Search Results - "differentiation"

Rroid2 regulates effector-to-memory CD8 ⁺ T cell differentiation during infection in vivo.

Authors: Erber J Stecher C Plajer V et al.

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Dec 02; Vol. 122 (48), pp. e2503450122. Date of Electronic Publication: 2025 Nov 24.

Publication Type: Journal Article

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH Terms: CD8-Positive T-Lymphocytes*/immunology , CD8-Positive T-Lymphocytes*/metabolism , CD8-Positive T-Lymphocytes*/cytology , Cell Differentiation*/immunology , Cell Differentiation*/genetics , Immunologic Memory* , RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/immunology , RNA, Long Noncoding*/metabolism, Animals ; Mice ; Mice, Knockout ; Inhibitor of Differentiation Protein 2/genetics ; Inhibitor of Differentiation Protein 2/metabolism ; Inhibitor of Differentiation Protein 2/immunology ; Humans ; Lectins, C-Type/genetics ; Lectins, C-Type/metabolism ; T-Box Domain Proteins/genetics ; T-Box Domain Proteins/metabolism ; T-Box Domain Proteins/immunology ; T-bet Transcription Factor ; Mice, Inbred C57BL ; Memory T Cells/immunology ; Receptors, Immunologic

Growth differentiation factor 11 modulates metabolism, mitigating the pro-tumoral behavior provided by M2-like macrophages in hepatocellular carcinoma-derived cells.

Authors: Escobedo-Calvario A Chávez-Rodríguez L Souza-Arroyo V et al.

Source: World journal of gastroenterology [World J Gastroenterol] 2025 Oct 28; Vol. 31 (40), pp. 111307.

Publication Type: Journal Article

Journal Info: Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 100883448 Publication Model: Print Cited Medium: Internet ISSN: 2219-2840 (Electronic) Linking ISSN: 10079327 NLM ISO Abbreviation: World J Gastroenterol Subsets: MEDLINE

MeSH Terms: Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/immunology , Carcinoma, Hepatocellular*/metabolism , Liver Neoplasms*/pathology , Liver Neoplasms*/immunology , Liver Neoplasms*/metabolism , Growth Differentiation Factors*/pharmacology , Growth Differentiation Factors*/metabolism , Tumor-Associated Macrophages*/metabolism , Tumor-Associated Macrophages*/immunology , Tumor-Associated Macrophages*/drug effects , Bone Morphogenetic Proteins*/pharmacology , Bone Morphogenetic Proteins*/metabolism , Macrophages*/metabolism, Humans ; Coculture Techniques ; Cell Proliferation/drug effects ; Cell Line, Tumor ; Tumor Microenvironment/immunology ; Tumor Microenvironment/drug effects ; Signal Transduction/drug effects ; Culture Media, Conditioned ; THP-1 Cells ; Cell Differentiation/drug effects ; Recombinant Proteins/pharmacology ; Cell Movement/drug effects

Germinal center formation is resilient to CD69 deletion on T follicular helper cells.

Authors: Guillaume SM Carslaw HA Innocentin S et al.

Source: Immunology and cell biology [Immunol Cell Biol] 2025 Oct; Vol. 103 (9), pp. 844-856. Date of Electronic Publication: 2025 Aug 04.

Publication Type: Journal Article

Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 8706300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1440-1711 (Electronic) Linking ISSN: 08189641 NLM ISO Abbreviation: Immunol Cell Biol Subsets: MEDLINE

MeSH Terms: Antigens, Differentiation, T-Lymphocyte*/metabolism , Antigens, Differentiation, T-Lymphocyte*/genetics , Germinal Center*/immunology , Germinal Center*/cytology , Lectins, C-Type*/metabolism , Lectins, C-Type*/genetics , Antigens, CD*/metabolism , Antigens, CD*/genetics , T Follicular Helper Cells*/immunology , T Follicular Helper Cells*/metabolism , Gene Deletion* , T-Lymphocytes, Helper-Inducer*/immunology, Animals ; B-Lymphocytes/immunology ; Cell Differentiation/immunology ; Mice, Inbred C57BL ; Mice ; Lymph Nodes/immunology ; Lymphocyte Activation ; Mice, Knockout

Exploring BMP9 and integrin alpha 10 as novel chondrogenic markers in human bone marrow-derived mesenchymal stem cells, chondroprogenitors, and chondrocytes: an immunohistochemistry study.

Authors: Priya M Ruksana C A Jeyaraj C et al.

Source: The Knee [Knee] 2025 Dec; Vol. 57, pp. 311-324. Date of Electronic Publication: 2025 Oct 04.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9430798 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5800 (Electronic) Linking ISSN: 09680160 NLM ISO Abbreviation: Knee Subsets: MEDLINE

MeSH Terms: Chondrocytes*/metabolism , Chondrocytes*/cytology , Mesenchymal Stem Cells*/metabolism , Mesenchymal Stem Cells*/cytology , Chondrogenesis*/physiology , Integrin alpha Chains*/metabolism , Growth Differentiation Factor 2*/metabolism, Humans ; Cell Differentiation ; Immunohistochemistry ; Biomarkers/metabolism ; Cartilage, Articular/metabolism ; Cartilage, Articular/cytology ; Cells, Cultured ; Bone Marrow Cells/metabolism ; Bone Marrow Cells/cytology

Id2 transcriptional repressor promotes retinal Müller glial cell fate choice by increasing Notch activity.

Authors: Fujieda K Sumihiro H Saito R et al.

Source: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2025 Jul 22; Vol. 771, pp. 151966. Date of Electronic Publication: 2025 May 07.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

MeSH Terms: Inhibitor of Differentiation Protein 2*/metabolism , Inhibitor of Differentiation Protein 2*/genetics , Ependymoglial Cells*/cytology , Ependymoglial Cells*/metabolism , Receptors, Notch*/metabolism , Retina*/cytology , Retina*/metabolism, Animals ; Mice ; Mice, Transgenic ; Cell Differentiation ; Inhibitor of Differentiation Proteins/metabolism ; Inhibitor of Differentiation Proteins/genetics

Characterization of growth differentiation factor 15 (GDF15) as a neurotropic adipokine permeable to the brain.

Authors: Schmid A Wilfurth E Höpfinger A et al.

Source: Scientific reports [Sci Rep] 2025 Aug 17; Vol. 15 (1), pp. 30138. Date of Electronic Publication: 2025 Aug 17.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Growth Differentiation Factor 15*/cerebrospinal fluid , Growth Differentiation Factor 15*/metabolism , Growth Differentiation Factor 15*/blood , Growth Differentiation Factor 15*/genetics , Brain*/metabolism , Adipokines*/metabolism , Adipokines*/cerebrospinal fluid, Humans ; Animals ; Mice ; Male ; Female ; Middle Aged ; 3T3-L1 Cells ; Diabetes Mellitus, Type 2/cerebrospinal fluid ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/metabolism ; Aged ; Adipocytes/metabolism ; Adult ; Cell Differentiation ; Overweight/cerebrospinal fluid ; Overweight/blood ; Overweight/metabolism ; Blood-Brain Barrier/metabolism

Bone, dentin and cementum differentially influence the differentiation of osteoclast-like cells.

Authors: Both A Ibrahim G Marciniak J et al.

Source: Scientific reports [Sci Rep] 2025 Jun 05; Vol. 15 (1), pp. 19857. Date of Electronic Publication: 2025 Jun 05.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Cell Differentiation* , Dentin*/metabolism , Osteoclasts*/cytology , Osteoclasts*/metabolism , Dental Cementum*/metabolism , Dental Cementum*/cytology , Bone and Bones*/metabolism , Bone and Bones*/cytology, Animals ; Mice ; Macrophages/metabolism ; Macrophages/cytology ; RANK Ligand/pharmacology ; Growth Differentiation Factor 15/genetics ; Growth Differentiation Factor 15/metabolism ; Macrophage Colony-Stimulating Factor/pharmacology ; HSP70 Heat-Shock Proteins/genetics ; HSP70 Heat-Shock Proteins/metabolism ; Insulin-Like Growth Factor I/metabolism ; Insulin-Like Growth Factor I/genetics

Protocol for investigating the impact of transcription regulator deficiency on tumor-specific CD8 ⁺ T cell responses via adoptive cell transfer.

Authors: Xu L Wang Y Ran M et al.

Source: STAR protocols [STAR Protoc] 2025 Jun 20; Vol. 6 (2), pp. 103703. Date of Electronic Publication: 2025 Mar 25.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101769501 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-1667 (Electronic) Linking ISSN: 26661667 NLM ISO Abbreviation: STAR Protoc Subsets: MEDLINE

MeSH Terms: CD8-Positive T-Lymphocytes*/immunology , CD8-Positive T-Lymphocytes*/metabolism , Adoptive Transfer*/methods , Inhibitor of Differentiation Proteins*/genetics , Inhibitor of Differentiation Proteins*/deficiency , Neoplasms*/immunology, Animals ; Mice ; Mice, Knockout ; Cell Differentiation

Differentiation of Cytotoxic CD8 ⁺ T Cell Subsets Under Tumor Progression: Can CD69 Be a New Therapeutic Target?

Authors: Koyama-Nasu R Wang Y Miyano H et al.

Source: Cancer science [Cancer Sci] 2025 Jun; Vol. 116 (6), pp. 1500-1507. Date of Electronic Publication: 2025 Mar 25.

Publication Type: Journal Article; Review

Journal Info: Publisher: Wiley Publishing on behalf of the Japanese Cancer Association Country of Publication: England NLM ID: 101168776 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1349-7006 (Electronic) Linking ISSN: 13479032 NLM ISO Abbreviation: Cancer Sci Subsets: MEDLINE

MeSH Terms: Antigens, Differentiation, T-Lymphocyte*/metabolism , Antigens, Differentiation, T-Lymphocyte*/immunology , Antigens, CD*/immunology , Antigens, CD*/metabolism , Neoplasms*/immunology , Neoplasms*/pathology , Lectins, C-Type*/metabolism , Lectins, C-Type*/immunology , Lectins, C-Type*/antagonists & inhibitors , CD8-Positive T-Lymphocytes*/immunology , T-Lymphocytes, Cytotoxic*/immunology, Humans ; Animals ; Tumor Microenvironment/immunology ; Cell Differentiation/immunology ; Disease Progression ; Hepatitis A Virus Cellular Receptor 2/metabolism

Human IL-6-Producing B Cells Promote the Differentiation of Monocytes Toward an Anti-Inflammatory CD16⁺CD163⁺CD206⁺PD-L1⁺ Phenotype in Tuberculosis.

Authors: Bénard A Balboa L Caouaille M et al.

Source: European journal of immunology [Eur J Immunol] 2025 Apr; Vol. 55 (4), pp. e202451509.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 1273201 Publication Model: Print Cited Medium: Internet ISSN: 1521-4141 (Electronic) Linking ISSN: 00142980 NLM ISO Abbreviation: Eur J Immunol Subsets: MEDLINE

MeSH Terms: Monocytes*/immunology , Monocytes*/cytology , Cell Differentiation*/immunology , Interleukin-6*/immunology , Interleukin-6*/biosynthesis , Interleukin-6*/metabolism , B-Lymphocytes*/immunology , B-Lymphocytes*/metabolism , Tuberculosis*/immunology, Humans ; Receptors, IgG/immunology ; Receptors, IgG/metabolism ; STAT3 Transcription Factor/metabolism ; STAT3 Transcription Factor/immunology ; CD163 Antigen ; Antigens, CD/immunology ; Antigens, CD/metabolism ; B7-H1 Antigen/immunology ; B7-H1 Antigen/metabolism ; Receptors, Cell Surface/immunology ; Receptors, Cell Surface/metabolism ; Antigens, Differentiation, Myelomonocytic/immunology ; Antigens, Differentiation, Myelomonocytic/metabolism ; Interferon-gamma/immunology ; Interferon-gamma/metabolism ; Signal Transduction/immunology ; Phenotype ; Cells, Cultured ; GPI-Linked Proteins

The Critical Role of Inhibitor of Differentiation 4 in Breast Cancer: From Mammary Gland Development to Tumor Progression.

Authors: Song Y Zhang P Bhushan S et al.

Source: Cancer medicine [Cancer Med] 2025 Apr; Vol. 14 (7), pp. e70856.

Publication Type: Journal Article; Review

Journal Info: Publisher: John Wiley & Sons Ltd Country of Publication: United States NLM ID: 101595310 Publication Model: Print Cited Medium: Internet ISSN: 2045-7634 (Electronic) Linking ISSN: 20457634 NLM ISO Abbreviation: Cancer Med Subsets: MEDLINE

MeSH Terms: Breast Neoplasms*/pathology , Breast Neoplasms*/metabolism , Breast Neoplasms*/genetics , Inhibitor of Differentiation Proteins*/metabolism , Inhibitor of Differentiation Proteins*/genetics , Mammary Glands, Human*/growth & development , Mammary Glands, Human*/metabolism , Mammary Glands, Human*/pathology, Humans ; Female ; Disease Progression ; Animals ; Cell Differentiation ; Gene Expression Regulation, Neoplastic ; Carcinogenesis/genetics ; Biomarkers, Tumor/metabolism

[ Tougu Xiaotong Capsule promotes repair of osteoarthritis cartilage damage in mice by activating the CXCL12/GDF5 pathway].

Authors: Fu C Xu L Chen R et al.

Source: Nan fang yi ke da xue xue bao = Journal of Southern Medical University [Nan Fang Yi Ke Da Xue Xue Bao] 2025 Jun 20; Vol. 45 (6), pp. 1122-1130.

Publication Type: English Abstract; Journal Article

Journal Info: Publisher: Nanfang yi ke da xue xue bao bian ji bu Country of Publication: China NLM ID: 101266132 Publication Model: Print Cited Medium: Print ISSN: 1673-4254 (Print) Linking ISSN: 16734254 NLM ISO Abbreviation: Nan Fang Yi Ke Da Xue Xue Bao Subsets: MEDLINE

MeSH Terms: Drugs, Chinese Herbal*/pharmacology , Drugs, Chinese Herbal*/therapeutic use , Osteoarthritis*/drug therapy , Osteoarthritis*/metabolism , Growth Differentiation Factor 5*/metabolism , Chemokine CXCL12*/metabolism, Animals ; Male ; Mice, Inbred C57BL ; Mice ; Signal Transduction/drug effects ; Cell Differentiation/drug effects ; Cartilage, Articular/drug effects ; Mesenchymal Stem Cells/cytology

CD73 promotes the maturation of murine NK cells and their survival in the tumor microenvironment.

Authors: Parra-Tello B García-Gómez M Rekus-Polanska E et al.

Source: Journal of leukocyte biology [J Leukoc Biol] 2025 May 07; Vol. 117 (5).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 8405628 Publication Model: Print Cited Medium: Internet ISSN: 1938-3673 (Electronic) Linking ISSN: 07415400 NLM ISO Abbreviation: J Leukoc Biol Subsets: MEDLINE

MeSH Terms: Killer Cells, Natural*/immunology , Killer Cells, Natural*/pathology , Killer Cells, Natural*/metabolism , 5'-Nucleotidase*/genetics , 5'-Nucleotidase*/metabolism , 5'-Nucleotidase*/immunology , Tumor Microenvironment*/immunology , Cell Differentiation*, Animals ; Mice ; Humans ; Mice, Knockout ; GPI-Linked Proteins ; Cell Survival ; Mice, Inbred C57BL ; Cell Line, Tumor ; T Lineage-Specific Activation Antigen 1 ; Cell Proliferation ; Receptors, Purinergic P2X7/metabolism ; Antigens, Differentiation, T-Lymphocyte/metabolism ; Melanoma/immunology ; Melanoma/pathology

Comprehensive analysis of GDFs as therapeutic targets and prognosis biomarkers in gastric cancer.

Authors: Zhu M Hong J Liu X et al.

Source: Medicine [Medicine (Baltimore)] 2025 Mar 28; Vol. 104 (13), pp. e41976.

Publication Type: Journal Article

Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE

MeSH Terms: Stomach Neoplasms*/genetics , Stomach Neoplasms*/mortality , Stomach Neoplasms*/metabolism , Stomach Neoplasms*/therapy , Biomarkers, Tumor*/genetics , Biomarkers, Tumor*/metabolism , Growth Differentiation Factors*/genetics , Growth Differentiation Factors*/metabolism, Humans ; Prognosis ; Gene Expression Profiling ; Growth Differentiation Factor 15 ; Gene Expression Regulation, Neoplastic

FOXL2 drives the differentiation of supporting gonadal cells in early ovarian development.

Authors: Danti L Lundin K Nedeczey-Ruzsák P et al.

Source: Reproductive biology and endocrinology : RB&E [Reprod Biol Endocrinol] 2025 Mar 18; Vol. 23 (1), pp. 44. Date of Electronic Publication: 2025 Mar 18.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101153627 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-7827 (Electronic) Linking ISSN: 14777827 NLM ISO Abbreviation: Reprod Biol Endocrinol Subsets: MEDLINE

MeSH Terms: Forkhead Box Protein L2*/genetics , Forkhead Box Protein L2*/metabolism , Forkhead Box Protein L2*/physiology , Ovary*/metabolism , Ovary*/growth & development , Ovary*/cytology , Ovary*/embryology , Cell Differentiation*/genetics , Cell Differentiation*/physiology, Female ; Humans ; Male ; Gene Expression Regulation, Developmental ; Sex Differentiation

In vitro ovarian tumor-conditioned CD163+ human macrophages retain phagocytic response to CD47 blockade.

Authors: Antonsen KW Jensen AG Sorensen BS et al.

Source: Cellular immunology [Cell Immunol] 2025 Mar-Apr; Vol. 409-410, pp. 104932. Date of Electronic Publication: 2025 Feb 17.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 1246405 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2163 (Electronic) Linking ISSN: 00088749 NLM ISO Abbreviation: Cell Immunol Subsets: MEDLINE

MeSH Terms: Ovarian Neoplasms*/immunology , Ovarian Neoplasms*/metabolism , Ovarian Neoplasms*/pathology , Phagocytosis*/immunology , Receptors, Cell Surface*/metabolism , Receptors, Cell Surface*/immunology , CD47 Antigen*/immunology , CD47 Antigen*/antagonists & inhibitors , CD47 Antigen*/metabolism , Antigens, CD*/metabolism , Antigens, CD*/immunology , Antigens, Differentiation, Myelomonocytic*/metabolism , Antigens, Differentiation, Myelomonocytic*/immunology , Macrophages*/immunology , Macrophages*/metabolism , Tumor-Associated Macrophages*/immunology , Tumor-Associated Macrophages*/metabolism, Humans ; Female ; CD163 Antigen ; Cell Line, Tumor ; Receptors, Immunologic/metabolism ; Culture Media, Conditioned/pharmacology ; Immunotherapy/methods ; Cell Differentiation

MyD88 determines T cell fate through BCAP-PI3K signaling.

Authors: Bayer AL Magri Z Muendlein H et al.

Source: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2025 Mar 01; Vol. 214 (3), pp. 433-445.

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 2985117R Publication Model: Print Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE

MeSH Terms: Myeloid Differentiation Factor 88*/genetics , Myeloid Differentiation Factor 88*/metabolism , Myeloid Differentiation Factor 88*/immunology , Signal Transduction*/immunology , Phosphatidylinositol 3-Kinases*/metabolism , Phosphatidylinositol 3-Kinases*/immunology , T-Lymphocytes*/immunology, Animals ; Mice ; Lymphocyte Activation/immunology ; Mice, Knockout ; Receptors, Antigen, T-Cell/metabolism ; Receptors, Antigen, T-Cell/immunology ; Mice, Inbred C57BL ; Apoptosis/immunology ; Cell Differentiation/immunology ; Cell Survival/immunology ; Proto-Oncogene Proteins c-akt/metabolism ; Adaptor Proteins, Signal Transducing

S100A8/A9 drives monocytes towards M2-like macrophage differentiation and associates with M2-like macrophages in osteoarthritic synovium.

Authors: van Kooten NJT Blom AB Teunissen van Manen IJ et al.

Source: Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2025 Jan 01; Vol. 64 (1), pp. 332-343.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 100883501 Publication Model: Print Cited Medium: Internet ISSN: 1462-0332 (Electronic) Linking ISSN: 14620324 NLM ISO Abbreviation: Rheumatology (Oxford) Subsets: MEDLINE

MeSH Terms: Calgranulin A*/metabolism , Calgranulin B*/metabolism , Cell Differentiation* , Macrophages*/metabolism , Monocytes*/metabolism , Synovial Membrane*/metabolism , Synovial Membrane*/cytology , Synovial Membrane*/pathology, Aged ; Female ; Humans ; Male ; Middle Aged ; Antigens, CD/metabolism ; Antigens, Differentiation, Myelomonocytic/metabolism ; Flow Cytometry ; Lectins, C-Type/metabolism ; Mannose Receptor ; Mannose-Binding Lectins/metabolism ; Osteoarthritis/metabolism ; Osteoarthritis/pathology ; Phagocytosis ; Phenotype ; Receptors, Cell Surface/metabolism ; CD163 Antigen

Disrupting Amh and androgen signaling reveals their distinct roles in zebrafish gonadal differentiation and gametogenesis.

Authors: Wu K Yue Y Zhou L et al.

Source: Communications biology [Commun Biol] 2025 Mar 05; Vol. 8 (1), pp. 371. Date of Electronic Publication: 2025 Mar 05.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE

MeSH Terms: Zebrafish*/genetics , Zebrafish*/metabolism , Anti-Mullerian Hormone*/metabolism , Anti-Mullerian Hormone*/genetics , Signal Transduction* , Zebrafish Proteins*/genetics , Zebrafish Proteins*/metabolism , Androgens*/metabolism , Gametogenesis* , Sex Differentiation* , Gonads*/metabolism , Gonads*/growth & development, Animals ; Male ; Female ; Receptors, Androgen/metabolism ; Receptors, Androgen/genetics ; Aromatase/genetics ; Aromatase/metabolism ; Cell Differentiation ; Spermatogenesis

GATA4 binding to the Sox9 enhancer mXYSRa/Enh13 is critical for testis differentiation in mouse.

Authors: Ogawa Y Tsuchiya I Yanai S et al.

Source: Communications biology [Commun Biol] 2025 Jan 18; Vol. 8 (1), pp. 81. Date of Electronic Publication: 2025 Jan 18.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE

MeSH Terms: GATA4 Transcription Factor*/metabolism , GATA4 Transcription Factor*/genetics , SOX9 Transcription Factor*/genetics , SOX9 Transcription Factor*/metabolism , Testis*/metabolism , Testis*/growth & development , Testis*/cytology , Enhancer Elements, Genetic* , Sex Differentiation*/genetics, Animals ; Male ; Mice ; Female ; Cell Differentiation ; Gene Expression Regulation, Developmental ; Binding Sites ; Protein Binding