Search Results - "ischemic stroke"

Indicators associated with outcomes of in-hospital ischemic stroke.

Authors: Kaneyoshi K Nezu T Aoki S et al.

Source: Clinical neurology and neurosurgery [Clin Neurol Neurosurg] 2025 Nov; Vol. 258, pp. 109160. Date of Electronic Publication: 2025 Sep 14.

Publication Type: Journal Article; Multicenter Study

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7502039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6968 (Electronic) Linking ISSN: 03038467 NLM ISO Abbreviation: Clin Neurol Neurosurg Subsets: MEDLINE

MeSH Terms: Ischemic Stroke*/therapy , Ischemic Stroke*/blood , Ischemic Stroke*/diagnosis , Ischemic Stroke*/epidemiology, Humans ; Male ; Female ; Aged ; Middle Aged ; Fibrin Fibrinogen Degradation Products/metabolism ; Fibrin Fibrinogen Degradation Products/analysis ; Retrospective Studies ; Aged, 80 and over ; Registries ; Treatment Outcome ; Hospitalization ; C-Reactive Protein/metabolism ; Biomarkers/blood

Targeted strategy by curcumin and tideglusib biomimetic nano-systems alleviates oxidative stress and inflammation under ischemic stroke.

Authors: Li J Yang Y Lin M et al.

Source: Drug delivery [Drug Deliv] 2025 Dec 31; Vol. 32 (1), pp. 2585599. Date of Electronic Publication: 2025 Nov 25.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9417471 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0464 (Electronic) Linking ISSN: 10717544 NLM ISO Abbreviation: Drug Deliv Subsets: MEDLINE

MeSH Terms: Curcumin*/administration & dosage , Curcumin*/pharmacology , Oxidative Stress*/drug effects , Ischemic Stroke*/drug therapy , Ischemic Stroke*/metabolism , Inflammation*/drug therapy, Animals ; Mice ; Male ; Reactive Oxygen Species/metabolism ; Neuroprotective Agents/administration & dosage ; Neuroprotective Agents/pharmacology ; Nanoparticles/chemistry ; Blood Platelets/metabolism ; Biomimetic Materials/chemistry ; Reperfusion Injury/drug therapy ; Brain Ischemia/drug therapy ; Mice, Inbred C57BL ; Rats ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/pharmacology

Spatial Myeloid Landscape of Large Artery Atherosclerotic and Cardioembolic Thrombi Retrieved by Mechanical Thrombectomy.

Authors: Jo S Ok T Lee CM et al.

Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2025 Dec 15; Vol. 39 (23), pp. e71283.

Publication Type: Journal Article

Journal Info: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

MeSH Terms: Thrombectomy*/methods , Atherosclerosis*/pathology , Atherosclerosis*/surgery , Atherosclerosis*/metabolism , Thrombosis*/pathology , Thrombosis*/surgery , Thrombosis*/metabolism , Embolic Stroke*/surgery , Embolic Stroke*/pathology , Embolic Stroke*/metabolism , Myeloid Cells*/metabolism , Myeloid Cells*/pathology , Ischemic Stroke*/surgery , Ischemic Stroke*/pathology, Humans ; Male ; Female ; Aged ; Middle Aged ; Neutrophils/metabolism ; Neutrophils/pathology ; Macrophages/metabolism ; Macrophages/pathology ; Aged, 80 and over ; Receptors, CXCR4/metabolism

An Interpretable Machine Learning Model Based on Metabolomics for Predicting Plaque Burden in Cryptogenic Stroke.

Authors: Liu ZM Zi YY Cheng XY et al.

Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2025 Dec 15; Vol. 39 (23), pp. e71266.

Publication Type: Journal Article; Multicenter Study

Journal Info: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

MeSH Terms: Machine Learning* , Metabolomics*/methods , Ischemic Stroke*/metabolism , Ischemic Stroke*/diagnosis , Ischemic Stroke*/pathology , Plaque, Atherosclerotic*/metabolism , Plaque, Atherosclerotic*/diagnosis , Plaque, Atherosclerotic*/pathology , Stroke*, Humans ; Male ; Female ; Aged ; Middle Aged ; Pilot Projects ; Biomarkers/blood

Naomaitong ameliorates cerebral and intestinal injury in ischemia stroke via modulation of gut-brain axis interactions: Akkermansia muciniphila-mediated regulation of tryptophan-serotonin metabolic pathways.

Authors: Liu B Huang H Li M et al.

Source: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2025 Dec 15; Vol. 266, pp. 117075. Date of Electronic Publication: 2025 Jul 22.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-264X (Electronic) Linking ISSN: 07317085 NLM ISO Abbreviation: J Pharm Biomed Anal Subsets: MEDLINE

MeSH Terms: Tryptophan*/metabolism , Gastrointestinal Microbiome*/drug effects , Serotonin*/metabolism , Ischemic Stroke*/drug therapy , Ischemic Stroke*/metabolism , Ischemic Stroke*/microbiology , Drugs, Chinese Herbal*/pharmacology , Drugs, Chinese Herbal*/therapeutic use , Brain-Gut Axis*/drug effects, Animals ; Rats ; Male ; Rats, Sprague-Dawley ; Infarction, Middle Cerebral Artery/drug therapy ; Disease Models, Animal ; Brain/drug effects ; Brain/metabolism ; Metabolic Networks and Pathways/drug effects ; Akkermansia

SCR Organism: Akkermansia muciniphila

Spatial and Temporal Assessment of Cerebral Blood Flow in a Novel Piglet Model of Neonatal Arterial Ischemic Stroke.

Authors: Wang Q Abdulrahim M Young L et al.

Source: Translational stroke research [Transl Stroke Res] 2025 Dec 06; Vol. 17 (1), pp. 4. Date of Electronic Publication: 2025 Dec 06.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101517297 Publication Model: Electronic Cited Medium: Internet ISSN: 1868-601X (Electronic) Linking ISSN: 18684483 NLM ISO Abbreviation: Transl Stroke Res Subsets: MEDLINE

MeSH Terms: Cerebrovascular Circulation*/physiology , Ischemic Stroke*/physiopathology , Ischemic Stroke*/diagnostic imaging , Infarction, Middle Cerebral Artery*/physiopathology , Infarction, Middle Cerebral Artery*/diagnostic imaging, Animals ; Disease Models, Animal ; Swine ; Animals, Newborn

Development of cell-permeable and plasma-stable peptidomimetic inhibitors against PSD-95/nNOS interaction as potential anti-ischemic stroke agents.

Authors: Wang J Liang R Zhang L et al.

Source: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 05; Vol. 299, pp. 118062. Date of Electronic Publication: 2025 Aug 15.

Publication Type: Journal Article

Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH Terms: Disks Large Homolog 4 Protein*/metabolism , Disks Large Homolog 4 Protein*/antagonists & inhibitors , Peptidomimetics*/pharmacology , Peptidomimetics*/chemistry , Peptidomimetics*/chemical synthesis , Nitric Oxide Synthase Type I*/metabolism , Nitric Oxide Synthase Type I*/antagonists & inhibitors , Ischemic Stroke*/drug therapy , Ischemic Stroke*/metabolism , Ischemic Stroke*/pathology , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/chemistry , Neuroprotective Agents*/chemical synthesis, Animals ; Mice ; Molecular Structure ; Structure-Activity Relationship ; Dose-Response Relationship, Drug ; Cell Survival/drug effects ; Humans ; Apoptosis/drug effects

A laboratory-based frailty index predicts mortality in ischemic stroke with carotid artery stenosis: a retrospective analysis from the MIMIC-IV database.

Authors: Li M He X Feng X et al.

Source: Neurosurgical review [Neurosurg Rev] 2025 Dec 03; Vol. 49 (1), pp. 43. Date of Electronic Publication: 2025 Dec 03.

Publication Type: Journal Article

Journal Info: Publisher: Springer Berlin Heidelberg Country of Publication: Germany NLM ID: 7908181 Publication Model: Electronic Cited Medium: Internet ISSN: 1437-2320 (Electronic) Linking ISSN: 03445607 NLM ISO Abbreviation: Neurosurg Rev Subsets: MEDLINE

MeSH Terms: Carotid Stenosis*/complications , Carotid Stenosis*/mortality , Ischemic Stroke*/mortality , Ischemic Stroke*/etiology , Frailty*/mortality , Frailty*/diagnosis , Brain Ischemia*/mortality, Humans ; Female ; Male ; Aged ; Retrospective Studies ; Aged, 80 and over ; Prognosis ; Middle Aged ; Databases, Factual

Vascular Endothelial Growth Factor-A and Collateral Circulation in Patients with Acute Ischemic Stroke due to Intracranial Large Vessel Occlusion.

Authors: Aguilera-Simón A Guasch-Jiménez M Moniche F et al.

Source: Translational stroke research [Transl Stroke Res] 2025 Dec 02; Vol. 17 (1), pp. 3. Date of Electronic Publication: 2025 Dec 02.

Publication Type: Journal Article; Multicenter Study

Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101517297 Publication Model: Electronic Cited Medium: Internet ISSN: 1868-601X (Electronic) Linking ISSN: 18684483 NLM ISO Abbreviation: Transl Stroke Res Subsets: MEDLINE

MeSH Terms: Vascular Endothelial Growth Factor A*/blood , Collateral Circulation*/physiology , Ischemic Stroke*/blood , Ischemic Stroke*/etiology , Ischemic Stroke*/diagnostic imaging , Ischemic Stroke*/physiopathology , Brain Ischemia*/blood, Humans ; Female ; Male ; Aged ; Aged, 80 and over ; Middle Aged ; Prospective Studies ; Endovascular Procedures

Comparison of CT-perfusion software packages and validation with true infarct core in patients with acute ischemic stroke.

Authors: Thormann M Faltass M Schwab R et al.

Source: BMC medical imaging [BMC Med Imaging] 2025 Dec 02; Vol. 25 (1), pp. 498. Date of Electronic Publication: 2025 Dec 02.

Publication Type: Journal Article; Comparative Study; Validation Study

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100968553 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2342 (Electronic) Linking ISSN: 14712342 NLM ISO Abbreviation: BMC Med Imaging Subsets: MEDLINE

MeSH Terms: Ischemic Stroke*/diagnostic imaging , Ischemic Stroke*/surgery , Tomography, X-Ray Computed*/methods , Software*, Humans ; Male ; Female ; Retrospective Studies ; Aged ; Middle Aged ; Thrombectomy ; Aged, 80 and over ; Perfusion Imaging/methods

β -escin mitigates neuroinflammation and apoptosis caused by ischemic stroke through the inhibition of the interleukin-6/Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway.

Authors: Yanqin D Shenglan L Yu Z et al.

Source: The Journal of international medical research [J Int Med Res] 2025 Dec; Vol. 53 (12), pp. 3000605251400652. Date of Electronic Publication: 2025 Dec 03.

Publication Type: Journal Article

Journal Info: Publisher: Sage Publications Country of Publication: England NLM ID: 0346411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-2300 (Electronic) Linking ISSN: 03000605 NLM ISO Abbreviation: J Int Med Res Subsets: MEDLINE

MeSH Terms: Interleukin-6*/metabolism , Apoptosis*/drug effects , STAT3 Transcription Factor*/metabolism , Signal Transduction*/drug effects , Janus Kinase 2*/metabolism , Ischemic Stroke*/drug therapy , Ischemic Stroke*/pathology , Ischemic Stroke*/complications , Neuroinflammatory Diseases*/drug therapy , Neuroinflammatory Diseases*/pathology , Neuroinflammatory Diseases*/etiology , Neuroprotective Agents*/pharmacology, Animals ; Male ; Rats ; Rats, Sprague-Dawley ; Disease Models, Animal

Knockdown of LncRNA PART1 Inhibits Nerve Injury Caused by Ischemic Stroke by Regulating the Expression of miR-638.

Authors: Xu G Li H Huang T et al.

Source: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica [APMIS] 2025 Dec; Vol. 133 (12), pp. e70096.

Publication Type: Journal Article

Journal Info: Publisher: Munksgaard Country of Publication: Denmark NLM ID: 8803400 Publication Model: Print Cited Medium: Internet ISSN: 1600-0463 (Electronic) Linking ISSN: 09034641 NLM ISO Abbreviation: APMIS Subsets: MEDLINE

MeSH Terms: MicroRNAs*/genetics , MicroRNAs*/metabolism , RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/metabolism , Ischemic Stroke*/genetics , Ischemic Stroke*/pathology , Ischemic Stroke*/complications , Ischemic Stroke*/metabolism, Humans ; Apoptosis ; Cell Survival ; Interleukin-6/metabolism ; Male ; Tumor Necrosis Factor-alpha/metabolism ; Female ; Middle Aged ; Superoxide Dismutase/metabolism ; Gene Knockdown Techniques ; Glucose ; Malondialdehyde/metabolism ; Aged ; L-Lactate Dehydrogenase/metabolism

Longitudinal Study of Spatial Correlations Between Brain Imaging Changes and Atlas-Based Neurotransmitter Maps in Subcortical Ischemic Stroke.

Authors: Li Y Wang J

Source: The European journal of neuroscience [Eur J Neurosci] 2025 Dec; Vol. 62 (11), pp. e70345.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Blackwell Country of Publication: France NLM ID: 8918110 Publication Model: Print Cited Medium: Internet ISSN: 1460-9568 (Electronic) Linking ISSN: 0953816X NLM ISO Abbreviation: Eur J Neurosci Subsets: MEDLINE

MeSH Terms: Ischemic Stroke*/diagnostic imaging , Ischemic Stroke*/metabolism , Ischemic Stroke*/physiopathology , Ischemic Stroke*/drug therapy , Brain*/diagnostic imaging , Brain*/metabolism , Neurotransmitter Agents*/metabolism, Humans ; Male ; Female ; Longitudinal Studies ; Middle Aged ; Aged ; Magnetic Resonance Imaging ; Gray Matter/diagnostic imaging ; Neuronal Plasticity/physiology ; Brain Mapping

Lactate dehydrogenase and short-term mortality in ICU patients with ischemic stroke: a single-center retrospective analysis of MIMIC-IV.

Authors: Zhou D Song J Fang K et al.

Source: European journal of medical research [Eur J Med Res] 2025 Dec 01; Vol. 30 (1), pp. 1196. Date of Electronic Publication: 2025 Dec 01.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 9517857 Publication Model: Electronic Cited Medium: Internet ISSN: 2047-783X (Electronic) Linking ISSN: 09492321 NLM ISO Abbreviation: Eur J Med Res Subsets: MEDLINE

MeSH Terms: L-Lactate Dehydrogenase*/blood , Ischemic Stroke*/mortality , Ischemic Stroke*/blood, Humans ; Female ; Male ; Retrospective Studies ; Aged ; Intensive Care Units/statistics & numerical data ; Middle Aged ; Hospital Mortality ; Prognosis ; Aged, 80 and over

Non-targeted metabolomics can identify disease-specific characteristics of ischemic stroke.

Authors: Zhang H Guo Z Zhao T et al.

Source: Metabolomics : Official journal of the Metabolomic Society [Metabolomics] 2025 Dec 01; Vol. 22 (1), pp. 2. Date of Electronic Publication: 2025 Dec 01.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101274889 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-3890 (Electronic) Linking ISSN: 15733882 NLM ISO Abbreviation: Metabolomics Subsets: MEDLINE

MeSH Terms: Metabolomics*/methods , Ischemic Stroke*/metabolism , Ischemic Stroke*/blood , Ischemic Stroke*/diagnosis , Brain Ischemia*/metabolism, Humans ; Biomarkers/blood ; Biomarkers/metabolism ; Male ; Female ; Middle Aged ; Tandem Mass Spectrometry/methods ; Aged ; Machine Learning ; Chromatography, Liquid/methods ; Algorithms ; Metabolic Networks and Pathways

Association Between Vasomotor Symptoms and Ischemic Stroke: A Case-Control Study.

Authors: Jiang X Qiu Q Wang Y et al.

Source: Brain and behavior [Brain Behav] 2025 Dec; Vol. 15 (12), pp. e71104.

Publication Type: Journal Article; Multicenter Study

Journal Info: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101570837 Publication Model: Print Cited Medium: Internet ISSN: 2162-3279 (Electronic) NLM ISO Abbreviation: Brain Behav Subsets: MEDLINE

MeSH Terms: Ischemic Stroke*/physiopathology , Ischemic Stroke*/epidemiology , Hot Flashes*/epidemiology , Hot Flashes*/physiopathology , Vasomotor System*/physiopathology , Stroke*/physiopathology, Humans ; Female ; Case-Control Studies ; Middle Aged ; Aged ; Risk Factors ; Postmenopause/physiology ; Perimenopause/physiology ; Severity of Illness Index

Identification of Six Potential Therapeutic Targets Common to Ischemic Stroke and Vascular Dementia: Genetic Insights From an Integrated Bioinformatics Analysis.

Authors: Lyu J Lin F Liu Y et al.

Source: Brain and behavior [Brain Behav] 2025 Dec; Vol. 15 (12), pp. e71096.

Publication Type: Journal Article

Journal Info: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101570837 Publication Model: Print Cited Medium: Internet ISSN: 2162-3279 (Electronic) NLM ISO Abbreviation: Brain Behav Subsets: MEDLINE

MeSH Terms: Dementia, Vascular*/genetics , Dementia, Vascular*/blood , Ischemic Stroke*/genetics , Ischemic Stroke*/blood , Blood Proteins*/genetics , Blood Proteins*/metabolism, Animals ; Humans ; Computational Biology/methods ; Rats ; Mendelian Randomization Analysis ; Risk Factors ; Furin/genetics ; Furin/blood ; Male ; Genome-Wide Association Study ; Diabetes Mellitus, Type 2/genetics ; Atrial Fibrillation/genetics ; Disease Models, Animal

NSUN2-mediated m⁵C methylation of HSPB1 mRNA suppresses inflammation and ferroptosis in ischemic stroke via activating the NRF2/HO-1/NQO-1 pathway.

Authors: Gao G Zhang B Liu N et al.

Source: Molecular immunology [Mol Immunol] 2025 Dec; Vol. 188, pp. 131-141. Date of Electronic Publication: 2025 Nov 21.

Publication Type: Journal Article

Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 7905289 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9142 (Electronic) Linking ISSN: 01615890 NLM ISO Abbreviation: Mol Immunol Subsets: MEDLINE

MeSH Terms: Inflammation*/genetics , Inflammation*/metabolism , Inflammation*/pathology , Ferroptosis*/genetics , Ischemic Stroke*/genetics , Ischemic Stroke*/metabolism , Ischemic Stroke*/pathology , Heat-Shock Proteins*/genetics , Heat-Shock Proteins*/metabolism , HSP27 Heat-Shock Proteins*/genetics , HSP27 Heat-Shock Proteins*/metabolism, Animals ; NF-E2-Related Factor 2/metabolism ; Heme Oxygenase-1/metabolism ; Mice ; Methylation ; Humans ; RNA, Messenger/metabolism ; RNA, Messenger/genetics ; Signal Transduction ; Male ; Mice, Inbred C57BL ; Molecular Chaperones ; NAD(P)H Dehydrogenase (Quinone)/metabolism

Novel 3-n-butylphthalide derivatives as potent multi-functional anti-IS agents with BBB protective function.

Authors: Shao L Lin G Chu Z et al.

Source: Bioorganic chemistry [Bioorg Chem] 2025 Dec; Vol. 167, pp. 109237. Date of Electronic Publication: 2025 Nov 15.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH Terms: Benzofurans*/pharmacology , Benzofurans*/chemistry , Benzofurans*/chemical synthesis , Blood-Brain Barrier*/drug effects , Blood-Brain Barrier*/metabolism , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/chemistry , Neuroprotective Agents*/chemical synthesis , Ischemic Stroke*/drug therapy , Ischemic Stroke*/metabolism, Animals ; Structure-Activity Relationship ; Molecular Structure ; Mice ; Dose-Response Relationship, Drug ; Humans ; Male ; Rats

Characterizing stroke-related cellular changes in the surviving neurons of mouse ischemic stroke.

Authors: Ikegami T Sasaki T Shimbo T et al.

Source: Neurochemistry international [Neurochem Int] 2025 Dec; Vol. 191, pp. 106086. Date of Electronic Publication: 2025 Nov 11.

Publication Type: Journal Article

Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 8006959 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9754 (Electronic) Linking ISSN: 01970186 NLM ISO Abbreviation: Neurochem Int Subsets: MEDLINE

MeSH Terms: Neurons*/metabolism , Neurons*/pathology , Ischemic Stroke*/pathology , Ischemic Stroke*/metabolism , Brain Ischemia*/pathology , Brain Ischemia*/metabolism, Animals ; Mice ; Mice, Inbred C57BL ; Male ; Cell Survival/physiology ; Infarction, Middle Cerebral Artery/pathology ; Infarction, Middle Cerebral Artery/metabolism