Výsledky vyhľadávania - "kidney"

Multidrug Resistance-Associated Protein 1 Aberration-Incurred Glutathione Efflux Drives Renal Ferroptosis and Acute Kidney Injury-Chronic Kidney Disease Progression.

Autori: Zhao J An H Zhou S a ďalší

Zdroj: Journal of cellular physiology [J Cell Physiol] 2025 Oct; Vol. 240 (10), pp. e70105.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0050222 Publication Model: Print Cited Medium: Internet ISSN: 1097-4652 (Electronic) Linking ISSN: 00219541 NLM ISO Abbreviation: J Cell Physiol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Ferroptosis*/drug effects , Acute Kidney Injury*/pathology , Acute Kidney Injury*/metabolism , Acute Kidney Injury*/genetics , Glutathione*/metabolism , Multidrug Resistance-Associated Proteins*/metabolism , Multidrug Resistance-Associated Proteins*/genetics , Renal Insufficiency, Chronic*/pathology , Renal Insufficiency, Chronic*/metabolism , Renal Insufficiency, Chronic*/genetics , Kidney*/pathology , Kidney*/metabolism, Animals ; Reperfusion Injury/pathology ; Reperfusion Injury/metabolism ; Reperfusion Injury/genetics ; Disease Progression ; Male ; Mice ; Disease Models, Animal ; Mice, Inbred C57BL ; Propionates/pharmacology ; Kidney Tubules/metabolism ; Kidney Tubules/pathology ; Quinolines

Anticancer drug-induced nephrotoxicity: biopsy-proven patterns and outcomes across chemotherapy, targeted therapy, and immune checkpoint inhibitors.

Autori: Tian J Lian J Xia Y a ďalší

Zdroj: Renal failure [Ren Fail] 2025 Dec; Vol. 47 (1), pp. 2590283. Date of Electronic Publication: 2025 Nov 25.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE

Výrazy zo slovníka MeSH: Immune Checkpoint Inhibitors*/adverse effects , Acute Kidney Injury*/chemically induced , Acute Kidney Injury*/pathology , Acute Kidney Injury*/epidemiology , Antineoplastic Agents*/adverse effects, Humans ; Male ; Female ; Retrospective Studies ; Middle Aged ; Aged ; Biopsy ; Molecular Targeted Therapy/adverse effects ; Kidney/pathology ; Kidney/drug effects ; Thrombotic Microangiopathies/chemically induced ; Thrombotic Microangiopathies/pathology ; Thrombotic Microangiopathies/epidemiology ; Nephritis, Interstitial/chemically induced ; Nephritis, Interstitial/pathology ; Adult

SCR Disease Name: Acute Tubulointerstitial Nephritis

The gut-kidney axis in high-altitude hypoxia: pathophysiological mechanisms and the central role of hypoxia inducible factor.

Autori: Wu P Li X Long W a ďalší

Zdroj: Annals of medicine [Ann Med] 2025 Dec; Vol. 57 (1), pp. 2557514. Date of Electronic Publication: 2025 Sep 12.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8906388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2060 (Electronic) Linking ISSN: 07853890 NLM ISO Abbreviation: Ann Med Subsets: MEDLINE

Výrazy zo slovníka MeSH: Altitude Sickness*/physiopathology , Altitude Sickness*/complications , Altitude Sickness*/metabolism , Altitude Sickness*/microbiology , Kidney*/physiopathology , Kidney*/metabolism , Gastrointestinal Microbiome*/physiology , Hypoxia*/physiopathology , Hypoxia-Inducible Factor 1*/metabolism, Humans ; Altitude ; Acute Kidney Injury/physiopathology ; Acute Kidney Injury/etiology ; Renal Insufficiency, Chronic/physiopathology ; Renal Insufficiency, Chronic/etiology ; Animals ; Intestinal Mucosa/metabolism

Progress of functional magnetic resonance imaging in the assessment of transplanted kidney function.

Autori: Ma J Jiang B Wan J a ďalší

Zdroj: Renal failure [Ren Fail] 2025 Dec; Vol. 47 (1), pp. 2560602. Date of Electronic Publication: 2025 Sep 24.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE

Výrazy zo slovníka MeSH: Kidney Transplantation* , Kidney*/diagnostic imaging , Kidney*/physiopathology , Kidney*/pathology , Magnetic Resonance Imaging*/methods , Graft Rejection*/diagnostic imaging , Kidney Failure, Chronic*/surgery, Humans ; Elasticity Imaging Techniques/methods ; Diffusion Magnetic Resonance Imaging ; Kidney Function Tests

Urotensin II system contributes to ischemic acute kidney injury in neonatal pigs.

Autori: de la Cruz JE Michael OS Kanthakumar P a ďalší

Zdroj: Renal failure [Ren Fail] 2025 Dec; Vol. 47 (1), pp. 2534018. Date of Electronic Publication: 2025 Jul 24.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE

Výrazy zo slovníka MeSH: Acute Kidney Injury*/etiology , Acute Kidney Injury*/metabolism , Acute Kidney Injury*/pathology , Urotensins*/metabolism , Reperfusion Injury*/complications , Reperfusion Injury*/metabolism, Animals ; Swine ; Animals, Newborn ; Disease Models, Animal ; Furin/metabolism ; Kidney Tubules, Proximal/metabolism ; Kidney/blood supply ; Kidney/pathology ; Receptors, G-Protein-Coupled/metabolism ; Cells, Cultured

The interplay between the cardiovascular system and pediatric congenital or acquired kidney diseases.

Autori: Leventoğlu E Kavgaci A Örün UA a ďalší

Zdroj: Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2025 Dec; Vol. 40 (12), pp. 3615-3622. Date of Electronic Publication: 2025 Mar 26.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Springer International Country of Publication: Germany NLM ID: 8708728 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-198X (Electronic) Linking ISSN: 0931041X NLM ISO Abbreviation: Pediatr Nephrol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Cardiovascular Diseases*/etiology , Cardiovascular Diseases*/physiopathology , Kidney Diseases*/complications , Kidney Diseases*/physiopathology , Kidney Diseases*/congenital , Cardiovascular System*/physiopathology, Humans ; Child ; Kidney/abnormalities ; Kidney/physiopathology

The critical role of ion channels in kidney disease: perspective from AKI and CKD.

Autori: Li CSZ Yu B Gao Q a ďalší

Zdroj: Renal failure [Ren Fail] 2025 Dec; Vol. 47 (1), pp. 2488139. Date of Electronic Publication: 2025 Apr 28.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE

Výrazy zo slovníka MeSH: Acute Kidney Injury*/metabolism , Acute Kidney Injury*/physiopathology , Renal Insufficiency, Chronic*/metabolism , Renal Insufficiency, Chronic*/physiopathology , Ion Channels*/metabolism , Transient Receptor Potential Channels*/metabolism, Humans ; Oxidative Stress ; Animals ; Kidney/metabolism ; Kidney/pathology

Donor-derived cell-free DNA significantly improves rejection yield in kidney transplant biopsies.

Autori: Bromberg JS Brennan DC Taber DJ a ďalší

Korporácia: Bromberg JS Brennan DC Taber DJ a ďalší

Zdroj: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2025 Dec; Vol. 25 (12), pp. 2529-2542. Date of Electronic Publication: 2025 Aug 06.

Spôsob vydávania: Journal Article; Multicenter Study

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 100968638 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-6143 (Electronic) Linking ISSN: 16006135 NLM ISO Abbreviation: Am J Transplant Subsets: MEDLINE

Výrazy zo slovníka MeSH: Kidney Transplantation*/adverse effects , Graft Rejection*/diagnosis , Graft Rejection*/etiology , Graft Rejection*/blood , Cell-Free Nucleic Acids*/blood , Cell-Free Nucleic Acids*/genetics , Tissue Donors* , Kidney Failure, Chronic*/surgery , Biomarkers*/blood, Humans ; Male ; Female ; Biopsy ; Middle Aged ; Prospective Studies ; Adult ; Follow-Up Studies ; Graft Survival ; Prognosis ; Glomerular Filtration Rate ; Risk Factors ; Kidney Function Tests

Effect of lipopolysaccharide on ganglioside expression in human induced pluripotent stem cell-derived kidney organoids.

Autori: Ryu JS Yu JO Kim KK a ďalší

Zdroj: Enzyme and microbial technology [Enzyme Microb Technol] 2025 Dec; Vol. 191, pp. 110730. Date of Electronic Publication: 2025 Aug 06.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 8003761 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0909 (Electronic) Linking ISSN: 01410229 NLM ISO Abbreviation: Enzyme Microb Technol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Induced Pluripotent Stem Cells*/cytology , Induced Pluripotent Stem Cells*/drug effects , Induced Pluripotent Stem Cells*/metabolism , Organoids*/metabolism , Organoids*/drug effects , Organoids*/cytology , Lipopolysaccharides*/pharmacology , Kidney*/metabolism , Kidney*/cytology , Kidney*/drug effects , Gangliosides*/metabolism , Gangliosides*/genetics, Humans ; Acute Kidney Injury/metabolism ; Acute Kidney Injury/etiology ; Cell Differentiation/drug effects ; Reactive Oxygen Species/metabolism ; Sepsis/complications ; Membrane Potential, Mitochondrial/drug effects

Utilization of the modified Bosniak classification system for complex renal cysts.

Autori: Frumer M Ben-Meir D Shenhar C a ďalší

Zdroj: Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2025 Dec; Vol. 40 (12), pp. 3637-3645. Date of Electronic Publication: 2025 Jun 12.

Spôsob vydávania: Journal Article; Meta-Analysis; Systematic Review; Review

Informácie o časopise: Publisher: Springer International Country of Publication: Germany NLM ID: 8708728 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-198X (Electronic) Linking ISSN: 0931041X NLM ISO Abbreviation: Pediatr Nephrol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Kidney Diseases, Cystic*/classification , Kidney Diseases, Cystic*/diagnosis , Kidney Diseases, Cystic*/pathology , Kidney Diseases, Cystic*/therapy , Kidney Neoplasms*/diagnosis , Kidney Neoplasms*/pathology , Kidney Neoplasms*/classification, Humans ; Child ; Retrospective Studies ; Kidney/pathology ; Kidney/diagnostic imaging

Single-cell chromatin accessibility landscape of T cell-mediated rejection and BK polyomavirus-associated nephropathy after kidney transplantation.

Autori: Zhou J Wu H Zhou Q a ďalší

Zdroj: Renal failure [Ren Fail] 2025 Dec; Vol. 47 (1), pp. 2526722. Date of Electronic Publication: 2025 Jul 09.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE

Výrazy zo slovníka MeSH: Kidney Transplantation*/adverse effects , BK Virus* , Polyomavirus Infections*/immunology , Polyomavirus Infections*/virology , Polyomavirus Infections*/complications , Chromatin*/metabolism , Chromatin*/genetics , Graft Rejection*/immunology , Graft Rejection*/genetics , Graft Rejection*/pathology , T-Lymphocytes*/immunology , Tumor Virus Infections*/immunology , Tumor Virus Infections*/virology , Kidney Diseases*/virology , Kidney Diseases*/immunology, Humans ; Single-Cell Analysis ; Male ; Kidney/pathology ; Kidney/immunology ; Female ; Middle Aged

Lactate metabolism and lactylation in kidney diseases: insights into mechanisms and therapeutic opportunities.

Autori: Cheng Y Guo L

Zdroj: Renal failure [Ren Fail] 2025 Dec; Vol. 47 (1), pp. 2469746. Date of Electronic Publication: 2025 Feb 26.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE

Výrazy zo slovníka MeSH: Lactic Acid*/metabolism , Diabetic Nephropathies*/metabolism , Acute Kidney Injury*/metabolism , Kidney*/metabolism, Humans ; Kidney Neoplasms/metabolism ; Glycolysis ; Carcinoma, Renal Cell/metabolism ; Animals ; Protein Processing, Post-Translational

Natural products targeting TGF-β/Smad signaling in renal fibrosis: Multiomics-based novel molecular mechanisms and therapeutic strategies.

Autori: Jiang CH Zhang SJ Li P a ďalší

Zdroj: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2025 Nov 25; Vol. 148, pp. 157496. Date of Electronic Publication: 2025 Oct 30.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE

Výrazy zo slovníka MeSH: Transforming Growth Factor beta*/metabolism , Signal Transduction*/drug effects , Smad Proteins*/metabolism , Biological Products*/pharmacology , Biological Products*/therapeutic use , Renal Insufficiency, Chronic*/drug therapy , Renal Insufficiency, Chronic*/metabolism , Acute Kidney Injury*/drug therapy , Acute Kidney Injury*/metabolism , Kidney Diseases*/drug therapy, Humans ; Fibrosis/drug therapy ; Animals ; Kidney/pathology ; Kidney/drug effects ; Multiomics

High prevalence of renal amyloidosis in cats in an overcrowded colony.

Autori: Yutsudo A Kurahara N Yamano S a ďalší

Zdroj: The Journal of veterinary medical science [J Vet Med Sci] 2025 Nov 01; Vol. 87 (11), pp. 1216-1220. Date of Electronic Publication: 2025 Sep 24.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Japanese Society Of Veterinary Science Country of Publication: Japan NLM ID: 9105360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1347-7439 (Electronic) Linking ISSN: 09167250 NLM ISO Abbreviation: J Vet Med Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Amyloidosis*/veterinary , Amyloidosis*/epidemiology , Amyloidosis*/pathology , Cat Diseases*/epidemiology , Cat Diseases*/pathology , Cat Diseases*/etiology , Kidney Diseases*/veterinary , Kidney Diseases*/pathology , Kidney Diseases*/epidemiology, Animals ; Cats ; Prevalence ; Male ; Female ; Acute Kidney Injury/veterinary ; Acute Kidney Injury/pathology ; Kidney/pathology

Medullary sponge kidney: in-depth phenotyping for a better understanding of functional and structural abnormalities.

Autori: Tournebize C De Mul A Abid N a ďalší

Zdroj: Journal of nephrology [J Nephrol] 2025 Nov; Vol. 38 (8), pp. 2363-2373. Date of Electronic Publication: 2025 Sep 19.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Springer Country of Publication: Italy NLM ID: 9012268 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1724-6059 (Electronic) Linking ISSN: 11218428 NLM ISO Abbreviation: J Nephrol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Medullary Sponge Kidney*/physiopathology , Medullary Sponge Kidney*/diagnostic imaging , Medullary Sponge Kidney*/pathology , Kidney Medulla*/diagnostic imaging , Kidney Medulla*/physiopathology , Kidney Medulla*/pathology, Humans ; Female ; Male ; Glomerular Filtration Rate ; Middle Aged ; Adult ; Phenotype ; Magnetic Resonance Imaging ; Case-Control Studies ; Aged ; Kidney/physiopathology ; Kidney/diagnostic imaging ; Young Adult ; Diffusion Magnetic Resonance Imaging

Adult Dual Kidney Transplantation Following Dual Renal Endarterectomy: A Case Series.

Autori: Cabrales A Vyas J Orlando G a ďalší

Zdroj: Clinical transplantation [Clin Transplant] 2025 Nov; Vol. 39 (11), pp. e70377.

Spôsob vydávania: Journal Article; Case Reports

Informácie o časopise: Publisher: Munksgaard Country of Publication: Denmark NLM ID: 8710240 Publication Model: Print Cited Medium: Internet ISSN: 1399-0012 (Electronic) Linking ISSN: 09020063 NLM ISO Abbreviation: Clin Transplant Subsets: MEDLINE

Výrazy zo slovníka MeSH: Kidney Transplantation*/methods , Endarterectomy*/methods , Kidney Failure, Chronic*/surgery , Tissue Donors*/supply & distribution , Renal Artery Obstruction*/surgery , Renal Artery*/surgery, Humans ; Middle Aged ; Male ; Female ; Follow-Up Studies ; Prognosis ; Kidney Function Tests ; Aged ; Graft Survival ; Glomerular Filtration Rate ; Adult

Emerging applications of nanotechnology in the treatment of acute kidney injury.

Autori: Zeng L Kim J Choi HS a ďalší

Zdroj: Nanomedicine (London, England) [Nanomedicine (Lond)] 2025 Nov; Vol. 20 (21), pp. 2661-2685. Date of Electronic Publication: 2025 Sep 15.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101278111 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1748-6963 (Electronic) Linking ISSN: 17435889 NLM ISO Abbreviation: Nanomedicine (Lond) Subsets: MEDLINE

Výrazy zo slovníka MeSH: Acute Kidney Injury*/drug therapy , Acute Kidney Injury*/therapy , Nanomedicine*/methods , Nanoparticles*/chemistry , Nanoparticles*/therapeutic use , Nanotechnology*/methods, Humans ; Animals ; Drug Delivery Systems/methods ; Tissue Distribution ; Kidney/drug effects ; Kidney/pathology ; Nanoparticle Drug Delivery System

Syndecan-1 regulates lipid metabolism and mitigates fibrosis during the transition from acute kidney injury to chronic kidney disease.

Autori: Shen D Lin L Su Y a ďalší

Zdroj: Metabolism: clinical and experimental [Metabolism] 2025 Nov; Vol. 172, pp. 156374. Date of Electronic Publication: 2025 Aug 07.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 0375267 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8600 (Electronic) Linking ISSN: 00260495 NLM ISO Abbreviation: Metabolism Subsets: MEDLINE

Výrazy zo slovníka MeSH: Acute Kidney Injury*/metabolism , Acute Kidney Injury*/pathology , Renal Insufficiency, Chronic*/metabolism , Renal Insufficiency, Chronic*/pathology , Lipid Metabolism*/physiology , Syndecan-1*/metabolism , Syndecan-1*/genetics , Syndecan-1*/physiology, Animals ; Fibrosis/metabolism ; Mice ; Humans ; Mice, Knockout ; Male ; Disease Progression ; Mice, Inbred C57BL ; Kidney/pathology ; Kidney/metabolism

Trans-Omic Analysis Identifies the 'PRMT1-STAT3-Integrin αVβ6 Axis' as a Novel Therapeutic Target in Tacrolimus-Induced Chronic Nephrotoxicity.

Autori: Nishida S Ishima T Iwami D a ďalší

Zdroj: International journal of molecular sciences [Int J Mol Sci] 2025 Oct 22; Vol. 26 (21). Date of Electronic Publication: 2025 Oct 22.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Protein-Arginine N-Methyltransferases*/metabolism , Protein-Arginine N-Methyltransferases*/genetics , STAT3 Transcription Factor*/metabolism , STAT3 Transcription Factor*/genetics , Tacrolimus*/adverse effects , Integrins*/metabolism , Integrins*/genetics , Kidney Diseases*/chemically induced , Kidney Diseases*/metabolism, Animals ; Mice ; Male ; Proteomics/methods ; Kidney/metabolism ; Kidney/drug effects ; Kidney/pathology ; Mice, Inbred ICR ; Kidney Transplantation ; Signal Transduction

Inhibition of Hedgehog signaling does not mitigate polycystic kidney disease severity in a Pkd1 mutant mouse model.

Autori: Gombart SK Houghtaling S Ho TH a ďalší

Zdroj: Journal of cell science [J Cell Sci] 2025 Oct 15; Vol. 138 (20). Date of Electronic Publication: 2025 Jul 31.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Company of Biologists Country of Publication: England NLM ID: 0052457 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-9137 (Electronic) Linking ISSN: 00219533 NLM ISO Abbreviation: J Cell Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Hedgehog Proteins*/metabolism , Hedgehog Proteins*/genetics , Signal Transduction* , TRPP Cation Channels*/genetics , TRPP Cation Channels*/metabolism , Polycystic Kidney, Autosomal Dominant*/genetics , Polycystic Kidney, Autosomal Dominant*/pathology , Polycystic Kidney, Autosomal Dominant*/metabolism , Polycystic Kidney Diseases*/pathology , Polycystic Kidney Diseases*/genetics , Polycystic Kidney Diseases*/metabolism, Animals ; Mice ; Disease Models, Animal ; Zinc Finger Protein GLI1/metabolism ; Cilia/metabolism ; Smoothened Receptor/metabolism ; Smoothened Receptor/genetics ; Mutation ; Zinc Finger Protein Gli2 ; Zinc Finger Protein Gli3 ; X-Ray Microtomography ; Kruppel-Like Transcription Factors/genetics ; Kruppel-Like Transcription Factors/metabolism ; Kidney/pathology ; Kidney/metabolism ; Nerve Tissue Proteins/metabolism ; Nerve Tissue Proteins/genetics