Výsledky vyhľadávania - "Viral Nonstructural Proteins/genetics"

Efficient and robust reverse genetics system for bovine rotavirus generation and its application for antiviral screening

Autori: Qin, Songkang Li, Kuan-Hao Liu, Ben-Jin a ďalší

Zdroj: Virol Sin

Predmety: Rotavirus, Rotavirus/drug effects, High-throughput screen, Immunology, Green Fluorescent Proteins, Drug Evaluation, Preclinical, Small chemical compound, Genome, Viral, Viral Nonstructural Proteins, Virus Replication, Antiviral Agents, Green Fluorescent Proteins/genetics, Rotavirus Infections, Cell Line, Veterinary medicine & animal health, Reverse Genetics/methods, NSP3 protein, Rotavirus, Virology, Cricetinae, Animals, Bovine rotavirus (BRV), Rotavirus Infections/virology, Plasmids/genetics, Virus Replication/drug effects, Reporter virus, Life sciences, Médecine vétérinaire & santé animale, Reverse Genetics, Viral Nonstructural Proteins/genetics, Infectious Diseases, Optimized reverse genetics system, Rotavirus/genetics, Sciences du vivant, Molecular Medicine, Cattle, Drug Evaluation, Preclinical/methods, Research Article, Plasmids

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39349279

Essential role of cis -encoded mature NS3 in the genome packaging of classical swine fever virus

Autori: Lamp, Benjamin Barth, Sandra Reuscher, Carina a ďalší

Zdroj: J Virol

Predmety: Serine Endopeptidases Genetics, 0301 basic medicine, 0303 health sciences, Virus Assembly Genetics, Classical Swine Fever Virus Genetics, Swine, Viral Proteases, Structure and Assembly, Viral Genome Packaging, Genome, Viral, RNA Helicases Genetics, Virus Replication, Nucleoside-Triphosphatase, Classical Swine Fever Virology, Cell Line, DEAD-box RNA Helicases, 03 medical and health sciences, RNA Helicases Metabolism, RNA, Viral Metabolism, RNA, Viral Genetics, Viral Nonstructural Proteins Metabolism, Animals, Viral Nonstructural Proteins Genetics, Serine Endopeptidases Metabolism, Classical Swine Fever Virus Physiology

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39723819

Inhibition of interferon I induction by non-structural protein NSs of Puumala virus and other vole-associated orthohantaviruses: phenotypic plasticity of the protein and potential functional domains

Autori: Florian Binder Giulia Gallo Elias Bendl a ďalší

Zdroj: Arch Virol
Archives of Virology, Vol. 166, No 11 (2021) pp. 2999-3012

Predmety: Puumala virus/isolation, Chlorocebus aethiops [MeSH], Viral Nonstructural Proteins/genetics [MeSH], Interferon Type I/genetics [MeSH], Virology, Virus Replication [MeSH], Gene Expression Regulation, Viral [MeSH], Infectious Diseases, Original Article, Interferon-beta/genetics [MeSH], Interferon Type I/metabolism [MeSH], Puumala virus/physiology [MeSH], Viral Nonstructural Proteins/metabolism [MeSH], Vero Cells [MeSH], Interferon-beta/metabolism [MeSH], A549 Cells [MeSH], Puumala virus/pathogenicity [MeSH], Mutation [MeSH], Humans [MeSH], Host-Pathogen Interactions/physiology [MeSH], Medical Microbiology, Animals [MeSH], Viral Nonstructural Proteins/chemistry [MeSH], Germany [MeSH], HEK293 Cells [MeSH], Hemorrhagic Fever with Renal Syndrome [MeSH], Adaptation, Physiological [MeSH], Promoter Regions, Genetic [MeSH], Puumala virus / pathogenicity, Gene Expression Regulation, Viral, 0301 basic medicine, Interferon Type I / metabolism, Physiological, Viral Nonstructural Proteins / genetics, Viral Nonstructural Proteins, Viral Nonstructural Proteins / metabolism, Virus Replication, Puumala virus, Promoter Regions, 03 medical and health sciences, Genetic, Germany, Host-Pathogen Interactions / physiology, Chlorocebus aethiops, Animals, Humans, Puumala virus / physiology, Viral, Adaptation, Promoter Regions, Genetic, Puumala virus / isolation & purification, Vero Cells, ddc:616, 0303 health sciences, Interferon-beta, Adaptation, Physiological, Interferon-beta / metabolism, 3. Good health, HEK293 Cells, Gene Expression Regulation, A549 Cells, Hemorrhagic Fever with Renal Syndrome, Host-Pathogen Interactions, Interferon Type I, Mutation, Interferon-beta / genetics, Viral Nonstructural Proteins / chemistry, Interferon Type I / genetics

Popis súboru: application/pdf; pdf

Prístupová URL adresa: https://link.springer.com/content/pdf/10.1007/s00705-021-05159-y.pdf
https://pubmed.ncbi.nlm.nih.gov/34389893
https://www.openagrar.de/receive/openagrar_mods_00073286
https://link.springer.com/content/pdf/10.1007/s00705-021-05159-y.pdf
https://pubmed.ncbi.nlm.nih.gov/34389893/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8362652
https://link.springer.com/article/10.1007/s00705-021-05159-y
https://archive-ouverte.unige.ch/unige:157928
https://doi.org/10.1007/s00705-021-05159-y
https://archive-ouverte.unige.ch/unige:157928
https://repository.publisso.de/resource/frl:6446492

SARS-CoV-2 nsp3 and nsp4 are minimal constituents of a pore spanning replication organelle

Autori: Zimmermann, Liv Zhao, Xiaohan Makroczyova, Jana a ďalší

Zdroj: Nat Commun
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)

Predmety: Organelles / metabolism, Organelles, SARS-CoV-2, Science, Viral Nonstructural Proteins / genetics, COVID-19, Viral Nonstructural Proteins, Virus Replication, Article, 3. Good health, Humans, SARS-CoV-2 / metabolism, Viral Nonstructural Proteins / metabolism

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38036567
https://doaj.org/article/ec898bd6b18840459e8a9139b107c87a
https://archive-ouverte.unige.ch/unige:181546
https://doi.org/10.1038/s41467-023-43666-5

Evidence of viral adaptation to HLA class I-restricted immune pressure in chronic hepatitis C virus infection

Autori: Gaudieri, S. Rauch, A. Park, L. P. a ďalší

Predmety: Adaptation, Biological Amino Acid Substitution DNA Mutational Analysis Epitopes/genetics Female Gene Frequency Genes, MHC Class I Hepacivirus/*genetics/*immunology/isolation & purification Hepatitis C, Chronic/*immunology/*virology Histocompatibility Antigens Class I/*immunology Humans Male Models, Molecular Mutation, Missense Phylogeny Polymorphism, Genetic *Selection (Genetics) Sequence Homology, Amino Acid Statistics Viral Nonstructural Proteins/genetics

Relation: Journal of Virology; https://iris.unil.ch/handle/iris/74950; serval:BIB_613FDD2DF7AA; 000241821300019

Dostupnosť: https://iris.unil.ch/handle/iris/74950
https://doi.org/10.1128/JVI.00912-06

A novel hepatitis C virus (HCV) subtype from Somalia and its classification into HCV clade 3.

Autori: Abid, K. Quadri, R. Veuthey, A.L. a ďalší

Predmety: Adult, Base Sequence, DNA, Viral, Female, Genotype, Hepacivirus/classification, Hepacivirus/genetics, Hepatitis C, Chronic/virology, Humans, Male, Middle Aged, Molecular Sequence Data, Phylogeny, Sequence Analysis, Sequence Homology, Nucleic Acid, Somalia, Viral Core Proteins/genetics, Viral Envelope Proteins/genetics, Viral Nonstructural Proteins/genetics

Popis súboru: application/pdf

Relation: Journal of General Virology; https://iris.unil.ch/handle/iris/67991; serval:BIB_05E7BC554311; 000087542300008

Dostupnosť: https://iris.unil.ch/handle/iris/67991
https://doi.org/10.1099/0022-1317-81-6-1485

Influenza A viruses balance ER stress with host protein synthesis shutoff.

Autori: Mazel-Sanchez, B. Iwaszkiewicz, J. Bonifacio, JPP a ďalší

Predmety: A549 Cells, Endoplasmic Reticulum/metabolism, Endoplasmic Reticulum Stress/physiology, HEK293 Cells, Host-Pathogen Interactions/physiology, Humans, Influenza A virus/genetics, Influenza A virus/metabolism, Influenza A virus/pathogenicity, Neuraminidase/metabolism, Unfolded Protein Response/genetics, Unfolded Protein Response/physiology, Viral Nonstructural Proteins/genetics, Virus Replication/genetics, CPSF30, ER stress, NS1, influenza virus, neuraminidase

Relation: Proceedings of the National Academy of Sciences; https://iris.unil.ch/handle/iris/233000; serval:BIB_E216ED6F6864

Dostupnosť: https://iris.unil.ch/handle/iris/233000
https://doi.org/10.1073/pnas.2024681118

Real World Experience of Chronic Hepatitis C Retreatment with Genotype Specific Regimens in Nonresponders to Previous Interferon-Free Therapy

Autori: Dorota Zarębska-Michaluk Iwona Buczyńska Krzysztof Simon a ďalší

Zdroj: Can J Gastroenterol Hepatol
Canadian Journal of Gastroenterology and Hepatology, Vol 2019 (2019)

Predmety: chronic - pathology, Liver cirrhosis - pathology, Adult, Liver Cirrhosis, Male, 0301 basic medicine, Genotype, Sustained Virologic Response, chronic - drug therapy, Liver cirrhosis - virology, Antiviral agents - therapeutic use, RC799-869, Hepacivirus, Viral Nonstructural Proteins, Antiviral Agents, viral - genetics, Young Adult, 03 medical and health sciences, Liver cirrhosis - drug therapy, Drug Resistance, Viral, Humans, Treatment Failure, Middle aged, Aged, Retrospective Studies, chronic - virology, Sustained virologic response, 0303 health sciences, Diseases of the digestive system. Gastroenterology, Hepatitis C, Chronic, Middle Aged, Hepatitis C, Hepacivirus - genetics, 3. Good health, Retrospective studies, Young adult, Treatment failure, Drug resistance, Retreatment, Viral nonstructural proteins - genetics, Female, Research Article

Popis súboru: text/xhtml

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/30941326
https://doaj.org/article/f0b4cc9cd55c42378960d4bcea26b40e
https://www.hindawi.com/journals/cjgh/2019/4029541/
https://europepmc.org/article/MED/30941326
http://downloads.hindawi.com/journals/cjgh/2019/4029541.pdf
https://www.ncbi.nlm.nih.gov/pubmed/30941326
https://downloads.hindawi.com/journals/cjgh/2019/4029541.pdf
https://www.hindawi.com/journals/cjgh/2019/4029541/reprint/
https://www.termedia.pl/VIII-Congress-of-the-Polish-Association-for-the-Study-of-the-Liver-6-8-June-2019-Mikolajki-Abstracts
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36755
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1.html
https://www.termedia.pl/VIII-Congress-of-the-Polish-Association-for-the-Study-of-the-Liver-6-8-June-2019-Mikolajki-Abstracts
80
36755
1
1.html

The european prevalence of resistance associated substitutions among direct acting antiviral failures

Autori: Popping, Stephanie Cento, Valeria Seguin-Devaux, Carole a ďalší

Zdroj: Popping, S, Cento, V, Seguin-Devaux, C, Boucher, C A B, de Salazar, A, Heger, E, Mor, O, Sayan, M, Salmon-Ceron, D, Weis, N, Krarup, H B, de Knegt, R J, Săndulescu, O, Chulanov, V, van de Vijver, D A M C, García, F, Ceccherini-Silberstein, F & on behalf of the HepCare as Part of the European Society for Translational Antiviral Research (ESAR) 2022, 'The european prevalence of resistance associated substitutions among direct acting antiviral failures', Viruses, vol. 14, no. 1, 16. https://doi.org/10.3390/v14010016

Predmety: Direct-acting antivirals, Elimination, Hepatitis C, Resistance, Resistance associated substitutions, Europe, Humans, Middle Aged, Drug Resistance, Viral, Genotype, Male, RNA-Dependent RNA Polymerase/genetics, Retreatment, Hepatitis C/drug therapy, Treatment Failure, Viral Nonstructural Proteins/genetics, Antiviral Agents/pharmacology, Female, Hepacivirus/drug effects, Mutation, Sustained Virologic Response, Drug Therapy, Combination

Popis súboru: application/pdf

Relation: info:eu-repo/semantics/altIdentifier/pmid/35062220; info:eu-repo/semantics/altIdentifier/pissn/1999-4915

Dostupnosť: https://vbn.aau.dk/da/publications/708d168e-7eec-470b-805a-40488c3a722d
https://doi.org/10.3390/v14010016
https://vbn.aau.dk/ws/files/459265887/Popping_et_al._2022_._The_European_Prevalence_of_Resistance_Associated_Substitutions_among_Direct_Acting_Antiviral_Failures.pdf
https://www.scopus.com/pages/publications/85121665234

Significance of mutations in the region coding for NS3/4 protease in patients infected with HCV genotype 1b

Autori: Tadeusz Wojciech Łapiński Joanna Kiśluk Robert Flisiak a ďalší

Zdroj: Advances in Clinical and Experimental Medicine. 27:1593-1600

Predmety: 0301 basic medicine, Genotype, chronic - drug therapy, Antiviral agents - therapeutic use, Hepacivirus, Viral Nonstructural Proteins, Antiviral Agents, viral - genetics, Amino acid sequence, 03 medical and health sciences, Drug Resistance, Viral, Humans, Hepacivirus - isolation & purification, Viral load, Amino Acid Sequence, chronic - diagnosis, chronic - genetics, Hepatitis C, Chronic, Viral Load, Hepatitis C, Peptide hydrolases, Hepacivirus - genetics, 3. Good health, Cryoglobulinemia, Drug resistance, Mutation, Viral nonstructural proteins - genetics, Peptide Hydrolases

Prístupová URL adresa: https://advances.umw.edu.pl/pdf/2018/27/11/1593.pdf
https://pubmed.ncbi.nlm.nih.gov/30048050
https://pubmed.ncbi.nlm.nih.gov/30048050/
https://www.ncbi.nlm.nih.gov/pubmed/30048050
http://www.advances.umed.wroc.pl/en/article/2018/27/11/1593/
https://www.advances.umed.wroc.pl/pdf/2018/27/11/1593.pdf

Prevalence of NS5A resistance associated substitutions in patients with hepatitis C virus genotypes 1a and 3: Impact on current therapeutic strategies: Impact on current therapeutic strategies

Autori: Marta Grandal Berta Pernas Andrés Tabernilla a ďalší

Prispievatelia: Marta Grandal Berta Pernas Andrés Tabernilla a ďalší

Zdroj: RUC. Repositorio da Universidade da Coruña
instname

Predmety: RASs, Adult, Male, 0301 basic medicine, Genotype, Ribavirin/pharmacology, Mutation, Missense, Mutación missense, Antiviral Agents/pharmacology, Hepacivirus, Viral Nonstructural Proteins, Proteínas mutantes, NS5A, Antiviral Agents, 03 medical and health sciences, Hepatitis C, Chronic/drug therapy, Drug Resistance, Viral, Ribavirin, Prevalence, Humans, genotype 3, Sustitución de aminoácidos, Farmacorresistencia viral, Genotype 1a, Análisis de secuencia de ADN, Ribavirina, Sequence Analysis, DNA, Genotype 3, Hepatitis C, Chronic, Middle Aged, genotype 1a, 3. Good health, Viral Nonstructural Proteins/genetics, Amino Acid Substitution, Antivirales, Mutant Proteins, Mutant Proteins/genetics, Prevalencia, HCV-infection, Genotipo, Hepacivirus/classification, Hepatitis C crónica, Follow-Up Studies

Popis súboru: application/pdf

Prístupová URL adresa: https://ruc.udc.es/dspace/bitstream/2183/20798/2/Grndal_Prvlence.pdf
https://pubmed.ncbi.nlm.nih.gov/29427437
http://hdl.handle.net/2183/20798
https://onlinelibrary.wiley.com/doi/10.1002/jmv.25048
https://pubmed.ncbi.nlm.nih.gov/29427437/
https://www.ncbi.nlm.nih.gov/pubmed/29427437
https://hdl.handle.net/2183/20798
https://hdl.handle.net/10668/12111
https://biblio.vub.ac.be/vubir/(c980fe18-9b60-4b2f-a117-6b7b6e60b7ee).html

Viral genome wide association study identifies novel hepatitis C virus polymorphisms associated with sofosbuvir treatment failure.

Autori: Smith, D.A. Fernandez-Antunez, C. Magri, A. a ďalší

Prispievatelia: Smith, D.A. Fernandez-Antunez, C. Magri, A. a ďalší

Zdroj: Nature communications, vol. 12, no. 1, pp. 6105

Predmety: Antiviral Agents/therapeutic use, Genome, Viral/genetics, Genotype, Hepacivirus/drug effects, Hepacivirus/genetics, Hepacivirus/isolation & purification, Hepatitis C, Chronic/drug therapy, Chronic/virology, Humans, Polymorphism, Genetic, Sofosbuvir/therapeutic use, Treatment Failure, Viral Load/drug effects, Viral Load/genetics, Viral Nonstructural Proteins/genetics

Popis súboru: application/pdf

Relation: info:eu-repo/semantics/altIdentifier/pmid/34671027; info:eu-repo/semantics/altIdentifier/eissn/2041-1723; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_1FACB16015187; https://serval.unil.ch/notice/serval:BIB_1FACB1601518; https://doi.org/10.1101/2020.05.05.077230; https://serval.unil.ch/resource/serval:BIB_1FACB1601518.P001/REF.pdf

Dostupnosť: https://serval.unil.ch/notice/serval:BIB_1FACB1601518
https://doi.org/10.1038/s41467-021-25649-6
https://doi.org/10.1101/2020.05.05.077230
https://serval.unil.ch/resource/serval:BIB_1FACB1601518.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_1FACB16015187

Inhibition of interferon I induction by non-structural protein NSs of Puumala virus and other vole-associated orthohantaviruses: phenotypic plasticity of the protein and potential functional domains

Autori: Binder, Florian Gallo, Giulia Bendl, Elias a ďalší

Zdroj: ISSN: 0304-8608 ; Archives of Virology, vol. 166, no. 11 (2021) p. 2999-3012.

Predmety: info:eu-repo/classification/ddc/616, A549 Cells, Adaptation, Physiological, Animals, Chlorocebus aethiops, Gene Expression Regulation, Viral, Germany, HEK293 Cells, Hemorrhagic Fever with Renal Syndrome, Host-Pathogen Interactions / physiology, Humans, Interferon Type I / genetics, Interferon Type I / metabolism, Interferon-beta / genetics, Interferon-beta / metabolism, Mutation, Promoter Regions, Genetic, Puumala virus / isolation & purification, Puumala virus / pathogenicity, Puumala virus / physiology, Vero Cells, Viral Nonstructural Proteins / chemistry, Viral Nonstructural Proteins / genetics, Viral Nonstructural Proteins / metabolism, Virus Replication

Relation: info:eu-repo/semantics/altIdentifier/pmid/34389893; unige:157928

Dostupnosť: https://archive-ouverte.unige.ch/unige:157928

Baseline and Post-Treatment Hepatitis C NS5A Resistance in Relapsed Patients from a Multicentric Real-Life Cohort

Autori: Halfon, Philippe Scholtes, Caroline Izopet, Jacques a ďalší

Prispievatelia: Halfon, Philippe Scholtes, Caroline Izopet, Jacques a ďalší

Zdroj: Antiviral Therapy. 23:307-314

Predmety: Male, 0301 basic medicine, Genotype, Viral Nonstructural Proteins / genetics, Antiviral Agents / therapeutic use, DNA Mutational Analysis, Drug Resistance, Hepacivirus, Viral Nonstructural Proteins, Antiviral Agents, Viral Nonstructural Proteins / antagonists & inhibitors, 03 medical and health sciences, Drug Therapy, Drug Resistance, Viral, Humans, Viral, Treatment Failure, 0303 health sciences, Viral Load, Hepatitis C, 3. Good health, [SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences, Treatment Outcome, Antiviral Agents / pharmacology, Hepatitis C / virology, Hepacivirus / drug effects, Drug Therapy, Combination, Female, Hepatitis C / drug therapy, Hepacivirus / genetics

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/28730994
https://www.ncbi.nlm.nih.gov/pubmed/28730994
https://pubmed.ncbi.nlm.nih.gov/28730994/
https://journals.sagepub.com/doi/abs/10.3851/IMP3184
https://www.intmedpress.com/journals/avt/abstract.cfm?id=3184&pid=48

NS5A resistance-associated substitutions in patients with genotype 1 hepatitis C virus: Prevalence and effect on treatment outcome

Autori: Zeuzem, S Mizokami, M Pianko, S a ďalší

Prispievatelia: Zeuzem, S Mizokami, M Pianko, S a ďalší

Zdroj: Journal of Hepatology. 66:910-918

Predmety: Male, 0301 basic medicine, Benzimidazoles / therapeutic use, Viral Nonstructural Proteins / genetics, Drug Resistance, 32 Biomedical and Clinical Sciences, HCV genotype 1, Viral Nonstructural Proteins, NS5A, anzsrc-for: 1103 Clinical Sciences, Hepatitis, Chronic / drug therapy, 80 and over, Viral, Chronic, 3202 Clinical Sciences, Antiviral Agents / therapeutic use, Aged, 80 and over, Sustained virologic response, 0303 health sciences, Fluorenes / therapeutic use, Liver Disease, 3 Good Health and Well Being, Middle Aged, Hepatitis C, 3. Good health, Infectious Diseases, Treatment Outcome, anzsrc-for: 3202 Clinical Sciences, Female, Infection, Ledipasvir, anzsrc-for: 1117 Public Health and Health Services, Adult, Adolescent, Genotype, Chronic Liver Disease and Cirrhosis, Clinical Trials and Supportive Activities, Antiviral Agents, ledipasvir-sofosbuvir, 12. Responsible consumption, Young Adult, 03 medical and health sciences, anzsrc-for: 32 Biomedical and Clinical Sciences, Hepatitis - C, Clinical Research, Drug Resistance, Viral, NS5A RAS, Humans, Aged, Fluorenes, Chronic / virology, Hepatitis C, Chronic, Emerging Infectious Diseases, Viral Nonstructural Proteins / antagonists & inhibitors, Benzimidazoles, Sofosbuvir, Digestive Diseases, RAS

Popis súboru: application/pdf

Prístupová URL adresa: https://discovery.dundee.ac.uk/ws/files/11735101/1_s2.0_S0168827817300119_main.pdf
https://pubmed.ncbi.nlm.nih.gov/28108232
https://www.ncbi.nlm.nih.gov/pubmed/28108232
https://pubmed.ncbi.nlm.nih.gov/28108232/
https://europepmc.org/article/MED/28108232
http://www.sciencedirect.com/science/article/pii/S0168827817300119
https://moh-it.pure.elsevier.com/en/publications/ns5a-resistance-associated-substitutions-in-patients-with-genotyp

Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus

Autori: M Azim Ansari Vincent Pedergnana Camilla L C Ip a ďalší

Prispievatelia: M Azim Ansari Vincent Pedergnana Camilla L C Ip a ďalší

Zdroj: Nat Genet
Nature genetics, vol. 49, no. 5, pp. 666-673

Predmety: 0301 basic medicine, IL28B, Hepacivirus, Adaptive Immunity, Viral Nonstructural Proteins, HLA Antigens, INFECTION, Innate, WIDE ASSOCIATION, HCV CLEARANCE, Viral, Chronic, Genetics & Heredity, Principal Component Analysis, 0303 health sciences, Genome, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, GENETIC-VARIATION, 11 Medical And Health Sciences, Viral Load, Hepatitis C, 3. Good health, Host-Pathogen Interactions, Life Sciences & Biomedicine, Human, INTERFERON, Genotype, name=Genetics, Genome, Viral, Adaptive Immunity/genetics, Alleles, Genetic Variation, Genome, Human/genetics, Genome, Viral/genetics, HLA Antigens/genetics, Hepacivirus/genetics, Hepacivirus/physiology, Hepatitis C, Chronic/genetics, Hepatitis C, Chronic/virology, Host-Pathogen Interactions/genetics, Humans, Immunity, Innate/genetics, Interleukins/genetics, Logistic Models, Viral Load/genetics, Viral Nonstructural Proteins/genetics, Article, 03 medical and health sciences, DIRECT-ACTING ANTIVIRALS, Science & Technology, Genome, Human, Interleukins, Immunity, DISEASE ASSOCIATION, 06 Biological Sciences, Hepatitis C, Chronic, Immunity, Innate, GENOTYPES 1, RESISTANCE, STOP-HCV Consortium, Developmental Biology

Popis súboru: application/pdf; 666 - +

Prístupová URL adresa: https://www.nature.com/articles/ng.3835.pdf
https://pubmed.ncbi.nlm.nih.gov/28394351
https://hal.science/hal-03691457v1
https://doi.org/10.1038/ng.3835
https://eprints.gla.ac.uk/138360/7/138360.pdf
https://dl.uswr.ac.ir/handle/Hannan/31989
https://serval.unil.ch/notice/serval:BIB_179F1128ACCA
https://eprints.soton.ac.uk/413488/
http://eprints.gla.ac.uk/138360/
https://www.cabdirect.org/cabdirect/abstract/20173180744
http://europepmc.org/abstract/MED/28394351
http://hdl.handle.net/10044/1/44869
https://ora.ox.ac.uk/objects/uuid:f82608ed-7142-4e4c-9d07-789b16d72c09
https://doi.org/10.1038/ng.3835
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_179F1128ACCA9
http://europepmc.org/abstract/med/28394351
https://serval.unil.ch/resource/serval:BIB_179F1128ACCA.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_179F1128ACCA

Comparative genome analysis of novel coronavirus (SARS-CoV-2) from different geographical locations and the effect of mutations on major target proteins: An in silico insight

Prispievatelia: Mohd Imran Khan Zainul A Khan Mohammad Hassan Baig a ďalší

Predmety: Betacoronavirus / classification, Betacoronavirus / genetics, Cysteine Endopeptidases / chemistry, Cysteine Endopeptidases / genetics, Genetic Variation, Genome, Viral, Molecular Dynamics Simulation, Mutation, Nucleocapsid Proteins / chemistry, Nucleocapsid Proteins / genetics, Phylogeny, Spike Glycoprotein, Coronavirus / chemistry, Coronavirus / genetics, Viral Envelope Proteins / chemistry, Viral Envelope Proteins / genetics, Viral Nonstructural Proteins / chemistry, Viral Nonstructural Proteins / genetics

Relation: PLOS ONE; J02540; https://ir.ymlib.yonsei.ac.kr/handle/22282913/179946; T202003452

Dostupnosť: https://ir.ymlib.yonsei.ac.kr/handle/22282913/179946
https://doi.org/10.1371/journal.pone.0238344

Dengue Non-structural Protein 5 Polymerase Complexes With Promyelocytic Leukemia Protein (PML) Isoforms III and IV to Disrupt PML-Nuclear Bodies in Infected Cells

Autori: Federico Giovannoni María Fatima Ladelfa Martin Monte a ďalší

Zdroj: Front Cell Infect Microbiol
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
Frontiers in Cellular and Infection Microbiology, 9:284

Predmety: 0301 basic medicine, PML-NBs disruption, Gene Expression, Promyelocytic Leukemia Protein, Viral Nonstructural Proteins, FOS: Health sciences, Cell Nucleus/metabolism [MeSH], Viral Nonstructural Proteins/genetics [MeSH], Cell Line [MeSH], Cell Nucleus/metabolism, Dengue Virus/physiology [MeSH], Gene Expression [MeSH], Host-Pathogen Interactions [MeSH], Virus Replication [MeSH], Protein Binding, Dengue/metabolism, Promyelocytic Leukemia Protein/metabolism, Protein Transport [MeSH], Viral Nonstructural Proteins/metabolism [MeSH], Host-Pathogen Interactions, Viral Nonstructural Proteins/genetics, Promyelocytic Leukemia Protein/metabolism [MeSH], Humans, Dengue/metabolism [MeSH], Protein Isoforms [MeSH], Protein Isoforms, Humans [MeSH], Dengue/virology [MeSH], Protein Transport, Dengue Virus/classification, Dengue/virology, Serogroup, Viral Nonstructural Proteins/metabolism, Protein Binding [MeSH], Dengue Virus/classification [MeSH], Dengue Virus/physiology, Cell Line, Serogroup [MeSH], Virus Replication, Gene, Dengue virus, Promyelocytic leukemia protein, Dengue, Cellular and Infection Microbiology, Acute promyelocytic leukemia, 0303 health sciences, Ebola Virus Research and Outbreaks, NON-STRUCTURAL PROTEIN 5 POLYMERASE, QR1-502, 3. Good health, Infectious Diseases, Medicine, Viral Hemorrhagic Fevers and Zoonotic Infections, promyelocytic leukemia protein, Microbiology, 03 medical and health sciences, Virology, Health Sciences, Genetics, Retinoic acid, Global Impact of Arboviral Diseases, PML isoform, DENGUE VIRUS, Biology, PROMYELOCYTIC LEUKEMIA PROTEIN, non-structural protein 5 polymerase, Cell Nucleus, dengue virus, Public Health, Environmental and Occupational Health, PML-NBS DISRUPTION, Dengue Virus, Dengue fever, PML ISOFORM, FOS: Biological sciences

Popis súboru: application/pdf

Prístupová URL adresa: https://www.frontiersin.org/articles/10.3389/fcimb.2019.00284/pdf
https://pubmed.ncbi.nlm.nih.gov/31456950
https://doaj.org/article/61a236af8d7d419cb73603cc7e3ee455
https://www.frontiersin.org/articles/10.3389/fcimb.2019.00284/full
https://research.monash.edu/en/publications/dengue-non-structural-protein-5-polymerase-complexes-with-promyel
https://www.cabdirect.org/cabdirect/abstract/20193471539
https://www.ncbi.nlm.nih.gov/pubmed/31456950
https://www.frontiersin.org/article/10.3389/fcimb.2019.00284/full
http://hdl.handle.net/11336/121628
https://repository.publisso.de/resource/frl:6475694

Daclatasvirvstelaprevir plus peginterferon alfa/ribavirin for hepatitis C virus genotype 1

Autori: Jacobson, Ira Zeuzem, Stefan Flisiak, Robert a ďalší

Zdroj: World Journal of Gastroenterology. 22:3418-3431

Predmety: Male, 0301 basic medicine, chronic - drug therapy, Antiviral agents - adverse effects, Recombinant proteins - adverse effects, Hepacivirus, Polyethylene Glycols, 0302 clinical medicine, viral - blood, Interferon-alpha - adverse effects, Viral load, Treatment outcome, Middle aged, Imidazoles - adverse effects, chronic - diagnosis, chronic - virology, Interleukins - genetics, Oligopeptides - adverse effects, Polyethylene glycols - adverse effects, Polyethylene glycols - therapeutic use, Oligopeptides - therapeutic use, Imidazoles, Middle Aged, Hepatitis C, 3. Good health, Drug Therapy, Combination, Female, Drug therapy, Oligopeptides, Adult, Imidazoles - therapeutic use, Adolescent, Genotype, Antiviral agents - therapeutic use, Recombinant proteins - therapeutic use, Antiviral Agents, viral - genetics, Viral nonstructural proteins - antagonists & inhibitors, Interferon-alpha - therapeutic use, 03 medical and health sciences, Chronic hepatitis C, Daclatasvir, Direct-acting antiviral, Genotype 1b, Liver disease, NS5A inhibitor, Aged, Drug Resistance, Viral, Hepatitis C, Chronic, Humans, Interferon-alpha, Interleukins, Polymorphism, Genetic, RNA, Viral, Recombinant Proteins, Ribavirin, Time Factors, Treatment Outcome, Viral Load, Viral Nonstructural Proteins, Young Adult, Gastroenterology, Polymorphism, combination, chronic - genetics, Time factors, Hepacivirus - genetics, Ribavirin - therapeutic use, Young adult, Drug resistance, RNA, Viral nonstructural proteins - genetics, Hepacivirus - drug effects, Carbamates, Interferons, genetic, Ribavirin - adverse effects

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/27022224
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806200/
https://www.wjgnet.com/1007-9327/full/v22/i12/3418.htm
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806200/
https://flore.unifi.it/handle/2158/1084507
http://europepmc.org/articles/PMC4806200
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806200/table/T3/
https://hdl.handle.net/2158/1084507
http://www.wjgnet.com/1007-9327/mcsy.asp
https://doi.org/10.3748/wjg.v22.i12.3418

Nucleocapsid Protein Recruitment to Replication-Transcription Complexes Plays a Crucial Role in Coronaviral Life Cycle

Autori: Mario Mauthe Franziska Kriegenburg Mustafa Ulasli a ďalší

Prispievatelia: Mario Mauthe Franziska Kriegenburg Mustafa Ulasli a ďalší

Zdroj: Journal of Virology
J Virol
Cong, Y, Ulasli, M, Schepers, H, Mauthe, M, V'kovski, P, Kriegenburg, F, Thiel, V, de Haan, C A M & Reggiori, F 2020, ' Nucleocapsid Protein Recruitment to Replication-Transcription Complexes Plays a Crucial Role in Coronaviral Life Cycle ', Journal of Virology, vol. 94, no. 4, e01925-19 . https://doi.org/10.1128/JVI.01925-19

Predmety: 0301 basic medicine, MURINE CORONAVIRUS, Transcription, Genetic, Immunology, Virus Replication/physiology, coronavirus, Viral Nonstructural Proteins, Virus Replication, Microbiology, Cell Line, RNA-BINDING, Mice, 03 medical and health sciences, SDG 3 - Good Health and Well-being, RESPIRATORY SYNDROME CORONAVIRUS, Virology, Taverne, viral mRNA synthesis, Animals, Humans, RNA, Viral/biosynthesis, PHOSPHORYLATION, N-TERMINAL DOMAIN, Murine hepatitis virus, Nucleocapsid Proteins/genetics, MULTIMERIZATION, Nucleocapsid Proteins, replication-transcription complexes, Genome Replication and Regulation of Viral Gene Expression, 3. Good health, Viral Nonstructural Proteins/genetics, Insect Science, nucleocapsid N protein, INFECTIOUS-BRONCHITIS VIRUS, replication-transcriptioncomplexes, RNA, Viral, Transcription, Genetic/physiology, MEMBRANE, Murine hepatitis virus/physiology, MOUSE HEPATITIS-VIRUS, NUCLEOPROTEIN

Popis súboru: application/pdf

Prístupová URL adresa: https://europepmc.org/articles/pmc6997762?pdf=render
https://pubmed.ncbi.nlm.nih.gov/31776274
https://hdl.handle.net/11370/a61120c2-ec6c-46e3-b9fd-0cea07e28511
https://doi.org/10.1128/JVI.01925-19
https://research.rug.nl/en/publications/a61120c2-ec6c-46e3-b9fd-0cea07e28511
https://research-portal.uu.nl/en/publications/dd4320db-6f6f-48a4-81ed-0337ae86b594
https://doi.org/10.1128/JVI.01925-19
https://pubmed.ncbi.nlm.nih.gov/31776274/
https://doi.org/10.1128%2FJVI.01925-19
https://www.narcis.nl/publication/RecordID/oai%3Adspace.library.uu.nl%3A1874%2F395019
https://boris.unibe.ch/145422/
https://journals.asm.org/doi/pdf/10.1128/JVI.01925-19
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997762
https://dspace.library.uu.nl/handle/1874/395019