Výsledky vyhľadávania - "YAP-Signaling Proteins"

Targeted degradation of endogenous YAP by nanobody bioPROTAC inhibits tumor progression.

Autori: Zhou R Wang H Zhang GM a ďalší

Zdroj: Nature communications [Nat Commun] 2025 Oct 23; Vol. 16 (1), pp. 9374. Date of Electronic Publication: 2025 Oct 23.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Výrazy zo slovníka MeSH: Genetic Vectors* , Neoplasms*/therapy , Proteolysis Targeting Chimera*/administration & dosage , Proteolysis Targeting Chimera*/chemical synthesis , Single-Domain Antibodies*/administration & dosage , Single-Domain Antibodies*/chemistry , YAP-Signaling Proteins*/antagonists & inhibitors , YAP-Signaling Proteins*/immunology , YAP-Signaling Proteins*/metabolism, Animals ; Female ; Humans ; Male ; Mice ; Cell Line, Tumor ; Dependovirus ; Lentivirus ; Nanoparticle Drug Delivery System ; Proof of Concept Study ; Xenograft Model Antitumor Assays ; Zebrafish ; Proteasome Endopeptidase Complex/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Nuclear Proteins ; Transcription Factors

Abnormal expression of Hippo-YAP1 signalling pathway and progesterone resistance mechanism in endometrial polyps.

Autori: Yu X Kong W Shang K a ďalší

Zdroj: Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology [J Obstet Gynaecol] 2025 Dec; Vol. 45 (1), pp. 2533965. Date of Electronic Publication: 2025 Jul 23.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8309140 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1364-6893 (Electronic) Linking ISSN: 01443615 NLM ISO Abbreviation: J Obstet Gynaecol Subsets: MEDLINE

Výrazy zo slovníka MeSH: YAP-Signaling Proteins*/metabolism , Hippo Signaling Pathway* , Polyps*/metabolism , Polyps*/pathology , Polyps*/genetics , Uterine Diseases*/metabolism , Uterine Diseases*/pathology , Uterine Diseases*/genetics, Female ; Humans ; Endometrium/pathology ; Endometrium/metabolism ; Endometrium/abnormalities ; Adult ; Middle Aged ; Prolactin/metabolism ; Receptors, Progesterone/metabolism ; Protein Serine-Threonine Kinases/metabolism ; Signal Transduction ; Progesterone ; Adaptor Proteins, Signal Transducing/metabolism ; Transcription Factors/metabolism

SCR Disease Name: Progesterone Resistance

Yes-associated protein regulates autophagy to restore skin barrier function in atopic dermatitis.

Autori: Jia J Ma X Wang T a ďalší

Zdroj: Frontiers in immunology [Front Immunol] 2025 Nov 19; Vol. 16, pp. 1681148. Date of Electronic Publication: 2025 Nov 19 (Print Publication: 2025).

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Dermatitis, Atopic*/metabolism , Dermatitis, Atopic*/pathology , Dermatitis, Atopic*/immunology , Dermatitis, Atopic*/genetics , Dermatitis, Atopic*/etiology , Autophagy* , Skin*/metabolism , Skin*/pathology , Skin*/immunology , YAP-Signaling Proteins*/metabolism , Adaptor Proteins, Signal Transducing*/genetics , Adaptor Proteins, Signal Transducing*/metabolism, Humans ; Animals ; Filaggrin Proteins ; Mice ; Disease Models, Animal ; Female ; Male ; HaCaT Cells

The YAP1/GPX4 axis alleviates osteoporosis by affecting ferroptosis in osteoblasts.

Autori: Deng M Zhou Y Liu G a ďalší

Zdroj: Molecular medicine (Cambridge, Mass.) [Mol Med] 2025 Oct 21; Vol. 31 (1), pp. 315. Date of Electronic Publication: 2025 Oct 21.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 9501023 Publication Model: Electronic Cited Medium: Internet ISSN: 1528-3658 (Electronic) Linking ISSN: 10761551 NLM ISO Abbreviation: Mol Med Subsets: MEDLINE

Výrazy zo slovníka MeSH: Ferroptosis*/genetics , Osteoblasts*/metabolism , Phospholipid Hydroperoxide Glutathione Peroxidase*/metabolism , Phospholipid Hydroperoxide Glutathione Peroxidase*/genetics , Osteoporosis*/metabolism , Osteoporosis*/pathology , Osteoporosis*/etiology , Osteoporosis*/genetics , YAP-Signaling Proteins*/metabolism , Adaptor Proteins, Signal Transducing*/metabolism , Adaptor Proteins, Signal Transducing*/genetics , Cell Cycle Proteins*/metabolism, Animals ; Mice ; Female ; Humans ; Mice, Knockout ; Disease Models, Animal ; Bone Density ; Signal Transduction

YAP/Nrf2 suppresses ferroptosis to alleviate acute lung injury induced by intestinal ischemia/reperfusion.

Autori: Tang L Yang C Peng Y a ďalší

Zdroj: Redox biology [Redox Biol] 2025 Oct; Vol. 86, pp. 103811. Date of Electronic Publication: 2025 Aug 05.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE

Výrazy zo slovníka MeSH: NF-E2-Related Factor 2*/metabolism , NF-E2-Related Factor 2*/genetics , Acute Lung Injury*/etiology , Acute Lung Injury*/metabolism , Acute Lung Injury*/pathology , Ferroptosis* , Reperfusion Injury*/complications , Reperfusion Injury*/metabolism , Reperfusion Injury*/pathology , YAP-Signaling Proteins*/metabolism , Intestines*/pathology , Adaptor Proteins, Signal Transducing*/metabolism , Adaptor Proteins, Signal Transducing*/genetics, Animals ; Mice ; Humans ; Male ; Disease Models, Animal ; Signal Transduction

Mechanical Stimulation Induces Yap Mediated OCTN2 Transcription to Enhance Carnitine Metabolism in Sarcopenia.

Autori: Lu Y Bai Y Li W a ďalší

Zdroj: Journal of cachexia, sarcopenia and muscle [J Cachexia Sarcopenia Muscle] 2025 Oct; Vol. 16 (5), pp. e70052.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders Country of Publication: Germany NLM ID: 101552883 Publication Model: Print Cited Medium: Internet ISSN: 2190-6009 (Electronic) Linking ISSN: 21905991 NLM ISO Abbreviation: J Cachexia Sarcopenia Muscle Subsets: MEDLINE

Výrazy zo slovníka MeSH: Sarcopenia*/metabolism , Sarcopenia*/genetics , Sarcopenia*/pathology , Carnitine*/metabolism , Solute Carrier Family 22 Member 5*/genetics , Solute Carrier Family 22 Member 5*/metabolism , YAP-Signaling Proteins*/metabolism, Female ; Humans ; Animals ; Male ; Aged ; Mice ; Muscle, Skeletal/metabolism ; Middle Aged ; Disease Models, Animal

Yes-Associated Protein (YAP) Is Associated With Disease Severity and Visual Prognosis in Epiretinal Membrane.

Autori: Yang HS Jo YH Kim D a ďalší

Zdroj: Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2025 Aug 01; Vol. 66 (11), pp. 39.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Association For Research In Vision And Ophthalmology (Arvo) Country of Publication: United States NLM ID: 7703701 Publication Model: Print Cited Medium: Internet ISSN: 1552-5783 (Electronic) Linking ISSN: 01460404 NLM ISO Abbreviation: Invest Ophthalmol Vis Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Vitrectomy* , Epiretinal Membrane*/diagnosis , Epiretinal Membrane*/pathology , Epiretinal Membrane*/surgery , YAP-Signaling Proteins*/analysis , YAP-Signaling Proteins*/metabolism , Visual Acuity*, Prospective Studies ; Severity of Illness Index ; Prognosis ; Biomarkers/analysis ; Biomarkers/metabolism ; Tomography, Optical Coherence ; Treatment Outcome ; Disease Progression ; Postoperative Period ; Vitreous Body/pathology ; Vitreous Body/surgery ; Humans ; Male ; Female ; Middle Aged ; Aged ; Aged, 80 and over

Nucleus YAP expression as a prognostic biomarker for local recurrence in eyelid sebaceous carcinoma.

Autori: Byeon HJ Kim H Chang MS a ďalší

Zdroj: Scientific reports [Sci Rep] 2025 Sep 26; Vol. 15 (1), pp. 33113. Date of Electronic Publication: 2025 Sep 26.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Výrazy zo slovníka MeSH: Eyelid Neoplasms*/metabolism , Adenocarcinoma, Sebaceous*/metabolism , Sebaceous Gland Neoplasms*/metabolism , YAP-Signaling Proteins*/metabolism , Receptors, Androgen*/metabolism , Neoplasm Recurrence, Local*/metabolism, Humans ; Male ; Female ; Young Adult ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/metabolism ; Immunohistochemistry

Unlocking the power of immune checkpoint inhibitors: Targeting YAP1 reduces anti-PD1 resistance in skin cutaneous melanoma.

Autori: Kovács SA Kovács T Lánczky A a ďalší

Zdroj: British journal of pharmacology [Br J Pharmacol] 2025 Aug; Vol. 182 (16), pp. 3903-3922. Date of Electronic Publication: 2025 May 05.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: YAP-Signaling Proteins*/antagonists & inhibitors , Immune Checkpoint Inhibitors*/pharmacology , Immune Checkpoint Inhibitors*/therapeutic use , Skin Neoplasms*/drug therapy , Skin Neoplasms*/metabolism , Skin Neoplasms*/pathology , Skin Neoplasms*/genetics , Drug Resistance, Neoplasm*/drug effects , Melanoma*/drug therapy , Melanoma*/pathology , Melanoma*/genetics , Melanoma*/metabolism , Programmed Cell Death 1 Receptor*/antagonists & inhibitors , Adaptor Proteins, Signal Transducing*/antagonists & inhibitors , Adaptor Proteins, Signal Transducing*/metabolism , Transcription Factors*/antagonists & inhibitors , Transcription Factors*/metabolism, Animals ; Mice ; Mice, Inbred C57BL ; Humans ; Cell Line, Tumor ; Verteporfin/pharmacology ; Female ; Melanoma, Experimental/drug therapy

Estrogen-induced YAP1 activation disrupts chorionic trophoblast barrier integrity in spontaneous preterm labor.

Autori: Lin Q Cao J Zhu Y a ďalší

Zdroj: Placenta [Placenta] 2025 Aug; Vol. 168, pp. 241-252. Date of Electronic Publication: 2025 Jul 03.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8006349 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3102 (Electronic) Linking ISSN: 01434004 NLM ISO Abbreviation: Placenta Subsets: MEDLINE

Výrazy zo slovníka MeSH: Trophoblasts*/metabolism , YAP-Signaling Proteins*/metabolism , Estradiol*/blood , Obstetric Labor, Premature*/blood , Obstetric Labor, Premature*/diagnosis , Chorion*/cytology , Chorion*/metabolism, Humans ; Female ; Pregnancy ; Plasminogen Activator Inhibitor 1/blood ; Enzyme-Linked Immunosorbent Assay ; Signal Transduction/physiology ; Pregnancy Trimester, Second/blood ; Early Diagnosis ; Biomarkers/analysis ; Keratin-6/metabolism

NF2 is Essential for Human Endoderm Development.

Autori: Jeong M Han D Bhetariya P a ďalší

Zdroj: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 May; Vol. 12 (17), pp. e2410909. Date of Electronic Publication: 2025 Feb 08.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

Výrazy zo slovníka MeSH: Endoderm*/growth & development , Endoderm*/metabolism , Neurofibromin 2*/genetics , Neurofibromin 2*/metabolism , YAP-Signaling Proteins*/genetics , YAP-Signaling Proteins*/metabolism , Neurofibromatosis 2*/genetics , Neurofibromatosis 2*/pathology, Humans ; Induced Pluripotent Stem Cells ; Mutation ; Gene Knockout Techniques ; Cell Differentiation ; Gene Expression Regulation, Developmental ; Cell Line ; Fibroblasts ; Primary Cell Culture ; Dermis/cytology ; Dermis/pathology ; Exons/genetics ; Animals ; Mice

Baricitinib Mitigates Methotrexate-Induced Liver Fibrosis Model via YAP Pathway.

Autori: Ulusan M Erdogan MA Simsek O a ďalší

Zdroj: Medicina (Kaunas, Lithuania) [Medicina (Kaunas)] 2025 May 06; Vol. 61 (5). Date of Electronic Publication: 2025 May 06.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: MDPI Country of Publication: Switzerland NLM ID: 9425208 Publication Model: Electronic Cited Medium: Internet ISSN: 1648-9144 (Electronic) Linking ISSN: 1010660X NLM ISO Abbreviation: Medicina (Kaunas) Subsets: MEDLINE

Výrazy zo slovníka MeSH: Methotrexate*/adverse effects , Sulfonamides*/therapeutic use , Sulfonamides*/pharmacology , Purines*/therapeutic use , Purines*/pharmacology , YAP-Signaling Proteins* , Pyrazoles*/therapeutic use , Pyrazoles*/pharmacology , Liver Cirrhosis*/drug therapy , Liver Cirrhosis*/chemically induced , Azetidines*/therapeutic use , Azetidines*/pharmacology, Animals ; Rats ; Rats, Wistar ; Disease Models, Animal ; Male ; Signal Transduction/drug effects

Matrix stiffening from collagen fibril density and alignment modulates YAP-mediated T-cell immune suppression.

Autori: Sapudom J Alatoom A Tipay PS a ďalší

Zdroj: Biomaterials [Biomaterials] 2025 Apr; Vol. 315, pp. 122900. Date of Electronic Publication: 2024 Oct 20.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5905 (Electronic) Linking ISSN: 01429612 NLM ISO Abbreviation: Biomaterials Subsets: MEDLINE

Výrazy zo slovníka MeSH: T-Lymphocytes*/immunology , T-Lymphocytes*/metabolism , Extracellular Matrix*/metabolism , YAP-Signaling Proteins*/metabolism, Humans ; Collagen/metabolism ; Collagen/chemistry ; Lymphocyte Activation ; Animals ; Transcription Factors/metabolism ; Adaptor Proteins, Signal Transducing/metabolism ; Cell Proliferation ; Signal Transduction ; Cell Movement

A novel Cdc42-YAP-fibronectin signaling axis regulates ameloblast differentiation during early enamel formation.

Autori: Zhang J Gao J Zeng X a ďalší

Zdroj: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2025 Feb; Vol. 1871 (2), pp. 167570. Date of Electronic Publication: 2024 Nov 14.

Spôsob vydávania: Journal Article; Research Support, Non-U.S. Gov't

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-260X (Electronic) Linking ISSN: 09254439 NLM ISO Abbreviation: Biochim Biophys Acta Mol Basis Dis Subsets: MEDLINE

Výrazy zo slovníka MeSH: cdc42 GTP-Binding Protein*/metabolism , cdc42 GTP-Binding Protein*/genetics , Ameloblasts*/metabolism , Ameloblasts*/cytology , Cell Differentiation* , Signal Transduction* , YAP-Signaling Proteins*/metabolism , YAP-Signaling Proteins*/genetics , Fibronectins*/metabolism , Fibronectins*/genetics , Adaptor Proteins, Signal Transducing*/metabolism , Adaptor Proteins, Signal Transducing*/genetics , Amelogenesis*/genetics , Mice, Knockout*, Animals ; Mice ; Dental Enamel/metabolism ; Cell Cycle Proteins/metabolism ; Cell Cycle Proteins/genetics

YAP1 and WWTR1 are required for murine pregnancy initiation.

Autori: Moldovan GE Massri N Vegter EL a ďalší

Zdroj: Reproduction (Cambridge, England) [Reproduction] 2025 Jan 02; Vol. 169 (1). Date of Electronic Publication: 2025 Jan 02 (Print Publication: 2025).

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Published for the Society for Reproduction and Fertility by BioScientifica Country of Publication: England NLM ID: 100966036 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1741-7899 (Electronic) Linking ISSN: 14701626 NLM ISO Abbreviation: Reproduction Subsets: MEDLINE

Výrazy zo slovníka MeSH: YAP-Signaling Proteins*/metabolism , YAP-Signaling Proteins*/genetics , Adaptor Proteins, Signal Transducing*/genetics , Adaptor Proteins, Signal Transducing*/metabolism, Female ; Animals ; Pregnancy ; Mice ; Trans-Activators/genetics ; Trans-Activators/metabolism ; Decidua/metabolism ; Signal Transduction ; Embryo Implantation ; Mutation ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism

Doublecortin-like kinase 1 promotes stem cell-like properties through the Hippo-YAP pathway in prostate cancer.

Autori: Jiang D Li J Ma H a ďalší

Zdroj: International journal of medical sciences [Int J Med Sci] 2025 Jan 01; Vol. 22 (2), pp. 460-472. Date of Electronic Publication: 2025 Jan 01 (Print Publication: 2025).

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101213954 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-1907 (Electronic) Linking ISSN: 14491907 NLM ISO Abbreviation: Int J Med Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Doublecortin-Like Kinases* , Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/pathology , Hippo Signaling Pathway* , Prostatic Neoplasms*/pathology , Prostatic Neoplasms*/genetics , Prostatic Neoplasms*/metabolism , Kruppel-Like Factor 4* , Intracellular Signaling Peptides and Proteins*/metabolism , Intracellular Signaling Peptides and Proteins*/genetics , Protein Serine-Threonine Kinases*/metabolism , Protein Serine-Threonine Kinases*/genetics , Signal Transduction* , Gene Expression Regulation, Neoplastic* , YAP-Signaling Proteins*/metabolism , YAP-Signaling Proteins*/genetics, Humans ; Male ; Animals ; Cell Line, Tumor ; Mice ; Transcription Factors/metabolism ; Transcription Factors/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Adaptor Proteins, Signal Transducing/genetics

miR-6760-5p suppresses neoangiogenesis by targeting Yes-associated protein 1 in patients with moyamoya disease undergoing indirect revascularization.

Autori: Wen Y Chen J Long T a ďalší

Zdroj: Gene [Gene] 2025 Feb 10; Vol. 937, pp. 149152. Date of Electronic Publication: 2024 Dec 09.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 7706761 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0038 (Electronic) Linking ISSN: 03781119 NLM ISO Abbreviation: Gene Subsets: MEDLINE

Výrazy zo slovníka MeSH: Moyamoya Disease*/genetics , Moyamoya Disease*/metabolism , MicroRNAs*/genetics , MicroRNAs*/metabolism , YAP-Signaling Proteins* , Adaptor Proteins, Signal Transducing*/genetics , Adaptor Proteins, Signal Transducing*/metabolism , Human Umbilical Vein Endothelial Cells*/metabolism , Transcription Factors*/genetics , Transcription Factors*/metabolism , Cell Proliferation*/genetics , Neovascularization, Pathologic*/genetics , Neovascularization, Pathologic*/metabolism, Humans ; Cell Movement ; Female ; Male

HSP90 inhibitor AUY922 suppresses tumor growth and modulates immune response through YAP1-TEAD pathway inhibition in gastric cancer.

Autori: Yoshimura K Zou G Fan Y a ďalší

Zdroj: Cancer letters [Cancer Lett] 2025 Feb 01; Vol. 610, pp. 217354. Date of Electronic Publication: 2024 Nov 26.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE

Výrazy zo slovníka MeSH: Stomach Neoplasms*/immunology , Stomach Neoplasms*/drug therapy , Stomach Neoplasms*/pathology , Stomach Neoplasms*/metabolism , HSP90 Heat-Shock Proteins*/antagonists & inhibitors , HSP90 Heat-Shock Proteins*/metabolism , YAP-Signaling Proteins* , Tumor Microenvironment*/drug effects , Transcription Factors*/metabolism , Transcription Factors*/genetics , Adaptor Proteins, Signal Transducing*/metabolism , Isoxazoles*/pharmacology , Resorcinols*/pharmacology , Apoptosis*/drug effects, Humans ; Cell Line, Tumor ; Animals ; Mice ; Cell Proliferation/drug effects ; Signal Transduction/drug effects ; Adenocarcinoma/drug therapy ; Adenocarcinoma/immunology ; Adenocarcinoma/pathology ; Adenocarcinoma/metabolism ; Xenograft Model Antitumor Assays ; Gene Expression Regulation, Neoplastic/drug effects ; TEA Domain Transcription Factors

YAP1 overexpression aggravates the progress of diabetic retinopathy by activating the TUG1/miR-144-3p/VEGFA signaling pathway in the hypoxia-induced DR MRMECs model.

Autori: Yang Y; Department of Ophthalmology, Sichuan Provincial People's Hospital, Chengdu, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. Electronic address: yangying2682023@163.com.

Zdroj: Tissue & cell [Tissue Cell] 2025 Feb; Vol. 92, pp. 102620. Date of Electronic Publication: 2024 Nov 17.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 0214745 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3072 (Electronic) Linking ISSN: 00408166 NLM ISO Abbreviation: Tissue Cell Subsets: MEDLINE

Výrazy zo slovníka MeSH: MicroRNAs*/genetics , MicroRNAs*/metabolism , Diabetic Retinopathy*/metabolism , Diabetic Retinopathy*/pathology , Diabetic Retinopathy*/genetics , YAP-Signaling Proteins*/metabolism , Vascular Endothelial Growth Factor A*/metabolism , Vascular Endothelial Growth Factor A*/genetics , Signal Transduction* , RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/metabolism , Endothelial Cells*/metabolism , Endothelial Cells*/pathology, Animals ; Mice ; Disease Models, Animal ; Cell Hypoxia/genetics ; Cell Proliferation/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Adaptor Proteins, Signal Transducing/genetics ; Cell Movement/genetics ; Apoptosis/genetics

Inflammatory spindle cell PEComa of the lung with YAP1::TFE3 fusion: a report of two cases and a potential relationship with clear cell stromal tumour.

Autori: Kojima N Nishino S Sasahara Y a ďalší

Zdroj: Histopathology [Histopathology] 2025 Feb; Vol. 86 (3), pp. 365-372. Date of Electronic Publication: 2024 Sep 26.

Spôsob vydávania: Case Reports; Journal Article

Informácie o časopise: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 7704136 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2559 (Electronic) Linking ISSN: 03090167 NLM ISO Abbreviation: Histopathology Subsets: MEDLINE

Výrazy zo slovníka MeSH: Lung Neoplasms*/pathology , Lung Neoplasms*/genetics , Lung Neoplasms*/metabolism , Lung Neoplasms*/diagnosis , Basic Helix-Loop-Helix Leucine Zipper Transcription Factors*/genetics , Basic Helix-Loop-Helix Leucine Zipper Transcription Factors*/metabolism , Perivascular Epithelioid Cell Neoplasms*/genetics , Perivascular Epithelioid Cell Neoplasms*/pathology , Perivascular Epithelioid Cell Neoplasms*/diagnosis , Perivascular Epithelioid Cell Neoplasms*/metabolism , YAP-Signaling Proteins* , Transcription Factors*/genetics , Transcription Factors*/metabolism, Humans ; Male ; Middle Aged ; Aged ; Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Oncogene Proteins, Fusion/genetics ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Biomarkers, Tumor/analysis