Suchergebnisse - "X-Box Binding Protein 1"

Tauroursodeoxycholic acid ameliorates palmitic acid induced endoplasmic reticulum stress and impaired autophagy via IRE1- XBP1-FoxO1 pathway in KGN cells.

Autoren: Cao M Qiao F Wang Q et al.

Quelle: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 4), pp. 117377. Date of Electronic Publication: 2025 Oct 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Taurochenodeoxycholic Acid*/pharmacology , Autophagy*/drug effects , Autophagy*/physiology , Palmitic Acid*/toxicity , Palmitic Acid*/antagonists & inhibitors , Endoplasmic Reticulum Stress*/drug effects , Endoplasmic Reticulum Stress*/physiology , Endoribonucleases*/metabolism , X-Box Binding Protein 1*/metabolism , X-Box Binding Protein 1*/genetics , Granulosa Cells*/drug effects , Granulosa Cells*/metabolism , Forkhead Box Protein O1*/metabolism , Protein Serine-Threonine Kinases*/metabolism, Humans ; Female ; Signal Transduction/drug effects ; Signal Transduction/physiology

Defining the role of β-cell IRE1α/XBP1 pathway and its gene regulatory network components in non-obese diabetic mice.

Autoren: Lee H Eynullazada K Ou Q et al.

Quelle: Nature communications [Nat Commun] 2025 Nov 26; Vol. 16 (1), pp. 10574. Date of Electronic Publication: 2025 Nov 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: X-Box Binding Protein 1*/genetics , X-Box Binding Protein 1*/metabolism , Endoribonucleases*/metabolism , Endoribonucleases*/genetics , Insulin-Secreting Cells*/metabolism , Insulin-Secreting Cells*/pathology , Protein Serine-Threonine Kinases*/metabolism , Protein Serine-Threonine Kinases*/genetics , Gene Regulatory Networks* , Diabetes Mellitus, Type 1*/genetics , Diabetes Mellitus, Type 1*/metabolism , Diabetes Mellitus, Type 1*/pathology , Diabetes Mellitus, Experimental*/genetics , Diabetes Mellitus, Experimental*/metabolism , Diabetes Mellitus, Experimental*/pathology, Animals ; Mice ; Mice, Knockout ; Apoptosis/genetics ; Signal Transduction ; Mice, Inbred C57BL ; Unfolded Protein Response ; Male ; Mice, Inbred NOD

XBP1s Mediates Cross-resistance to Combination Treatment of CDK4/6 Inhibitors plus Endocrine Therapy in Breast Cancer.

Autoren: Sang Y Liu S Zhou X et al.

Quelle: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Nov; Vol. 12 (44), pp. e09588. Date of Electronic Publication: 2025 Sep 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

MeSH-Schlagworte: Breast Neoplasms*/drug therapy , Breast Neoplasms*/genetics , Breast Neoplasms*/metabolism , Breast Neoplasms*/pathology , X-Box Binding Protein 1*/metabolism , X-Box Binding Protein 1*/genetics , Drug Resistance, Neoplasm*/genetics , Cyclin-Dependent Kinase 4*/antagonists & inhibitors, Humans ; Female ; Cyclin-Dependent Kinase 6/antagonists & inhibitors ; Animals ; Fulvestrant/pharmacology ; Mice ; Cell Line, Tumor ; Piperazines/pharmacology ; Pyridines/pharmacology ; Protein Kinase Inhibitors/pharmacology ; Cell Proliferation/drug effects ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use

IRE1/Xbp1 promotes the clearance of poly(GR) dipeptide repeats in amyotrophic lateral sclerosis.

Autoren: Li Y Liu D Li S

Quelle: The Journal of biological chemistry [J Biol Chem] 2025 Nov; Vol. 301 (11), pp. 110764. Date of Electronic Publication: 2025 Sep 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

MeSH-Schlagworte: Amyotrophic Lateral Sclerosis*/metabolism , Amyotrophic Lateral Sclerosis*/genetics , Amyotrophic Lateral Sclerosis*/pathology , Protein Serine-Threonine Kinases*/metabolism , Protein Serine-Threonine Kinases*/genetics , X-Box Binding Protein 1*/metabolism , X-Box Binding Protein 1*/genetics , Dipeptides*/metabolism , Dipeptides*/genetics , Endoribonucleases*/metabolism , Endoribonucleases*/genetics, Animals ; Humans ; C9orf72 Protein/genetics ; C9orf72 Protein/metabolism ; Mice ; Disease Models, Animal ; Signal Transduction ; Drosophila melanogaster

Atg16l1 and Xbp1 cooperatively protect from transcription-associated mutagenesis and small intestinal carcinogenesis.

Autoren: Kakavand N Xiang H Laue G et al.

Quelle: Oncogene [Oncogene] 2025 Nov; Vol. 44 (45), pp. 4413-4426. Date of Electronic Publication: 2025 Oct 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE

MeSH-Schlagworte: X-Box Binding Protein 1*/genetics , X-Box Binding Protein 1*/metabolism , Autophagy-Related Proteins*/genetics , Autophagy-Related Proteins*/metabolism , Intestinal Neoplasms*/genetics , Intestinal Neoplasms*/pathology , Intestinal Neoplasms*/metabolism , Carcinogenesis*/genetics , Intestine, Small*/pathology , Intestine, Small*/metabolism , Mutagenesis*, Animals ; Mice ; Endoplasmic Reticulum Stress/genetics ; Autophagy/genetics ; Mice, Knockout ; DNA Damage ; Transcription, Genetic ; Humans ; Cell Transformation, Neoplastic/genetics

Endoplasmic reticulum-resident protein DNAJC10 inhibits glioblastoma metastasis by suppressing XBP-1s-driven EGFR transcription.

Autoren: Zhao E Yu Y Gao Y et al.

Quelle: Molecular biomedicine [Mol Biomed] 2025 Oct 24; Vol. 6 (1), pp. 84. Date of Electronic Publication: 2025 Oct 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 9918283581406676 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-8651 (Electronic) Linking ISSN: 26628651 NLM ISO Abbreviation: Mol Biomed Subsets: MEDLINE

MeSH-Schlagworte: X-Box Binding Protein 1*/metabolism , X-Box Binding Protein 1*/genetics , Glioblastoma*/genetics , Glioblastoma*/pathology , Glioblastoma*/metabolism , HSP40 Heat-Shock Proteins*/metabolism , HSP40 Heat-Shock Proteins*/genetics , Brain Neoplasms*/pathology , Brain Neoplasms*/genetics , Brain Neoplasms*/metabolism , Transcription, Genetic* , Endoplasmic Reticulum*/metabolism, Humans ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Animals ; Cell Line, Tumor ; Mice ; Gene Expression Regulation, Neoplastic ; Unfolded Protein Response ; Cell Movement/genetics ; Protein Serine-Threonine Kinases/metabolism ; Neoplasm Metastasis ; Endoribonucleases/metabolism ; Mice, Nude ; Male ; Female

Ghrelin attenuates metabolic dysfunction-associated steatotic liver disease by activating glutamine metabolism via inhibition of the IRE1α-XBP-1 pathway.

Autoren: Zhao Q Xu J Xia Z et al.

Quelle: Biochemical pharmacology [Biochem Pharmacol] 2025 Oct; Vol. 240, pp. 117089. Date of Electronic Publication: 2025 Jun 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Endoribonucleases*/metabolism , Endoribonucleases*/antagonists & inhibitors , Glutamine*/metabolism , Protein Serine-Threonine Kinases*/metabolism , Protein Serine-Threonine Kinases*/antagonists & inhibitors , X-Box Binding Protein 1*/metabolism , X-Box Binding Protein 1*/antagonists & inhibitors , Ghrelin*/pharmacology , Ghrelin*/therapeutic use , Fatty Liver*/metabolism , Fatty Liver*/drug therapy , Non-alcoholic Fatty Liver Disease*/metabolism , Non-alcoholic Fatty Liver Disease*/drug therapy, Animals ; Male ; Mice, Inbred C57BL ; Humans ; Mice ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Hep G2 Cells ; Diet, High-Fat/adverse effects ; Endoplasmic Reticulum Stress/drug effects

Endoplasmic reticulum stress regulates intestinal motility in acute pancreatitis by regulating the expression and phosphorylation of nNOS through IRE1α/XBP1s-PI3K/Akt signaling axis.

Autoren: Liu H Cao J Li X et al.

Quelle: Cellular signalling [Cell Signal] 2025 Dec; Vol. 136, pp. 112123. Date of Electronic Publication: 2025 Sep 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3913 (Electronic) Linking ISSN: 08986568 NLM ISO Abbreviation: Cell Signal Subsets: MEDLINE

MeSH-Schlagworte: Gastrointestinal Motility* , Nitric Oxide Synthase Type I*/metabolism , Phosphatidylinositol 3-Kinases*/metabolism , X-Box Binding Protein 1*/metabolism , Pancreatitis*/metabolism , Pancreatitis*/pathology , Pancreatitis*/physiopathology , Endoplasmic Reticulum Stress* , Endoribonucleases*/metabolism , Protein Serine-Threonine Kinases*/metabolism, Animals ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Male ; Rats ; Rats, Sprague-Dawley ; Nitric Oxide/metabolism ; Myocytes, Smooth Muscle/metabolism ; Multienzyme Complexes

Oligoclonal tumor-specific CD8 T-cell revival and IRE1α/XBP1-GDF15-mediated immunosuppressive niches determine neoadjuvant chemoimmunotherapy efficacy in cervical cancer.

Autoren: Cao G Wang Y Zeng H et al.

Quelle: Journal for immunotherapy of cancer [J Immunother Cancer] 2025 Nov 19; Vol. 13 (11). Date of Electronic Publication: 2025 Nov 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE

MeSH-Schlagworte: Uterine Cervical Neoplasms*/immunology , Uterine Cervical Neoplasms*/drug therapy , Uterine Cervical Neoplasms*/pathology , Uterine Cervical Neoplasms*/genetics , X-Box Binding Protein 1*/metabolism , Protein Serine-Threonine Kinases*/metabolism , Neoadjuvant Therapy*/methods , Endoribonucleases*/metabolism , CD8-Positive T-Lymphocytes*/immunology , CD8-Positive T-Lymphocytes*/metabolism , Immunotherapy*/methods, Humans ; Female ; Animals ; Mice ; Tumor Microenvironment/immunology

Tetramethylpyrazine Promotes Functional Recovery after Spinal Cord Injury by Regulating 5-Methylcytosine RNA Modification via the NSUN2-XBP1 Axis.

Autoren: Xiao Z Wang Z Jiang H et al.

Quelle: Molecular neurobiology [Mol Neurobiol] 2025 Nov 19; Vol. 63 (1), pp. 74. Date of Electronic Publication: 2025 Nov 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

MeSH-Schlagworte: Spinal Cord Injuries*/drug therapy , Spinal Cord Injuries*/metabolism , Spinal Cord Injuries*/physiopathology , Pyrazines*/pharmacology , Pyrazines*/therapeutic use , Recovery of Function*/drug effects , X-Box Binding Protein 1*/metabolism , 5-Methylcytosine*/metabolism , Methyltransferases*/metabolism, Animals ; Rats ; Rats, Sprague-Dawley ; PC12 Cells ; Apoptosis/drug effects ; Male ; Signal Transduction/drug effects ; Oxidative Stress/drug effects ; Cytokines/metabolism

Investigation of the mechanism by which sigma-1 receptor protein mediates the IRE1-XBP-1s pathway to alleviate cerebral ischemia-reperfusion injury.

Autoren: Dong Y Ding L Sheng F et al.

Quelle: European journal of medical research [Eur J Med Res] 2025 Oct 30; Vol. 30 (1), pp. 1041. Date of Electronic Publication: 2025 Oct 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 9517857 Publication Model: Electronic Cited Medium: Internet ISSN: 2047-783X (Electronic) Linking ISSN: 09492321 NLM ISO Abbreviation: Eur J Med Res Subsets: MEDLINE

MeSH-Schlagworte: Receptors, sigma*/metabolism , Receptors, sigma*/antagonists & inhibitors , X-Box Binding Protein 1*/metabolism , Reperfusion Injury*/metabolism , Reperfusion Injury*/drug therapy , Reperfusion Injury*/pathology , Protein Serine-Threonine Kinases*/metabolism , Endoribonucleases*/metabolism , Brain Ischemia*/metabolism , Brain Ischemia*/pathology , Brain Ischemia*/drug therapy, Animals ; Sigma-1 Receptor ; Rats ; Male ; Humans ; Signal Transduction/drug effects ; Rats, Sprague-Dawley ; Pentazocine/pharmacology ; Transcription Factor CHOP/metabolism ; Apoptosis/drug effects ; Cell Line, Tumor ; Multienzyme Complexes

DNAJC5 promotes cisplatin resistance in epithelial ovarian cancer by autophagy induced by the BiP/IRE1α/XBP1 endoplasmic reticulum stress pathway.

Autoren: Huang S Chen L Chen Y et al.

Quelle: Scientific reports [Sci Rep] 2025 Oct 02; Vol. 15 (1), pp. 34323. Date of Electronic Publication: 2025 Oct 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Cisplatin*/pharmacology , Cisplatin*/therapeutic use , Drug Resistance, Neoplasm*/genetics , Autophagy*/drug effects , Carcinoma, Ovarian Epithelial*/drug therapy , Carcinoma, Ovarian Epithelial*/metabolism , Carcinoma, Ovarian Epithelial*/pathology , Carcinoma, Ovarian Epithelial*/genetics , Endoplasmic Reticulum Stress*/drug effects , X-Box Binding Protein 1*/metabolism , Ovarian Neoplasms*/drug therapy , Ovarian Neoplasms*/metabolism , Ovarian Neoplasms*/pathology , Ovarian Neoplasms*/genetics , HSP40 Heat-Shock Proteins*/metabolism , HSP40 Heat-Shock Proteins*/genetics, Humans ; Female ; Cell Line, Tumor ; Signal Transduction/drug effects ; Protein Serine-Threonine Kinases/metabolism ; Endoplasmic Reticulum Chaperone BiP ; Animals ; Heat-Shock Proteins/metabolism ; Mice ; Gene Expression Regulation, Neoplastic/drug effects ; Antineoplastic Agents/pharmacology ; Middle Aged ; Endoribonucleases

Xbp1 controls the reparative function of intestinal ILC2s during colitis.

Autoren: Cui Y Zhao Z Shen J et al.

Quelle: The Journal of experimental medicine [J Exp Med] 2026 Jan 05; Vol. 223 (1). Date of Electronic Publication: 2025 Oct 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE

MeSH-Schlagworte: X-Box Binding Protein 1*/metabolism , X-Box Binding Protein 1*/genetics , Lymphocytes*/immunology , Lymphocytes*/metabolism , Colitis*/immunology , Colitis*/pathology , Immunity, Innate* , Intestines*/immunology , Intestines*/pathology, Animals ; Mice ; Unfolded Protein Response ; Mice, Knockout ; Mice, Inbred C57BL ; Interferon-gamma/metabolism ; Colitis, Ulcerative/immunology ; Colitis, Ulcerative/pathology ; Endoribonucleases/metabolism ; Protein Serine-Threonine Kinases/metabolism ; Interleukin-17/metabolism ; Folic Acid/metabolism

Harnessing indole scaffolds to identify small-molecule IRE1α inhibitors modulating XBP1 mRNA splicing.

Autoren: Liu Y Avathan Veettil AK Gasper R et al.

Quelle: Nature communications [Nat Commun] 2025 Sep 26; Vol. 16 (1), pp. 8531. Date of Electronic Publication: 2025 Sep 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: X-Box Binding Protein 1*/genetics , X-Box Binding Protein 1*/metabolism , Endoribonucleases*/antagonists & inhibitors , Endoribonucleases*/metabolism , Endoribonucleases*/chemistry , Endoribonucleases*/genetics , RNA Splicing*/drug effects , Protein Serine-Threonine Kinases*/antagonists & inhibitors , Protein Serine-Threonine Kinases*/metabolism , Protein Serine-Threonine Kinases*/chemistry , Protein Serine-Threonine Kinases*/genetics , Indoles*/pharmacology , Indoles*/chemistry, Humans ; Endoplasmic Reticulum Stress/drug effects ; RNA, Messenger/metabolism ; RNA, Messenger/genetics ; Small Molecule Libraries/pharmacology ; Small Molecule Libraries/chemistry ; HEK293 Cells ; Crystallography, X-Ray

The IRE1/XBP1s Axis Regulates Innate Immune Responses in Conventional Dendritic Cells During ZIKV Infection.

Autoren: Guzmán-Rodríguez M Hernández-Díaz T Lisboa P et al.

Quelle: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2025 Sep 15; Vol. 39 (17), pp. e71025.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

MeSH-Schlagworte: Dendritic Cells*/immunology , Dendritic Cells*/virology , Dendritic Cells*/metabolism , Zika Virus Infection*/immunology , Zika Virus Infection*/metabolism , Zika Virus Infection*/virology , Immunity, Innate* , X-Box Binding Protein 1*/metabolism , X-Box Binding Protein 1*/immunology , X-Box Binding Protein 1*/genetics , Protein Serine-Threonine Kinases*/metabolism , Protein Serine-Threonine Kinases*/immunology , Protein Serine-Threonine Kinases*/genetics , Endoribonucleases*/metabolism , Endoribonucleases*/immunology , Endoribonucleases*/genetics , Zika Virus*/immunology, Animals ; Mice ; Mice, Inbred C57BL ; Unfolded Protein Response ; Cytokines/metabolism ; Interferon Type I ; Mice, Knockout ; Signal Transduction

Unfolded protein response transcription factor XBP1 suppresses necroptosis-induced colitis by reinforcing the mucus barrier.

Autoren: Kaya GG Schwarzer R Dannappel M et al.

Quelle: Immunity [Immunity] 2025 Sep 09; Vol. 58 (9), pp. 2208-2225.e6. Date of Electronic Publication: 2025 Aug 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE

MeSH-Schlagworte: X-Box Binding Protein 1*/metabolism , X-Box Binding Protein 1*/genetics , Necroptosis*/immunology , Colitis*/immunology , Colitis*/metabolism , Colitis*/pathology , Intestinal Mucosa*/metabolism , Intestinal Mucosa*/immunology , Intestinal Mucosa*/pathology , Unfolded Protein Response* , Mucus*/metabolism, Animals ; Mice ; Caspase 8/metabolism ; Caspase 8/genetics ; Mice, Knockout ; Mice, Inbred C57BL ; Mucin-2/metabolism ; Mucin-2/genetics ; Disease Models, Animal ; Endoplasmic Reticulum Stress ; Colon/pathology ; Epithelial Cells/metabolism ; Inflammatory Bowel Diseases/immunology

Macrophages Atp6v0d2 regulates XBP1-mediated cholesterol metabolism to suppress metabolic dysfunction-associated steatohepatitis progression.

Autoren: Wang Z Chen X Li J et al.

Quelle: International immunopharmacology [Int Immunopharmacol] 2025 Aug 28; Vol. 161, pp. 115088. Date of Electronic Publication: 2025 Jun 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

MeSH-Schlagworte: Macrophages*/metabolism , Macrophages*/immunology , Cholesterol*/metabolism , X-Box Binding Protein 1*/metabolism , X-Box Binding Protein 1*/genetics , Fatty Liver*/metabolism , Fatty Liver*/pathology , Non-alcoholic Fatty Liver Disease*, Animals ; Mice ; Mice, Knockout ; Male ; Mice, Inbred C57BL ; Liver/pathology ; Liver/metabolism ; Membrane Glycoproteins/genetics ; Membrane Glycoproteins/metabolism ; Disease Progression ; Receptors, Immunologic/genetics ; Receptors, Immunologic/metabolism ; Humans ; Disease Models, Animal ; Endoplasmic Reticulum Stress ; Obesity

Neutrophil extracellular traps induce fibroblast ferroptosis via IRE1α/XBP1-mediated ER stress to impair diabetic wound healing.

Autoren: Zhao H Liu Y

Quelle: Free radical biology & medicine [Free Radic Biol Med] 2025 Aug 16; Vol. 236, pp. 17-27. Date of Electronic Publication: 2025 May 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

MeSH-Schlagworte: Endoplasmic Reticulum Stress* , Ferroptosis* , Wound Healing* , Fibroblasts*/metabolism , Fibroblasts*/pathology , Protein Serine-Threonine Kinases*/genetics , Protein Serine-Threonine Kinases*/metabolism , X-Box Binding Protein 1*/genetics , X-Box Binding Protein 1*/metabolism , Endoribonucleases*/genetics , Endoribonucleases*/metabolism , Extracellular Traps*/metabolism , Diabetes Mellitus, Experimental*/pathology , Diabetes Mellitus, Experimental*/metabolism, Animals ; Mice ; Humans ; Neutrophils/metabolism ; Neutrophils/pathology ; Male ; Mice, Inbred C57BL

Fbxo42 promotes the degradation of Ataxin-2 granules to trigger terminal Xbp1 signaling.

Autoren: Santos CC Schweizer N Cairrão F et al.

Quelle: Nature communications [Nat Commun] 2025 Aug 13; Vol. 16 (1), pp. 7523. Date of Electronic Publication: 2025 Aug 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: X-Box Binding Protein 1*/metabolism , X-Box Binding Protein 1*/genetics , Drosophila Proteins*/metabolism , Drosophila Proteins*/genetics , Ataxin-2*/metabolism , Ataxin-2*/genetics , F-Box Proteins*/metabolism , F-Box Proteins*/genetics , Cytoplasmic Granules*/metabolism, Animals ; Unfolded Protein Response ; Signal Transduction ; Drosophila melanogaster/metabolism ; Drosophila melanogaster/genetics ; Endoplasmic Reticulum Stress ; Ubiquitination ; Proteolysis ; Humans ; Endoplasmic Reticulum/metabolism ; Cell Death ; RNA, Messenger/metabolism ; RNA, Messenger/genetics ; DNA-Binding Proteins

Identifying ferroptosis-related genes in lung adenocarcinoma using random walk with restart in the PPI network.

Autoren: Liu C He P Qiao R et al.

Quelle: Scientific reports [Sci Rep] 2025 Aug 06; Vol. 15 (1), pp. 28832. Date of Electronic Publication: 2025 Aug 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Ferroptosis*/genetics , Adenocarcinoma of Lung*/genetics , Adenocarcinoma of Lung*/pathology , Adenocarcinoma of Lung*/metabolism , Lung Neoplasms*/genetics , Lung Neoplasms*/pathology , Lung Neoplasms*/metabolism , X-Box Binding Protein 1*/genetics , X-Box Binding Protein 1*/metabolism , Protein Interaction Maps*/genetics, Humans ; Gene Expression Regulation, Neoplastic ; Tumor Microenvironment/genetics ; Gene Regulatory Networks ; Algorithms ; Gene Expression Profiling