absorbed dose, standalone pbpk model, absorbed dose, tumor heterogeneity, administered activity, without aai, wilcoxon signed, selected radiation, salivary glands, salivary gland

Dostupnost: https://doi.org/10.1371/journal.pcbi.1013247.s001
https://figshare.com/articles/journal_contribution/Fig_A_Classification_of_compartments_and_their_sub-compartments_/29585695

Fig A: The results of fitting the designed PBPK model to data obtained from -camera imaging for patient 1.

Autoři: Aryan Golzaryan Mohammad Souri Farshad M. Kashkooli a další

Témata: Biophysics, Medicine, Physiology, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, local sensitivity analysis, interstitial fluid pressure, gamma camera imaging, calculated absorbed doses, injected activity amount, 7 %), resulting, statistical analysis using, multiscale modeling framework, minimizing side effects, increase clearance rate, aai proved beneficial, tumor absorbed dose, standalone pbpk model, absorbed dose, tumor heterogeneity, administered activity, without aai, wilcoxon signed, selected radiation, salivary glands, salivary gland

Dostupnost: https://doi.org/10.1371/journal.pcbi.1013247.s002
https://figshare.com/articles/journal_contribution/Fig_A_The_results_of_fitting_the_designed_PBPK_model_to_data_obtained_from_-camera_imaging_for_patient_1_/29585698

Remodeling the Tumor Microenvironment via Metal-Phenolic Network-Coated Poly(lactic acid- co -glycolic acid) Nanoparticles for Inducing Multimodal Combination Therapy in Non-Small Cell Lung Cancer

Autoři: Yang Wang Dianpeng Li Min He a další

Témata: Biochemistry, Medicine, Molecular Biology, Pharmacology, Cancer, Infectious Diseases, Space Science, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, strongly acidic environment, stable multifunctional nanocomplex, minimizing side effects, lactic acid -<, hydroxyl free radicals, gluconic acid enhances, generates gluconic acid, current chemotherapy agents, adenosine triphosphate levels, >- glycolic acid, pdftg selectively accumulates, 3 +, 2 +, x , subsequently releasing fe, mitochondrial damage results, 2 , tumor microenvironment offer, multimode treatment strategies, mitochondrial damage, co <

Dostupnost: https://doi.org/10.1021/acsabm.5c00634.s001
https://figshare.com/articles/journal_contribution/Remodeling_the_Tumor_Microenvironment_via_Metal-Phenolic_Network-Coated_Poly_lactic_acid-_i_co_i_-glycolic_acid_Nanoparticles_for_Inducing_Multimodal_Combination_Therapy_in_Non-Small_Cell_Lung_Cancer/29399905

SMVSNN: An Intelligent Framework for Anticancer Drug–Drug Interaction Prediction Utilizing Spiking Multi-view Siamese Neural Networks

Autoři: Guoliang Tan Yijun Liu Wujian Ye a další

Témata: Neuroscience, Pharmacology, Space Science, Biological Sciences not elsewhere classified, Information Systems not elsewhere classified, synergistic drug combinations, previous computational methods, predicting potential ddis, overly direct concatenation, minimizing side effects, integrate latent information, increasingly replacing traditional, complementary drug actions, authoritative public databases, 19 drug interactions, fused features using, drug pair features, including 904 drugs, spiking neural perceptron, novel ddi analysis, 7730 ddi records, existing data encoding, drug pair data, traditional intelligent algorithms, intelligent algorithms, two drugs, spiking neurons, spiking multi, data science, processed features

Dostupnost: https://doi.org/10.1021/acs.jcim.4c02205.s001
https://figshare.com/articles/journal_contribution/SMVSNN_An_Intelligent_Framework_for_Anticancer_Drug_Drug_Interaction_Prediction_Utilizing_Spiking_Multi-view_Siamese_Neural_Networks/29123461

Tumor-specific homing and anti-tumor effects of iRGD-MMAF.

Autoři: Norio Miyamura Chisato M. Yamazaki Yasuaki Anami a další

Témata: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Cancer, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, mmaf homed selectively, minimizing side effects, mmaf conjugate internalized, specific delivery scaffold, specific cytotoxic agent, extravascular tumor tissue, specific delivery, mmaf ), tumor effects, specific entry, drug conjugate, cytotoxic peptide, %22">xlink ">, v integrin, tumor tissues, results indicate, penetrating capacity, injected systemically

Dostupnost: https://doi.org/10.1371/journal.pone.0331564.g003
https://figshare.com/articles/figure/Tumor-specific_homing_and_anti-tumor_effects_of_iRGD-MMAF_/30034415

αv integrin-dependent internalization and cytotoxicity of iRGD-MMAF.

Autoři: Norio Miyamura Chisato M. Yamazaki Yasuaki Anami a další

Témata: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Cancer, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, mmaf homed selectively, minimizing side effects, mmaf conjugate internalized, specific delivery scaffold, specific cytotoxic agent, extravascular tumor tissue, specific delivery, mmaf ), tumor effects, specific entry, drug conjugate, cytotoxic peptide, %22">xlink ">, v integrin, tumor tissues, results indicate, penetrating capacity, injected systemically

Dostupnost: https://doi.org/10.1371/journal.pone.0331564.g002
https://figshare.com/articles/figure/_v_integrin-dependent_internalization_and_cytotoxicity_of_iRGD-MMAF_/30034409

Tumor-specific delivery of a co-injected dye with iRGD-MMAF.

Autoři: Norio Miyamura Chisato M. Yamazaki Yasuaki Anami a další

Témata: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Cancer, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, mmaf homed selectively, minimizing side effects, mmaf conjugate internalized, specific delivery scaffold, specific cytotoxic agent, extravascular tumor tissue, specific delivery, mmaf ), tumor effects, specific entry, drug conjugate, cytotoxic peptide, %22">xlink ">, v integrin, tumor tissues, results indicate, penetrating capacity, injected systemically

Dostupnost: https://doi.org/10.1371/journal.pone.0331564.g004
https://figshare.com/articles/figure/Tumor-specific_delivery_of_a_co-injected_dye_with_iRGD-MMAF_/30034418

Chemical structure of iRGD-MMAF conjugates.

Autoři: Norio Miyamura Chisato M. Yamazaki Yasuaki Anami a další

Témata: Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Cancer, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, mmaf homed selectively, minimizing side effects, mmaf conjugate internalized, specific delivery scaffold, specific cytotoxic agent, extravascular tumor tissue, specific delivery, mmaf ), tumor effects, specific entry, drug conjugate, cytotoxic peptide, %22">xlink ">, v integrin, tumor tissues, results indicate, penetrating capacity, injected systemically

Dostupnost: https://doi.org/10.1371/journal.pone.0331564.g001
https://figshare.com/articles/figure/Chemical_structure_of_iRGD-MMAF_conjugates_/30034406

Measured and estimated parameters of 4 patients for PBPK Model.

Autoři: Aryan Golzaryan Mohammad Souri Farshad M. Kashkooli a další

Témata: Biophysics, Medicine, Physiology, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, local sensitivity analysis, interstitial fluid pressure, gamma camera imaging, calculated absorbed doses, injected activity amount, 7 %), resulting, statistical analysis using, multiscale modeling framework, minimizing side effects, increase clearance rate, aai proved beneficial, tumor absorbed dose, standalone pbpk model, absorbed dose, tumor heterogeneity, administered activity, without aai, wilcoxon signed, selected radiation, salivary glands, salivary gland

Relation: https://figshare.com/articles/dataset/Measured_and_estimated_parameters_of_4_patients_for_PBPK_Model_/29585743

Dostupnost: https://doi.org/10.1371/journal.pcbi.1013247.t002
https://figshare.com/articles/dataset/Measured_and_estimated_parameters_of_4_patients_for_PBPK_Model_/29585743

Impact of amino acid administration on RPT Efficacy. Kidney and salivary gland organs are individually designated as organs-at-risk, determining the maximum safe injected activity. Subsequently, the absorbed dose to tumors is computed. Left column indicates the maximum possible activity that can be injected and the tumor absorbed dose when the kidney is the organ at risk, with and without amino acid administration. Right column indicates the maximum possible activity that can be injected and the tumor absorbed dose when the salivary gland is the organ at risk, with and without amino acid administration.

Autoři: Aryan Golzaryan Mohammad Souri Farshad M. Kashkooli a další

Témata: Biophysics, Medicine, Physiology, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, local sensitivity analysis, interstitial fluid pressure, gamma camera imaging, calculated absorbed doses, injected activity amount, 7 %), resulting, statistical analysis using, multiscale modeling framework, minimizing side effects, increase clearance rate, aai proved beneficial, tumor absorbed dose, standalone pbpk model, absorbed dose, tumor heterogeneity, administered activity, without aai, wilcoxon signed, selected radiation, salivary glands, salivary gland

Dostupnost: https://doi.org/10.1371/journal.pcbi.1013247.t003
https://figshare.com/articles/dataset/Impact_of_amino_acid_administration_on_RPT_Efficacy_Kidney_and_salivary_gland_organs_are_individually_designated_as_organs-at-risk_determining_the_maximum_safe_injected_activity_Subsequently_the_absorbed_dose_to_tumors_is_computed_Left_colu/29585746

Parameters considered in CDR equation for simulating spatiotemporal distribution in tumor microenvironment.

Autoři: Aryan Golzaryan Mohammad Souri Farshad M. Kashkooli a další

Témata: Biophysics, Medicine, Physiology, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, local sensitivity analysis, interstitial fluid pressure, gamma camera imaging, calculated absorbed doses, injected activity amount, 7 %), resulting, statistical analysis using, multiscale modeling framework, minimizing side effects, increase clearance rate, aai proved beneficial, tumor absorbed dose, standalone pbpk model, absorbed dose, tumor heterogeneity, administered activity, without aai, wilcoxon signed, selected radiation, salivary glands, salivary gland

Relation: https://figshare.com/articles/dataset/Parameters_considered_in_CDR_equation_for_simulating_spatiotemporal_distribution_in_tumor_microenvironment_/29585740

Dostupnost: https://doi.org/10.1371/journal.pcbi.1013247.t001
https://figshare.com/articles/dataset/Parameters_considered_in_CDR_equation_for_simulating_spatiotemporal_distribution_in_tumor_microenvironment_/29585740

Comparison of radiopharmaceutical concentration in tumor vascular space, with and without amino acid administration, across 4 mCRPC patients.

Autoři: Aryan Golzaryan Mohammad Souri Farshad M. Kashkooli a další

Témata: Biophysics, Medicine, Physiology, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, local sensitivity analysis, interstitial fluid pressure, gamma camera imaging, calculated absorbed doses, injected activity amount, 7 %), resulting, statistical analysis using, multiscale modeling framework, minimizing side effects, increase clearance rate, aai proved beneficial, tumor absorbed dose, standalone pbpk model, absorbed dose, tumor heterogeneity, administered activity, without aai, wilcoxon signed, selected radiation, salivary glands, salivary gland

Relation: https://figshare.com/articles/figure/Comparison_of_radiopharmaceutical_concentration_in_tumor_vascular_space_with_and_without_amino_acid_administration_across_4_mCRPC_patients_/29585737

Dostupnost: https://doi.org/10.1371/journal.pcbi.1013247.g010
https://figshare.com/articles/figure/Comparison_of_radiopharmaceutical_concentration_in_tumor_vascular_space_with_and_without_amino_acid_administration_across_4_mCRPC_patients_/29585737

The spatiotemporal distribution of radiopharmaceuticals that internalized into tumor cells at (A) 500 min, (B) 1000 min, (C) 3000 min, (D) 6000 min, and (E) 30000 min post-treatment for patient 1.

Autoři: Aryan Golzaryan Mohammad Souri Farshad M. Kashkooli a další

Témata: Biophysics, Medicine, Physiology, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, local sensitivity analysis, interstitial fluid pressure, gamma camera imaging, calculated absorbed doses, injected activity amount, 7 %), resulting, statistical analysis using, multiscale modeling framework, minimizing side effects, increase clearance rate, aai proved beneficial, tumor absorbed dose, standalone pbpk model, absorbed dose, tumor heterogeneity, administered activity, without aai, wilcoxon signed, selected radiation, salivary glands, salivary gland

Dostupnost: https://doi.org/10.1371/journal.pcbi.1013247.g008
https://figshare.com/articles/figure/The_spatiotemporal_distribution_of_radiopharmaceuticals_that_internalized_into_tumor_cells_at_A_500_min_B_1000_min_C_3000_min_D_6000_min_and_E_30000_min_post-treatment_for_patient_1_/29585731

The spatiotemporal distribution of radiopharmaceuticals in tumor interstitial space at (A) 500 min, (B) 1000 min, (C) 3000 min, (D) 6000 min, and (E) 30000 min post-treatment for patient 1.

Autoři: Aryan Golzaryan Mohammad Souri Farshad M. Kashkooli a další

Témata: Biophysics, Medicine, Physiology, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, local sensitivity analysis, interstitial fluid pressure, gamma camera imaging, calculated absorbed doses, injected activity amount, 7 %), resulting, statistical analysis using, multiscale modeling framework, minimizing side effects, increase clearance rate, aai proved beneficial, tumor absorbed dose, standalone pbpk model, absorbed dose, tumor heterogeneity, administered activity, without aai, wilcoxon signed, selected radiation, salivary glands, salivary gland

Dostupnost: https://doi.org/10.1371/journal.pcbi.1013247.g006
https://figshare.com/articles/figure/The_spatiotemporal_distribution_of_radiopharmaceuticals_in_tumor_interstitial_space_at_A_500_min_B_1000_min_C_3000_min_D_6000_min_and_E_30000_min_post-treatment_for_patient_1_/29585725

Interstitial fluid pressure (IFP) and intravascular fluid pressure (IVP) validation; (A) Simulated distribution of IFP and (B) IVP within the tumor microenvironment.

Autoři: Aryan Golzaryan Mohammad Souri Farshad M. Kashkooli a další

Témata: Biophysics, Medicine, Physiology, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, local sensitivity analysis, interstitial fluid pressure, gamma camera imaging, calculated absorbed doses, injected activity amount, 7 %), resulting, statistical analysis using, multiscale modeling framework, minimizing side effects, increase clearance rate, aai proved beneficial, tumor absorbed dose, standalone pbpk model, absorbed dose, tumor heterogeneity, administered activity, without aai, wilcoxon signed, selected radiation, salivary glands, salivary gland

Relation: https://figshare.com/articles/figure/Interstitial_fluid_pressure_IFP_and_intravascular_fluid_pressure_IVP_validation_A_Simulated_distribution_of_IFP_and_B_IVP_within_the_tumor_microenvironment_/29585716

Dostupnost: https://doi.org/10.1371/journal.pcbi.1013247.g004
https://figshare.com/articles/figure/Interstitial_fluid_pressure_IFP_and_intravascular_fluid_pressure_IVP_validation_A_Simulated_distribution_of_IFP_and_B_IVP_within_the_tumor_microenvironment_/29585716

The modeling of angiogenesis process over a span of 30 days is depicted and compared qualitatively with actual microvasculature surrounding and within tumors.

Autoři: Aryan Golzaryan Mohammad Souri Farshad M. Kashkooli a další

Témata: Biophysics, Medicine, Physiology, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, local sensitivity analysis, interstitial fluid pressure, gamma camera imaging, calculated absorbed doses, injected activity amount, 7 %), resulting, statistical analysis using, multiscale modeling framework, minimizing side effects, increase clearance rate, aai proved beneficial, tumor absorbed dose, standalone pbpk model, absorbed dose, tumor heterogeneity, administered activity, without aai, wilcoxon signed, selected radiation, salivary glands, salivary gland

Relation: https://figshare.com/articles/figure/The_modeling_of_angiogenesis_process_over_a_span_of_30_days_is_depicted_and_compared_qualitatively_with_actual_microvasculature_surrounding_and_within_tumors_/29585713

Dostupnost: https://doi.org/10.1371/journal.pcbi.1013247.g003
https://figshare.com/articles/figure/The_modeling_of_angiogenesis_process_over_a_span_of_30_days_is_depicted_and_compared_qualitatively_with_actual_microvasculature_surrounding_and_within_tumors_/29585713

Illustration of the strategy.

Autoři: Aryan Golzaryan Mohammad Souri Farshad M. Kashkooli a další

Témata: Biophysics, Medicine, Physiology, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, local sensitivity analysis, interstitial fluid pressure, gamma camera imaging, calculated absorbed doses, injected activity amount, 7 %), resulting, statistical analysis using, multiscale modeling framework, minimizing side effects, increase clearance rate, aai proved beneficial, tumor absorbed dose, standalone pbpk model, absorbed dose, tumor heterogeneity, administered activity, without aai, wilcoxon signed, selected radiation, salivary glands, salivary gland

Relation: https://figshare.com/articles/figure/Illustration_of_the_strategy_/29585707

Dostupnost: https://doi.org/10.1371/journal.pcbi.1013247.g001
https://figshare.com/articles/figure/Illustration_of_the_strategy_/29585707