Suchergebnisse - "intermediate filaments"

Intermediate filaments promote glioblastoma cell invasion by controlling nuclear deformations and mechanosensitive expression of MMP14.

Autoren: van Bodegraven EJ Infante E Peglion F et al.

Quelle: Cell reports [Cell Rep] 2025 Nov 25; Vol. 44 (11), pp. 116553. Date of Electronic Publication: 2025 Nov 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

MeSH-Schlagworte: Glioblastoma*/pathology , Glioblastoma*/metabolism , Glioblastoma*/genetics , Matrix Metalloproteinase 14*/metabolism , Matrix Metalloproteinase 14*/genetics , Intermediate Filaments*/metabolism , Brain Neoplasms*/pathology , Brain Neoplasms*/metabolism , Brain Neoplasms*/genetics , Cell Nucleus*/metabolism , Cell Nucleus*/pathology, Humans ; Neoplasm Invasiveness ; Cell Line, Tumor ; Animals ; Mice ; Vimentin/metabolism ; Vimentin/genetics ; Gene Expression Regulation, Neoplastic

A dynamic biointerface in mussels mediated by a mechanoresponsive intermediate filament-based biopolymer.

Autoren: Youssef L Sivasundarampillai J Prowse ENP et al.

Quelle: Nature communications [Nat Commun] 2025 Oct 28; Vol. 16 (1), pp. 9523. Date of Electronic Publication: 2025 Oct 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Bivalvia*/metabolism , Bivalvia*/physiology , Intermediate Filaments*/metabolism , Intermediate Filament Proteins*/metabolism , Intermediate Filament Proteins*/chemistry , Intermediate Filament Proteins*/genetics, Animals ; Cilia/metabolism ; Biopolymers/metabolism ; Biopolymers/chemistry ; Mechanotransduction, Cellular

Molecular insights into the role of desmin intermediate filament network in chromatin landscape, cardiomyocyte differentiation, and maturation.

Autoren: Tsikitis M Diokmetzidou A Liakopoulos P et al.

Quelle: Cell death & disease [Cell Death Dis] 2025 Oct 16; Vol. 16 (1), pp. 723. Date of Electronic Publication: 2025 Oct 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE

MeSH-Schlagworte: Desmin*/metabolism , Desmin*/genetics , Myocytes, Cardiac*/metabolism , Myocytes, Cardiac*/cytology , Cell Differentiation* , Chromatin*/metabolism , Intermediate Filaments*/metabolism, Animals ; Mice ; Receptor, Notch1/metabolism ; Receptor, Notch1/genetics

Vimentin intermediate filaments facilitate transportation of hepatitis C virus components.

Autoren: Xing Y Cui S Huang X et al.

Quelle: European journal of cell biology [Eur J Cell Biol] 2025 Sep; Vol. 104 (3), pp. 151505. Date of Electronic Publication: 2025 Jul 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Germany NLM ID: 7906240 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-1298 (Electronic) Linking ISSN: 01719335 NLM ISO Abbreviation: Eur J Cell Biol Subsets: MEDLINE

MeSH-Schlagworte: Vimentin*/metabolism , Hepacivirus*/metabolism , Hepacivirus*/physiology , Intermediate Filaments*/metabolism , Intermediate Filaments*/virology , Hepatitis C*/virology , Hepatitis C*/metabolism, Humans ; Virus Replication

Vimentin intermediate filaments orchestrate DNA nonhomologous end joining repair and lipolysis after DNA damage.

Autoren: Wang F Rong M Zhang L et al.

Quelle: Oncogene [Oncogene] 2025 Sep; Vol. 44 (33), pp. 3025-3036. Date of Electronic Publication: 2025 Jun 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE

MeSH-Schlagworte: DNA End-Joining Repair* , Vimentin*/metabolism , Vimentin*/genetics , Intermediate Filaments*/metabolism , Intermediate Filaments*/genetics , Lipolysis*/genetics , DNA Damage*, Humans ; DNA Breaks, Double-Stranded ; Lipase/metabolism ; Lipase/genetics ; DNA-Activated Protein Kinase/metabolism ; Ku Autoantigen/metabolism ; Ku Autoantigen/genetics ; Acyltransferases

Optogenetic and chemical genetic tools for rapid repositioning of vimentin intermediate filaments.

Autoren: Pasolli M Meiring JCM Conboy JP et al.

Quelle: The Journal of cell biology [J Cell Biol] 2025 Sep 01; Vol. 224 (9). Date of Electronic Publication: 2025 Jul 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 0375356 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-8140 (Electronic) Linking ISSN: 00219525 NLM ISO Abbreviation: J Cell Biol Subsets: MEDLINE

MeSH-Schlagworte: Vimentin*/metabolism , Vimentin*/genetics , Intermediate Filaments*/metabolism , Intermediate Filaments*/genetics , Optogenetics*/methods, Humans ; Microtubules/metabolism ; Animals ; Endoplasmic Reticulum/metabolism ; Mitochondria/metabolism ; HeLa Cells

The Kelch 3 motif on gigaxonin mediates the interaction with NUDCD3 and regulates vimentin filament morphology.

Autoren: Phillips CL So C Gillis MF et al.

Quelle: European journal of cell biology [Eur J Cell Biol] 2025 Sep; Vol. 104 (3), pp. 151508. Date of Electronic Publication: 2025 Jul 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Germany NLM ID: 7906240 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-1298 (Electronic) Linking ISSN: 01719335 NLM ISO Abbreviation: Eur J Cell Biol Subsets: MEDLINE

MeSH-Schlagworte: Vimentin*/metabolism , Intermediate Filaments*/metabolism , Cytoskeletal Proteins*/metabolism , Cytoskeletal Proteins*/genetics , Cytoskeletal Proteins*/chemistry, Humans ; HEK293 Cells ; Protein Binding ; Amino Acid Motifs

Vimentin intermediate filaments as structural and mechanical coordinators of mesenchymal cells.

Autoren: Guo M Wong IY Moore AS et al.

Quelle: Nature cell biology [Nat Cell Biol] 2025 Aug; Vol. 27 (8), pp. 1210-1218. Date of Electronic Publication: 2025 Aug 05.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE

MeSH-Schlagworte: Vimentin*/metabolism , Vimentin*/chemistry , Vimentin*/genetics , Intermediate Filaments*/metabolism , Intermediate Filaments*/ultrastructure , Mesenchymal Stem Cells*/metabolism, Humans ; Animals ; Epithelial-Mesenchymal Transition ; Actin Cytoskeleton/metabolism

Exploring the Prognostic Role of Neurofilaments and SEMA3A in Multiple Sclerosis Progression.

Autoren: Pavelek Z Souček O Krejsek J et al.

Quelle: International journal of molecular sciences [Int J Mol Sci] 2025 Sep 08; Vol. 26 (17). Date of Electronic Publication: 2025 Sep 08.

Publikationsart: Journal Article; Observational Study

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: Semaphorin-3A*/blood , Multiple Sclerosis, Chronic Progressive*/blood , Multiple Sclerosis, Chronic Progressive*/diagnosis , Multiple Sclerosis, Relapsing-Remitting*/blood , Multiple Sclerosis, Relapsing-Remitting*/diagnosis , Intermediate Filaments*/metabolism , Neurofilament Proteins*/blood, Humans ; Female ; Male ; Adult ; Biomarkers/blood ; Disease Progression ; Middle Aged ; Prognosis ; Interleukin-6/blood ; Progranulins/blood

Regenerative potential of the intermediate filaments of albino rat parotid glands subjected to fractionated radiotherapy: an immunohistochemical analysis.

Autoren: Hassan SS Azab ET Alqutub AW et al.

Quelle: Acta odontologica Scandinavica [Acta Odontol Scand] 2025 Aug 21; Vol. 84, pp. 472-478. Date of Electronic Publication: 2025 Aug 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Medical Journals Sweden AB Country of Publication: Sweden NLM ID: 0370344 Publication Model: Electronic Cited Medium: Internet ISSN: 1502-3850 (Electronic) Linking ISSN: 00016357 NLM ISO Abbreviation: Acta Odontol Scand Subsets: MEDLINE

MeSH-Schlagworte: Parotid Gland*/radiation effects , Parotid Gland*/metabolism , Intermediate Filaments*/radiation effects , Regeneration*/radiation effects, Animals ; Rats ; Immunohistochemistry ; Male ; Keratins/metabolism ; Dose Fractionation, Radiation

Intermediate filament IFFO1 negatively regulates the migration of lung cancer cells by inhibiting the IQGAP3-Cdc42 interaction.

Autoren: Ye Y Shen F Yan M et al.

Quelle: Cell death & disease [Cell Death Dis] 2025 Jul 10; Vol. 16 (1), pp. 509. Date of Electronic Publication: 2025 Jul 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE

MeSH-Schlagworte: Lung Neoplasms*/pathology , Lung Neoplasms*/metabolism , Lung Neoplasms*/genetics , Cell Movement*/genetics , cdc42 GTP-Binding Protein*/metabolism , GTPase-Activating Proteins*/metabolism , Intermediate Filaments*/metabolism , ras GTPase-Activating Proteins*/metabolism, Humans ; Animals ; Cell Proliferation/genetics ; Cell Line, Tumor ; Mice ; Female ; Mice, Nude ; Male ; Signal Transduction

The scaffolding and activation of NLRP3 on acidic vesicles depends on their biophysical properties and is independent of intermediate filaments.

Autoren: de Paz Linares G Mossemann J Sayed B et al.

Quelle: Molecular biology of the cell [Mol Biol Cell] 2025 Jul 01; Vol. 36 (7), pp. ar85. Date of Electronic Publication: 2025 May 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society for Cell Biology Country of Publication: United States NLM ID: 9201390 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-4586 (Electronic) Linking ISSN: 10591524 NLM ISO Abbreviation: Mol Biol Cell Subsets: MEDLINE

MeSH-Schlagworte: NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , Inflammasomes*/metabolism , Intermediate Filaments*/metabolism, Animals ; Mice ; Interleukin-1beta/metabolism ; Macrophages/metabolism ; Vimentin/metabolism ; Vimentin/genetics ; Caspase 1/metabolism ; Mice, Knockout ; Mice, Inbred C57BL ; Pyroptosis ; Vacuolar Proton-Translocating ATPases/metabolism

Continuous self-repair protects vimentin intermediate filaments from fragmentation.

Autoren: Tran QD Lenz M Lamour G et al.

Quelle: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Jun 17; Vol. 122 (24), pp. e2417660122. Date of Electronic Publication: 2025 Jun 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH-Schlagworte: Vimentin*/metabolism , Vimentin*/chemistry , Intermediate Filaments*/metabolism , Intermediate Filaments*/chemistry, Microscopy, Atomic Force ; Humans ; Protein Multimerization

Vimentin intermediate filaments coordinate actin stress fibers and podosomes to determine the extracellular matrix degradation by macrophages.

Autoren: Huang X Li Z Huang Y et al.

Quelle: Developmental cell [Dev Cell] 2025 Jun 23; Vol. 60 (12), pp. 1669-1685.e6. Date of Electronic Publication: 2025 Feb 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 101120028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1551 (Electronic) Linking ISSN: 15345807 NLM ISO Abbreviation: Dev Cell Subsets: MEDLINE

MeSH-Schlagworte: Vimentin*/metabolism , Vimentin*/genetics , Extracellular Matrix*/metabolism , Macrophages*/metabolism , Podosomes*/metabolism , Stress Fibers*/metabolism , Intermediate Filaments*/metabolism , Actins*/metabolism, Humans ; Animals ; Mice ; Mice, Nude ; A549 Cells ; Lysosomes/metabolism ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology

Vimentin filament transport and organization revealed by single-particle tracking and 3D FIB-SEM.

Autoren: Renganathan B Moore AS Yeo WH et al.

Quelle: The Journal of cell biology [J Cell Biol] 2025 Apr 07; Vol. 224 (4). Date of Electronic Publication: 2025 Mar 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 0375356 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-8140 (Electronic) Linking ISSN: 00219525 NLM ISO Abbreviation: J Cell Biol Subsets: MEDLINE

MeSH-Schlagworte: Vimentin*/metabolism , Intermediate Filaments*/metabolism , Intermediate Filaments*/ultrastructure , Microscopy, Electron, Scanning*/methods , Single Molecule Imaging*/methods, Microtubules/metabolism ; Microtubules/ultrastructure ; Humans ; Imaging, Three-Dimensional/methods ; Protein Transport ; Volume Electron Microscopy

Versatility of vimentin assemblies: From filaments to biomolecular condensates and back.

Autoren: Pérez-Sala D Zorrilla S

Quelle: European journal of cell biology [Eur J Cell Biol] 2025 Jun; Vol. 104 (2), pp. 151487. Date of Electronic Publication: 2025 Apr 02.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Germany NLM ID: 7906240 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-1298 (Electronic) Linking ISSN: 01719335 NLM ISO Abbreviation: Eur J Cell Biol Subsets: MEDLINE

MeSH-Schlagworte: Vimentin*/metabolism , Vimentin*/chemistry , Intermediate Filaments*/metabolism , Biomolecular Condensates*/metabolism , Biomolecular Condensates*/chemistry , Cytoskeleton*/metabolism, Humans ; Animals ; Protein Processing, Post-Translational

The unexpected structure and dynamics of vimentin networks.

Autoren: Bhattacharyya K Klumpp S

Quelle: The Journal of cell biology [J Cell Biol] 2025 Apr 07; Vol. 224 (4). Date of Electronic Publication: 2025 Mar 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 0375356 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-8140 (Electronic) Linking ISSN: 00219525 NLM ISO Abbreviation: J Cell Biol Subsets: MEDLINE

MeSH-Schlagworte: Vimentin*/metabolism , Vimentin*/chemistry , Intermediate Filaments*/metabolism, Humans ; Animals

The unconventional role of vimentin intermediate filaments.

Autoren: Huang X Zhao S Xing Y et al.

Quelle: Current opinion in cell biology [Curr Opin Cell Biol] 2025 Apr; Vol. 93, pp. 102483. Date of Electronic Publication: 2025 Feb 19.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: England NLM ID: 8913428 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0410 (Electronic) Linking ISSN: 09550674 NLM ISO Abbreviation: Curr Opin Cell Biol Subsets: MEDLINE

MeSH-Schlagworte: Vimentin*/metabolism , Vimentin*/chemistry , Intermediate Filaments*/metabolism, Humans ; Animals ; Cytoskeleton/metabolism

Keratin-72 restricts HIV-1 infection in resting CD4 ⁺ T cells by sequestering capsids in intermediate filaments.

Autoren: He Y Xu M Ouyang J et al.

Quelle: Nature communications [Nat Commun] 2025 Mar 27; Vol. 16 (1), pp. 2998. Date of Electronic Publication: 2025 Mar 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: CD4-Positive T-Lymphocytes*/virology , CD4-Positive T-Lymphocytes*/metabolism , CD4-Positive T-Lymphocytes*/immunology , HIV-1*/physiology , Intermediate Filaments*/metabolism , Intermediate Filaments*/virology , Capsid*/metabolism , HIV Infections*/virology , HIV Infections*/metabolism , HIV Infections*/immunology, Humans ; Virus Replication ; Viral Regulatory and Accessory Proteins/metabolism ; HEK293 Cells ; Animals ; Keratins/metabolism

Neurofilament accumulation disrupts autophagy in giant axonal neuropathy.

Autoren: Paumier JM Zewe J Panja C et al.

Quelle: JCI insight [JCI Insight] 2025 Mar 10; Vol. 10 (5). Date of Electronic Publication: 2025 Mar 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE

MeSH-Schlagworte: Autophagy*/genetics , Giant Axonal Neuropathy*/pathology , Giant Axonal Neuropathy*/metabolism , Giant Axonal Neuropathy*/genetics , Cytoskeletal Proteins*/genetics , Cytoskeletal Proteins*/metabolism , Neurofilament Proteins*/metabolism , Intermediate Filaments*/metabolism , Intermediate Filaments*/pathology, Animals ; Mice ; Ganglia, Spinal/metabolism ; Ganglia, Spinal/pathology ; Lysosomes/metabolism ; Humans ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/metabolism ; Disease Models, Animal ; Mice, Knockout ; Axons/pathology ; Axons/metabolism