Výsledky vyhľadávania - "cGAS-STING pathway"

Metabolic modulation-driven self-reinforcing pyroptosis-STING nanoadjuvant for potentiated metalloimmunotherapy

Autori: Linzhu Zhang Di Wang Yiming Liu a ďalší

Zdroj: Bioactive Materials, Vol 53, Iss, Pp 641-655 (2025)

Predmety: cGAS-STING pathway, Glucose metabolism, CoF2 nanoenzymes, Transarterial embolization, QH301-705.5, Pyroptosis, TA401-492, Biology (General), Materials of engineering and construction. Mechanics of materials

Prístupová URL adresa: https://doaj.org/article/a412d08ed6f54595a147b7b7c6b3578d

A self-accelerating ‘copper bomb’ strategy activated innate and adaptive immune response against triple-negative breast cancer

Autori: Xinzhi Xu Hang Zhou Ruixia Hong a ďalší

Zdroj: Bioact Mater
Bioactive Materials, Vol 49, Iss, Pp 193-206 (2025)

Predmety: Triple-negative breast cancer, QH301-705.5, Cuproptosis, TA401-492, mtDNA-cGAS-STING pathway, Immune response, Biology (General), Proteotoxic stress, Materials of engineering and construction. Mechanics of materials, Article

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40130080
https://doaj.org/article/fc941cbb90754818866ba7fafeb8884c

Therapeutic Effect of Brucea Javanica Oil Emulsion in Mice with Irinotecan-Induced Delayed Diarrhea

Autori: Lai Z Zhang Y Hu X a ďalší

Zdroj: Drug Des Devel Ther
Drug Design, Development and Therapy, Vol Volume 19, Iss Issue 1, Pp 5329-5347 (2025)

Predmety: cGAS-STING pathway, delayed diarrhea, Therapeutics. Pharmacology, RM1-950, chemotherapy, Brucea javanica oil emulsion, irinotecan, Original Research

Prístupová URL adresa: https://doaj.org/article/cf374817a31843e1bf8e5173142be4b7

RNF185 promotes esophageal squamous cell carcinoma progression by regulating BAK1 ubiquitination and activating the cGAS–STING–IRF3 pathway

Autori: Ke-Hao Wang Hui Zhu Meng-Dan Xu a ďalší

Zdroj: European Journal of Medical Research, Vol 30, Iss 1, Pp 1-14 (2025)

Predmety: RNF185, Esophageal squamous cell carcinoma (ESCC), BAK1 ubiquitination, CGAS–STING pathway, Mitochondrial apoptosis, Medicine

Popis súboru: electronic resource

Relation: https://doaj.org/toc/2047-783X

Prístupová URL adresa: https://doaj.org/article/51027bbcda8744fd93793fc16bcf91aa

Mechanism of interaction between ANXA6 and cGAS to regulate STING signaling pathway and promote ferroptosis in cervical cancer

Autori: Si Ouyang Kaixin Xiong Peijie Chen a ďalší

Zdroj: Cancer Cell International, Vol 25, Iss 1, Pp 1-13 (2025)

Predmety: Cervical cancer, ANXA6, Ferroptosis, CGAS-STING pathway, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

Popis súboru: electronic resource

Relation: https://doaj.org/toc/1475-2867

Prístupová URL adresa: https://doaj.org/article/3d309dcdc8b94585a643903cbe87e6a6

Bridging innate and adaptive tumor immunity: cGAS–STING pathway activation to potentiate immune checkpoint blockade

Autori: Zhuo Li Wei Zheng Yisi Liu a ďalší

Zdroj: Journal of Experimental & Clinical Cancer Research, Vol 44, Iss 1, Pp 1-16 (2025)

Predmety: CGAS–STING pathway, STING agonist, Immune checkpoint inhibitor, Tumor microenvironment, Cancer immunotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

Popis súboru: electronic resource

Relation: https://doaj.org/toc/1756-9966

Prístupová URL adresa: https://doaj.org/article/d6d225456bda45a9811bb169161fc38f

Polydopamine as a biocompatible and precise mitochondrial targeted therapeutic platform for reversing myocardial ischemia-reperfusion injury

Autori: Tianjiao Zhao Yunying Huang Wensheng Chen a ďalší

Zdroj: Bioactive Materials, Vol 53, Iss , Pp 908-931 (2025)

Predmety: Myocardial ischemia-reperfusion injury, Mitochondrial targeting, Oxidative stress, mPTP opening, cGAS-STING pathway, Materials of engineering and construction. Mechanics of materials, TA401-492, Biology (General), QH301-705.5

Popis súboru: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2452199X25003305; https://doaj.org/toc/2452-199X

Prístupová URL adresa: https://doaj.org/article/4bc8a0afa9674c908218395cc4164207

Dihydroorotate dehydrogenase inhibition activates STING pathway and pyroptosis to enhance NK cell-dependent tumor immunotherapy

Autori: Yongrui Hai Ruizhuo Lin Weike Liao a ďalší

Zdroj: Molecular Biomedicine, Vol 6, Iss 1, Pp 1-19 (2025)

Predmety: Pyrimidine metabolism, DHODH, NK cells, Pyroptosis, CGAS-STING pathway, Medicine

Popis súboru: electronic resource

Relation: https://doaj.org/toc/2662-8651

Prístupová URL adresa: https://doaj.org/article/9461aa479cc04b2b8305f31d3c550bbb

ACOX2 destabilizes the MRE11-RAD50-NBS1 complex and boosts anticancer immunity via the cGAS-STING pathway in clear cell renal cell carcinoma

Autori: Shiqi Ye Wenhao Xu Zheqi Chen a ďalší

Zdroj: Molecular Cancer, Vol 24, Iss 1, Pp 1-24 (2025)

Predmety: ACOX2, MRE11-RAD50-NBS1 complex, Homologous recombination repair, cGAS-STING pathway, Tertiary lymphoid structures, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

Popis súboru: electronic resource

Relation: https://doaj.org/toc/1476-4598

Prístupová URL adresa: https://doaj.org/article/27d08e8f7c5d472cbedde39fdd0b5467

cGAS-STING signaling in brain aging and neurodegeneration: molecular links and therapeutic perspectives

Autori: Huayu Li Ruixin Cai Yu Zhou a ďalší

Zdroj: Journal of Neuroinflammation, Vol 22, Iss 1, Pp 1-21 (2025)

Predmety: Aging, Neuroinflammation, Microglia, Neurodegenerative diseases, cGAS-STING pathway, Neurology. Diseases of the nervous system, RC346-429

Popis súboru: electronic resource

Relation: https://doaj.org/toc/1742-2094

Prístupová URL adresa: https://doaj.org/article/9a40cacc658c42a09eb3c39555bfeae5

Drug loaded cerium oxide nanozymes prevent radiation-Induced cataracts via suppressing the cGAS-STING pathway

Autori: Qifang Chen Peilin Gu Hongwei Li a ďalší

Zdroj: Journal of Nanobiotechnology, Vol 23, Iss 1, Pp 1-18 (2025)

Predmety: Radiation-induced cataracts, Nanozymes, CGAS-STING pathway, Antioxidative, Anti-inflammatory, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5

Popis súboru: electronic resource

Relation: https://doaj.org/toc/1477-3155

Prístupová URL adresa: https://doaj.org/article/76da3b956e2c4ef78c87be6acaa055ee

The cGAS‒STING pathway in colorectal cancer: bridging innate immunity and therapeutic strategies

Autori: Wen-Jing Li Guang-Hui Dong Yao Bi a ďalší

Zdroj: Journal of Experimental & Clinical Cancer Research, Vol 44, Iss 1, Pp 1-23 (2025)

Predmety: Colorectal cancer, Innate immunity, cGAS-STING pathway, Nanocarrier, Immunotherapy, Tumor microenvironment, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

Popis súboru: electronic resource

Relation: https://doaj.org/toc/1756-9966

Prístupová URL adresa: https://doaj.org/article/b38c48fe79a348abb59c17a8234a7bef

Induction of the STING-dependent DNA damage pathway by cucurbitacin B enhances immunotherapy efficacy in osteosarcoma

Autori: Bin Luo Qing Lu Qiang Wang a ďalší

Zdroj: Iranian Journal of Basic Medical Sciences, Vol 28, Iss 10, Pp 1319-1327 (2025)

Predmety: cgas-sting pathway, cucurbitacin b, dna damage, osteosarcoma, pd-l1, Medicine

Popis súboru: electronic resource

Relation: https://ijbms.mums.ac.ir/article_26171_cdac19068778a291910b98226c18fc18.pdf; https://doaj.org/toc/2008-3866; https://doaj.org/toc/2008-3874

Prístupová URL adresa: https://doaj.org/article/41df197eb3734f6ea192ae76c1e0840b

Oral Lipid-Based Nanomedicine for the Inhibition of the cGAS-STING Pathway in Inflammatory Bowel Disease Treatment

Autori: Léo Guilbaud Cheng Chen Inês Domingues a ďalší

Prispievatelia: Léo Guilbaud Cheng Chen Inês Domingues a ďalší

Zdroj: Mol Pharm
Molecular pharmaceutics, Vol. 22, no.4, p. 2108-2121 (2025)

Predmety: cGAS-STING pathway, lipid nanocapsules, Macrophages, Dextran Sulfate, Membrane Proteins, Administration, Oral, GLP-2 secretion, Inflammatory Bowel Diseases, Colitis, Nucleotidyltransferases, Lipids, mucosal healing, Mice, Inbred C57BL, Mice, Disease Models, Animal, Nanomedicine, RAW 264.7 Cells, Nanocapsules, inflammatory bowel disease, Animals, Humans, re-epithelialization, Signal Transduction

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40032274
https://hdl.handle.net/2078.1/306111
https://hdl.handle.net/11577/3561362
https://doi.org/10.1021/acs.molpharmaceut.4c01297

Enhanced Cancer Immunotherapy by Bacterial Cytoplasmic Membranes Coated Nanovaccines for Co-Delivery of Ovalbumin Antigen and Immune Adjuvants to Dendritic Cells in Lymph Nodes

Autori: Peiqi Zhao Yali Fan Ziyou Wang a ďalší

Zdroj: Int J Nanomedicine
International Journal of Nanomedicine, Vol Volume 20, Pp 2289-2304 (2025)

Predmety: Medicine (General), Ovalbumin, tumor nanovaccine, Nanovaccines, Cancer Vaccines, Mice, R5-920, Adjuvants, Immunologic, Neoplasms, Cell Line, Tumor, Animals, Humans, Original Research, Manganese, Dendritic Cells, Silicon Dioxide, Mice, Inbred C57BL, mr imaging, cgas-sting pathway, Nanoparticles, Female, immunotherapy, Immunotherapy, Lymph Nodes, Mannose, Mannose Receptor

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40007905
https://doaj.org/article/f741e2db7cd840a291972895ce88759b

FAHD1 prevents neuronal ferroptosis by modulating R-loop and the cGAS–STING pathway

Autori: Wang Bitao Yang Yubiao Zeng Zhi a ďalší

Zdroj: Open Medicine, Vol 20, Iss 1, Pp 2029-44 (2025)

Predmety: fahd1, neuronal ferroptosis, oxidative stress, r-loop, cgas–sting pathway, Medicine

Popis súboru: electronic resource

Relation: https://doaj.org/toc/2391-5463

Prístupová URL adresa: https://doaj.org/article/9da22fa444994f66a1a43979f6b0b53e

Crosstalk Between Cell Death and the cGAS-STING Pathway in Sepsis-Associated Acute Lung Injury

Autori: Li X Wang M Li Y a ďalší

Zdroj: Journal of Inflammation Research, Vol 18, Iss Issue 1, Pp 13291-13312 (2025)

Predmety: Sepsis, ALI, Cell Death, cGAS-STING Pathway, Inflammatory Response, Therapeutic Targets, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950

Popis súboru: electronic resource

Relation: https://www.dovepress.com/crosstalk-between-cell-death-and-the-cgas-sting-pathway-in-sepsis-asso-peer-reviewed-fulltext-article-JIR; https://doaj.org/toc/1178-7031

Prístupová URL adresa: https://doaj.org/article/e510ea4ab7f243659408e2a1b17b2ae0

Multifunctional nanoagent for enhanced cancer radioimmunotherapy via pyroptosis and cGAS-STING activation

Autori: Ziting Xu Yang Gao Li Zhang a ďalší

Zdroj: Journal of Nanobiotechnology, Vol 23, Iss 1, Pp 1-16 (2025)

Predmety: Radiosensitization, Pyroptosis, cGAS-STING pathway, Ca overload, Radioimmunotherapy, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5

Popis súboru: electronic resource

Relation: https://doaj.org/toc/1477-3155

Prístupová URL adresa: https://doaj.org/article/028ae9e5bd424af8b50cf68bec09c1ad

The cGAS-STING pathway: a dual regulator of immune response in cancer and therapeutic implications

Autori: Zhanghao Huang Jun Zhu You Lang Zhou a ďalší

Zdroj: Journal of Translational Medicine, Vol 23, Iss 1, Pp 1-14 (2025)

Predmety: cGAS-STING pathway, Immune response, Tumor evasion, Autophagy, Therapeutic strategies, Medicine

Popis súboru: electronic resource

Relation: https://doaj.org/toc/1479-5876

Prístupová URL adresa: https://doaj.org/article/31b9e99f409542ecaf76e996e38e5fca

Inhibition of the cGAS–STING pathway: contributing to the treatment of cerebral ischemia-reperfusion injury

Autori: Hang Yang Yulei Xia Yue Ma a ďalší

Zdroj: Neural Regeneration Research, Vol 20, Iss 7, Pp 1900-1918 (2025)

Predmety: calcium homeostasis, cellular autophagy, cerebral ischemia-reperfusion injury, cgas–sting pathway, ferroptosis, gut–brain–microbiota axis, inflammatory, light chain 3, microglial cells, syntaxin-17 protein, Neurology. Diseases of the nervous system, RC346-429

Popis súboru: electronic resource

Relation: https://journals.lww.com/10.4103/NRR.NRR-D-24-00015; https://doaj.org/toc/1673-5374; https://doaj.org/toc/1876-7958

Prístupová URL adresa: https://doaj.org/article/ac4c404f25084738af3e1eecbb0bcd56