Suchergebnisse - "heterogeneity"

Genetic heterogeneity and homogeneity among orofacial cleft subtypes: genome-wide association studies in the cleft collective.

Autoren: Dack K Ludwig KU Stergiakouli E et al.

Quelle: Human molecular genetics [Hum Mol Genet] 2025 Nov 18; Vol. 34 (23), pp. 1934-1950.

Publikationsart: Journal Article; Meta-Analysis

Info zur Zeitschrift: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE

MeSH-Schlagworte: Cleft Lip*/genetics , Cleft Lip*/pathology , Cleft Palate*/genetics , Genetic Heterogeneity*, Humans ; Genome-Wide Association Study ; Polymorphism, Single Nucleotide ; Genetic Predisposition to Disease ; Female ; Male

Decoding cancer heterogeneity through super-enhancer landscapes: from subtype discovery to therapeutic opportunity.

Autoren: Cai S Wang Z Sun X et al.

Quelle: Briefings in bioinformatics [Brief Bioinform] 2025 Nov 01; Vol. 26 (6).

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 100912837 Publication Model: Print Cited Medium: Internet ISSN: 1477-4054 (Electronic) Linking ISSN: 14675463 NLM ISO Abbreviation: Brief Bioinform Subsets: MEDLINE

MeSH-Schlagworte: Neoplasms*/genetics , Neoplasms*/therapy , Neoplasms*/classification , Genetic Heterogeneity* , Enhancer Elements, Genetic*, Humans ; Epigenesis, Genetic ; Precision Medicine ; Gene Expression Regulation, Neoplastic

Extrachromosomal DNA in cancer: Molecular mechanisms underlying oncogene amplification and tumor heterogeneity.

Autoren: Li H Lu J Bian Y et al.

Quelle: Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2025 Nov; Vol. 215, pp. 104898. Date of Electronic Publication: 2025 Aug 15.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Scientific Publishers Country of Publication: Netherlands NLM ID: 8916049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0461 (Electronic) Linking ISSN: 10408428 NLM ISO Abbreviation: Crit Rev Oncol Hematol Subsets: MEDLINE

MeSH-Schlagworte: Neoplasms*/genetics , Neoplasms*/pathology , Oncogenes* , Gene Amplification* , Genetic Heterogeneity* , DNA, Circular*/genetics, Humans ; Animals ; Gene Expression Regulation, Neoplastic

Modeling changes in genetic heterogeneity using games with resources.

Autoren: Hajdowska K Swierniak A Borys D

Quelle: Computer methods and programs in biomedicine [Comput Methods Programs Biomed] 2025 Oct; Vol. 270, pp. 108916. Date of Electronic Publication: 2025 Jul 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8506513 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7565 (Electronic) Linking ISSN: 01692607 NLM ISO Abbreviation: Comput Methods Programs Biomed Subsets: MEDLINE

MeSH-Schlagworte: Game Theory* , Genetic Heterogeneity* , Models, Genetic*, Humans ; Phenotype ; Computer Simulation ; Population Dynamics

Youth depression: An overview of genetic findings and the challenge of heterogeneity.

Autoren: Thapar A Oginni O Dennison CA et al.

Quelle: Journal of affective disorders [J Affect Disord] 2025 Dec 15; Vol. 391, pp. 120049. Date of Electronic Publication: 2025 Aug 11.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE

MeSH-Schlagworte: Depressive Disorder*/genetics , Depressive Disorder*/psychology , Depressive Disorder*/diagnosis , Genetic Heterogeneity*, Humans ; Adolescent ; Genetic Predisposition to Disease/genetics ; Age of Onset ; Child ; Genome-Wide Association Study ; Gene-Environment Interaction ; Multifactorial Inheritance

Enhanced tumor heterogeneity mediates poor prognosis in females with TP53 mutation in lung adenocarcinoma.

Autoren: Mai L Yang X Shao C et al.

Quelle: International journal of biological macromolecules [Int J Biol Macromol] 2025 Dec; Vol. 334 (Pt 1), pp. 149083. Date of Electronic Publication: 2025 Nov 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH-Schlagworte: Tumor Suppressor Protein p53*/genetics , Adenocarcinoma of Lung*/genetics , Adenocarcinoma of Lung*/pathology , Adenocarcinoma of Lung*/mortality , Mutation* , Lung Neoplasms*/genetics , Lung Neoplasms*/pathology , Lung Neoplasms*/mortality , Genetic Heterogeneity*, Humans ; Female ; Male ; Prognosis ; Middle Aged ; Aged

Genomic heterogeneity and lineage-specific beta-lactamases in recurrent Achromobacter bloodstream infection patients.

Autoren: Huang HP Huang YT Yeh TK et al.

Quelle: Emerging microbes & infections [Emerg Microbes Infect] 2025 Dec; Vol. 14 (1), pp. 2547721. Date of Electronic Publication: 2025 Aug 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101594885 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2222-1751 (Electronic) Linking ISSN: 22221751 NLM ISO Abbreviation: Emerg Microbes Infect Subsets: MEDLINE

MeSH-Schlagworte: beta-Lactamases*/genetics , beta-Lactamases*/metabolism , Achromobacter*/genetics , Achromobacter*/classification , Achromobacter*/drug effects , Achromobacter*/isolation & purification , Achromobacter*/enzymology , Gram-Negative Bacterial Infections*/microbiology , Gram-Negative Bacterial Infections*/epidemiology , Bacteremia*/microbiology , Genetic Heterogeneity*, Humans ; Phylogeny ; Male ; Female ; Retrospective Studies ; Whole Genome Sequencing ; Anti-Bacterial Agents/pharmacology ; Genome, Bacterial ; Middle Aged ; Microbial Sensitivity Tests ; Taiwan/epidemiology ; Aged ; Recurrence ; Adult ; Bacterial Proteins/genetics ; Drug Resistance, Bacterial/genetics ; Urinary Tract Infections/microbiology

Resolving inter- and intra-patient heterogeneity in NPM1-mutated AML at single-cell resolution.

Autoren: Karakaslar EO Argiro EM Struckman NE et al.

Quelle: Leukemia [Leukemia] 2025 Dec; Vol. 39 (12), pp. 2916-2925. Date of Electronic Publication: 2025 Sep 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE

MeSH-Schlagworte: Leukemia, Myeloid, Acute*/genetics , Leukemia, Myeloid, Acute*/pathology , Single-Cell Analysis*/methods , Mutation* , Nuclear Proteins*/genetics , Genetic Heterogeneity* , Biomarkers, Tumor*/genetics, Humans ; Nucleophosmin ; Prognosis ; Female ; Gene Expression Profiling ; Male ; Flow Cytometry ; Middle Aged ; Aged ; Adult ; Transcriptome

Heterogeneity of Acute Myeloid Leukemia patients explored through single-cell and single-sample gene regulatory networks.

Autoren: Fernandes L Saccenti E

Quelle: Biochimica et biophysica acta. Gene regulatory mechanisms [Biochim Biophys Acta Gene Regul Mech] 2025 Dec; Vol. 1868 (4), pp. 195119. Date of Electronic Publication: 2025 Nov 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731723 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-4320 (Electronic) Linking ISSN: 18749399 NLM ISO Abbreviation: Biochim Biophys Acta Gene Regul Mech Subsets: MEDLINE

MeSH-Schlagworte: Leukemia, Myeloid, Acute*/genetics , Leukemia, Myeloid, Acute*/pathology , Gene Regulatory Networks* , Single-Cell Analysis*/methods , Genetic Heterogeneity* , Gene Expression Regulation, Leukemic*, Humans ; Gene Expression Profiling

Streptococcus suis serotype 5: Emerging zoonotic threat with distinct genomic heterogeneity.

Autoren: Zhang X Zhu J Kerdsin A et al.

Quelle: Virulence [Virulence] 2025 Dec; Vol. 16 (1), pp. 2523882. Date of Electronic Publication: 2025 Jun 26.

Publikationsart: Journal Article; Research Support, Non-U.S. Gov't

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101531386 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-5608 (Electronic) Linking ISSN: 21505594 NLM ISO Abbreviation: Virulence Subsets: MEDLINE

MeSH-Schlagworte: Streptococcus suis*/genetics , Streptococcus suis*/pathogenicity , Streptococcus suis*/classification , Streptococcus suis*/isolation & purification , Streptococcal Infections*/microbiology , Streptococcal Infections*/veterinary , Streptococcal Infections*/pathology , Zoonoses*/microbiology , Genetic Heterogeneity* , Bacterial Zoonoses*/microbiology, Animals ; Humans ; Phylogeny ; Serogroup ; Swine ; Mice ; Virulence ; Swine Diseases/microbiology ; Genome, Bacterial ; Cytokines ; Female ; Mice, Inbred BALB C

High Allelic Heterogeneity in Kazakhstani Patients with Neurofibromatosis Type 1: Results from the First Molecular Study.

Autoren: Idrissova Z Rakhimbekova F Orazgaliyeva M et al.

Quelle: Genes [Genes (Basel)] 2025 Nov 19; Vol. 16 (11). Date of Electronic Publication: 2025 Nov 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101551097 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4425 (Electronic) Linking ISSN: 20734425 NLM ISO Abbreviation: Genes (Basel) Subsets: MEDLINE

MeSH-Schlagworte: Neurofibromatosis 1*/genetics , Neurofibromatosis 1*/pathology , Neurofibromatosis 1*/epidemiology , Neurofibromin 1*/genetics , Genetic Heterogeneity*, Humans ; Male ; Female ; Child ; Adolescent ; Child, Preschool ; Young Adult ; Kazakhstan/epidemiology ; Alleles ; Adult ; High-Throughput Nucleotide Sequencing ; Mutation ; Infant ; Genetic Association Studies

Insights into genetic heterogeneity and drug resistance in Leishmania donovani of the Indian sub-continent from genomic data.

Autoren: Verma A Kumari I Jha AN

Quelle: Antonie van Leeuwenhoek [Antonie Van Leeuwenhoek] 2025 Nov 19; Vol. 118 (12), pp. 198. Date of Electronic Publication: 2025 Nov 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: Netherlands NLM ID: 0372625 Publication Model: Electronic Cited Medium: Internet ISSN: 1572-9699 (Electronic) Linking ISSN: 00036072 NLM ISO Abbreviation: Antonie Van Leeuwenhoek Subsets: MEDLINE

MeSH-Schlagworte: Leishmania donovani*/genetics , Leishmania donovani*/drug effects , Drug Resistance*/genetics , Genetic Heterogeneity*, India ; Humans ; Genome, Protozoan ; Leishmaniasis, Visceral/parasitology ; Antiprotozoal Agents/pharmacology ; Genomics ; Protozoan Proteins/genetics

Interrogating subclonal heterogeneity of liver cancer with single-cell multi-omics analysis.

Autoren: Zhang L Hu D Peng X et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 07; Vol. 15 (1), pp. 39021. Date of Electronic Publication: 2025 Nov 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Liver Neoplasms*/genetics , Liver Neoplasms*/pathology , Single-Cell Analysis*/methods , Carcinoma, Hepatocellular*/genetics , Carcinoma, Hepatocellular*/pathology , Genetic Heterogeneity*, Humans ; DNA Methylation ; Gene Expression Regulation, Neoplastic ; Transcriptome ; Gene Expression Profiling ; Cell Cycle Proteins/genetics ; Male ; Multiomics

Molecular investigation of primary aldosteronism: exploring genetic heterogeneity in understudied populations.

Autoren: Maeda LK Mermejo LM Fernandes-Rosa FL et al.

Quelle: Archives of endocrinology and metabolism [Arch Endocrinol Metab] 2025 Nov 06; Vol. 69 (6), pp. e250228. Date of Electronic Publication: 2025 Nov 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Segmento Farma Editores Country of Publication: Brazil NLM ID: 101652058 Publication Model: Electronic Cited Medium: Internet ISSN: 2359-4292 (Electronic) Linking ISSN: 23593997 NLM ISO Abbreviation: Arch Endocrinol Metab Subsets: MEDLINE

MeSH-Schlagworte: Hyperaldosteronism*/genetics , Genetic Heterogeneity* , Adrenal Cortex Neoplasms*/genetics , Adrenocortical Adenoma*/genetics, Humans ; Female ; Male ; Middle Aged ; Adult ; G Protein-Coupled Inwardly-Rectifying Potassium Channels/genetics ; Aged ; Sodium-Potassium-Exchanging ATPase/genetics ; Genetic Association Studies ; CLC-2 Chloride Channels ; Chloride Channels/genetics ; Plasma Membrane Calcium-Transporting ATPases/genetics

Divergent Clonal Evolution and Early Dissemination Promote Genetic Heterogeneity of Metastases in Castration-Resistant Prostate Cancer.

Autoren: Hosseini N Mannan R Rebernick RJ et al.

Quelle: Cancer research [Cancer Res] 2025 Nov 03; Vol. 85 (21), pp. 4251-4268.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

MeSH-Schlagworte: Prostatic Neoplasms, Castration-Resistant*/genetics , Prostatic Neoplasms, Castration-Resistant*/pathology , Clonal Evolution*/genetics , Genetic Heterogeneity*, Humans ; Male ; Neoplasm Metastasis ; Mutation ; Exome Sequencing ; DNA Copy Number Variations ; Phylogeny

Concerns regarding the standard deviation of individual responses for assessing treatment response heterogeneity.

Autoren: Caldwell AR Allison DB Brown AW et al.

Quelle: Journal of applied physiology (Bethesda, Md. : 1985) [J Appl Physiol (1985)] 2025 Nov 01; Vol. 139 (5), pp. 1220-1227. Date of Electronic Publication: 2025 Sep 30.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: American Physiological Society Country of Publication: United States NLM ID: 8502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1601 (Electronic) Linking ISSN: 01617567 NLM ISO Abbreviation: J Appl Physiol (1985) Subsets: MEDLINE

MeSH-Schlagworte: Treatment Effect Heterogeneity*, Humans ; Treatment Outcome

Intragenomic mutational heterogeneity: structural and functional insights from gene evolution.

Autoren: Hara Y Kuraku S

Quelle: Trends in genetics : TIG [Trends Genet] 2025 Nov; Vol. 41 (11), pp. 974-983. Date of Electronic Publication: 2025 May 05.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Trends Journals Country of Publication: England NLM ID: 8507085 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0168-9525 (Print) Linking ISSN: 01689525 NLM ISO Abbreviation: Trends Genet Subsets: MEDLINE

MeSH-Schlagworte: Evolution, Molecular* , Mutation* , Genetic Heterogeneity*, Humans ; Mutation Rate ; Animals ; Genome ; Phenotype

Young KRAB-zinc finger gene clusters are highly dynamic incubators of ERV-driven genetic heterogeneity in mice.

Autoren: Bruno M Farhana SM Mitra A et al.

Quelle: Nature communications [Nat Commun] 2025 Oct 30; Vol. 16 (1), pp. 9608. Date of Electronic Publication: 2025 Oct 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Multigene Family* , Endogenous Retroviruses*/genetics , Zinc Fingers*/genetics , Genetic Heterogeneity* , Repressor Proteins*/genetics, Animals ; Mice ; Mice, Inbred C57BL ; Evolution, Molecular ; Retroelements/genetics

Deciphering splicing heterogeneity at single-cell resolution by SCSES.

Autoren: Wen X Lv X Guo D et al.

Quelle: Nature communications [Nat Commun] 2025 Oct 27; Vol. 16 (1), pp. 9459. Date of Electronic Publication: 2025 Oct 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Single-Cell Analysis*/methods , Alternative Splicing*/genetics , Genetic Heterogeneity*, Humans ; Algorithms ; Sequence Analysis, RNA/methods ; RNA-Seq ; Computational Biology/methods ; Animals ; Transcriptome/genetics ; Gene Expression Profiling/methods

Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression in patients.

Autoren: Smith AL Denny N Chahrour C et al.

Quelle: Blood [Blood] 2025 Oct 23; Vol. 146 (17), pp. 2073-2087.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE

MeSH-Schlagworte: Enhancer Elements, Genetic* , Precursor Cell Lymphoblastic Leukemia-Lymphoma*/genetics , Precursor Cell Lymphoblastic Leukemia-Lymphoma*/pathology , Histone-Lysine N-Methyltransferase*/genetics , Myeloid-Lymphoid Leukemia Protein*/genetics , Gene Expression Regulation, Leukemic* , Genetic Heterogeneity*, Humans ; Myeloid Ecotropic Viral Integration Site 1 Protein/genetics ; Transcriptional Elongation Factors/genetics ; DNA-Binding Proteins