Suchergebnisse - "WNT signal transduction"

Baicalin Modulates CDH11/Wnt/α-catenin Pathway: A Novel Therapeutic Strategy Against Tibial Dyschondroplasia in Broiler Chickens.

Autoren: Liu, Kai Mehmood, Khalid Li, Ying et al.

Quelle: Pakistan Veterinary Journal. 2025, Vol. 45 Issue 3, p1146-1156. 11p.

Schlagworte: Wnt signal transduction, Broiler chickens, Bone remodeling, Cartilage diseases, Metabolic bone disorders, Anti-inflammatory agents, Cadherins, Cartilage cells

ZNF831-YTHDF1-DNMT1/3a feedback loop regulates lung carcinogenesis and progression through WNT7B-FZD5-β-catenin signalling axis.

Autoren: Chen, Dongjiao Chen, Hongqiang Zeng, Yong et al.

Quelle: Free Radical Biology & Medicine. Dec2025, Vol. 241, p338-352. 15p.

Schlagwörter: *LUNG cancer, *WNT signal transduction, *RNA-binding proteins, *TRANSCRIPTION factors, *DNA methyltransferases, *WNT proteins, *CATENINS

Rbm8a deficiency causes hematopoietic defects by modulating Wnt/PCP signaling.

Autoren: Kocere, Agnese Chiavacci, Elena Soneson, Charlotte et al.

Quelle: Developmental Biology. Dec2025, Vol. 528, p34-56. 23p.

Schlagwörter: *THROMBOCYTOPENIA, *WNT signal transduction, *BLOOD diseases, *LABORATORY zebrafish, *PROGENITOR cells

A novel sulfonamide derivative suppresses gastrointestinal cancer progression by targeting Axin2 and β-catenin.

Autoren: Li, Xiaojie Wen, Huijuan Chang, Le et al.

Quelle: Scientific Reports. 11/25/2025, Vol. 15 Issue 1, p1-13. 13p.

Schlagwörter: *GASTROINTESTINAL cancer, *WNT signal transduction, *CELL cycle regulation, *ANTINEOPLASTIC agents, *CATENINS, *CANCER invasiveness, *SULFONE derivatives

Regulatory Pathways Governing Odonto/Osteogenic Differentiation in Dental Pulp Stem Cells.

Autoren: Kornsuthisopon, Chatvadee Nowwarote, Nunthawan Srisuwan, Tanida et al.

Quelle: International Endodontic Journal. Nov2025, p1. 24p. 7 Illustrations.

Schlagwörter: *TRANSFORMING growth factors-beta, *WNT signal transduction, *DENTITION, *REGENERATIVE medicine, *CELL communication, *EXTRACELLULAR matrix, *DENTIN, *MESENCHYMAL stem cells

STT3A is essential for Wnt signaling and represents a target for cancers driven by RNF43 deficiency.

Autoren: He, Zhengjin Chen, Shishuang Suo, Jinlong et al.

Quelle: Cell Chemical Biology. Nov2025, Vol. 32 Issue 11, p1321-13133. 11813p.

Schlagwörter: *WNT signal transduction, *DRUG target, *CANCER treatment, *CANCER invasiveness, *WNT proteins, *PROTEINS, *GLYCOSYLATION

Smurf1 promotes gastric cancer progression by regulating Axin2-dependent Wnt signaling pathway.

Autoren: Yu, Jinling Jing, Jiachen Feng, Zhen et al.

Quelle: Scientific Reports. 11/19/2025, Vol. 15 Issue 1, p1-10. 10p.

Schlagwörter: *STOMACH cancer, *WNT signal transduction, *CANCER invasiveness, *ONCOGENES, *UBIQUITINATION, *CELL proliferation

The Wnt/β-catenin-P2-HNF4α feedback loop facilitates colorectal tumorigenesis and malignancy.

Autoren: Bai, Weiyu Dong, Rui Lu, Chenglu et al.

Quelle: Journal of Translational Medicine. 11/17/2025, Vol. 23 Issue 1, p1-16. 16p.

Schlagwörter: *COLORECTAL cancer, *WNT signal transduction, *CATENINS, *DRUG target, *HEPATOCYTE nuclear factors, *NEOPLASTIC cell transformation, *CLOSED loop systems, *CARCINOGENS

Cloning and Expression of Col10a1 Gene and Its Response to Wnt/TGF-β Signaling Inhibitors in the Chinese Three-Keeled Pond Turtle (Mauremys reevesii).

Autoren: Li, Yue Zhu, Junxian Ren, Tong et al.

Quelle: Animals (2076-2615). Nov2025, Vol. 15 Issue 22, p3315. 15p.

Schlagwörter: *OSSIFICATION, *WNT signal transduction, *TRANSFORMING growth factors-beta, *EMYDIDAE, *DEVELOPMENTAL biology, *MOLECULAR cloning, *COLLAGEN

The planarian dorsal–ventral boundary regulates anterior–posterior axis growth and patterning.

Autoren: Maybrun, Chloe L. Oderberg, Isaac M. Gaviño, Michael A. et al.

Quelle: PLoS Biology. 11/11/2025, Vol. 23 Issue 11, p1-23. 23p.

Schlagwörter: *REGENERATION (Biology), *WNT signal transduction, *GENETIC regulation, *PLATYHELMINTHES

TRIML2 promotes malignant progression of head and neck squamous cell carcinoma via canonical Wnt signaling and tumor immune escape.

Autoren: Luo, Xi Zhang, Yang Wang, Yingjian et al.

Quelle: Journal of Translational Medicine. 11/13/2025, Vol. 23 Issue 1, p1-19. 19p.

Schlagwörter: *HEAD & neck cancer, *WNT signal transduction, *BIOMARKERS, *TUMOR-infiltrating immune cells, *BIOLOGICAL research methodology, *IMMUNOTHERAPY, *CELLULAR signal transduction, *CANCER invasiveness

Structural basis for Porcupine inhibition.

Autoren: Black, Katrina A. Mobbs, Jesse I. Venugopal, Hariprasad et al.

Quelle: Communications Chemistry. 11/12/2025, Vol. 8 Issue 1, p1-9. 9p.

Schlagwörter: *WNT signal transduction, *DRUG target, *MORPHOLOGY, *PORCUPINES, *DRUG design, *CANCER treatment, *ELECTRON cryomicroscopy, *CHEMICAL inhibitors

A frameshift variant in activity-dependent neuroprotective protein (ADNP) causes nucleocytoskeletal alterations in a dizygotic male twin: a case study.

Autoren: D'Incal, Claudio Peter Van Dijck, Anke Annear, Dale John et al.

Quelle: Clinical Epigenetics. 11/10/2025, Vol. 17 Issue 1, p1-12. 12p.

Schlagwörter: *AUTISM, *WNT signal transduction, *NEURAL development, *ZINC-finger proteins, *INTELLECTUAL disabilities, *DNA methylation, *DIZYGOTIC twins, *MOLECULAR genetics

Methionine induced placental angiogenesis through activating WNT3A/CTNNB1-PIGF-VEGFR1 pathway.

Autoren: Zou, Yijin Tu, Jiayu Wang, Ziqi et al.

Quelle: Cell Communication & Signaling. 11/7/2025, Vol. 23 Issue 1, p1-15. 15p.

Schlagwörter: *METHIONINE, *WNT signal transduction, *REPRODUCTIVE health, *PLACENTAL growth factor, *OXIDATIVE stress, *NEOVASCULARIZATION, *VASCULAR endothelial growth factor receptors

A Photothermal Nano‐Switch for Tumor‐Selective Wnt Hyperactivation in Vivo.

Autoren: Fang, Chunyan Liu, Yamin Zhang, Bo et al.

Quelle: Angewandte Chemie. 11/3/2025, Vol. 137 Issue 45, p1-13. 13p.

Schlagwörter: *WNT signal transduction, *CANCER treatment, *NANORODS, *CATENINS, *ANTINEOPLASTIC agents, *OPTICAL switches

GSK3β Regulates a Novel β‐Catenin Degradation Pathway via the GID Complex in Wnt Signaling.

Autoren: Shimizu, Masahiro Shibuya, Hiroshi

Quelle: Genes to Cells. Nov2025, Vol. 30 Issue 6, p1-11. 11p.

Schlagwörter: *WNT signal transduction, *GLYCOGEN synthase kinase-3, *CELLULAR control mechanisms, *UBIQUITIN ligases, *CATABOLISM, *CATENINS, *UBIQUITINATION

Mechanistic Insights and Therapeutic Potential of Wnt5a Signaling in Alveolar Epithelial Cell Development and Bronchopulmonary Dysplasia.

Autoren: Huang, Jinglan Li, Xin Huang, Lan et al.

Quelle: Stem Cell Reviews & Reports. Nov2025, Vol. 21 Issue 8, p2372-2385. 14p.

Schlagwörter: *WNT signal transduction, *BRONCHOPULMONARY dysplasia, *REGENERATION (Biology), *PROGENITOR cells, *MECHANOTRANSDUCTION (Cytology), *DEVELOPMENTAL biology, *CELL communication, *TREATMENT effectiveness

Alteration of the Secretome in Airway Epithelial Cells by Air Pollutants: Evidence from an Air–Liquid Interface Model.

Autoren: Lu, Hankun Xiang, Jiahui Zhou, Xiaoyu et al.

Quelle: Lung (0341-2040). 10/13/2025, Vol. 203 Issue 1, p1-12. 12p.

Schlagwörter: *AIR pollutants, *WNT signal transduction, *OZONE, *DIESEL motor exhaust gas, *RESPIRATORY mucosa, *INFLAMMATION, *MEMBRANE permeability (Biology)

VAB-8/KIF26, LIN-17/Frizzled, and EFN-4/Ephrin, control distinct stages of posterior neuroblast migration downstream of the MAB-5/Hox transcription factor in Caenorhabditis elegans.

Autoren: Jain, Vedant D. Lundquist, Erik A.

Quelle: PLoS Genetics. 10/10/2025, Vol. 21 Issue 10, p1-26. 26p.

Schlagwörter: *CAENORHABDITIS elegans, *WNT signal transduction, *HOMEOBOX genes, *MOLECULAR motor proteins, *EPHRINS, *SECRETED frizzled-related proteins

Wnt induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL.

Autoren: Luo, Dong Zheng, Jing Lv, Shuning et al.

Quelle: eLife. 10/10/2025, p1-23. 23p.

Schlagwörter: *WNT signal transduction, *UBIQUITIN ligases, *SECRETED frizzled-related proteins, *PROTEINS, *CHEMICAL reactions, *ENDOCYTOSIS