Search Results - "alpha-synuclein"

In situ exogenous alpha-synuclein aggregates inhibit murine ventricular voltage-gated inward sodium and outward potassium currents.

Authors: Lee B Ahmad S Edling CE et al.

Source: Journal of Parkinson's disease [J Parkinsons Dis] 2025 Nov; Vol. 15 (7), pp. 1194-1207. Date of Electronic Publication: 2025 Aug 28.

Publication Type: Journal Article

Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101567362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1877-718X (Electronic) Linking ISSN: 18777171 NLM ISO Abbreviation: J Parkinsons Dis Subsets: MEDLINE

MeSH Terms: alpha-Synuclein*/pharmacology , alpha-Synuclein*/metabolism , Heart Ventricles*/metabolism , Heart Ventricles*/drug effects , Stellate Ganglion*/drug effects , Stellate Ganglion*/metabolism , Voltage-Gated Sodium Channels*/metabolism, Animals ; Mice ; Male ; Patch-Clamp Techniques ; Mice, Inbred C57BL ; Myocardium/metabolism ; Potassium/metabolism

Experimental Ischemic Stroke-Induced Alpha-Synuclein Pathology Enhances Endothelial Inflammatory Response and Impairs Angiogenesis.

Authors: Bogale TA Mercurio D Valente A et al.

Source: Stroke [Stroke] 2025 Dec; Vol. 56 (12), pp. 3424-3437. Date of Electronic Publication: 2025 Sep 18.

Publication Type: Journal Article

Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0235266 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4628 (Electronic) Linking ISSN: 00392499 NLM ISO Abbreviation: Stroke Subsets: MEDLINE

MeSH Terms: alpha-Synuclein*/genetics , alpha-Synuclein*/metabolism , Ischemic Stroke*/pathology , Ischemic Stroke*/metabolism , Ischemic Stroke*/genetics , Endothelial Cells*/metabolism , Endothelial Cells*/pathology , Neovascularization, Pathologic*/metabolism , Neovascularization, Pathologic*/pathology , Brain Ischemia*/pathology , Brain Ischemia*/metabolism, Animals ; Mice ; Mice, Inbred C57BL ; Inflammation/pathology ; Inflammation/metabolism ; Male ; Disease Models, Animal ; Mice, Knockout ; Angiogenesis

Interactions of Neurodegenerative Disease Positron Emission Tomography Imaging Probe Candidates with the C-Terminus of α-Synuclein Fibrils.

Authors: Shaffer KD Perez RM Lougee MG et al.

Source: Chembiochem : a European journal of chemical biology [Chembiochem] 2025 Nov 17; Vol. 26 (22), pp. e202500578. Date of Electronic Publication: 2025 Oct 13.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE

MeSH Terms: alpha-Synuclein*/chemistry , alpha-Synuclein*/metabolism , Positron-Emission Tomography* , Neurodegenerative Diseases*/diagnostic imaging, Humans ; Parkinson Disease/diagnostic imaging ; Ligands

The G2019S LRRK2 mutation exacerbates α-synuclein and tau neuropathology through divergent pathways in Parkinson's disease models.

Authors: Tsafaras G Cabezudo D Wetzels L et al.

Source: Acta neuropathologica [Acta Neuropathol] 2025 Nov 11; Vol. 150 (1), pp. 51. Date of Electronic Publication: 2025 Nov 11.

Publication Type: Journal Article

Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE

MeSH Terms: Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/genetics , Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/metabolism , alpha-Synuclein*/metabolism , alpha-Synuclein*/genetics , tau Proteins*/metabolism , tau Proteins*/genetics , Parkinson Disease*/pathology , Parkinson Disease*/genetics , Parkinson Disease*/metabolism, Animals ; Humans ; Mice ; Mutation/genetics ; Disease Models, Animal ; Mice, Transgenic ; Male ; Female ; Brain/pathology ; Brain/metabolism ; Dopaminergic Neurons/pathology ; Dopaminergic Neurons/metabolism ; Mice, Inbred C57BL

NIR fluorescent substrate-driven discovery of prolyl endopeptidase natural inhibitors and its inhibition of alpha-synuclein aggregation and promotion of autophagy.

Authors: Zhang J Bian KJ Wang YJ et al.

Source: Chemico-biological interactions [Chem Biol Interact] 2025 Nov 01; Vol. 421, pp. 111733. Date of Electronic Publication: 2025 Sep 05.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE

MeSH Terms: alpha-Synuclein*/metabolism , alpha-Synuclein*/antagonists & inhibitors , Autophagy*/drug effects , Fluorescent Dyes*/chemistry , Serine Endopeptidases*/metabolism , Protein Aggregates*/drug effects , Biological Products*/chemistry , Biological Products*/pharmacology, Animals ; Mice ; Humans ; Molecular Docking Simulation ; Prolyl Oligopeptidases/metabolism ; Kinetics ; Flavonoids/pharmacology ; Flavonoids/chemistry ; Drug Discovery

Structural polymorphism of α-synuclein fibrils alters the pathway of Hsc70-mediated disaggregation.

Authors: Jäger S Tittelmeier J Dang TL et al.

Source: The EMBO journal [EMBO J] 2025 Nov; Vol. 44 (22), pp. 6499-6526. Date of Electronic Publication: 2025 Oct 06.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE

MeSH Terms: alpha-Synuclein*/metabolism , alpha-Synuclein*/chemistry , alpha-Synuclein*/genetics , HSC70 Heat-Shock Proteins*/metabolism , Amyloid*/metabolism , Amyloid*/chemistry , Protein Aggregates* , Protein Aggregation, Pathological*/metabolism, Humans ; Protein Conformation

ATP Hydrolysis by α-Synuclein Amyloids is Mediated by Enclosing β-Strand.

Authors: Frey L Buratti FA Horvath I et al.

Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Nov; Vol. 12 (44), pp. e08441. Date of Electronic Publication: 2025 Oct 16.

Publication Type: Journal Article

Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

MeSH Terms: alpha-Synuclein*/metabolism , alpha-Synuclein*/chemistry , alpha-Synuclein*/genetics , Adenosine Triphosphate*/metabolism , Adenosine Triphosphate*/chemistry , Amyloid*/metabolism , Amyloid*/chemistry , Amyloid*/ultrastructure, Hydrolysis ; Humans ; Cryoelectron Microscopy ; Protein Conformation, beta-Strand ; Parkinson Disease/metabolism

Early Dopaminergic Dysfunction Induces PRO-VGF Changes in Blood and Brain of Rats with Alpha-Synuclein Overexpression.

Authors: Manca E Corsi S Fanni S et al.

Source: Neurochemical research [Neurochem Res] 2025 Oct 30; Vol. 50 (6), pp. 344. Date of Electronic Publication: 2025 Oct 30.

Publication Type: Journal Article

Journal Info: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 7613461 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-6903 (Electronic) Linking ISSN: 03643190 NLM ISO Abbreviation: Neurochem Res Subsets: MEDLINE

MeSH Terms: alpha-Synuclein*/genetics , alpha-Synuclein*/metabolism , alpha-Synuclein*/biosynthesis , Brain*/metabolism , Dopamine*/metabolism , Dopaminergic Neurons*/metabolism, Animals ; Male ; Rats ; Humans ; Rats, Sprague-Dawley ; Substantia Nigra/metabolism ; Tyrosine 3-Monooxygenase/metabolism ; Parkinson Disease/metabolism

DDOX expands the repertoire of tetracyclines for Parkinson's disease by preventing the cellular uptake and intracellular impact of α-synuclein preformed fibrils.

Authors: Teran MDM Tomas-Grau RH Soliz-Santander ES et al.

Source: Scientific reports [Sci Rep] 2025 Oct 29; Vol. 15 (1), pp. 37769. Date of Electronic Publication: 2025 Oct 29.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: alpha-Synuclein*/metabolism , alpha-Synuclein*/chemistry , Parkinson Disease*/drug therapy , Parkinson Disease*/metabolism , Parkinson Disease*/pathology , Neuroprotective Agents*/pharmacology , Doxycycline*/pharmacology , Doxycycline*/analogs & derivatives , Doxycycline*/chemistry , Tetracyclines*/pharmacology , Tetracyclines*/chemistry, Humans ; Molecular Docking Simulation ; Protein Aggregates/drug effects ; Lysosomes/metabolism ; Lysosomes/drug effects

Brain region-specific and systemic transcriptomic alterations in a human alpha-synuclein overexpressing rat model.

Authors: Hoof V Casadei N Riess O et al.

Source: Aging [Aging (Albany NY)] 2025 Oct 20; Vol. 17 (10), pp. 2598-2636. Date of Electronic Publication: 2025 Oct 20.

Publication Type: Journal Article

Journal Info: Publisher: Impact Journals, LLC Country of Publication: United States NLM ID: 101508617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-4589 (Electronic) Linking ISSN: 19454589 NLM ISO Abbreviation: Aging (Albany NY) Subsets: MEDLINE

MeSH Terms: alpha-Synuclein*/genetics , alpha-Synuclein*/metabolism , Transcriptome* , Brain*/metabolism , Synucleinopathies*/genetics , Synucleinopathies*/metabolism, Animals ; Rats, Transgenic ; Rats ; Humans ; Disease Models, Animal ; Male ; Gene Expression Profiling

A pathogenic alpha synuclein variant exacerbates disease progression in a neuron-specific Gba-KO mouse.

Authors: Duffy HBD Byrnes C Zhu H et al.

Source: Neurobiology of disease [Neurobiol Dis] 2025 Oct 15; Vol. 215, pp. 107070. Date of Electronic Publication: 2025 Aug 27.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE

MeSH Terms: alpha-Synuclein*/genetics , alpha-Synuclein*/metabolism , Glucosylceramidase*/genetics , Glucosylceramidase*/deficiency , Glucosylceramidase*/metabolism , Neurons*/metabolism , Neurons*/pathology , Synucleinopathies*/genetics , Synucleinopathies*/metabolism , Synucleinopathies*/pathology, Animals ; Mice, Knockout ; Disease Progression ; Mice ; Humans ; Brain/metabolism ; Brain/pathology ; Disease Models, Animal ; Mice, Inbred C57BL ; Male

Spectral Profiling of Early αsyn Aggregation in HEK293 Cells Modified to Stably Express Human WT and A53T-αsyn.

Authors: Swaminathan P Godø KS Bjørn EB et al.

Source: Cells [Cells] 2025 Oct 02; Vol. 14 (19). Date of Electronic Publication: 2025 Oct 02.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

MeSH Terms: alpha-Synuclein*/metabolism , alpha-Synuclein*/genetics , alpha-Synuclein*/chemistry , Protein Aggregates* , Protein Aggregation, Pathological*/metabolism, Humans ; HEK293 Cells ; Mutation/genetics

Genetic code expansion and enzymatic modifications as accessible methods for studying site-specific post-translational modifications of alpha-synuclein and tau.

Authors: Saleh IG Shimogawa M Ramirez J et al.

Source: Protein science : a publication of the Protein Society [Protein Sci] 2025 Oct; Vol. 34 (10), pp. e70302.

Publication Type: Journal Article

Journal Info: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet ISSN: 1469-896X (Electronic) Linking ISSN: 09618368 NLM ISO Abbreviation: Protein Sci Subsets: MEDLINE

MeSH Terms: alpha-Synuclein*/genetics , alpha-Synuclein*/metabolism , alpha-Synuclein*/chemistry , Protein Processing, Post-Translational* , tau Proteins*/genetics , tau Proteins*/metabolism , tau Proteins*/chemistry , Genetic Code*, Humans ; Isotope Labeling

Rising Stars: Molecular Mechanisms and Chemical Interventions of α-Synuclein Amyloid Aggregation in Parkinson's Disease.

Authors: Zhang S Liu K Li D et al.

Source: Journal of molecular biology [J Mol Biol] 2025 Dec 15; Vol. 437 (24), pp. 169475. Date of Electronic Publication: 2025 Oct 09.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE

MeSH Terms: alpha-Synuclein*/metabolism , alpha-Synuclein*/chemistry , alpha-Synuclein*/genetics , Parkinson Disease*/metabolism , Parkinson Disease*/pathology , Parkinson Disease*/drug therapy , Amyloid*/metabolism , Amyloid*/chemistry , Protein Aggregation, Pathological*/metabolism, Humans ; Animals ; Protein Aggregates ; Autophagy

Inhibition or genetic reduction of ASAH1/acid ceramidase restore α-synuclein clearance in mutant GBA1 dopamine neurons from Parkinson's patients.

Authors: Kumar M Feldman RA

Source: Human molecular genetics [Hum Mol Genet] 2025 Dec 04; Vol. 34 (24), pp. 2075-2087.

Publication Type: Journal Article

Journal Info: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE

MeSH Terms: Glucosylceramidase*/genetics , Glucosylceramidase*/metabolism , Parkinson Disease*/genetics , Parkinson Disease*/metabolism , Parkinson Disease*/pathology , alpha-Synuclein*/metabolism , alpha-Synuclein*/genetics , Acid Ceramidase*/genetics , Acid Ceramidase*/metabolism , Acid Ceramidase*/antagonists & inhibitors , Dopaminergic Neurons*/metabolism , Dopaminergic Neurons*/pathology, Humans ; Induced Pluripotent Stem Cells/metabolism ; Mutation ; Lysosomes/metabolism ; Gaucher Disease/genetics ; Gaucher Disease/pathology ; Gaucher Disease/metabolism ; Autophagy

Dermal Alpha-Synuclein Aggregation in Seed Amplification Assays for Parkinson's Disease Subtype Differentiation.

Authors: Vieregge M Kuzkina A Janzen A et al.

Source: European journal of neurology [Eur J Neurol] 2025 Dec; Vol. 32 (12), pp. e70453.

Publication Type: Journal Article

Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 9506311 Publication Model: Print Cited Medium: Internet ISSN: 1468-1331 (Electronic) Linking ISSN: 13515101 NLM ISO Abbreviation: Eur J Neurol Subsets: MEDLINE

MeSH Terms: Parkinson Disease*/metabolism , Parkinson Disease*/diagnosis , Parkinson Disease*/classification , Parkinson Disease*/pathology , Parkinson Disease*/complications , alpha-Synuclein*/metabolism , Skin*/metabolism , Skin*/pathology , Skin*/innervation, Humans ; Male ; Female ; Aged ; Middle Aged ; REM Sleep Behavior Disorder/metabolism

Animal Models of Parkinson's Disease.

Authors: Dawson VL Dawson TM

Source: Cold Spring Harbor perspectives in medicine [Cold Spring Harb Perspect Med] 2025 Dec 01; Vol. 15 (12). Date of Electronic Publication: 2025 Dec 01.

Publication Type: Journal Article; Review

Journal Info: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 101571139 Publication Model: Electronic Cited Medium: Internet ISSN: 2157-1422 (Electronic) Linking ISSN: 21571422 NLM ISO Abbreviation: Cold Spring Harb Perspect Med Subsets: MEDLINE

MeSH Terms: Parkinson Disease*/genetics , Parkinson Disease*/pathology , Disease Models, Animal* , alpha-Synuclein*/genetics , alpha-Synuclein*/metabolism, Animals ; Mice ; Humans ; Mice, Knockout ; Mice, Transgenic

Development of a CRISPR/Cas13a-based electrochemiluminescence biosensing strategy for sensitive detection of α-synuclein oligomers in neurodegenerative diseases.

Authors: Gong Y Li G Meng Y et al.

Source: Bioelectrochemistry (Amsterdam, Netherlands) [Bioelectrochemistry] 2025 Dec; Vol. 166, pp. 109038. Date of Electronic Publication: 2025 Jun 28.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 100953583 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-562X (Electronic) Linking ISSN: 15675394 NLM ISO Abbreviation: Bioelectrochemistry Subsets: MEDLINE

MeSH Terms: alpha-Synuclein*/blood , alpha-Synuclein*/analysis , Biosensing Techniques*/methods , CRISPR-Cas Systems* , Neurodegenerative Diseases*/blood , Neurodegenerative Diseases*/diagnosis , Luminescent Measurements*/methods , Electrochemical Techniques*/methods, Humans ; Limit of Detection

Co-Expression of Mutant Tau and α-Synuclein in Neurons Promotes Tau Phosphorylation, Neuronal Loss, and Neuroinflammation in Mouse Brain.

Authors: Yamamoto Y Kubota T Noguchi D et al.

Source: Molecular neurobiology [Mol Neurobiol] 2025 Dec; Vol. 62 (12), pp. 15832-15843. Date of Electronic Publication: 2025 Jul 25.

Publication Type: Journal Article

Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

MeSH Terms: alpha-Synuclein*/metabolism , alpha-Synuclein*/genetics , tau Proteins*/metabolism , tau Proteins*/genetics , Neurons*/metabolism , Neurons*/pathology , Brain*/pathology , Brain*/metabolism , Neuroinflammatory Diseases*/pathology , Neuroinflammatory Diseases*/metabolism , Mutation*/genetics, Animals ; Phosphorylation ; Mice, Transgenic ; Mice ; Mice, Inbred C57BL ; Microglia/metabolism ; Microglia/pathology

Autophagy activation ameliorates cognitive deficits and alpha-synuclein pathology in an adeno-associated viral vector mediated rat model of Lewy body disorders.

Authors: Cinar E Yalcin-Cakmakli G Akyel H et al.

Source: Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2025 Dec; Vol. 257, pp. 174096. Date of Electronic Publication: 2025 Sep 10.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0367050 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5177 (Electronic) Linking ISSN: 00913057 NLM ISO Abbreviation: Pharmacol Biochem Behav Subsets: MEDLINE

MeSH Terms: alpha-Synuclein*/metabolism , alpha-Synuclein*/genetics , Autophagy*/drug effects , Autophagy*/physiology , Dependovirus*/genetics , Lewy Body Disease*/pathology , Lewy Body Disease*/metabolism , Lewy Body Disease*/psychology , Lewy Body Disease*/therapy , Cognitive Dysfunction*/therapy, Animals ; Rats ; Male ; Disease Models, Animal ; Genetic Vectors ; Sirolimus/pharmacology ; Humans ; Rats, Sprague-Dawley