Search Results - "cellular indexing of transcriptome and epitope by sequencing"

Multiomics dissection of human RAG deficiency reveals distinctive patterns of immune dysregulation but a common inflammatory signature

Authors: Marita Bosticardo Kerry Dobbs Ottavia M. Delmonte et al.

Contributors: Marita Bosticardo Kerry Dobbs Ottavia M. Delmonte et al.

Source: Science Immunology. 10

Subject Terms: Male, sequence analysis, cell maturation, severe combined immune deficiency disease, preschool child, DISEASE, immunology, rituximab, cellular indexing of transcriptome and epitope by sequencing, nuclear protein, genetic variability, T lymphocyte, RAG1 protein, genetics, gene mutation, Child, IMMUNODEFICIENCY, epitope, child, B-Lymphocytes, adult, steroid, allele, RAG gene, Nuclear Proteins, B-Lymphocytes/immunology, EXPANSION, interferon, Inflammation/immunology, I IFNS, RAG-1 protein, autoantigen, 3204 Immunology, DNA-Binding Proteins, DIFFERENTIATION, female, Phenotype, Child, Preschool, Female, Omenn syndrome, Centralized Sequencing Program Group§§, Life Sciences & Biomedicine, Centralized Sequencing Program Group, phenotype, Immunology, leaky severe combined immune deficiency disease, Article, male, immune dysregulation, Humans, controlled study, cyclosporine, human, IMMUNOGLOBULIN-SECRETING CELLS, Preschool, Inflammation, Homeodomain Proteins, Science & Technology, B lymphocyte, MUTATIONS, RAG2 protein, human, human cell, 3202 Clinical sciences, RAG2 protein, immune deficiency, Multiomics, major clinical study, DNA binding protein, human tissue, Th2 cell, inflammation, homeodomain protein, adolescent, ANTIBODIES, Mutation, T-CELLS, AUTOANTIBODIES, genetic disorder, Homeodomain Proteins/genetics, mutation, transcriptome, DNA-Binding Proteins/genetics, autoantibody, multiomics

Access URL: https://pubmed.ncbi.nlm.nih.gov/39792639