Search Results - "complement membrane attack complex"

Complement component C6 deficiency exacerbates colorectal tumorigenesis by abolishing membrane attack complex formation and potentiating M2-like tumor-associated macrophage responses.

Authors: Hao Y Li L Lv X et al.

Source: International immunopharmacology [Int Immunopharmacol] 2025 Dec 03; Vol. 166, pp. 115576. Date of Electronic Publication: 2025 Sep 20.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

MeSH Terms: Colorectal Neoplasms*/immunology , Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/genetics , Complement Membrane Attack Complex*/metabolism , Complement Membrane Attack Complex*/immunology , Complement C6*/genetics , Complement C6*/deficiency , Complement C6*/metabolism , Complement C6*/immunology , Tumor-Associated Macrophages*/immunology, Animals ; Humans ; Mice ; Mice, Inbred C57BL ; Azoxymethane ; Mice, Knockout ; Dextran Sulfate ; Tumor Microenvironment/immunology ; Carcinogenesis/immunology ; Male ; Cytokines/metabolism ; Female ; Disease Models, Animal ; Colitis/immunology ; Colitis/chemically induced

CD59, Disulphide-Locked Human C9 and Horse C9 Inhibit Human Membrane Attack Complex Assembly by Similar Mechanisms.

Authors: Cooke RS Spicer BA Harrison RA et al.

Source: Immunology [Immunology] 2025 Nov; Vol. 176 (3), pp. 363-372. Date of Electronic Publication: 2025 Jun 16.

Publication Type: Journal Article

Journal Info: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 0374672 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2567 (Electronic) Linking ISSN: 00192805 NLM ISO Abbreviation: Immunology Subsets: MEDLINE

MeSH Terms: CD59 Antigens*/immunology , CD59 Antigens*/metabolism , Complement Membrane Attack Complex*/metabolism , Complement Membrane Attack Complex*/immunology , Complement C9*/immunology , Complement C9*/metabolism , Complement C9*/chemistry , Disulfides*/chemistry , Disulfides*/metabolism, Humans ; Animals ; Horses ; Hemolysis/immunology ; Protein Binding

Complement activation assessed by C3bc and C5b-9 terminal complex as diagnostic biomarkers for deep vein thrombosis.

Authors: Wikan VE Øverli Ø Ueland T et al.

Source: PloS one [PLoS One] 2025 Oct 06; Vol. 20 (10), pp. e0333206. Date of Electronic Publication: 2025 Oct 06 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

MeSH Terms: Venous Thrombosis*/diagnosis , Venous Thrombosis*/blood , Complement Membrane Attack Complex*/metabolism , Complement Membrane Attack Complex*/analysis , Complement Activation* , Complement C3b*/metabolism, Humans ; Male ; Female ; Middle Aged ; Biomarkers/blood ; Cross-Sectional Studies ; Fibrin Fibrinogen Degradation Products/metabolism ; Aged ; Adult ; C-Reactive Protein/metabolism ; ROC Curve

Targeting the alternative complement pathway by iptacopan abrogates C3 and strongly reduces C5b-9 deposition within glomeruli in IgA nephropathy recurrence after kidney transplantation.

Authors: Sanna E Nicassio SR Mella A et al.

Source: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2025 Dec; Vol. 25 (12), pp. 2651-2657. Date of Electronic Publication: 2025 Aug 23.

Publication Type: Case Reports; Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 100968638 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-6143 (Electronic) Linking ISSN: 16006135 NLM ISO Abbreviation: Am J Transplant Subsets: MEDLINE

MeSH Terms: Glomerulonephritis, IGA*/drug therapy , Glomerulonephritis, IGA*/metabolism , Glomerulonephritis, IGA*/pathology , Glomerulonephritis, IGA*/surgery , Kidney Transplantation*/adverse effects , Complement C3*/metabolism , Complement Pathway, Alternative*/drug effects , Complement Membrane Attack Complex*/metabolism , Kidney Glomerulus*/metabolism , Kidney Glomerulus*/pathology , Kidney Glomerulus*/drug effects , Graft Rejection*/etiology , Graft Rejection*/drug therapy, Humans ; Male ; Female ; Adult ; Recurrence ; Middle Aged ; Prognosis ; Follow-Up Studies ; Glomerular Filtration Rate ; Graft Survival/drug effects ; Kidney Function Tests ; Benzoates ; Indoles ; Piperidines

Exploring the Value of sC5b-9 in the Diagnosis of Haematopoietic Stem Cell Transplant-Associated Thrombotic Microangiopathy in Children.

Authors: Luo L Xiong H Chen Z et al.

Source: Journal of cellular and molecular medicine [J Cell Mol Med] 2025 Oct; Vol. 29 (20), pp. e70906.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101083777 Publication Model: Print Cited Medium: Internet ISSN: 1582-4934 (Electronic) Linking ISSN: 15821838 NLM ISO Abbreviation: J Cell Mol Med Subsets: MEDLINE

MeSH Terms: Thrombotic Microangiopathies*/diagnosis , Thrombotic Microangiopathies*/etiology , Thrombotic Microangiopathies*/blood , Hematopoietic Stem Cell Transplantation*/adverse effects , Complement Membrane Attack Complex*/metabolism, Humans ; Male ; Female ; Child ; Child, Preschool ; Retrospective Studies ; Adolescent ; Infant ; Biomarkers/blood ; Transplantation, Homologous

Inhibition of terminal complement complex formation alleviates murine antibody-mediated TRALI.

Authors: Chen D Liang H Xu X et al.

Source: Blood [Blood] 2025 Aug 07; Vol. 146 (6), pp. 759-764.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE

MeSH Terms: Complement Membrane Attack Complex*/immunology , Complement Membrane Attack Complex*/antagonists & inhibitors , Complement Membrane Attack Complex*/metabolism , Transfusion-Related Acute Lung Injury*/immunology , Transfusion-Related Acute Lung Injury*/prevention & control , Transfusion-Related Acute Lung Injury*/pathology , Complement C5*/immunology , Complement C5*/genetics, Animals ; Mice ; Mice, Knockout ; Mice, Inbred C57BL ; Complement Activation ; Antibodies, Monoclonal/pharmacology ; Male ; Receptor, Anaphylatoxin C5a/genetics

Terminal complement complexes with or without C9 potentiate antimicrobial activity against Neisseria gonorrhoeae .

Authors: Lamb ER Criss AK

Source: MBio [mBio] 2025 May 14; Vol. 16 (5), pp. e0014125. Date of Electronic Publication: 2025 Mar 31.

Publication Type: Journal Article

Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE

MeSH Terms: Neisseria gonorrhoeae*/drug effects , Neisseria gonorrhoeae*/immunology , Anti-Bacterial Agents*/pharmacology , Complement Membrane Attack Complex*/immunology , Complement Membrane Attack Complex*/metabolism , Complement C9*/immunology , Complement C9*/metabolism, Humans ; Microbial Sensitivity Tests ; Gonorrhea/immunology ; Gonorrhea/microbiology ; Azithromycin/pharmacology ; Complement Activation

The membrane attack complex drives thrombotic microangiopathy in complement mediated atypical hemolytic uremic syndrome.

Authors: Smith-Jackson K Walsh P Zelek WM et al.

Source: Kidney international [Kidney Int] 2025 Apr; Vol. 107 (4), pp. 700-713. Date of Electronic Publication: 2025 Jan 21.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0323470 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1755 (Electronic) Linking ISSN: 00852538 NLM ISO Abbreviation: Kidney Int Subsets: MEDLINE

MeSH Terms: Atypical Hemolytic Uremic Syndrome*/immunology , Atypical Hemolytic Uremic Syndrome*/genetics , Atypical Hemolytic Uremic Syndrome*/pathology , Atypical Hemolytic Uremic Syndrome*/drug therapy , Complement Membrane Attack Complex*/metabolism , Complement Membrane Attack Complex*/immunology , Thrombotic Microangiopathies*/immunology , Thrombotic Microangiopathies*/genetics , Thrombotic Microangiopathies*/pathology , Thrombotic Microangiopathies*/prevention & control , Kidney*/pathology , Kidney*/immunology , Kidney*/drug effects, Animals ; Receptor, Anaphylatoxin C5a/genetics ; Receptor, Anaphylatoxin C5a/antagonists & inhibitors ; Receptor, Anaphylatoxin C5a/deficiency ; Receptor, Anaphylatoxin C5a/metabolism ; Disease Models, Animal ; Mice ; Complement C3/genetics ; Complement C3/immunology ; Mice, Knockout ; Humans ; Complement C5a/metabolism ; Complement C5a/immunology ; Mice, Inbred C57BL ; Male ; Complement Inactivating Agents/pharmacology ; Complement Activation

Validation for soluble C5b-9 detection and comparative analysis of three quantification methods.

Authors: Profaizer T Saadalla A Nandakumar V

Source: Journal of immunological methods [J Immunol Methods] 2025 Jun; Vol. 541, pp. 113882. Date of Electronic Publication: 2025 May 22.

Publication Type: Journal Article; Comparative Study; Validation Study

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 1305440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7905 (Electronic) Linking ISSN: 00221759 NLM ISO Abbreviation: J Immunol Methods Subsets: MEDLINE

MeSH Terms: Complement Membrane Attack Complex*/analysis, Humans ; Enzyme-Linked Immunosorbent Assay/methods ; Enzyme-Linked Immunosorbent Assay/standards ; Reproducibility of Results ; Biomarkers/blood ; Complement Activation

Monocyte/macrophage pyroptosis and C5b-9-induced cyst enlargement in Pkd1-/- mice.

Authors: Yang Y Kong D Chen M et al.

Source: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association [Nephrol Dial Transplant] 2025 May 30; Vol. 40 (6), pp. 1161-1174.

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 8706402 Publication Model: Print Cited Medium: Internet ISSN: 1460-2385 (Electronic) Linking ISSN: 09310509 NLM ISO Abbreviation: Nephrol Dial Transplant Subsets: MEDLINE

MeSH Terms: Macrophages*/pathology , Macrophages*/metabolism , Monocytes*/pathology , Monocytes*/metabolism , Pyroptosis* , Complement Membrane Attack Complex* , TRPP Cation Channels*/genetics , Polycystic Kidney, Autosomal Dominant*/pathology , Polycystic Kidney, Autosomal Dominant*/metabolism, Animals ; Mice ; Mice, Knockout ; Mice, Inbred C57BL ; Male ; Cells, Cultured

Claudin-2 enhances human antibody-mediated complement-dependent cytotoxicity of porcine endothelial cells by modulating antibody binding and complement activation.

Authors: Li W Yang F Yang D et al.

Source: Frontiers in immunology [Front Immunol] 2025 Feb 18; Vol. 16, pp. 1547512. Date of Electronic Publication: 2025 Feb 18 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH Terms: Claudin-2*/genetics , Claudin-2*/metabolism , Complement Membrane Attack Complex*/immunology , Complement Membrane Attack Complex*/metabolism , Antibodies*/immunology , Endothelial Cells*/cytology , Endothelial Cells*/immunology , Endothelial Cells*/metabolism , Complement C3c*/immunology , Complement C3c*/metabolism, Humans ; Animals ; Swine ; Cytotoxicity Tests, Immunologic ; Gene Expression Regulation ; RNA, Small Interfering/genetics ; Cell Membrane Permeability ; Cell Shape ; Cell Proliferation ; Apoptosis

Terminal complement complex deposition on chondrocytes promotes premature senescence in age- and trauma-related osteoarthritis.

Authors: Ruths L Hengge J Teixeira GQ et al.

Source: Frontiers in immunology [Front Immunol] 2025 Jan 14; Vol. 15, pp. 1470907. Date of Electronic Publication: 2025 Jan 14 (Print Publication: 2024).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH Terms: Chondrocytes*/immunology , Chondrocytes*/metabolism , Chondrocytes*/pathology , Osteoarthritis*/immunology , Osteoarthritis*/pathology , Osteoarthritis*/metabolism , Osteoarthritis*/etiology , Cellular Senescence*/immunology , Complement Membrane Attack Complex*/metabolism , Complement Membrane Attack Complex*/immunology , Aging*/immunology , Wounds and Injuries*/immunology , Wounds and Injuries*/complications, Animals ; Humans ; Mice ; Male ; Mice, Knockout ; Mice, Inbred C57BL ; Cartilage, Articular/immunology ; Cartilage, Articular/pathology ; Cartilage, Articular/metabolism ; CD59 Antigens/genetics ; Swine ; Disease Models, Animal

Acinetobacter baumannii Clinical Isolates Resist Complement-Mediated Lysis by Inhibiting the Complement Cascade and Improperly Depositing MAC.

Authors: Magda M Boschloo W Bettoni S et al.

Source: Journal of innate immunity [J Innate Immun] 2025; Vol. 17 (1), pp. 112-125. Date of Electronic Publication: 2025 Jan 22.

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Karger Country of Publication: Switzerland NLM ID: 101469471 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1662-8128 (Electronic) Linking ISSN: 1662811X NLM ISO Abbreviation: J Innate Immun Subsets: MEDLINE

MeSH Terms: Acinetobacter baumannii*/immunology , Acinetobacter baumannii*/genetics , Acinetobacter baumannii*/pathogenicity , Acinetobacter baumannii*/physiology , Acinetobacter Infections*/immunology , Acinetobacter Infections*/microbiology , Complement Membrane Attack Complex*/metabolism , Complement Membrane Attack Complex*/immunology , Complement System Proteins*/metabolism , Complement System Proteins*/immunology, Animals ; Humans ; Complement Activation ; Moths ; Virulence/genetics ; Immune Evasion ; Immunity, Innate ; Virulence Factors/genetics

Validation and performance of MicroVue sC5b-9 Plus ELISA on the Dynex DS2 platform.

Authors: Wilson RJ Bhandari M Dickerson JA et al.

Source: Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 2025 Feb 15; Vol. 568, pp. 120127. Date of Electronic Publication: 2025 Jan 07.

Publication Type: Journal Article; Validation Study

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 1302422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3492 (Electronic) Linking ISSN: 00098981 NLM ISO Abbreviation: Clin Chim Acta Subsets: MEDLINE

MeSH Terms: Complement Membrane Attack Complex*/analysis , Thrombotic Microangiopathies*/diagnosis , Thrombotic Microangiopathies*/blood, Humans ; Enzyme-Linked Immunosorbent Assay/methods ; Male ; Female ; Middle Aged ; Adult

Predictive complement biomarkers for relapse in neuromyelitis optica spectrum disorders.

Authors: Miyamoto K Murakami K Sakata M et al.

Source: Multiple sclerosis and related disorders [Mult Scler Relat Disord] 2025 Feb; Vol. 94, pp. 106282. Date of Electronic Publication: 2025 Jan 21.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier B. V Country of Publication: Netherlands NLM ID: 101580247 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-0356 (Electronic) Linking ISSN: 22110348 NLM ISO Abbreviation: Mult Scler Relat Disord Subsets: MEDLINE

MeSH Terms: Neuromyelitis Optica*/blood , Neuromyelitis Optica*/cerebrospinal fluid , Neuromyelitis Optica*/diagnosis , Complement Membrane Attack Complex*/metabolism , Complement System Proteins*/metabolism, Humans ; Female ; Male ; Biomarkers/blood ; Biomarkers/cerebrospinal fluid ; Adult ; Recurrence ; Middle Aged ; Prognosis ; Young Adult ; Follow-Up Studies

Understanding rare genetic variants within the terminal pathway of complement system in preeclampsia.

Authors: Lokki AI Triebwasser M Daly E et al.

Corporate Authors: Lokki AI Triebwasser M Daly E et al.

Source: Genes and immunity [Genes Immun] 2025 Feb; Vol. 26 (1), pp. 22-26. Date of Electronic Publication: 2024 Dec 17.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 100953417 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5470 (Electronic) Linking ISSN: 14664879 NLM ISO Abbreviation: Genes Immun Subsets: MEDLINE

MeSH Terms: Pre-Eclampsia*/genetics , Pre-Eclampsia*/immunology , Complement Membrane Attack Complex*/genetics , Complement C5*/genetics, Humans ; Female ; Pregnancy ; Adult ; Genetic Predisposition to Disease ; Polymorphism, Single Nucleotide ; Complement Activation/genetics ; Case-Control Studies ; Mutation, Missense ; Genetic Variation

The complement pathway and the pathophysiology of fibroproliferative cutaneous scarring.

Authors: Kruglikov IL Walendzik K Scherer PE

Source: Frontiers in immunology [Front Immunol] 2025 Oct 31; Vol. 16, pp. 1701998. Date of Electronic Publication: 2025 Oct 31 (Print Publication: 2025).

Publication Type: Journal Article; Review

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH Terms: Keloid*/immunology , Keloid*/pathology , Skin*/immunology , Skin*/pathology , Skin*/microbiology , Cicatrix, Hypertrophic*/immunology , Cicatrix, Hypertrophic*/pathology , Complement Activation*/immunology, Humans ; Animals ; Staphylococcus aureus/immunology ; Wound Healing/immunology ; Complement System Proteins/immunology ; Complement Membrane Attack Complex/metabolism ; Complement Membrane Attack Complex/immunology

Pore-forming aegerolysin and MACPF proteins in extremotolerant or extremophilic fungi.

Authors: Kraševec N; Department of Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Ljubljana, Slovenia.

Source: IUBMB life [IUBMB Life] 2024 Nov; Vol. 76 (11), pp. 922-936. Date of Electronic Publication: 2024 Jul 05.

Publication Type: Journal Article

Journal Info: Publisher: Published for the International Union of Biochemistry and Molecular Biology by Taylor & Francis Country of Publication: England NLM ID: 100888706 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-6551 (Electronic) Linking ISSN: 15216543 NLM ISO Abbreviation: IUBMB Life Subsets: MEDLINE

MeSH Terms: Complement Membrane Attack Complex*/metabolism , Complement Membrane Attack Complex*/genetics , Extremophiles*/genetics , Extremophiles*/metabolism , Fungal Proteins*/genetics , Fungal Proteins*/metabolism , Fungi*/genetics , Fungi*/metabolism , Hemolysin Proteins*/genetics , Hemolysin Proteins*/metabolism , Perforin*/genetics , Perforin*/metabolism, Genome, Fungal ; Phylogeny

Update in the diagnosis of complement-mediated thrombotic microangiopathy/atypical hemolytic uremic syndrome.

Authors: Cole MA; Johns Hopkins University, Department of Medicine, Division of Hematology, Baltimore, MD.

Source: Hematology. American Society of Hematology. Education Program [Hematology Am Soc Hematol Educ Program] 2025 Dec 05; Vol. 2025 (1), pp. 164-175.

Publication Type: Journal Article; Review

Journal Info: Publisher: American Society of Hematology Country of Publication: United States NLM ID: 100890099 Publication Model: Print Cited Medium: Internet ISSN: 1520-4383 (Electronic) Linking ISSN: 15204383 NLM ISO Abbreviation: Hematology Am Soc Hematol Educ Program Subsets: MEDLINE

MeSH Terms: Atypical Hemolytic Uremic Syndrome*/diagnosis , Thrombotic Microangiopathies*/diagnosis , Complement System Proteins*/metabolism, Humans ; Complement Membrane Attack Complex/metabolism ; Algorithms ; Shiga-Toxigenic Escherichia coli

Extracellular mitochondrial DNA activates complement and is associated with complement activation in patients with out-of-hospital cardiac arrest.

Authors: de Boer E Strandmoe AL Sokolova M et al.

Source: Scientific reports [Sci Rep] 2025 Nov 20; Vol. 15 (1), pp. 41000. Date of Electronic Publication: 2025 Nov 20.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: DNA, Mitochondrial*/metabolism , DNA, Mitochondrial*/genetics , Complement Activation* , Out-of-Hospital Cardiac Arrest*/immunology , Out-of-Hospital Cardiac Arrest*/genetics , Out-of-Hospital Cardiac Arrest*/metabolism , Out-of-Hospital Cardiac Arrest*/blood , Complement System Proteins*/metabolism, Humans ; Female ; Middle Aged ; Male ; Adult ; Pregnancy ; Aged ; Complement Membrane Attack Complex/metabolism ; Placenta/metabolism