Suchergebnisse - "enzyme"

Evaluating CYP enzyme induction by cigarette smoking: a new in vitro approach using primary human hepatocytes.

Autoren: Lenich AK Ruez S

Quelle: Archives of toxicology [Arch Toxicol] 2025 Nov; Vol. 99 (11), pp. 4513-4530. Date of Electronic Publication: 2025 Jul 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE

MeSH-Schlagworte: Hepatocytes*/drug effects , Hepatocytes*/enzymology , Cigarette Smoking*/adverse effects , Smoke*/adverse effects , Cytochrome P-450 Enzyme System* , Cytochrome P-450 Enzyme Inducers*, Humans ; Cells, Cultured ; Enzyme Induction/drug effects ; Cytochrome P-450 CYP1A2/genetics ; Cytochrome P-450 CYP1A2/metabolism ; Cytochrome P-450 CYP1A2/biosynthesis ; Cytochrome P-450 CYP1A1/genetics ; Cytochrome P-450 CYP1A1/metabolism ; Cytochrome P-450 CYP1A1/biosynthesis ; Male ; Tobacco Products

Cellular Potency Optimization of Novel Heme-Binding Imidazo[5,1- b ]thiazoles, Imidazo[1,5- a ]pyridines and Pyrazines as Potent IDO1 Inhibitors Devoid of Cytochrome P450 Inhibition.

Autoren: Cren S Lotz-Jenne C Kimmerlin T et al.

Quelle: Journal of medicinal chemistry [J Med Chem] 2025 Oct 09; Vol. 68 (19), pp. 20130-20153. Date of Electronic Publication: 2025 Sep 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Indoleamine-Pyrrole 2,3,-Dioxygenase*/antagonists & inhibitors , Indoleamine-Pyrrole 2,3,-Dioxygenase*/metabolism , Pyridines*/pharmacology , Pyridines*/chemistry , Pyridines*/chemical synthesis , Thiazoles*/pharmacology , Thiazoles*/chemistry , Thiazoles*/chemical synthesis , Thiazoles*/metabolism , Imidazoles*/pharmacology , Imidazoles*/chemistry , Imidazoles*/chemical synthesis , Pyrazines*/pharmacology , Pyrazines*/chemistry , Pyrazines*/metabolism , Pyrazines*/chemical synthesis , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/chemical synthesis , Enzyme Inhibitors*/metabolism , Heme*/metabolism, Humans ; Structure-Activity Relationship ; Cytochrome P-450 Enzyme Inhibitors/pharmacology ; Cytochrome P-450 Enzyme System/metabolism ; Animals

Preparation of branched starch by α-amylase and thermophilic glycogen branching enzyme modification.

Autoren: Zhu J Gao Y Li X et al.

Quelle: Food chemistry [Food Chem] 2025 Nov 30; Vol. 493 (Pt 1), pp. 145748. Date of Electronic Publication: 2025 Jul 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Starch*/chemistry , Starch*/metabolism , alpha-Amylases*/chemistry , 1,4-alpha-Glucan Branching Enzyme*/chemistry , 1,4-alpha-Glucan Branching Enzyme*/metabolism , 1,4-alpha-Glucan Branching Enzyme*/genetics , Archaeal Proteins*/chemistry , Archaeal Proteins*/genetics , Fungal Proteins*/chemistry, Hot Temperature ; Enzyme Stability ; Zea mays/chemistry ; Biocatalysis

Structural and mechanistic insights into activators of alcohol dehydrogenase.

Autoren: Baby EK Savitha R Kinsella GK et al.

Quelle: International journal of biological macromolecules [Int J Biol Macromol] 2025 Nov; Vol. 330 (Pt 3), pp. 148040. Date of Electronic Publication: 2025 Oct 01.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH-Schlagworte: Alcohol Dehydrogenase*/chemistry , Alcohol Dehydrogenase*/metabolism , Enzyme Activators*/chemistry , Enzyme Activators*/pharmacology , Enzyme Activators*/metabolism, Enzyme Activation ; Humans ; Animals ; Peptides/chemistry ; Peptides/pharmacology

In-situ formed silicon nanoparticles as high-fidelity fluorometric probe for sulfatase activity assay.

Autoren: Nsanzamahoro S Bezuneh TT Nan F et al.

Quelle: Talanta [Talanta] 2025 Dec 01; Vol. 295, pp. 128314. Date of Electronic Publication: 2025 May 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2984816R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3573 (Electronic) Linking ISSN: 00399140 NLM ISO Abbreviation: Talanta Subsets: MEDLINE

MeSH-Schlagworte: Sulfatases*/analysis , Sulfatases*/antagonists & inhibitors , Silicon*/chemistry , Nanoparticles*/chemistry , Fluorescent Dyes*/chemistry , Enzyme Assays*/methods, Fluorometry/methods ; Sensitivity and Specificity ; Enzyme Inhibitors/isolation & purification ; Enzyme Inhibitors/pharmacology ; Catechols/chemistry ; Substrate Specificity ; Silicon Compounds/chemical synthesis ; Silicon Compounds/chemistry

Performance and stability of urease inhibitors: Complementary effects of phenyl phosphorodiamidate and N-(n-butyl)thiophosphoric triamide under pH and temperature variations.

Autoren: Jeon YJ Ahn JH Yun YM

Quelle: Bioresource technology [Bioresour Technol] 2025 Dec; Vol. 438, pp. 133267. Date of Electronic Publication: 2025 Sep 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Applied Science Country of Publication: England NLM ID: 9889523 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2976 (Electronic) Linking ISSN: 09608524 NLM ISO Abbreviation: Bioresour Technol Subsets: MEDLINE

MeSH-Schlagworte: Urease*/antagonists & inhibitors , Urease*/metabolism , Temperature* , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Organothiophosphorus Compounds*/pharmacology, Hydrogen-Ion Concentration ; Molecular Docking Simulation ; Enzyme Stability/drug effects ; Animals ; Ammonia ; Urea ; Manure ; Organophosphorus Compounds

Molecular Aspects of Soluble Guanylate Cyclase Activation and Stimulator Function.

Autoren: Houghton KA Thomas WC Marletta MA

Quelle: Biochemistry [Biochemistry] 2025 Nov 18; Vol. 64 (22), pp. 4529-4541. Date of Electronic Publication: 2025 Oct 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

MeSH-Schlagworte: Soluble Guanylyl Cyclase*/metabolism , Soluble Guanylyl Cyclase*/chemistry , Soluble Guanylyl Cyclase*/genetics , Enzyme Activators*/pharmacology , Enzyme Activators*/chemistry, Humans ; Animals ; Nitric Oxide/metabolism ; Enzyme Activation/drug effects ; Models, Molecular

Activating human 15-lipoxygenase-1 beyond flatland: discovery of non-aromatic modulators.

Autoren: Somaraki M Zachilas I Tsapinou E et al.

Quelle: Organic & biomolecular chemistry [Org Biomol Chem] 2025 Nov 05; Vol. 23 (43), pp. 9942-9949. Date of Electronic Publication: 2025 Nov 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101154995 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-0539 (Electronic) Linking ISSN: 14770520 NLM ISO Abbreviation: Org Biomol Chem Subsets: MEDLINE

MeSH-Schlagworte: Arachidonate 15-Lipoxygenase*/metabolism , Arachidonate 15-Lipoxygenase*/chemistry , Lipoxygenase Inhibitors*/chemistry , Lipoxygenase Inhibitors*/pharmacology , Lipoxygenase Inhibitors*/chemical synthesis , Drug Discovery* , Enzyme Activators*/chemistry , Enzyme Activators*/pharmacology , Enzyme Activators*/chemical synthesis, Humans ; Structure-Activity Relationship ; Molecular Structure ; Models, Molecular ; Enzyme Activation/drug effects ; Dose-Response Relationship, Drug

Novel AMP-activated protein kinase activators and their potential for mitigating renal injury and fibrosis.

Autoren: Harley G Mount PF

Quelle: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2025 Nov; Vol. 392 (11), pp. 103741. Date of Electronic Publication: 2025 Oct 09.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

MeSH-Schlagworte: AMP-Activated Protein Kinases*/metabolism , Acute Kidney Injury*/drug therapy , Acute Kidney Injury*/pathology , Acute Kidney Injury*/metabolism , Kidney*/drug effects , Kidney*/pathology , Enzyme Activators*/pharmacology , Enzyme Activators*/therapeutic use , Kidney Diseases*/drug therapy , Kidney Diseases*/pathology, Humans ; Animals ; Fibrosis/drug therapy ; Enzyme Activation/drug effects

Small-molecule allosteric activator of ubiquitin-specific protease 7 (USP7).

Autoren: Jaen Maisonet I Sharafi M Korchak EJ et al.

Quelle: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Oct 21; Vol. 122 (42), pp. e2510496122. Date of Electronic Publication: 2025 Oct 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH-Schlagworte: Ubiquitin-Specific Peptidase 7*/metabolism , Ubiquitin-Specific Peptidase 7*/genetics , Ubiquitin-Specific Peptidase 7*/chemistry , Small Molecule Libraries*/pharmacology , Small Molecule Libraries*/chemistry , Enzyme Activators*/pharmacology , Enzyme Activators*/chemistry, Humans ; Allosteric Regulation ; HEK293 Cells ; Enzyme Activation/drug effects

Assessing Cytochrome P450 Drug Interaction Risk for Dordaviprone Using Physiologically Based Pharmacokinetic Modeling.

Autoren: Jaiswal S Patel NK Jones HM et al.

Quelle: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2025 Oct; Vol. 14 (10), pp. 1695-1704. Date of Electronic Publication: 2025 Aug 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley Country of Publication: United States NLM ID: 101580011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2163-8306 (Electronic) Linking ISSN: 21638306 NLM ISO Abbreviation: CPT Pharmacometrics Syst Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Models, Biological* , Cytochrome P-450 Enzyme System*/metabolism, Humans ; Drug Interactions ; Cytochrome P-450 CYP3A Inhibitors/pharmacology ; Cytochrome P-450 CYP3A Inhibitors/pharmacokinetics ; Cytochrome P-450 CYP3A Inducers/pharmacokinetics ; Cytochrome P-450 CYP3A Inducers/pharmacology ; Area Under Curve ; Cytochrome P-450 CYP3A/metabolism ; Computer Simulation ; Male ; Adult ; Female ; Itraconazole/pharmacology ; Cytochrome P-450 Enzyme Inducers/pharmacology ; Cytochrome P-450 Enzyme Inducers/pharmacokinetics ; Middle Aged ; Cytochrome P-450 CYP2D6 Inhibitors

Characterisation of a Self-Sufficient Cytochrome P450 Enzyme From the Bacterium Thermosporothrix hazakensis and Its Conversion Into a Peroxygenase.

Autoren: Podgorski MN Lee JHZ Scaffidi-Muta JM et al.

Quelle: Microbial biotechnology [Microb Biotechnol] 2025 Oct; Vol. 18 (10), pp. e70234.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 101316335 Publication Model: Print Cited Medium: Internet ISSN: 1751-7915 (Electronic) Linking ISSN: 17517915 NLM ISO Abbreviation: Microb Biotechnol Subsets: MEDLINE

MeSH-Schlagworte: Cytochrome P-450 Enzyme System*/metabolism , Cytochrome P-450 Enzyme System*/genetics , Cytochrome P-450 Enzyme System*/chemistry , Mixed Function Oxygenases*/metabolism , Mixed Function Oxygenases*/genetics , Mixed Function Oxygenases*/chemistry , Bacterial Proteins*/metabolism , Bacterial Proteins*/genetics , Bacterial Proteins*/chemistry , Flavobacteriaceae*/enzymology , Flavobacteriaceae*/genetics, Escherichia coli/genetics ; Escherichia coli/metabolism ; Oxidation-Reduction ; Fatty Acids/metabolism ; Enzyme Stability ; Hydrogen Peroxide/metabolism

Evaluation of cytomegalovirus cell-mediated immunity assays in the healthy Singapore cohort and challenges of test validation.

Autoren: Ng SH Tan SYL Thean SM et al.

Quelle: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [J Clin Virol] 2025 Dec; Vol. 181, pp. 105858. Date of Electronic Publication: 2025 Aug 29.

Publikationsart: Journal Article; Validation Study; Evaluation Study

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 9815671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5967 (Electronic) Linking ISSN: 13866532 NLM ISO Abbreviation: J Clin Virol Subsets: MEDLINE

MeSH-Schlagworte: Cytomegalovirus Infections*/diagnosis , Cytomegalovirus Infections*/immunology , Cytomegalovirus*/immunology , Enzyme-Linked Immunospot Assay*/methods , Immunity, Cellular*, Humans ; Sensitivity and Specificity ; Singapore ; Enzyme-Linked Immunosorbent Assay/methods ; Antibodies, Viral/blood ; Healthy Volunteers ; Male ; Female ; Adult ; Interferon-gamma/blood ; Cohort Studies ; Immunoglobulin G/blood ; Reproducibility of Results ; Middle Aged ; Reagent Kits, Diagnostic

Methods for Assessing MAGL Enzymatic Activity: An Extensive Review of Past and Emerging Approaches.

Autoren: Bononi G Landucci E Di Stefano M et al.

Quelle: International journal of molecular sciences [Int J Mol Sci] 2025 Oct 09; Vol. 26 (19). Date of Electronic Publication: 2025 Oct 09.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: Monoacylglycerol Lipases*/metabolism , Monoacylglycerol Lipases*/antagonists & inhibitors , Enzyme Assays*/methods, Humans ; Animals ; Enzyme Inhibitors/pharmacology ; Neoplasms/drug therapy ; Lipid Metabolism

A novel screening method for cytochrome P450 induction in early drug discovery using advanced biomimetic chromatography targeting the pregnane X receptor.

Autoren: Okawa H Kobayashi S Taniguchi T et al.

Quelle: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2026 Jan 15; Vol. 268, pp. 117219. Date of Electronic Publication: 2025 Nov 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-264X (Electronic) Linking ISSN: 07317085 NLM ISO Abbreviation: J Pharm Biomed Anal Subsets: MEDLINE

MeSH-Schlagworte: Pregnane X Receptor*/metabolism , Drug Discovery*/methods , Cytochrome P-450 Enzyme System*/metabolism , Cytochrome P-450 Enzyme System*/biosynthesis , Biomimetics*/methods , Cytochrome P-450 Enzyme Inducers*/pharmacology, Humans ; Enzyme Induction/drug effects

Induction of human cytochrome P450 enzyme activities by metabolism disrupting chemicals in the hepatic cell line HepaRG.

Autoren: Person E Cabaton NJ Urien L et al.

Quelle: Toxicology [Toxicology] 2026 Jan; Vol. 519, pp. 154300. Date of Electronic Publication: 2025 Oct 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0361055 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3185 (Electronic) Linking ISSN: 0300483X NLM ISO Abbreviation: Toxicology Subsets: MEDLINE

MeSH-Schlagworte: Cytochrome P-450 Enzyme System*/biosynthesis , Cytochrome P-450 Enzyme System*/metabolism , Endocrine Disruptors*/toxicity , Cytochrome P-450 Enzyme Inducers*/toxicity , Liver*/drug effects , Liver*/enzymology , Hepatocytes*/drug effects , Hepatocytes*/enzymology, Humans ; Enzyme Induction/drug effects ; Fluorocarbons/toxicity ; Benzhydryl Compounds/toxicity ; Caprylates/toxicity ; Triclosan/toxicity ; Phenols/toxicity ; Trialkyltin Compounds/toxicity ; Dichlorodiphenyl Dichloroethylene/toxicity ; Organophosphates/toxicity ; Cell Line ; Bisphenol A Compounds

Structure-guided discovery of marine natural products as glucokinase activators for type 2 diabetes mellitus: A computational perspective.

Autoren: Krishnakumar H Jayaraman M Prabhu D et al.

Quelle: Journal of molecular graphics & modelling [J Mol Graph Model] 2026 Jan; Vol. 142, pp. 109181. Date of Electronic Publication: 2025 Sep 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science, Inc Country of Publication: United States NLM ID: 9716237 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4243 (Electronic) Linking ISSN: 10933263 NLM ISO Abbreviation: J Mol Graph Model Subsets: MEDLINE

MeSH-Schlagworte: Glucokinase*/chemistry , Glucokinase*/metabolism , Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/enzymology , Biological Products*/chemistry , Biological Products*/pharmacology , Hypoglycemic Agents*/chemistry , Hypoglycemic Agents*/pharmacology , Drug Discovery* , Enzyme Activators*/chemistry , Enzyme Activators*/pharmacology , Aquatic Organisms*/chemistry, Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protein Binding ; Ligands ; Structure-Activity Relationship ; Enzyme Activation/drug effects

Angiotensin-Converting Enzyme Inhibition and/or Angiotensin Receptor Blockade Modulate Cytokine Profiles and Improve Clinical Outcomes in Experimental COVID-19 Infection.

Autoren: da Silva-Santos Y Pagni RL Gamon THM et al.

Quelle: International journal of molecular sciences [Int J Mol Sci] 2025 Aug 08; Vol. 26 (16). Date of Electronic Publication: 2025 Aug 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: Angiotensin-Converting Enzyme Inhibitors*/pharmacology , Angiotensin-Converting Enzyme Inhibitors*/therapeutic use , Angiotensin Receptor Antagonists*/pharmacology , Angiotensin Receptor Antagonists*/therapeutic use , Cytokines*/metabolism , COVID-19 Drug Treatment*, Animals ; Angiotensin-Converting Enzyme 2/metabolism ; Angiotensin-Converting Enzyme 2/genetics ; COVID-19/virology ; COVID-19/metabolism ; Mice ; SARS-CoV-2/drug effects ; SARS-CoV-2/physiology ; Viral Load/drug effects ; Humans ; Losartan/pharmacology ; Losartan/therapeutic use ; Lisinopril/pharmacology ; Lisinopril/therapeutic use ; Mice, Transgenic ; Lung/drug effects ; Lung/virology ; Lung/metabolism ; Lung/pathology ; Disease Models, Animal ; Virus Replication/drug effects ; Male ; Female

Enhancing the thermal stability and activity of the engineered self-sufficient P450 SPα -SOX by switching the domains linker.

Autoren: Giuriato D Catucci G Correddu D et al.

Quelle: International journal of biological macromolecules [Int J Biol Macromol] 2025 Aug; Vol. 319 (Pt 3), pp. 145497. Date of Electronic Publication: 2025 Jun 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH-Schlagworte: Protein Engineering*/methods , Cytochrome P-450 Enzyme System*/chemistry , Cytochrome P-450 Enzyme System*/genetics , Cytochrome P-450 Enzyme System*/metabolism , Temperature* , Recombinant Fusion Proteins*/chemistry , Recombinant Fusion Proteins*/genetics , Recombinant Fusion Proteins*/metabolism, Enzyme Stability ; Protein Domains ; Kinetics

In vitro enantioselective inhibition of key human CYP450 enzymes by the chiral fungicide penconazole.

Autoren: Barbetta MFS Baviera GS Perovani IS et al.

Quelle: Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2025 Sep; Vol. 118, pp. 104790. Date of Electronic Publication: 2025 Aug 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9612020 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7077 (Electronic) Linking ISSN: 13826689 NLM ISO Abbreviation: Environ Toxicol Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Triazoles*/chemistry , Triazoles*/toxicity , Triazoles*/pharmacology , Fungicides, Industrial*/chemistry , Fungicides, Industrial*/toxicity , Fungicides, Industrial*/pharmacology , Cytochrome P-450 Enzyme Inhibitors*/chemistry , Cytochrome P-450 Enzyme Inhibitors*/pharmacology, Humans ; Microsomes, Liver/drug effects ; Microsomes, Liver/enzymology ; Stereoisomerism ; Cytochrome P-450 Enzyme System/metabolism