Suchergebnisse - "alpha-Glucosidases"

Mechanistic study of α-mangostin derivatives as potent α-glucosidase inhibitors.

Autoren: Sanachai K Chamni S Nutho B et al.

Quelle: Molecular diversity [Mol Divers] 2025 Dec; Vol. 29 (6), pp. 6293-6309. Date of Electronic Publication: 2025 Feb 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE

MeSH-Schlagworte: Glycoside Hydrolase Inhibitors*/chemistry , Glycoside Hydrolase Inhibitors*/pharmacology , Xanthones*/chemistry , Xanthones*/pharmacology , alpha-Glucosidases*/metabolism , alpha-Glucosidases*/chemistry, Molecular Docking Simulation ; Molecular Dynamics Simulation ; Structure-Activity Relationship ; Catalytic Domain ; Kinetics ; Humans

Infantile-onset Pompe disease entering adulthood: Insights from 2 decades of enzyme replacement therapy experience.

Autoren: Regmi N Kenney-Jung D Stafford G et al.

Quelle: Genetics in medicine : official journal of the American College of Medical Genetics [Genet Med] 2025 Dec; Vol. 27 (12), pp. 101590. Date of Electronic Publication: 2025 Sep 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 9815831 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0366 (Electronic) Linking ISSN: 10983600 NLM ISO Abbreviation: Genet Med Subsets: MEDLINE

MeSH-Schlagworte: Glycogen Storage Disease Type II*/drug therapy , Glycogen Storage Disease Type II*/therapy , Enzyme Replacement Therapy*/methods , alpha-Glucosidases*/therapeutic use , alpha-Glucosidases*/administration & dosage, Humans ; Male ; Female ; Adolescent ; Adult ; Young Adult ; Child ; Magnetic Resonance Imaging ; Treatment Outcome ; Infant ; Age of Onset ; Brain/pathology

Inhibition mechanisms of daidzein and genistein against α-amylase and α-glucosidase.

Autoren: Kou X Li H Xu X

Quelle: International journal of biological macromolecules [Int J Biol Macromol] 2025 Dec; Vol. 333 (Pt 1), pp. 148794. Date of Electronic Publication: 2025 Nov 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH-Schlagworte: Genistein*/pharmacology , Genistein*/chemistry , Isoflavones*/pharmacology , Isoflavones*/chemistry , alpha-Glucosidases*/chemistry , alpha-Glucosidases*/metabolism , alpha-Amylases*/antagonists & inhibitors , alpha-Amylases*/chemistry , alpha-Amylases*/metabolism , Glycoside Hydrolase Inhibitors*/pharmacology , Glycoside Hydrolase Inhibitors*/chemistry, Animals ; Molecular Docking Simulation ; Mice ; Kinetics

Biochemical characterization and activity enhancement of a GH13 thermostable oligo-α-1,6-glucosidase from Geobacillus stearothermophilus.

Autoren: Hekim S Kaçıran A Akmehmet AN et al.

Quelle: International journal of biological macromolecules [Int J Biol Macromol] 2025 Dec; Vol. 332 (Pt 1), pp. 148568. Date of Electronic Publication: 2025 Oct 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH-Schlagworte: Geobacillus stearothermophilus*/enzymology , Geobacillus stearothermophilus*/genetics , alpha-Glucosidases*/chemistry , alpha-Glucosidases*/genetics , alpha-Glucosidases*/metabolism, Enzyme Stability ; Temperature ; Kinetics ; Molecular Docking Simulation ; Mutagenesis, Site-Directed ; Hydrogen-Ion Concentration ; Substrate Specificity

Macromolecular scaffolds with nitrogen-sulfur motifs: Dual α-glucosidase and urease inhibition with molecular docking and mechanistic evaluation.

Autoren: Khan S Iqbal T Abass KS et al.

Quelle: International journal of biological macromolecules [Int J Biol Macromol] 2025 Dec; Vol. 332 (Pt 1), pp. 148369. Date of Electronic Publication: 2025 Oct 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH-Schlagworte: Molecular Docking Simulation* , Urease*/antagonists & inhibitors , Urease*/chemistry , Urease*/metabolism , alpha-Glucosidases*/chemistry , alpha-Glucosidases*/metabolism , Glycoside Hydrolase Inhibitors*/chemistry , Glycoside Hydrolase Inhibitors*/pharmacology , Glycoside Hydrolase Inhibitors*/chemical synthesis , Nitrogen*/chemistry , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemical synthesis , Sulfur*/chemistry, Structure-Activity Relationship ; Indoles/chemistry ; Sulfonamides/chemistry ; Sulfonamides/pharmacology ; Thiadiazoles/chemistry

A stable GH31 α-glucosidase as a model system for the study of mutations leading to human glycogen storage disease type II.

Autoren: Iacono R Paragliola FMP Strazzulli A et al.

Quelle: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2468859. Date of Electronic Publication: 2025 Feb 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

MeSH-Schlagworte: alpha-Glucosidases*/genetics , alpha-Glucosidases*/metabolism , alpha-Glucosidases*/chemistry , Glycogen Storage Disease Type II*/genetics , Glycogen Storage Disease Type II*/enzymology , Glycogen Storage Disease Type II*/metabolism , Mutation*, Humans ; Enzyme Stability ; Structure-Activity Relationship ; Molecular Structure ; Models, Molecular

Formation of branched oligosaccharides during sake brewing via transglycosylation by Aspergillus oryzae α-glucosidases.

Autoren: Honda C Kosuge MT Katsuta R et al.

Quelle: Food chemistry [Food Chem] 2025 Nov 30; Vol. 493 (Pt 2), pp. 145845. Date of Electronic Publication: 2025 Aug 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

MeSH-Schlagworte: Aspergillus oryzae*/enzymology , Aspergillus oryzae*/genetics , Aspergillus oryzae*/metabolism , Oligosaccharides*/chemistry , Oligosaccharides*/metabolism , Fungal Proteins*/metabolism , Fungal Proteins*/genetics , Fungal Proteins*/chemistry , alpha-Glucosidases*/metabolism , alpha-Glucosidases*/genetics , alpha-Glucosidases*/chemistry , Alcoholic Beverages*/analysis , Alcoholic Beverages*/microbiology, Glycosylation ; Oryza/microbiology ; Oryza/metabolism ; Fermentation

Nanoflower-structured MnO 2 /Au composites with enhanced catalytic performance for colorimetric assay of α-glucosidase.

Autoren: Zhang X Cao J Chen X et al.

Quelle: Analytica chimica acta [Anal Chim Acta] 2025 Nov 22; Vol. 1376, pp. 344632. Date of Electronic Publication: 2025 Sep 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0370534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4324 (Electronic) Linking ISSN: 00032670 NLM ISO Abbreviation: Anal Chim Acta Subsets: MEDLINE

MeSH-Schlagworte: Manganese Compounds*/chemistry , Colorimetry*/methods , Oxides*/chemistry , Gold*/chemistry , alpha-Glucosidases*/metabolism , alpha-Glucosidases*/analysis , alpha-Glucosidases*/blood , Nanocomposites*/chemistry , Nanostructures*/chemistry, Humans ; Catalysis ; Benzidines/chemistry ; Limit of Detection ; Biocatalysis

Identification of novel triazolopyrimidines as potent α-glucosidase inhibitor through design, synthesis, biological evaluations, and computational analysis.

Autoren: Peytam F Norouzbahari M Gulcan HO et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 12; Vol. 15 (1), pp. 39667. Date of Electronic Publication: 2025 Nov 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Glycoside Hydrolase Inhibitors*/pharmacology , Glycoside Hydrolase Inhibitors*/chemical synthesis , Glycoside Hydrolase Inhibitors*/chemistry , alpha-Glucosidases*/metabolism , alpha-Glucosidases*/chemistry , Pyrimidines*/chemistry , Pyrimidines*/pharmacology , Pyrimidines*/chemical synthesis , Triazoles*/chemistry , Triazoles*/pharmacology , Triazoles*/chemical synthesis, Molecular Docking Simulation ; Drug Design ; Humans ; Molecular Dynamics Simulation ; Structure-Activity Relationship ; Kinetics ; Diabetes Mellitus, Type 2/drug therapy

Synthesis, in vitro, and in silico studies of 4-chlorophenyl-sulfonyl Indole based thiosemicarbazones as competitive α-glucosidase inhibitors.

Autoren: Naseer I Ullah S Batool Z et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 06; Vol. 15 (1), pp. 38832. Date of Electronic Publication: 2025 Nov 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Glycoside Hydrolase Inhibitors*/chemical synthesis , Glycoside Hydrolase Inhibitors*/pharmacology , Glycoside Hydrolase Inhibitors*/chemistry , Thiosemicarbazones*/chemical synthesis , Thiosemicarbazones*/chemistry , Thiosemicarbazones*/pharmacology , alpha-Glucosidases*/metabolism , alpha-Glucosidases*/chemistry , Indoles*/chemistry, Molecular Docking Simulation ; Molecular Dynamics Simulation ; Humans ; Structure-Activity Relationship ; Hypoglycemic Agents/chemical synthesis ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/chemistry ; Catalytic Domain

Design, Synthesis, and Biological Evaluation of 1,2,3-Triazole-Quinazolinone Derivatives as Promising α-Glucosidase Inhibitors with Favorable Drug-Like Properties.

Autoren: Sirichai T Uipanit S Borwornpinyo S et al.

Quelle: Chemistry, an Asian journal [Chem Asian J] 2025 Nov; Vol. 20 (22), pp. e70365. Date of Electronic Publication: 2025 Oct 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101294643 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1861-471X (Electronic) Linking ISSN: 1861471X NLM ISO Abbreviation: Chem Asian J Subsets: MEDLINE

MeSH-Schlagworte: Glycoside Hydrolase Inhibitors*/chemical synthesis , Glycoside Hydrolase Inhibitors*/pharmacology , Glycoside Hydrolase Inhibitors*/chemistry , Quinazolinones*/chemistry , Quinazolinones*/pharmacology , Quinazolinones*/chemical synthesis , Triazoles*/chemistry , Triazoles*/pharmacology , Triazoles*/chemical synthesis , alpha-Glucosidases*/metabolism , alpha-Glucosidases*/chemistry , Drug Design*, Humans ; Structure-Activity Relationship ; Molecular Docking Simulation ; Saccharomyces cerevisiae/enzymology ; Molecular Structure ; Dose-Response Relationship, Drug

Synthesis, in vitro and kinetic study of thiazolidinone derivatives: insight from a network medicinal approach for thymidine phosphorylase and alpha glucosidase.

Autoren: Khan S Iqbal T Chinnam S et al.

Quelle: Future medicinal chemistry [Future Med Chem] 2025 Nov; Vol. 17 (21), pp. 2573-2582. Date of Electronic Publication: 2025 Oct 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Thymidine Phosphorylase*/antagonists & inhibitors , Thymidine Phosphorylase*/metabolism , alpha-Glucosidases*/metabolism , alpha-Glucosidases*/chemistry , Glycoside Hydrolase Inhibitors*/chemistry , Glycoside Hydrolase Inhibitors*/chemical synthesis , Glycoside Hydrolase Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemical synthesis , Thiazolidines*/chemistry , Thiazolidines*/chemical synthesis , Thiazolidines*/pharmacology , Thiazolidines*/pharmacokinetics, Kinetics ; Molecular Docking Simulation ; Humans ; Structure-Activity Relationship

Clinical modeling of motor function to predict treatment efficacy and enable in silico treatment comparisons in infantile-onset Pompe disease.

Autoren: Rachedi F Jreich R Sparks S et al.

Quelle: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2025 Nov; Vol. 14 (11), pp. 1797-1809. Date of Electronic Publication: 2024 Dec 13.

Publikationsart: Journal Article; Comparative Study

Info zur Zeitschrift: Publisher: Wiley Country of Publication: United States NLM ID: 101580011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2163-8306 (Electronic) Linking ISSN: 21638306 NLM ISO Abbreviation: CPT Pharmacometrics Syst Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Glycogen Storage Disease Type II*/drug therapy , Glycogen Storage Disease Type II*/physiopathology , alpha-Glucosidases*/therapeutic use , alpha-Glucosidases*/administration & dosage , Models, Biological*, Humans ; Computer Simulation ; Treatment Outcome ; Male ; Female ; Infant ; Child, Preschool ; Oligosaccharides/urine ; Child

Long-Term Functional Correction of Pompe Disease and Increased α-Glucosidase Expression after Gene Therapy with Novel Combinations of Muscle-Targeted Transcriptional Cis -Regulatory Elements.

Autoren: Pham QH Bheemsetty VA Nguyen PA et al.

Quelle: Human gene therapy [Hum Gene Ther] 2025 Nov; Vol. 36 (21-22), pp. 1423-1440. Date of Electronic Publication: 2025 Jul 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: M.A. Liebert Country of Publication: United States NLM ID: 9008950 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-7422 (Electronic) Linking ISSN: 10430342 NLM ISO Abbreviation: Hum Gene Ther Subsets: MEDLINE

MeSH-Schlagworte: Glycogen Storage Disease Type II*/therapy , Glycogen Storage Disease Type II*/genetics , Genetic Therapy*/methods , alpha-Glucosidases*/genetics , alpha-Glucosidases*/metabolism , Regulatory Elements, Transcriptional*, Animals ; Mice ; Dependovirus/genetics ; Humans ; Genetic Vectors/genetics ; Genetic Vectors/administration & dosage ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Mice, Knockout ; Promoter Regions, Genetic ; Disease Models, Animal

Thioflavonols as potent α-glucosidase inhibitors: in vitro , in vivo , and computational analysis.

Autoren: Mughal EU Naeem N Shakoor B et al.

Quelle: Future medicinal chemistry [Future Med Chem] 2025 Nov; Vol. 17 (22), pp. 1-20. Date of Electronic Publication: 2025 Oct 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Glycoside Hydrolase Inhibitors*/chemistry , Glycoside Hydrolase Inhibitors*/pharmacology , Glycoside Hydrolase Inhibitors*/therapeutic use , Glycoside Hydrolase Inhibitors*/chemical synthesis , alpha-Glucosidases*/metabolism , alpha-Glucosidases*/chemistry , Hypoglycemic Agents*/chemistry , Hypoglycemic Agents*/pharmacology , Hypoglycemic Agents*/chemical synthesis , Hypoglycemic Agents*/therapeutic use, Molecular Docking Simulation ; Humans ; Structure-Activity Relationship ; Molecular Dynamics Simulation ; Animals ; Molecular Structure ; Diabetes Mellitus, Type 2/drug therapy ; Density Functional Theory

An Indirect Treatment Comparison of Avalglucosidase Alfa versus Cipaglucosidase Alfa Plus Miglustat in Patients with Late-Onset Pompe Disease.

Autoren: Roberts ME Proskorovsky I Guyot P et al.

Quelle: Advances in therapy [Adv Ther] 2025 Nov; Vol. 42 (11), pp. 5578-5599. Date of Electronic Publication: 2025 Sep 08.

Publikationsart: Comparative Study; Journal Article

Info zur Zeitschrift: Publisher: Health Communications Inc Country of Publication: United States NLM ID: 8611864 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1865-8652 (Electronic) Linking ISSN: 0741238X NLM ISO Abbreviation: Adv Ther Subsets: MEDLINE

MeSH-Schlagworte: 1-Deoxynojirimycin*/analogs & derivatives , 1-Deoxynojirimycin*/therapeutic use , 1-Deoxynojirimycin*/administration & dosage , 1-Deoxynojirimycin*/analogs & derivatives , alpha-Glucosidases*/therapeutic use , alpha-Glucosidases*/administration & dosage , Enzyme Replacement Therapy*/methods , Glycogen Storage Disease Type II*/drug therapy, Adult ; Female ; Humans ; Male ; Middle Aged ; Drug Therapy, Combination ; Treatment Outcome

Design, synthesis, kinetic analysis, molecular docking, and mechanistic studies of novel coumarin-oxadiazole derivatives as α-glucosidase and PTP1B inhibitors.

Autoren: Zhao Y Peng Z Wang G

Quelle: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2025 Nov 01; Vol. 129, pp. 118321. Date of Electronic Publication: 2025 Jul 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Protein Tyrosine Phosphatase, Non-Receptor Type 1*/antagonists & inhibitors , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/metabolism , Oxadiazoles*/chemistry , Oxadiazoles*/pharmacology , Oxadiazoles*/chemical synthesis , Coumarins*/chemistry , Coumarins*/pharmacology , Coumarins*/chemical synthesis , alpha-Glucosidases*/metabolism , alpha-Glucosidases*/chemistry , Glycoside Hydrolase Inhibitors*/chemistry , Glycoside Hydrolase Inhibitors*/chemical synthesis , Glycoside Hydrolase Inhibitors*/pharmacology , Drug Design* , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/chemical synthesis , Hypoglycemic Agents*/chemical synthesis , Hypoglycemic Agents*/pharmacology , Hypoglycemic Agents*/chemistry, Molecular Docking Simulation ; Kinetics ; Humans ; Animals ; Structure-Activity Relationship ; Molecular Structure

Low-triggering-potential electrochemiluminescence biosensor based on hydrogen-bonded organic framework and luminol-derived carbon dots for α-glucosidase detection.

Autoren: Yang Y Cao X Song L et al.

Quelle: Biosensors & bioelectronics [Biosens Bioelectron] 2025 Nov 01; Vol. 287, pp. 117761. Date of Electronic Publication: 2025 Jul 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Advanced Technology Country of Publication: England NLM ID: 9001289 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4235 (Electronic) Linking ISSN: 09565663 NLM ISO Abbreviation: Biosens Bioelectron Subsets: MEDLINE

MeSH-Schlagworte: Biosensing Techniques*/methods , Luminol*/chemistry , alpha-Glucosidases*/isolation & purification , alpha-Glucosidases*/chemistry , alpha-Glucosidases*/blood , alpha-Glucosidases*/analysis , Quantum Dots*/chemistry, Carbon/chemistry ; Electrochemical Techniques/methods ; Luminescent Measurements/methods ; Hydrogen Bonding ; Limit of Detection ; Metal-Organic Frameworks/chemistry ; Humans ; Perylene/chemistry ; Perylene/analogs & derivatives

Exploring the Antidiabetic Properties of Polyalthia longifolia Leaf and Stem Extracts: In Vitro α-Glucosidase and Glycation Inhibition.

Autoren: Froldi G Simo MK Tomasi L et al.

Quelle: Molecules (Basel, Switzerland) [Molecules] 2025 Oct 31; Vol. 30 (21). Date of Electronic Publication: 2025 Oct 31.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

MeSH-Schlagworte: Plant Extracts*/pharmacology , Plant Extracts*/chemistry , Hypoglycemic Agents*/pharmacology , Hypoglycemic Agents*/chemistry , Plant Leaves*/chemistry , Glycoside Hydrolase Inhibitors*/pharmacology , Glycoside Hydrolase Inhibitors*/chemistry , alpha-Glucosidases*/metabolism , alpha-Glucosidases*/chemistry , Plant Stems*/chemistry , Polyalthia*/chemistry, Humans ; HT29 Cells ; Cell Survival/drug effects ; Glycosylation/drug effects ; Flavonoids/chemistry ; Flavonoids/pharmacology ; Phenols/chemistry ; Phenols/pharmacology

Discovery of α-glucosidase inhibitors from Paenibacillus sp. JNUCC 31 via genome mining, fatty acid profiling, and in silico analysis.

Autoren: Xu Y Liang X Hyun CG

Quelle: Scientific reports [Sci Rep] 2025 Oct 31; Vol. 15 (1), pp. 38133. Date of Electronic Publication: 2025 Oct 31.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Glycoside Hydrolase Inhibitors*/pharmacology , Glycoside Hydrolase Inhibitors*/chemistry , Glycoside Hydrolase Inhibitors*/isolation & purification , Glycoside Hydrolase Inhibitors*/metabolism , Paenibacillus*/genetics , Paenibacillus*/metabolism , Paenibacillus*/chemistry , Fatty Acids*/metabolism , Fatty Acids*/chemistry , alpha-Glucosidases*/metabolism , alpha-Glucosidases*/chemistry, Molecular Docking Simulation ; Computer Simulation ; Humans ; Genome, Bacterial ; Adenosine/chemistry ; Adenosine/pharmacology ; Kinetics ; Uridine/pharmacology ; Uridine/chemistry