Suchergebnisse - "messenger"

IRE1α RNase activity is critical for early embryo development by degrading maternal transcripts.

Autoren: Li C Tan YP Gao D et al.

Quelle: Nucleic acids research [Nucleic Acids Res] 2025 Jun 06; Vol. 53 (11).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

MeSH-Schlagworte: Endoribonucleases*/genetics , Endoribonucleases*/metabolism , Embryonic Development*/genetics , Protein Serine-Threonine Kinases*/genetics , Protein Serine-Threonine Kinases*/metabolism , RNA Stability* , RNA, Messenger, Stored*/metabolism , RNA, Messenger, Stored*/genetics, Animals ; Female ; Mice ; Oocytes/metabolism ; Gene Expression Regulation, Developmental ; Zygote/metabolism ; RNA, Messenger/metabolism ; RNA, Messenger/genetics ; Unfolded Protein Response/genetics ; X-Box Binding Protein 1/metabolism

ZAR1 and ZAR2 orchestrate the dynamics of maternal mRNA polyadenylation during mouse oocyte development.

Autoren: Wu YK Su R Jiang ZY et al.

Quelle: Genome biology [Genome Biol] 2025 May 08; Vol. 26 (1), pp. 120. Date of Electronic Publication: 2025 May 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100960660 Publication Model: Electronic Cited Medium: Internet ISSN: 1474-760X (Electronic) Linking ISSN: 14747596 NLM ISO Abbreviation: Genome Biol Subsets: MEDLINE

MeSH-Schlagworte: Oocytes*/metabolism , Oocytes*/growth & development , Polyadenylation* , Oogenesis*/genetics , Egg Proteins*/metabolism , Egg Proteins*/genetics , RNA, Messenger, Stored*/metabolism , RNA, Messenger, Stored*/genetics , RNA-Binding Proteins*/metabolism , RNA-Binding Proteins*/genetics, Animals ; Mice ; Female ; 3' Untranslated Regions ; RNA, Messenger/metabolism ; RNA, Messenger/genetics ; Gene Expression Regulation, Developmental ; Transcriptome ; RNA Stability

TargetRX Atlas: a database of experimentally supported mRNAs and drug targets in disease.

Autoren: Liu Y Xu F Wang T et al.

Quelle: Computers in biology and medicine [Comput Biol Med] 2025 Nov; Vol. 198 (Pt A), pp. 111191. Date of Electronic Publication: 2025 Oct 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 1250250 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0534 (Electronic) Linking ISSN: 00104825 NLM ISO Abbreviation: Comput Biol Med Subsets: MEDLINE

MeSH-Schlagworte: RNA, Messenger*/genetics , RNA, Messenger*/metabolism , Databases, Genetic*, Humans ; Computational Biology/methods

Tumor microenvironment-responsive dynamic self-assembly of DNAzyme nanowires for high-contrast imaging of multiple messenger RNAs and chemotherapy.

Autoren: Yuan H Li HJ Wang LJ et al.

Quelle: Biosensors & bioelectronics [Biosens Bioelectron] 2025 Nov 01; Vol. 287, pp. 117728. Date of Electronic Publication: 2025 Jun 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Advanced Technology Country of Publication: England NLM ID: 9001289 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4235 (Electronic) Linking ISSN: 09565663 NLM ISO Abbreviation: Biosens Bioelectron Subsets: MEDLINE

MeSH-Schlagworte: DNA, Catalytic*/chemistry , RNA, Messenger*/genetics , RNA, Messenger*/isolation & purification , Nanowires*/chemistry , Nanowires*/ultrastructure , Doxorubicin*/chemistry , Doxorubicin*/pharmacology , Biosensing Techniques*/methods, Tumor Microenvironment/drug effects ; Tumor Microenvironment/genetics ; Humans ; Aptamers, Nucleotide/chemistry ; Cell Line, Tumor ; Female ; Oligodeoxyribonucleotides

Developing a high-throughput capillary gel electrophoresis workflow for mRNA integrity and poly(A) tail analysis.

Autoren: Su WC Yu Z Lieu R et al.

Quelle: Journal of chromatography. A [J Chromatogr A] 2025 Oct 25; Vol. 1761, pp. 466387. Date of Electronic Publication: 2025 Sep 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9318488 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3778 (Electronic) Linking ISSN: 00219673 NLM ISO Abbreviation: J Chromatogr A Subsets: MEDLINE

MeSH-Schlagworte: RNA, Messenger*/chemistry , RNA, Messenger*/analysis , Poly A*/analysis , Poly A*/chemistry , High-Throughput Screening Assays*/methods, Electrophoresis, Capillary/methods ; Workflow ; Nanoparticles/chemistry

Optoregulated mRNA Delivery Controls Pleiotropic Immune Signaling for Tumor-Targeted Therapy.

Autoren: Chen P Hu G Nakashima Y et al.

Quelle: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2025 Oct 20; Vol. 64 (43), pp. e202513610. Date of Electronic Publication: 2025 Sep 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

MeSH-Schlagworte: RNA, Messenger*/genetics , RNA, Messenger*/administration & dosage , Breast Neoplasms*/pathology , Breast Neoplasms*/therapy, Humans ; Animals ; Interleukin-2/genetics ; Interleukin-2/metabolism ; Mice ; Female ; Signal Transduction ; Photosensitizing Agents/chemistry ; Light ; Cell Line, Tumor ; Transfection

A promising frontier of circulating messenger RNA in liquid biopsy: From mechanisms to clinical applications.

Autoren: Li M Yu Y Liu G et al.

Quelle: International journal of cancer [Int J Cancer] 2025 Oct 15; Vol. 157 (8), pp. 1519-1537. Date of Electronic Publication: 2025 Jun 19.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE

MeSH-Schlagworte: RNA, Messenger*/blood , RNA, Messenger*/genetics , Neoplasms*/genetics , Neoplasms*/blood , Neoplasms*/diagnosis , Neoplasms*/pathology , Biomarkers, Tumor*/blood , Biomarkers, Tumor*/genetics, Humans ; Liquid Biopsy/methods ; Gene Expression Profiling/methods ; Cell-Free Nucleic Acids/blood

Unraveling the Disease Mechanisms of Neuropathic Pain Through Constructing miRNA-mRNA Networks Based on a Rat Model.

Autoren: Yao L Liu M

Quelle: Brain and behavior [Brain Behav] 2025 Oct; Vol. 15 (10), pp. e70812.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101570837 Publication Model: Print Cited Medium: Internet ISSN: 2162-3279 (Electronic) NLM ISO Abbreviation: Brain Behav Subsets: MEDLINE

MeSH-Schlagworte: Neuralgia*/genetics , Neuralgia*/metabolism , MicroRNAs*/genetics , MicroRNAs*/metabolism , RNA, Messenger*/genetics , RNA, Messenger*/metabolism , Gene Regulatory Networks*/genetics, Animals ; Rats ; Disease Models, Animal ; Protein Interaction Maps/genetics ; Computational Biology ; Rats, Sprague-Dawley ; Male

Regulatory Functions of TDP-43 and FMRP in Non-Neuronal Diseases: Are Co-Targeted mRNAs the Keys?

Autoren: Ahsan A Kar O Akter K et al.

Quelle: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2025 Dec 15; Vol. 39 (23), pp. e71292.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

MeSH-Schlagworte: Fragile X Mental Retardation Protein*/metabolism , Fragile X Mental Retardation Protein*/genetics , DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/genetics , RNA, Messenger*/genetics , RNA, Messenger*/metabolism , Neurodegenerative Diseases*/metabolism , Neurodegenerative Diseases*/genetics, Humans ; Animals ; Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/metabolism ; Fragile X Syndrome/genetics ; Fragile X Syndrome/metabolism

CircRHBDD1(4,5)/CCL2 mRNA interaction promotes breast cancer bone metastasis via bone metastatic niche formation.

Autoren: Li X Yu R Li M et al.

Quelle: Life sciences [Life Sci] 2025 Dec 15; Vol. 383, pp. 123885. Date of Electronic Publication: 2025 Aug 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE

MeSH-Schlagworte: Bone Neoplasms*/secondary , Bone Neoplasms*/genetics , Bone Neoplasms*/metabolism , Bone Neoplasms*/pathology , Breast Neoplasms*/pathology , Breast Neoplasms*/genetics , Breast Neoplasms*/metabolism , Chemokine CCL2*/genetics , Chemokine CCL2*/metabolism , RNA, Messenger*/genetics , RNA, Messenger*/metabolism , RNA, Circular*/genetics , RNA, Circular*/metabolism, Humans ; Female ; Animals ; Mice ; Cell Line, Tumor ; Mice, Nude ; Gene Expression Regulation, Neoplastic ; Mice, Inbred BALB C ; Osteogenesis

SAR studies of chabrolonaphthoquinone B via rational design and synthesis of analogues - Cytotoxicity evaluation uncovers anticancer activity via mRNA splicing modulation.

Autoren: Charalambous VY Sigala I Ouzounthanasis KA et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118175. Date of Electronic Publication: 2025 Sep 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Naphthoquinones*/pharmacology , Naphthoquinones*/chemistry , Naphthoquinones*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Drug Design* , RNA Splicing*/drug effects , RNA, Messenger*/genetics , RNA, Messenger*/metabolism, Humans ; Structure-Activity Relationship ; Drug Screening Assays, Antitumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Molecular Structure ; HeLa Cells ; Cell Line, Tumor

Vascular endothelial cell-targeted mRNA delivery via synthetic lipid nanoparticles for venous thrombosis prevention.

Autoren: Guo Z Fan L Ma Y et al.

Quelle: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2025 Dec 10; Vol. 388 (Pt 2), pp. 114147. Date of Electronic Publication: 2025 Sep 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE

MeSH-Schlagworte: RNA, Messenger*/administration & dosage , RNA, Messenger*/therapeutic use , Venous Thrombosis*/prevention & control , Nanoparticles*/chemistry , Nanoparticles*/administration & dosage , Lipids*/chemistry , Lipids*/administration & dosage , Tissue Plasminogen Activator*/genetics , Tissue Plasminogen Activator*/administration & dosage , Endothelial Cells*/metabolism , Fibrinolytic Agents*/administration & dosage , Fibrinolytic Agents*/therapeutic use, Animals ; Mice, Inbred ICR ; Humans ; Male ; Mice ; Liposomes

Music enhances lipid nanoparticle brain delivery and mRNA transfection in brain cells.

Autoren: Mora-Raimundo P Gilon A Kadosh H et al.

Quelle: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2025 Dec 10; Vol. 388 (Pt 1), pp. 114301. Date of Electronic Publication: 2025 Oct 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE

MeSH-Schlagworte: Nanoparticles*/administration & dosage , Brain*/metabolism , RNA, Messenger*/administration & dosage , RNA, Messenger*/genetics , Lipids*/administration & dosage , Lipids*/chemistry , Music*, Animals ; Neurons/metabolism ; Transfection ; Mice ; Cells, Cultured ; Sound ; Male ; Mice, Inbred C57BL ; Humans ; Liposomes

Hepatocyte-targeted lipid nanoparticle for full-length ATP7B mRNA delivery in Wilson disease.

Autoren: Ma Y Wang S Guo Z et al.

Quelle: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2025 Dec 10; Vol. 388 (Pt 1), pp. 114305. Date of Electronic Publication: 2025 Oct 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE

MeSH-Schlagworte: Hepatolenticular Degeneration*/therapy , Hepatolenticular Degeneration*/genetics , Hepatolenticular Degeneration*/metabolism , Copper-Transporting ATPases*/genetics , Hepatocytes*/metabolism , RNA, Messenger*/administration & dosage , RNA, Messenger*/genetics , Nanoparticles*/administration & dosage , Nanoparticles*/chemistry , Lipids*/chemistry , Lipids*/administration & dosage, Animals ; Humans ; Copper/metabolism ; Polyethylene Glycols/chemistry ; Mice ; Male ; Mice, Inbred C57BL ; Liver/metabolism ; Liposomes

Design of messenger RNA vaccines based on lipid-polymer hybrid nanoparticles.

Autoren: Baghel S Lokras A Dias BA et al.

Quelle: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2025 Dec 10; Vol. 388 (Pt 2), pp. 114385. Date of Electronic Publication: 2025 Nov 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE

MeSH-Schlagworte: Nanoparticles*/chemistry , Nanoparticles*/administration & dosage , RNA, Messenger*/administration & dosage , RNA, Messenger*/immunology , COVID-19 Vaccines*/administration & dosage , COVID-19 Vaccines*/immunology , Polylactic Acid-Polyglycolic Acid Copolymer*/chemistry , mRNA Vaccines*/administration & dosage , COVID-19*/prevention & control , COVID-19*/immunology , Lipids*/chemistry, Animals ; Mice ; Polyethylene Glycols/chemistry ; Female ; SARS-CoV-2/immunology ; Mice, Inbred BALB C ; Spike Glycoprotein, Coronavirus/immunology ; Spike Glycoprotein, Coronavirus/genetics ; Injections, Intramuscular ; Antibodies, Viral/blood ; Humans ; Liposomes

Conservation of mRNA operon formation in control of the heat shock response in mammalian cells.

Autoren: Pataki E Gerst JE

Quelle: Science advances [Sci Adv] 2025 Dec 05; Vol. 11 (49), pp. eadu0315. Date of Electronic Publication: 2025 Dec 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

MeSH-Schlagworte: Operon*/genetics , Heat-Shock Response*/genetics , RNA, Messenger*/genetics , RNA, Messenger*/metabolism, Animals ; Humans ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/metabolism ; Gene Expression Regulation ; Transcription, Genetic ; Histones/metabolism ; Histones/genetics ; Saccharomyces cerevisiae/genetics

Modular design of a self-amplifying mRNA vaccine for multivalent immunization against Neisseria meningitidis B.

Autoren: Chen G Wang S Xing R et al.

Quelle: Vaccine [Vaccine] 2025 Dec 05; Vol. 68, pp. 127964. Date of Electronic Publication: 2025 Nov 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2518 (Electronic) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE

MeSH-Schlagworte: Meningococcal Vaccines*/immunology , Meningococcal Vaccines*/administration & dosage , Meningococcal Vaccines*/genetics , Neisseria meningitidis, Serogroup B*/immunology , Neisseria meningitidis, Serogroup B*/genetics , RNA, Messenger*/immunology , RNA, Messenger*/genetics , mRNA Vaccines*/immunology , mRNA Vaccines*/administration & dosage, Animals ; Mice ; Antibodies, Bacterial/blood ; Female ; Antigens, Bacterial/immunology ; Antigens, Bacterial/genetics ; Bacterial Proteins/immunology ; Bacterial Proteins/genetics ; Porins/immunology ; Porins/genetics ; Mice, Inbred BALB C ; Nanoparticles ; Immunization ; Adhesins, Bacterial/immunology ; Adhesins, Bacterial/genetics ; Vaccines, Synthetic/immunology ; Vaccines, Synthetic/administration & dosage ; Vaccines, Synthetic/genetics ; Meningococcal Infections/prevention & control ; Liposomes

Timing of transcription controls the selective translation of newly synthesized mRNAs during acute environmental stress.

Autoren: Zedan M Schürch AP Heinrich S et al.

Quelle: Molecular cell [Mol Cell] 2025 Dec 04; Vol. 85 (23), pp. 4379-4392.e5. Date of Electronic Publication: 2025 Nov 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

MeSH-Schlagworte: Saccharomyces cerevisiae*/genetics , Saccharomyces cerevisiae*/metabolism , Protein Biosynthesis* , RNA, Messenger*/genetics , RNA, Messenger*/metabolism , RNA, Messenger*/biosynthesis , Transcription, Genetic* , Stress, Physiological* , RNA, Fungal*/genetics , RNA, Fungal*/metabolism, Gene Expression Regulation, Fungal ; Glucose/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; RNA Stability ; Time Factors

Transcriptome-wide mRNP condensation precedes stress granule formation and excludes new mRNAs.

Autoren: Glauninger H Bard JAM Wong Hickernell CJ et al.

Quelle: Molecular cell [Mol Cell] 2025 Dec 04; Vol. 85 (23), pp. 4393-4409.e11. Date of Electronic Publication: 2025 Nov 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

MeSH-Schlagworte: RNA, Messenger*/genetics , RNA, Messenger*/metabolism , Ribonucleoproteins*/genetics , Ribonucleoproteins*/metabolism , Saccharomyces cerevisiae*/genetics , Saccharomyces cerevisiae*/metabolism , Stress Granules*/metabolism , Stress Granules*/genetics , Saccharomyces cerevisiae Proteins*/genetics , Saccharomyces cerevisiae Proteins*/metabolism , Transcriptome* , RNA, Fungal*/genetics , RNA, Fungal*/metabolism , Cytoplasmic Granules*/metabolism, Gene Expression Regulation, Fungal ; Stress, Physiological ; Protein Biosynthesis ; Processing Bodies/metabolism ; Processing Bodies/genetics ; Peptide Chain Initiation, Translational

Metabolism-programming mRNA-lipid nanoparticles remodel the immune microenvironment to improve immunotherapy against MAFLD.

Autoren: Yu X Qi S Cao W et al.

Quelle: Science translational medicine [Sci Transl Med] 2025 Dec 03; Vol. 17 (827), pp. eadv2293. Date of Electronic Publication: 2025 Dec 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

MeSH-Schlagworte: Nanoparticles*/chemistry , Immunotherapy*/methods , RNA, Messenger*/metabolism , RNA, Messenger*/genetics , Lipids*/chemistry , Fatty Liver*/therapy , Fatty Liver*/immunology, Animals ; Humans ; Mice ; Hepatocytes/metabolism ; Carcinoma, Hepatocellular/therapy ; Liver Neoplasms/therapy ; Mice, Inbred C57BL ; Liver/pathology ; Liver/metabolism ; Liposomes