Výsledky vyhľadávania - "hSOD1(G93A)"

Subpial delivery of adeno-associated virus 9-synapsin-caveolin-1 (AAV9-SynCav1) preserves motor neuron and neuromuscular junction morphology, motor function, delays disease onset, and extends survival in hSOD1G93A mice

Autori: Wang, Shanshan Ichinomiya, Taiga Savchenko, Paul a ďalší

Zdroj: Theranostics. 12(12)

Predmety: Medical Biotechnology, Biomedical and Clinical Sciences, Neurosciences, Brain Disorders, Neurodegenerative, Genetics, ALS, Gene Therapy, Orphan Drug, Rare Diseases, Biotechnology, 2.1 Biological and endogenous factors, Neurological, Amyotrophic Lateral Sclerosis, Animals, Caveolin 1, Dependovirus, Disease Models, Animal, Female, Gene Transfer Techniques, Humans, Male, Mice, Mice, Transgenic, Motor Neurons, Neuromuscular Junction, Rats, Superoxide Dismutase, Synapsins, caveolin-1, membrane/lipid raft, gene therapy, hSOD1(G93A), amyotrophic lateral sclerosis, motor neuron, neuromuscular junction, hSOD1G93A, Oncology and Carcinogenesis, Oncology and carcinogenesis

Popis súboru: application/pdf

Prístupová URL adresa: https://escholarship.org/uc/item/68f3p9hv
https://escholarship.org/content/qt68f3p9hv/qt68f3p9hv.pdf

Lead exposure induces ferroptosis in ALS cell models by activating the MAPK/ERK signaling pathway.

Autori: Gao, Yi Zheng, Bingxue Peng, Xiaoxiao a ďalší

Zdroj: Ecotoxicol Environ Saf ; ISSN:1090-2414 ; Volume:306

Predmety: Amyotrophic lateral sclerosis, Ferroptosis, Lead, MAPK/ERK, hSOD1(G93A)

Relation: https://doi.org/10.1016/j.ecoenv.2025.119301; https://pubmed.ncbi.nlm.nih.gov/41151289

Dostupnosť: https://doi.org/10.1016/j.ecoenv.2025.119301
https://pubmed.ncbi.nlm.nih.gov/41151289

Brca1 is expressed in human microglia and is dysregulated in human and animal model of ALS

Autori: Marisa Teigell Markus Weber Jean Charles Sabourin a ďalší

Prispievatelia: Marisa Teigell Markus Weber Jean Charles Sabourin a ďalší

Zdroj: Mol Neurodegener
Addi. Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
instname

Predmety: 0301 basic medicine, hSOD1G93Amice, mouse model, Clinical Neurology, Mutation, Missense, microglia, amyotophic-lateral-sclerosis, motor-neuron disease, Mice, Transgenic, Nerve Tissue Proteins, Cellular and Molecular Neuroscience, transcriptomics, Mice, 03 medical and health sciences, renal-cell carcinoma, Animals, Humans, Point Mutation, Gene Regulatory Networks, Gliosis, alzheimers-disease, Transcriptomics, Molecular Biology, NEUROLOGY, breast-cancer, Motor Neurons, 0303 health sciences, DNA-repair, BRCA1 Protein, Superoxide Dismutase, hSOD1(G93A) mice, Gene Expression Profiling, [SCCO.NEUR] Cognitive science/Neuroscience, MOLECULAR BIOLOGY, Amyotrophic Lateral Sclerosis, CELLULAR AND MOLECULAR NEUROSCIENCE, Age Factors, gene-expression, Recombinant Proteins, 3. Good health, Disease Models, Animal, Spinal Cord, ALS patients, responses, Microglia, protein, Brca1, Research Article, DNA Damage

Popis súboru: application/pdf

Prístupová URL adresa: https://molecularneurodegeneration.biomedcentral.com/track/pdf/10.1186/s13024-015-0023-x
https://pubmed.ncbi.nlm.nih.gov/26227626
http://hdl.handle.net/10810/17836
https://esploro.libs.uga.edu/esploro/outputs/journalArticle/Brca1-is-expressed-in-human-microglia/9949316525002959
https://athenaeum.libs.uga.edu/handle/10724/32044
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521418/
http://www.molecularneurodegeneration.com/content/10/1/34
https://link.springer.com/article/10.1186/s13024-015-0023-x
http://europepmc.org/articles/PMC4521418
https://hal.science/hal-02156103v1/document
https://doi.org/10.1186/s13024-015-0023-x
https://hal.science/hal-02156103v1

Melittin restores proteasome function in an animal model of ALS

Autori: Lee Sang Min Yang Sun Choel Kim Seon Hwy a ďalší

Zdroj: Journal of Neuroinflammation, Vol 8, Iss 1, p 69 (2011)

Predmety: hSOD1 G93A, Melittin, Amyotrophic lateral sclerosis (ALS), α-synuclein, Neurology. Diseases of the nervous system, RC346-429

Relation: http://www.jneuroinflammation.com/content/8/1/69; https://doaj.org/toc/1742-2094; https://doaj.org/article/c3d9c0eccf7149efa7c57d86722a1db6

Dostupnosť: https://doi.org/10.1186/1742-2094-8-69
https://doaj.org/article/c3d9c0eccf7149efa7c57d86722a1db6

Generation of pre-implantation pig SCNT embryos harboring the amyotrophic lateral sclerosis related hSOD1G93A gene

Autori: Chieppa M. N. Perota A. Lagutina L. a ďalší

Predmety: amyotrophic lateral sclerosis (ALS), PIG, hSOD1 G93A gene, amyotrophic lateral sclerosis, SCNT embryos, Cu/Zn superoxide-dismutase1 (SOD1), somatic cell nuclear transfer (SCNT), swine model

Prístupová URL adresa: https://hdl.handle.net/10807/61927
https://hdl.handle.net/11585/121752

Generation of pre-implantation pig SCNT embryos harboring the amyotrophic lateral sclerosis related hSOD1 G93A gene

Autori: Chieppa M. N. Perota A. Lagutina L. a ďalší

Prispievatelia: Chieppa M. N. Perota A. Lagutina L. a ďalší

Predmety: PIG, hSOD1 G93A gene, amyotrophic lateral sclerosi, SCNT embryos

Popis súboru: STAMPA

Relation: info:eu-repo/semantics/altIdentifier/wos/WOS:000304234300173; volume:6; firstpage:84; lastpage:84; numberofpages:1; journal:PRION; http://hdl.handle.net/11585/121752

Dostupnosť: http://hdl.handle.net/11585/121752

in an animal model of ALS

Autori: Eun Jin Yang Seon Hwy Kim Sun Choel Yang a ďalší

Prispievatelia: Eun Jin Yang Seon Hwy Kim Sun Choel Yang a ďalší

Zdroj: ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/07/21/J_Neuroinflammation_2011_Jun_20_8_69.tar.gz

Predmety: hSOD1 G93A, Melittin, Amyotrophic lateral sclerosis (ALS, α-synuclein Background

Popis súboru: application/zip

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.350.1964

Dostupnosť: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.350.1964

Anti-Inflammatory Effects of Chaenomeles sinensis Extract in an ALS Animal Model.

Autori: Yang EJ Lee SH

Zdroj: Frontiers in bioscience (Landmark edition) [Front Biosci (Landmark Ed)] 2023 Dec 01; Vol. 28 (12), pp. 326.

Spôsob vydávania: Journal Article; Research Support, Non-U.S. Gov't; Comment

Informácie o časopise: Publisher: IMR Press Country of Publication: Singapore NLM ID: 101612996 Publication Model: Print Cited Medium: Internet ISSN: 2768-6698 (Electronic) Linking ISSN: 27686698 NLM ISO Abbreviation: Front Biosci (Landmark Ed) Subsets: MEDLINE

Výrazy zo slovníka MeSH: Amyotrophic Lateral Sclerosis*/drug therapy , Amyotrophic Lateral Sclerosis*/genetics , Amyotrophic Lateral Sclerosis*/pathology , Rosaceae*/chemistry, Humans ; Mice ; Animals ; Mice, Transgenic ; Disease Models, Animal ; Spinal Cord ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use

Brca1 is expressed in human microglia and is dysregulated in human and animal model of ALS

Autori: Neurociencias Neurozientziak Noristani, Harun Najib a ďalší

Témy: microglia, transcriptomics, hSOD1(G93A) mice, ALS patients, Brca1, amyotophic-lateral-sclerosis, motor-neuron disease, renal-cell carcinoma, mouse model, breast-cancer, alzheimers-disease, gene-expression, DNA-repair, responses, protein, info:eu-repo/semantics/article

URL: http://hdl.handle.net/10810/17836
http://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-015-0023-x#Abs1
1750-1326
http://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-015-0023-x#Abs1

Imaging of glial cell morphology, SOD1 distribution and elemental composition in the brainstem and hippocampus of the ALS hSOD1 ^G93A rat.

Autori: Stamenković S Dučić T Stamenković V a ďalší

Zdroj: Neuroscience [Neuroscience] 2017 Aug 15; Vol. 357, pp. 37-55. Date of Electronic Publication: 2017 May 31.

Spôsob vydávania: Journal Article; Research Support, Non-U.S. Gov't

Informácie o časopise: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7544 (Electronic) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE

Výrazy zo slovníka MeSH: Amyotrophic Lateral Sclerosis/*pathology , Brain Stem/*pathology , Hippocampus/*pathology , Neuroglia/*pathology , Superoxide Dismutase-1/*metabolism, Amyotrophic Lateral Sclerosis/metabolism ; Animals ; Brain Stem/metabolism ; Cell Proliferation ; Disease Models, Animal ; Hippocampus/metabolism ; Humans ; Immunohistochemistry ; Intracellular Space/metabolism ; Microscopy, Fluorescence ; Neuroglia/metabolism ; Prodromal Symptoms ; Rats, Sprague-Dawley ; Rats, Transgenic ; Superoxide Dismutase-1/genetics