Search Results - "complement component C5"

The Inflammatory Response Induced by Aspergillus fumigatus Conidia Is Dependent on Complement Activation: Insight from a Whole Blood Model

Authors: Fageräng, Beatrice Götz, Maximilian Peter Cyranka, Leon et al.

Source: Journal of Innate Immunity. 16(1):324-336

Subject Terms: Aspergillus fumigatus, CD14, Complement, Cytokines, Inflammatory response, Toll-like receptors, CD11b antigen, CD14 antigen, complement component C3, complement component C5, complement membrane attack complex, fibroblast growth factor, gamma interferon, granulocyte colony stimulating factor, interleukin 1 receptor, interleukin 17, interleukin 1beta, interleukin 4, interleukin 6, interleukin 8, lepirudin, macrophage inflammatory protein 1alpha, macrophage inflammatory protein 1beta, monocyte chemotactic protein 1, tumor necrosis factor, cytokine, lipopolysaccharide receptor, antigen expression, Article, blood sampling, cell population, clinical assessment, complement activation, complement inhibition, conidium, controlled study, cytokine release, Escherichia coli, flow cytometry, granulocyte, human, human cell, immunity, incubation time, inflammation, innate immunity, leukocyte activation, monocyte, nonhuman, species cultivation, aspergillosis, cell culture, fungus spore, immunology, metabolism, Cells, Cultured, Complement C3, Humans, Immunity, Innate, Lipopolysaccharide Receptors, Monocytes, Spores, Fungal

File Description: print

Access URL: https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-143043
https://doi.org/10.1159/000539368

Complement system is activated in acute inflammatory response to environmental particulates in the lungs

Authors: Kerui Zhang Akiko Honda Tomoya Sagawa et al.

Source: Ecotoxicology and Environmental Safety, Vol 297, Iss , Pp 118259- (2025)

Subject Terms: Particulate matter, Complement component C5 activation, C5aR1, C5b-9, Inflammatory response, Lung disease, Environmental pollution, TD172-193.5, Environmental sciences, GE1-350

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0147651325005950; https://doaj.org/toc/0147-6513

Access URL: https://doaj.org/article/1b55f108a96549c789058059bf1e8f55

Disseminated Cryptococcosis Following Eculizumab Therapy: Insight Into Pathogenesis

Authors: Lortholary, Olivier El-Sissy, Carine Leporrier, Jérémie et al.

Contributors: Lortholary, Olivier El-Sissy, Carine Leporrier, Jérémie et al.

Source: Open Forum Infect Dis

Subject Terms: [SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology, aHUS, complement component c5, cryptococcosis, atypical hemolytic uremic syndrome, pathogenesis, Brief Report, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, eculizumab, [SDV.IMM.IMM] Life Sciences [q-bio]/Immunology/Immunotherapy, 3. Good health

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/37065989
https://hal.science/hal-04335049v1/document
https://hal.science/hal-04335049v1
https://doi.org/10.1093/ofid/ofad159

STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians

Authors: Palomino-Morales, R J Rojas-Villarraga, A González, C I et al.

Source: Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario

Subject Terms: Genotype, Complement component C5, Case control study, Protein variant, Variation (Genetics), Tumor necrosis factor receptor associated factor 1, Autoimmunity, Major clinical study, Colombia, Polymorphism, Single Nucleotide, Article, Arthritis, Rheumatoid, Cohort Studies, 03 medical and health sciences, Systemic lupus erythematosus, 0302 clinical medicine, Gene Frequency, Risk Factors, STAT4 protein, Mouse strain, Rheumatoid, Genetic susceptibility, Humans, Lupus Erythematosus, Systemic, Rheumatoid arthritis, Polymorphism, Alleles, Priority journal, Genetic risk, Genetic polymorphism, Lupus Erythematosus, Arthritis, Systemic, Genetic Variation, Single Nucleotide, STAT4 Transcription Factor, TNF Receptor-Associated Factor 1, Polymerase chain reaction, 3. Good health, Case-Control Studies, Risk factor, Controlled study, Human

File Description: application/pdf

Access URL: https://www.nature.com/articles/gene200830.pdf
https://pubmed.ncbi.nlm.nih.gov/18432273
https://europepmc.org/abstract/MED/18432273
https://repository.urosario.edu.co/handle/10336/24142
https://nature.com/articles/gene200830
https://www.ncbi.nlm.nih.gov/pubmed/18432273
https://pubmed.ncbi.nlm.nih.gov/18432273/
https://www.nature.com/articles/gene200830.pdf
https://repository.urosario.edu.co/handle/10336/24142
https://doi.org/10.1038/gene.2008.30

THE EFFECTS OF THE FIBRIN-DERIVED PEPTIDE B??15-42 IN ACUTE AND CHRONIC RODENT MODELS OF MYOCARDIAL ISCHEMIA-REPERFUSION

Authors: Zacharowski, KD Zacharowski, PA Friedl, P et al.

Contributors: Zacharowski, KD Zacharowski, PA Friedl, P et al.

Source: Shock, 27(6), pp. 631-637.

Subject Terms: Male, Single drug dose, 0301 basic medicine, Biomedical Research, Myocardial Infarction, Fibrin derivative, Treatment response, Animal tissue, Mice, Heart infarction size, 0302 clinical medicine, Acute heart infarction, Treatment outcome, Leukocyte migration, Mice, Inbred BALB C, Heart protection, Ischemia-reperfusion, Free Radical Scavengers, Peptide derivative, 3. Good health, Reperfusion Injury, Heart muscle ischemia, Antigens, CD18, Myocardial Reperfusion, Preclinical study centers, Models, Biological, Article, Scavenger, Complement component C5 inhibitor, Cyclic N-Oxides, 03 medical and health sciences, Animals, Animal model, Animal experiment, Cytokine release, CD18 antigen, Ischemic preconditioning, Interleukin-6, Myocardium, Fibrinogen, Tempol, Nonhuman, Rats, Drug effect, Therapy effect, Fibrin-derived peptide, Myocardial infarction, Disease Models, Animal, CD18 Antigens, Rat, Heart muscle reperfusion, Spin Labels, Controlled study

Access URL: https://pubmed.ncbi.nlm.nih.gov/17505302
https://research-information.bris.ac.uk/en/publications/the-effects-of-the-fibrin-derived-peptide-bbeta15-42-in-acute-and
https://repository.tno.nl/islandora/object/uuid%3A680abf3c-dab3-4867-a0c3-a297a2a73a37
https://www.narcis.nl/publication/RecordID/oai%3Atudelft.nl%3Auuid%3A680abf3c-dab3-4867-a0c3-a297a2a73a37
https://www.ncbi.nlm.nih.gov/pubmed/17505302
https://research-information.bristol.ac.uk/en/publications/the-effects-of-the-fibrinderived-peptide-bbeta1542-in-acute-and-chronic-rodent-models-of-myocardial-ischemiareperfusion(55a0f6f0-23ce-4534-b4cd-c9fe6bac7a6f)/export.html
https://europepmc.org/article/MED/17505302
https://resolver.tno.nl/uuid:680abf3c-dab3-4867-a0c3-a297a2a73a37

Purification of the Active C5a Receptor from Human Polymorphonuclear Leukocytes as a Receptor-G i Complex

Authors: Rollins, Thomas E. Siciliano, Salvatore Kobayashi, Sumire et al.

Source: Proceedings of the National Academy of Sciences of the United States of America, 1991 Feb 01. 88(3), 971-975.

Access URL: https://www.jstor.org/stable/2356108

Complement activation by carbon nanotubes and its influence on the phagocytosis and cytokine response by macrophages

Authors: Pondman, K.M. Sobik, M. Nayak, A. et al.

Source: Nanomedicine: Nanotechnology, Biology, and Medicine

Subject Terms: ddc:620, C1q, Carbon nanotubes, Complement, Cytokines, Macrophage, Antigen-antibody reactions, Immune system, Macrophages, Anti-inflammatories, Cellular infiltration, Complement activations, Innate immune systems, Pro-inflammatory cytokines, Chemical activation, carbon nanotube, complement component C1q, complement component C3, complement component C5, complement membrane attack complex, interleukin 10, interleukin 12, interleukin 1beta, interleukin 6, messenger RNA, transforming growth factor beta, tumor necrosis factor alpha, cytokine, animal cell, article

File Description: application/pdf; text/plain; charset=utf-8

Relation: https://doi.org/10.34657/4526; https://oa.tib.eu/renate/handle/123456789/5897

Availability: https://oa.tib.eu/renate/handle/123456789/5897
https://doi.org/10.34657/4526

Anti-Complement Component C5 Therapy / 抗 C5 抗体療法

Authors: Hitomi Kobayashi Masami Takei 小林 ひとみ et al.

Source: 日大医学雑誌 / Journal of Nihon University Medical Association. 2017, 76(1):28

Adjuvant treatment with dexamethasone plus anti-C5 antibodies improves outcome of experimental pneumococcal meningitis: a randomized controlled trial

Authors: Kasanmoentalib, E. Valls Seron, Mercedes Morgan, B. et al.

Subject Terms: Pneumococcal meningitis, Randomized controlled trial, Dexamethasone, Complement component C5, Monoclonal antibody, Animal models

Relation: http://www.jneuroinflammation.com/content/12/1/149

Availability: http://www.jneuroinflammation.com/content/12/1/149

Anticoagulante en immunosuppressieve eiwitten in tekenspeeksel: De teek als apo-teek van de toekomst

Authors: Henderik, R. Folkerts, G. Hovius, J.W.R.

Source: Pharmaceutisch Weekblad. 144(7):24-27

Subject Terms: blood clotting factor 7a, autoimmune disease, CXCL1 chemokine, short survey, anticoagulant agent, b cell inhibitory protein, interleukin 2, CD209 antigen, evasin 1, inhibitor protein, complement component C5, hirulog, heparin derivative, thromboplastin, evasin 3, macrophage inflammatory protein 1beta, blood clotting factor 10, complement membrane attack complex, epitope, saliva, nonhuman, tick anticoagulant peptide, complement inhibitor, immunosuppressive agent, thrombin, tick, unclassified drug, antithrombin, beta interferon, CD4 antigen, macrophage inflammatory protein 1alpha, recombinant protein

Access URL: https://research-portal.uu.nl/en/publications/63435152-bfbc-438a-909b-62155ab50a18

A Novel Role for the Fifth Component of Complement (C5) in Cardiac Physiology

Authors: Mullick, Alaka Tremblay, Jessy Leon, Zully et al.

Source: PLoS One
PLoS ONE, Vol 6, Iss 8, p e22919 (2011)

Subject Terms: 0301 basic medicine, S29 gene, alpha myosin heavy chain gene, heart hypertrophy, neuropilin 1, calreticulin, Mice, heart function, heart injury, heat shock protein 70, isoprenaline, Mice, Inbred BALB C, 0303 health sciences, messenger RNA, Reverse Transcriptase Polymerase Chain Reaction, RGS2 gene, Mus, Complement C5, serine proteinase inhibitor, gene expression regulation, phenotypic variation, pyruvate dehydrogenase kinase 4, CALR gene, 3. Good health, immune response gene, Medicine, monocyte chemotactic protein 1, complement component C5 gene, signal transduction, Research Article, Science, interleukin 6, beta myosin heavy chain gene, Cardiomegaly, gene sequence, brain natriuretic peptide, heart protection, 03 medical and health sciences, myosin heavy chain alpha, regulator of G protein signaling gene, glucose transporter 1, Candida endocarditis, gene expression profiling, Animals, B type natriuretic peptide gene, gene identification, DNA Primers, Sepinh1 gene, Base Sequence, gene deletion, growth arrest and DNA damage inducible protein 45, disease predisposition, Isoproterenol, Mice, Inbred C57BL, gene function, Gene Expression Regulation, A type natriuretic peptide gene, neurophilin 1 gene, atrial natriuretic factor, complement component C5a receptor, alpha skeletal actin gene, heart stress, myosin heavy chain beta

Access URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0022919&type=printable
https://pubmed.ncbi.nlm.nih.gov/21829669
https://doaj.org/article/a51475531ada47c1b4698f5595d82c6e
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022919
https://paperity.org/p/61215199/a-novel-role-for-the-fifth-component-of-complement-c5-in-cardiac-physiology
http://ui.adsabs.harvard.edu/abs/2011PLoSO...622919M/abstract
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022919
http://europepmc.org/articles/PMC3148243
https://core.ac.uk/display/38584146
https://nrc-publications.canada.ca/eng/view/object/?id=b1c008f4-7bff-4774-b870-94f7fc5be6ca
https://doi.org/10.1371/journal.pone.0022919

Complement: An inflammatory pathway fulfilling multiple roles at the interface of innate immunity and development

Authors: Mastellos, D. Germenis, A. E. Lambris, J. D.

Source: http://www.scopus.com/inward/record.url?eid=2-s2.0-17844367629&partnerID=40&md5=9e47651c54172b3f4966de57838d1977.

Subject Terms: complement, complement component C3, complement component C3 receptor, complement component C5, complement component C5a, complement component C5a receptor, interleukin 6, stromal cell derived factor 1, tumor necrosis factor alpha, acute graft rejection, antiinflammatory activity, CD34 selection, cell migration, cell survival, cytokine release, embryo development, enzyme activation, hematopoietic stem cell transplantation, human, inflammation, innate immunity, limb regeneration, liver regeneration, lymphocyte homing, multiple organ failure, nonhuman, reproduction, review, tissue injury, tissue regeneration

Relation: http://hdl.handle.net/11615/30765

Availability: http://hdl.handle.net/11615/30765
https://doi.org/10.2174/1568010053622993

Complement system is activated in acute inflammatory response to environmental particulates in the lungs

Authors: Zhang, Kerui Honda, Akiko Sagawa, Tomoya et al.

Index Terms: Particulate matter, Complement component C5 activation, C5aR1, C5b-9, Inflammatory response, Lung disease, journal article

URL: http://hdl.handle.net/2433/294453
10.1016/j.ecoenv.2025.118259

Complement system is activated in acute inflammatory response to environmental particulates in the lungs.

Authors: Honda, Akiko Sagawa, Tomoya Miyasaka, Natsuko et al.

Index Terms: Particulate matter, Complement component C5 activation, C5aR1, C5b-9, Inflammatory response, Lung disease, Journal Article., VoR.

URL: http://hdl.handle.net/2433/294453
https://doi.org/10.1016/j.ecoenv.2025.118259
http://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/294453/1/j.ecoenv.2025.118259.pdf
40315749

Recurrent acute myocardial and renal infarction with aplastic anaemia/paroxysmal nocturnal haemoglobinuria syndrome: a case report.

Authors: Kato Y Hadase M Nakamura T

Source: European heart journal. Case reports [Eur Heart J Case Rep] 2024 Sep 23; Vol. 8 (10), pp. ytae526. Date of Electronic Publication: 2024 Sep 23 (Print Publication: 2024).

Publication Type: Case Reports; Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 101730741 Publication Model: eCollection Cited Medium: Internet ISSN: 2514-2119 (Electronic) Linking ISSN: 25142119 NLM ISO Abbreviation: Eur Heart J Case Rep Subsets: PubMed not MEDLINE

Molecular recognition and interaction between human plasminogen Kringle 5 and A2M domain in human complement C5 by biospecific methods coupled with molecular dynamics simulation.

Authors: Dai X Xue P Bian L

Source: International journal of biological macromolecules [Int J Biol Macromol] 2024 Jun; Vol. 270 (Pt 1), pp. 132356. Date of Electronic Publication: 2024 May 15.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH Terms: Molecular Dynamics Simulation* , Plasminogen*/chemistry , Plasminogen*/metabolism , Protein Binding*, Humans ; Binding Sites ; Complement C5a/chemistry ; Complement C5a/metabolism ; A549 Cells ; Protein Domains ; Cell Proliferation/drug effects ; Cell Movement/drug effects ; Peptide Fragments

Characterization of the bispecific VHH antibody gefurulimab (ALXN1720) targeting complement component 5, and designed for low volume subcutaneous administration.

Authors: Jindal S Pedersen DV Gera N et al.

Source: Molecular immunology [Mol Immunol] 2024 Jan; Vol. 165, pp. 29-41. Date of Electronic Publication: 2023 Dec 23.

Publication Type: Journal Article

Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 7905289 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9142 (Electronic) Linking ISSN: 01615890 NLM ISO Abbreviation: Mol Immunol Subsets: MEDLINE

MeSH Terms: Complement C5* , Single-Domain Antibodies*, Humans ; Complement System Proteins/metabolism ; Complement Activation ; Albumins

Antibodies against complement component C5 prevent antibody-mediated rejection after lung transplantation in murine orthotopic models with skin-graft-induced pre-sensitization.

Authors: Shiina Y Suzuki H Hata A et al.

Source: General thoracic and cardiovascular surgery [Gen Thorac Cardiovasc Surg] 2022 Dec; Vol. 70 (12), pp. 1032-1041. Date of Electronic Publication: 2022 Jun 29.

Publication Type: Journal Article

Journal Info: Publisher: Springer Japan Country of Publication: Japan NLM ID: 101303952 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1863-6713 (Electronic) Linking ISSN: 18636705 NLM ISO Abbreviation: Gen Thorac Cardiovasc Surg Subsets: MEDLINE

MeSH Terms: Lung Transplantation*/adverse effects , Cyclosporins*, Mice ; Animals ; Skin Transplantation ; Mice, Inbred C57BL ; Graft Rejection/etiology ; Antibodies/pharmacology ; Tissue Donors ; Methylprednisolone

An LC-MS/MS approach to assess total and free protein target in the serum of cynomolgus monkey.

Authors: Cao H Zhang G Ciociola K et al.

Source: Bioanalysis [Bioanalysis] 2019 Mar; Vol. 11 (5), pp. 393-406. Date of Electronic Publication: 2019 Mar 15.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101512484 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-6199 (Electronic) Linking ISSN: 17576180 NLM ISO Abbreviation: Bioanalysis

MeSH Terms: Blood Proteins/*metabolism , Chromatography, Liquid/*methods , Tandem Mass Spectrometry/*methods, Animals ; Macaca fascicularis

The rational design of affinity-attenuated OmCI for the purification of complement C5.

Authors: Macpherson A Liu X Dedi N et al.

Source: The Journal of biological chemistry [J Biol Chem] 2018 Sep 07; Vol. 293 (36), pp. 14112-14121. Date of Electronic Publication: 2018 Jul 20.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

MeSH Terms: Drug Discovery*, Complement C5/*isolation & purification, Animals ; Binding Sites ; Drug Design ; Humans ; Immune Evasion ; Mutagenesis, Site-Directed ; Protein Binding ; Tandem Affinity Purification