Suchergebnisse - "dicarboxylic acids"

Odd-Chain Dicarboxylic Acid Feeding Produces a Glutaric Aciduria Type 1-Like Metabolic Signature in Mice.

Autoren: Richert AC Zhang Y Bharathi SS et al.

Quelle: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2025 Nov 15; Vol. 39 (21), pp. e71215.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

MeSH-Schlagworte: Amino Acid Metabolism, Inborn Errors*/metabolism , Amino Acid Metabolism, Inborn Errors*/pathology , Glutaryl-CoA Dehydrogenase*/deficiency , Glutaryl-CoA Dehydrogenase*/metabolism , Dicarboxylic Acids*/metabolism , Dicarboxylic Acids*/administration & dosage , Brain Diseases, Metabolic*/metabolism , Brain Diseases, Metabolic*/chemically induced , Brain Diseases, Metabolic*/pathology, Animals ; Mice ; Glutarates/metabolism ; Mitochondria/metabolism ; Peroxisomes/metabolism ; Male ; Mice, Inbred C57BL

SCR Disease Name: Glutaric Acidemia I

The Effect of Exogenously Applied Dicarboxylic Acids (Photon) on the Maize (Zea mays) Metabolite Profile.

Autoren: Msomi M Nogemane N More G et al.

Quelle: Chemistry & biodiversity [Chem Biodivers] 2025 Nov; Vol. 22 (11), pp. e01243. Date of Electronic Publication: 2025 Jul 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE

MeSH-Schlagworte: Zea mays*/metabolism , Zea mays*/drug effects , Zea mays*/chemistry , Dicarboxylic Acids*/pharmacology , Dicarboxylic Acids*/chemistry , Dicarboxylic Acids*/metabolism , Photons* , Metabolome*/drug effects, Plant Leaves/metabolism ; Plant Leaves/drug effects

The enedioic acid analog 326E alleviates metabolic dysfunction-associated steatohepatitis via dual targeting at ACLY and PPARα.

Autoren: Xie Z Cheng L Hu Y et al.

Quelle: Cell metabolism [Cell Metab] 2025 Nov 04; Vol. 37 (11), pp. 2149-2166.e9. Date of Electronic Publication: 2025 Oct 22.

Publikationsart: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 101233170 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-7420 (Electronic) Linking ISSN: 15504131 NLM ISO Abbreviation: Cell Metab Subsets: MEDLINE

MeSH-Schlagworte: ATP Citrate (pro-S)-Lyase*/antagonists & inhibitors , ATP Citrate (pro-S)-Lyase*/metabolism , Dicarboxylic Acids*/pharmacology , Dicarboxylic Acids*/therapeutic use , Fatty Liver*/drug therapy , Fatty Liver*/metabolism , PPAR alpha*/metabolism, Animals ; Humans ; Male ; Mice ; Disease Models, Animal ; Lipid Metabolism/drug effects ; Lipogenesis/drug effects ; Liver/metabolism ; Liver/drug effects ; Macaca fascicularis ; Mice, Inbred C57BL

Biodegradation of Benzene-Dicarboxylic Acid Ester Isomers by a Thermally Activated Esterase from Desulfurellaceae Bacterium.

Autoren: Yang L Tang Y Chen Y et al.

Quelle: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2025 Nov 03; Vol. 31 (61), pp. e01905. Date of Electronic Publication: 2025 Oct 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9513783 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3765 (Electronic) Linking ISSN: 09476539 NLM ISO Abbreviation: Chemistry Subsets: MEDLINE

MeSH-Schlagworte: Esterases*/metabolism , Esterases*/chemistry , Phthalic Acids*/chemistry , Phthalic Acids*/metabolism , Esters*/chemistry , Esters*/metabolism , Dicarboxylic Acids*/chemistry , Dicarboxylic Acids*/metabolism , Benzene*/chemistry , Benzene*/metabolism, Biodegradation, Environmental ; Hydrolysis ; Temperature ; Isomerism

RB-TnSeq elucidates dicarboxylic-acid-specific catabolism in β-proteobacteria for improved plastic monomer upcycling.

Autoren: Pearson AN Lynch JM Ho CN et al.

Quelle: Applied and environmental microbiology [Appl Environ Microbiol] 2025 Oct 22; Vol. 91 (10), pp. e0092425. Date of Electronic Publication: 2025 Sep 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 7605801 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5336 (Electronic) Linking ISSN: 00992240 NLM ISO Abbreviation: Appl Environ Microbiol Subsets: MEDLINE

MeSH-Schlagworte: Dicarboxylic Acids*/metabolism , Plastics*/metabolism , Betaproteobacteria*/metabolism , Betaproteobacteria*/genetics, Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Fatty Acids/metabolism ; DNA Transposable Elements

Toward Developing an Antimelanoma Topical Gel from Coordination Polymers Derived from a Nitrile-Functionalized Terpyridine Ligand and Dicarboxylic Acids.

Autoren: Chanda T Ghosh S Dastidar P

Quelle: ACS applied bio materials [ACS Appl Bio Mater] 2025 Oct 20; Vol. 8 (10), pp. 9424-9438. Date of Electronic Publication: 2025 Oct 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: ACS Publications Country of Publication: United States NLM ID: 101729147 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2576-6422 (Electronic) Linking ISSN: 25766422 NLM ISO Abbreviation: ACS Appl Bio Mater Subsets: MEDLINE

MeSH-Schlagworte: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/administration & dosage , Dicarboxylic Acids*/chemistry , Dicarboxylic Acids*/pharmacology , Polymers*/chemistry , Polymers*/pharmacology , Polymers*/chemical synthesis , Pyridines*/chemistry , Pyridines*/pharmacology , Nitriles*/chemistry , Nitriles*/pharmacology , Biocompatible Materials*/chemistry , Biocompatible Materials*/pharmacology , Biocompatible Materials*/chemical synthesis , Coordination Complexes*/chemistry , Coordination Complexes*/pharmacology , Coordination Complexes*/chemical synthesis, Gels/chemistry ; Gels/pharmacology ; Gels/chemical synthesis ; Humans ; Ligands ; Drug Screening Assays, Antitumor ; Molecular Structure ; Materials Testing ; Cell Proliferation/drug effects ; Particle Size ; Animals ; Mice ; Cell Survival/drug effects ; Cell Line, Tumor ; Administration, Topical ; Melanoma/drug therapy

Cadmium(II) complexes with pyridine/dicarboxylic acid ligands as promising molecules for the treatment of oral candidiasis.

Autoren: Jimenez DL da Silva DTK da Paz Costa Sauda T et al.

Quelle: Journal of inorganic biochemistry [J Inorg Biochem] 2025 Oct; Vol. 271, pp. 112980. Date of Electronic Publication: 2025 Jun 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 7905788 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3344 (Electronic) Linking ISSN: 01620134 NLM ISO Abbreviation: J Inorg Biochem Subsets: MEDLINE

MeSH-Schlagworte: Cadmium*/chemistry , Antifungal Agents*/pharmacology , Antifungal Agents*/chemistry , Antifungal Agents*/chemical synthesis , Pyridines*/chemistry , Pyridines*/pharmacology , Coordination Complexes*/pharmacology , Coordination Complexes*/chemistry , Coordination Complexes*/chemical synthesis , Candidiasis, Oral*/drug therapy , Dicarboxylic Acids*/chemistry , Dicarboxylic Acids*/pharmacology, Biofilms/drug effects ; Microbial Sensitivity Tests ; Humans ; Candida albicans/drug effects ; Candida/drug effects ; Ligands ; Hemolysis/drug effects

[Efficacy and safety of bempedoic acid in the prevention of cardiovascular events: results of the CLEAR Outcomes study and subgroup analyses].

Transliterierter Titel: Efficacia e sicurezza clinica dell’acido bempedoico nella prevenzione degli eventi cardiovascolari: risultati dello studio CLEAR Outcomes e approfondimenti dalle sottoanalisi.

Autoren: Colivicchi F Arca M Di Fusco SA et al.

Quelle: Giornale italiano di cardiologia (2006) [G Ital Cardiol (Rome)] 2025 Oct; Vol. 26 (10), pp. 747-756.

Publikationsart: English Abstract; Journal Article

Info zur Zeitschrift: Publisher: Il Pensiero Scientifico Editore Country of Publication: Italy NLM ID: 101263411 Publication Model: Print Cited Medium: Internet ISSN: 1972-6481 (Electronic) Linking ISSN: 18276806 NLM ISO Abbreviation: G Ital Cardiol (Rome) Subsets: MEDLINE

MeSH-Schlagworte: Dicarboxylic Acids*/adverse effects , Dicarboxylic Acids*/therapeutic use , Dicarboxylic Acids*/administration & dosage , Cardiovascular Diseases*/prevention & control , Fatty Acids*/adverse effects , Fatty Acids*/therapeutic use , Fatty Acids*/administration & dosage , Hypolipidemic Agents*/therapeutic use , Hypolipidemic Agents*/adverse effects, Humans ; Cholesterol, LDL/blood ; Treatment Outcome ; Randomized Controlled Trials as Topic ; Male ; Female

Molecular targets of bempedoic acid and related decoy fatty acids.

Autoren: Supplee JG Marmorstein R Wellen KE

Quelle: Trends in endocrinology and metabolism: TEM [Trends Endocrinol Metab] 2025 Oct; Vol. 36 (10), pp. 917-928. Date of Electronic Publication: 2025 May 08.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Science Pub. Co Country of Publication: United States NLM ID: 9001516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3061 (Electronic) Linking ISSN: 10432760 NLM ISO Abbreviation: Trends Endocrinol Metab Subsets: MEDLINE

MeSH-Schlagworte: Dicarboxylic Acids*/pharmacology , Dicarboxylic Acids*/therapeutic use , Fatty Acids*/metabolism , Fatty Acids*/pharmacology, Humans ; Animals ; Lipid Metabolism/drug effects ; ATP Citrate (pro-S)-Lyase/metabolism ; ATP Citrate (pro-S)-Lyase/antagonists & inhibitors

Tailored biocatalysis for dicarboxylic acid production: A versatile enzymatic approach to galactaric and glucaric acids.

Autoren: Vasquez P Diaz A Marquez-Cortes R et al.

Quelle: Bioresource technology [Bioresour Technol] 2025 Dec; Vol. 438, pp. 133221. Date of Electronic Publication: 2025 Aug 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Applied Science Country of Publication: England NLM ID: 9889523 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2976 (Electronic) Linking ISSN: 09608524 NLM ISO Abbreviation: Bioresour Technol Subsets: MEDLINE

MeSH-Schlagworte: Aspergillus niger*/enzymology , Biocatalysis* , Dicarboxylic Acids*/metabolism , Glucose Oxidase*/metabolism , Glucaric Acid*/metabolism , Sugar Acids*/metabolism, Substrate Specificity ; Oxidation-Reduction ; Protein Engineering ; Glucose/metabolism

Metabolomics Reveals Glyoxylate and Dicarboxylate Metabolism Disorder in Elderly Trauma: A Retrospective Study.

Autoren: Huang C Gou Y Cong Y et al.

Quelle: Clinical interventions in aging [Clin Interv Aging] 2025 Nov 15; Vol. 20, pp. 2049-2064. Date of Electronic Publication: 2025 Nov 15 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Dove Medical Press Country of Publication: New Zealand NLM ID: 101273480 Publication Model: eCollection Cited Medium: Internet ISSN: 1178-1998 (Electronic) Linking ISSN: 11769092 NLM ISO Abbreviation: Clin Interv Aging Subsets: MEDLINE

MeSH-Schlagworte: Metabolomics* , Glyoxylates*/metabolism , Wounds and Injuries*/metabolism , Dicarboxylic Acids*/metabolism , Aging*/metabolism, Humans ; Retrospective Studies ; Aged ; Middle Aged ; Male ; Female ; Aged, 80 and over ; Adult ; Metabolic Networks and Pathways ; Pantothenic Acid

Sebacic acid promotes osteoblast differentiation.

Autoren: Rojasawasthien T Ito T Okamoto H et al.

Quelle: Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2025 Oct 24; Vol. 89 (11), pp. 1572-1578.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 9205717 Publication Model: Print Cited Medium: Internet ISSN: 1347-6947 (Electronic) Linking ISSN: 09168451 NLM ISO Abbreviation: Biosci Biotechnol Biochem Subsets: MEDLINE

MeSH-Schlagworte: Osteoblasts*/cytology , Osteoblasts*/drug effects , Osteoblasts*/metabolism , Cell Differentiation*/drug effects , Dicarboxylic Acids*/pharmacology , Decanoic Acids*/pharmacology, Animals ; Mice ; Alkaline Phosphatase/metabolism ; Fatty Acids, Monounsaturated/pharmacology ; Fatty Acids, Monounsaturated/metabolism ; Cell Line ; Osteogenesis/drug effects

Scaling-up the Bioconversion of Lignin to 2,4-Pyridinedicarboxylic Acid With Engineered Pseudomonas putida for Bio-Based Plastics Production.

Autoren: Seeger J Müller S Gómez-Álvarez H et al.

Quelle: Biotechnology and bioengineering [Biotechnol Bioeng] 2025 Oct; Vol. 122 (10), pp. 2770-2780. Date of Electronic Publication: 2025 Jul 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley Country of Publication: United States NLM ID: 7502021 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0290 (Electronic) Linking ISSN: 00063592 NLM ISO Abbreviation: Biotechnol Bioeng Subsets: MEDLINE

MeSH-Schlagworte: Lignin*/metabolism , Pseudomonas putida*/metabolism , Pseudomonas putida*/genetics , Metabolic Engineering*/methods , Plastics*/metabolism , Pyridines*/metabolism , Dicarboxylic Acids*/metabolism, Rhodococcus/metabolism ; Rhodococcus/genetics

Catalyst-Free and Green Crosslinking of Epoxy-Functionalized EPDM With Dicarboxylic Acids: Insights into Curing Mechanism, Recyclability and Thermal Stability.

Autoren: Tian C Zhang G Liu J et al.

Quelle: Macromolecular rapid communications [Macromol Rapid Commun] 2025 Oct; Vol. 46 (20), pp. e00502. Date of Electronic Publication: 2025 Jul 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9888239 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3927 (Electronic) Linking ISSN: 10221336 NLM ISO Abbreviation: Macromol Rapid Commun Subsets: MEDLINE

MeSH-Schlagworte: Dicarboxylic Acids*/chemistry , Epoxy Compounds*/chemistry , Cross-Linking Reagents*/chemistry, Catalysis ; Temperature ; Molecular Structure ; Polymerization ; Green Chemistry Technology

Unlocking chain length elongation to expand the long-chain dicarboxylic acid repertoire in Starmerella bombicola.

Autoren: Lee J De Sitter K Cornet I et al.

Quelle: Bioresource technology [Bioresour Technol] 2026 Jan; Vol. 440, pp. 133524. Date of Electronic Publication: 2025 Oct 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Applied Science Country of Publication: England NLM ID: 9889523 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2976 (Electronic) Linking ISSN: 09608524 NLM ISO Abbreviation: Bioresour Technol Subsets: MEDLINE

MeSH-Schlagworte: Dicarboxylic Acids*/metabolism , Dicarboxylic Acids*/chemistry , Metabolic Engineering*/methods, Fatty Acids/metabolism ; Rapeseed Oil

Circadian rhythm disturbance impairs intestinal mucus barrier and immune microenvironment via sebacic acid-mediated gut dysbiosis.

Autoren: Cheng L Wang X Wang Q et al.

Quelle: Microbiological research [Microbiol Res] 2026 Feb; Vol. 303, pp. 128375. Date of Electronic Publication: 2025 Oct 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: G. Fischer Country of Publication: Germany NLM ID: 9437794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-0623 (Electronic) Linking ISSN: 09445013 NLM ISO Abbreviation: Microbiol Res Subsets: MEDLINE

MeSH-Schlagworte: Dysbiosis*/microbiology , Dysbiosis*/immunology , Dysbiosis*/metabolism , Gastrointestinal Microbiome*/drug effects , Circadian Rhythm*/physiology , Intestinal Mucosa*/metabolism , Intestinal Mucosa*/microbiology , Intestinal Mucosa*/immunology , Decanoic Acids*/metabolism , Chronobiology Disorders*/microbiology , Dicarboxylic Acids*/metabolism, Humans ; Feces/chemistry ; Feces/microbiology ; Fatty Acids/metabolism ; Male ; Metabolome ; Bacteria/classification ; Bacteria/isolation & purification ; Bacteria/genetics

Phthalates and phthalate alternative in Greenlandic adults: Urinary concentrations and exposure determinants.

Autoren: Long M Wielsøe M Bonefeld-Jørgensen EC

Quelle: International journal of hygiene and environmental health [Int J Hyg Environ Health] 2026 Jan; Vol. 271, pp. 114695. Date of Electronic Publication: 2025 Oct 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Urban & Fischer Country of Publication: Germany NLM ID: 100898843 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-131X (Electronic) Linking ISSN: 14384639 NLM ISO Abbreviation: Int J Hyg Environ Health Subsets: MEDLINE

MeSH-Schlagworte: Phthalic Acids*/urine , Environmental Pollutants*/urine , Environmental Exposure*/analysis , Dicarboxylic Acids*/urine, Humans ; Greenland ; Female ; Male ; Adult ; Middle Aged ; Young Adult ; Aged ; Environmental Monitoring ; Adolescent ; Biological Monitoring ; Cyclohexanecarboxylic Acids

Protective potential of bempedoic acid as an AMPK activator in tamoxifen-induced steatohepatitis in rats.

Autoren: Mosaad M El-Sayed EK El Morsy EM

Quelle: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2025 Sep; Vol. 398 (9), pp. 12661-12672. Date of Electronic Publication: 2025 Apr 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Tamoxifen*/toxicity , AMP-Activated Protein Kinases*/metabolism , Fatty Acids*/pharmacology , Fatty Acids*/therapeutic use , Dicarboxylic Acids*/pharmacology , Dicarboxylic Acids*/therapeutic use , Fatty Liver*/chemically induced , Fatty Liver*/pathology , Fatty Liver*/prevention & control , Fatty Liver*/metabolism , Chemical and Drug Induced Liver Injury*/pathology , Chemical and Drug Induced Liver Injury*/prevention & control, Animals ; Female ; Rats ; Liver/drug effects ; Liver/pathology ; Liver/metabolism ; Rats, Wistar ; Oxidative Stress/drug effects

Retrospective Analysis of Efficacy and Side Effects of Topical 4% Erythromycin Versus 1% Clindamycin Versus 20% Azelaic Acid During Pregnancy.

Autoren: Hasanbeyzade S; Dermatology and Venerology Department, Hitit University, Erol Olçok Training and Research Hospital, Çorum, Türkiye.

Quelle: Journal of cosmetic dermatology [J Cosmet Dermatol] 2025 Sep; Vol. 24 (9), pp. e70410.

Publikationsart: Journal Article; Comparative Study

Info zur Zeitschrift: Publisher: Blackwell Science Country of Publication: England NLM ID: 101130964 Publication Model: Print Cited Medium: Internet ISSN: 1473-2165 (Electronic) Linking ISSN: 14732130 NLM ISO Abbreviation: J Cosmet Dermatol Subsets: MEDLINE

MeSH-Schlagworte: Acne Vulgaris*/drug therapy , Acne Vulgaris*/diagnosis , Clindamycin*/administration & dosage , Clindamycin*/adverse effects , Dicarboxylic Acids*/adverse effects , Dicarboxylic Acids*/administration & dosage , Dermatologic Agents*/adverse effects , Dermatologic Agents*/administration & dosage , Erythromycin*/adverse effects , Erythromycin*/administration & dosage , Anti-Bacterial Agents*/adverse effects , Anti-Bacterial Agents*/administration & dosage , Pregnancy Complications*/drug therapy , Pregnancy Complications*/diagnosis, Humans ; Female ; Retrospective Studies ; Pregnancy ; Adult ; Patient Satisfaction/statistics & numerical data ; Treatment Outcome ; Young Adult ; Administration, Cutaneous

Designing anti-bacterial supramolecular gels from primary ammonium dicarboxylate (PAD) salts for self-delivery applications.

Autoren: Roy N Ghosh S Dutta A et al.

Quelle: Faraday discussions [Faraday Discuss] 2025 Aug 28; Vol. 260 (0), pp. 283-309. Date of Electronic Publication: 2025 Aug 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Faraday Division, Royal Society of Chemistry Country of Publication: England NLM ID: 9212301 Publication Model: Electronic Cited Medium: Internet ISSN: 1364-5498 (Electronic) Linking ISSN: 13596640 NLM ISO Abbreviation: Faraday Discuss Subsets: MEDLINE

MeSH-Schlagworte: Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemical synthesis , Dicarboxylic Acids*/chemistry , Dicarboxylic Acids*/pharmacology , Drug Delivery Systems* , Ammonium Compounds*/chemistry , Drug Design*, Gels/chemistry ; Salts/chemistry ; Escherichia coli/drug effects ; Microbial Sensitivity Tests