Suchergebnisse - "Ventral Tegmental Area"

Reward-associated cues reduce H-current amplitude in midbrain dopamine neurons.

Autoren: Calo-Guadalupe CG Bosque-Cordero KY Capella-Muñiz J et al.

Quelle: Neuropharmacology [Neuropharmacology] 2025 Dec 15; Vol. 281, pp. 110699. Date of Electronic Publication: 2025 Sep 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

MeSH-Schlagworte: Reward* , Cues* , Dopaminergic Neurons*/drug effects , Dopaminergic Neurons*/physiology , Ventral Tegmental Area*/drug effects , Ventral Tegmental Area*/physiology , Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*/metabolism , Mesencephalon*/drug effects , Mesencephalon*/physiology, Animals ; Male ; Cocaine/administration & dosage ; Cocaine/pharmacology ; Rats ; Self Administration ; Rats, Sprague-Dawley ; Dopamine Uptake Inhibitors/administration & dosage ; Dopamine Uptake Inhibitors/pharmacology

Social Stress Increases Anxiety by GluA1-Dependent Synaptic Strengthening of Ventral Tegmental Area Inputs to the Basolateral Amygdala.

Autoren: Contesse T Gomes-Ribeiro J Royon L et al.

Quelle: Biological psychiatry [Biol Psychiatry] 2025 Nov 15; Vol. 98 (10), pp. 788-801. Date of Electronic Publication: 2025 Apr 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0213264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2402 (Electronic) Linking ISSN: 00063223 NLM ISO Abbreviation: Biol Psychiatry Subsets: MEDLINE

MeSH-Schlagworte: Ventral Tegmental Area*/physiopathology , Ventral Tegmental Area*/metabolism , Basolateral Nuclear Complex*/physiopathology , Basolateral Nuclear Complex*/metabolism , Receptors, AMPA*/metabolism , Receptors, AMPA*/genetics , Receptors, AMPA*/physiology , Stress, Psychological*/physiopathology , Anxiety*/physiopathology , Anxiety*/metabolism , Synapses*/physiology, Animals ; Male ; Mice ; Mice, Inbred C57BL ; Social Defeat ; Optogenetics ; Neurons/physiology ; Neural Pathways

Habenula-ventral tegmental area functional coupling and risk aversion in humans.

Autoren: Lin W Xu J Zhang X et al.

Quelle: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Nov 04; Vol. 122 (44), pp. e2500815122. Date of Electronic Publication: 2025 Oct 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH-Schlagworte: Habenula*/physiology , Habenula*/diagnostic imaging , Ventral Tegmental Area*/physiology , Ventral Tegmental Area*/diagnostic imaging , Risk-Taking*, Humans ; Magnetic Resonance Imaging ; Male ; Female ; Adult ; Prefrontal Cortex/physiology ; Prefrontal Cortex/diagnostic imaging ; Young Adult ; Nucleus Accumbens/physiology ; Learning/physiology

Blood oxygenation level-dependent responses in neuromodulatory nuclei and their associations with attention and memory across age groups.

Autoren: Riley E Cicero N Swallow K et al.

Quelle: Neurobiology of aging [Neurobiol Aging] 2025 Nov; Vol. 155, pp. 24-34. Date of Electronic Publication: 2025 Jul 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 8100437 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-1497 (Electronic) Linking ISSN: 01974580 NLM ISO Abbreviation: Neurobiol Aging Subsets: MEDLINE

MeSH-Schlagworte: Attention*/physiology , Aging*/psychology , Aging*/physiology , Memory*/physiology , Oxygen*/blood , Ventral Tegmental Area*/physiology , Ventral Tegmental Area*/metabolism , Basal Nucleus of Meynert*/physiology , Basal Nucleus of Meynert*/metabolism , Locus Coeruleus*/physiology , Locus Coeruleus*/metabolism, Humans ; Aged ; Middle Aged ; Male ; Adult ; Female ; Aged, 80 and over ; Young Adult ; Norepinephrine/metabolism ; Norepinephrine/physiology ; Dopamine/metabolism ; Dopamine/physiology ; Acetylcholine/metabolism ; Alzheimer Disease/psychology ; Alzheimer Disease/etiology ; Magnetic Resonance Imaging

Chemogenetic activation of VTA neurons induces anxiety-like behavior in a Parkinson's disease model.

Autoren: Lu X Qi Y Xue J et al.

Quelle: Experimental neurology [Exp Neurol] 2025 Nov; Vol. 393, pp. 115425. Date of Electronic Publication: 2025 Aug 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: United States NLM ID: 0370712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2430 (Electronic) Linking ISSN: 00144886 NLM ISO Abbreviation: Exp Neurol Subsets: MEDLINE

MeSH-Schlagworte: Ventral Tegmental Area*/pathology , Ventral Tegmental Area*/metabolism , Anxiety*/pathology , Anxiety*/etiology , Anxiety*/genetics , Anxiety*/metabolism , Anxiety*/psychology , Dopaminergic Neurons*/pathology , Dopaminergic Neurons*/metabolism, Animals ; Mice ; Female ; Male ; Mice, Inbred C57BL ; Disease Models, Animal ; Mice, Transgenic ; Parkinson Disease ; Chemogenetics

Inhibition of ventral tegmental area projections to the paraventricular thalamus attenuates conditioned cues-induced heroin seeking behavior in rats.

Autoren: Zhou Y Li W Cai D et al.

Quelle: Metabolic brain disease [Metab Brain Dis] 2025 Oct 27; Vol. 40 (8), pp. 298. Date of Electronic Publication: 2025 Oct 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: United States NLM ID: 8610370 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-7365 (Electronic) Linking ISSN: 08857490 NLM ISO Abbreviation: Metab Brain Dis Subsets: MEDLINE

MeSH-Schlagworte: Ventral Tegmental Area*/drug effects , Ventral Tegmental Area*/metabolism , Cues* , Heroin*/administration & dosage , Drug-Seeking Behavior*/drug effects , Drug-Seeking Behavior*/physiology , Midline Thalamic Nuclei*/drug effects , Midline Thalamic Nuclei*/metabolism, Animals ; Male ; Rats ; Rats, Sprague-Dawley ; Neural Pathways/drug effects ; Neostigmine/pharmacology ; Proto-Oncogene Proteins c-fos/metabolism ; Self Administration ; Tetrodotoxin/pharmacology ; Clozapine/pharmacology ; Clozapine/analogs & derivatives

Kappa Opioid Receptors Control a Stress-Sensitive Brain Circuit and Drive Cocaine Seeking.

Autoren: Martinez Damonte V Bailey LG Thakar A et al.

Quelle: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2025 Oct 22; Vol. 45 (43). Date of Electronic Publication: 2025 Oct 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Electronic Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE

MeSH-Schlagworte: Receptors, Opioid, kappa*/metabolism , Receptors, Opioid, kappa*/physiology , Receptors, Opioid, kappa*/genetics , Ventral Tegmental Area*/drug effects , Ventral Tegmental Area*/metabolism , Ventral Tegmental Area*/physiology , Drug-Seeking Behavior*/physiology , Drug-Seeking Behavior*/drug effects , Cocaine*/administration & dosage , Stress, Psychological*/metabolism , Stress, Psychological*/physiopathology , Cocaine-Related Disorders*/metabolism, Animals ; Male ; Mice ; Female ; Nucleus Accumbens/metabolism ; Nucleus Accumbens/drug effects ; Mice, Inbred C57BL ; Dopaminergic Neurons/physiology ; Mice, Knockout ; GABAergic Neurons ; Long-Term Potentiation/physiology ; Long-Term Potentiation/drug effects ; Neural Pathways

Distinct subcircuits within the mesolimbic dopamine system encode the salience and valence of social stimuli.

Autoren: Cross EA Borland JM Shaughnessy EK et al.

Quelle: Psychopharmacology [Psychopharmacology (Berl)] 2025 Oct; Vol. 242 (10), pp. 2219-2232. Date of Electronic Publication: 2025 Apr 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7608025 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2072 (Electronic) Linking ISSN: 00333158 NLM ISO Abbreviation: Psychopharmacology (Berl) Subsets: MEDLINE

MeSH-Schlagworte: Nucleus Accumbens*/metabolism , Nucleus Accumbens*/physiology , Dopamine*/metabolism , Ventral Tegmental Area*/physiology , Ventral Tegmental Area*/metabolism , Social Interaction* , Social Behavior*, Reward ; Animals ; Male ; Neural Pathways/physiology ; Mesolimbic System

Boosting the ventrolateral periaqueductal gray-ventral tegmental area pathway by disinhibition of group II mGluRs alleviates chronic restraint stress-induced depression-like behavior in mice.

Autoren: Lee MT Peng WH Hsu TW et al.

Quelle: Journal of psychopharmacology (Oxford, England) [J Psychopharmacol] 2025 Oct; Vol. 39 (10), pp. 1184-1200. Date of Electronic Publication: 2025 Jul 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Sage Publications Country of Publication: United States NLM ID: 8907828 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1461-7285 (Electronic) Linking ISSN: 02698811 NLM ISO Abbreviation: J Psychopharmacol Subsets: MEDLINE

MeSH-Schlagworte: Ventral Tegmental Area*/drug effects , Ventral Tegmental Area*/metabolism , Periaqueductal Gray*/drug effects , Periaqueductal Gray*/metabolism , Depression*/drug therapy , Depression*/physiopathology , Stress, Psychological*/drug therapy , Receptors, Metabotropic Glutamate*/antagonists & inhibitors , Receptors, Metabotropic Glutamate*/metabolism, Animals ; Male ; Mice ; Mice, Inbred C57BL ; Disease Models, Animal ; Behavior, Animal/drug effects ; Restraint, Physical ; Depressive Disorder, Major/drug therapy ; Depressive Disorder, Major/physiopathology ; Excitatory Amino Acid Antagonists/pharmacology ; Antidepressive Agents/pharmacology ; Amino Acids ; Xanthenes

Electroacupuncture ameliorates sleep deprivation-induced insomnia in mice by regulating the dopaminergic projections from VTA to NAc.

Autoren: Pan W Wang S Liu Y et al.

Quelle: Experimental neurology [Exp Neurol] 2025 Oct; Vol. 392, pp. 115351. Date of Electronic Publication: 2025 Jun 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: United States NLM ID: 0370712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2430 (Electronic) Linking ISSN: 00144886 NLM ISO Abbreviation: Exp Neurol Subsets: MEDLINE

MeSH-Schlagworte: Electroacupuncture*/methods , Sleep Deprivation*/complications , Sleep Deprivation*/physiopathology , Sleep Deprivation*/therapy , Sleep Initiation and Maintenance Disorders*/etiology , Sleep Initiation and Maintenance Disorders*/physiopathology , Sleep Initiation and Maintenance Disorders*/therapy , Ventral Tegmental Area*/cytology , Ventral Tegmental Area*/physiopathology , Nucleus Accumbens*/cytology , Nucleus Accumbens*/physiopathology, Disease Models, Animal ; Chronic Disease/therapy ; Neural Pathways/physiopathology ; Dopaminergic Neurons/physiology ; Stereotaxic Techniques ; Chemogenetics ; Electroencephalography ; Acupuncture Points ; Animals ; Mice ; Sleep Stages/physiology ; Mice, Inbred C57BL ; Male

VTA dopaminergic neuronal activity during NREM sleep is modulated by learning and facilitates motor memory consolidation.

Autoren: Sulaman BA Chen E Crane A et al.

Quelle: Science advances [Sci Adv] 2025 Dec 05; Vol. 11 (49), pp. eadw7427. Date of Electronic Publication: 2025 Dec 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

MeSH-Schlagworte: Dopaminergic Neurons*/physiology , Dopaminergic Neurons*/metabolism , Memory Consolidation*/physiology , Ventral Tegmental Area*/physiology , Ventral Tegmental Area*/cytology , Learning*/physiology, Animals ; Mice ; Male ; Optogenetics ; Sleep/physiology ; Motor Skills/physiology

The role of mesolimbic circuitry in aversive signaling and opioid dependence.

Autoren: Branco P Cox J Wu Y et al.

Quelle: Neuron [Neuron] 2025 Dec 03; Vol. 113 (23), pp. 3924-3941. Date of Electronic Publication: 2025 Sep 17.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE

MeSH-Schlagworte: Ventral Tegmental Area*/physiopathology , Ventral Tegmental Area*/drug effects , Ventral Tegmental Area*/metabolism , Opioid-Related Disorders*/physiopathology , Opioid-Related Disorders*/psychology , Opioid-Related Disorders*/metabolism , Dopaminergic Neurons*/physiology , Dopaminergic Neurons*/drug effects , Avoidance Learning*/physiology , Avoidance Learning*/drug effects , Limbic System*/physiopathology, Humans ; Animals ; Reinforcement, Psychology ; Reward ; Chronic Pain/physiopathology

Cocaine and Morphine Converge to Disrupt Chloride Homeostasis in Ventral Tegmental Area GABA Neurons.

Autoren: Pearson AC Kimmey BA Taormina MB et al.

Quelle: Addiction biology [Addict Biol] 2025 Dec; Vol. 30 (12), pp. e70104.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 9604935 Publication Model: Print Cited Medium: Internet ISSN: 1369-1600 (Electronic) Linking ISSN: 13556215 NLM ISO Abbreviation: Addict Biol Subsets: MEDLINE

MeSH-Schlagworte: Ventral Tegmental Area*/drug effects , Ventral Tegmental Area*/metabolism , Morphine*/pharmacology , Cocaine*/pharmacology , GABAergic Neurons*/drug effects , GABAergic Neurons*/metabolism , Chlorides*/metabolism , Dopamine Uptake Inhibitors*/pharmacology, Animals ; Homeostasis/drug effects ; Rats ; Male ; K Cl- Cotransporters ; Symporters/drug effects ; Symporters/metabolism ; Self Administration ; Rats, Sprague-Dawley ; Receptors, Dopamine D1/drug effects

High Resolution Postmortem MRI Discovers Developing Structural Connectivity in the Human Ascending Arousal Network.

Autoren: Licandro R Olchanyi M Ferraz da Silva LF et al.

Quelle: Human brain mapping [Hum Brain Mapp] 2025 Dec 01; Vol. 46 (17), pp. e70422.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley Country of Publication: United States NLM ID: 9419065 Publication Model: Print Cited Medium: Internet ISSN: 1097-0193 (Electronic) Linking ISSN: 10659471 NLM ISO Abbreviation: Hum Brain Mapp Subsets: MEDLINE

MeSH-Schlagworte: Nerve Net*/growth & development , Nerve Net*/diagnostic imaging , Nerve Net*/anatomy & histology , Arousal*/physiology , Connectome*/methods , Ventral Tegmental Area*/diagnostic imaging , Ventral Tegmental Area*/growth & development , Ventral Tegmental Area*/anatomy & histology , Brain*/growth & development , Brain*/diagnostic imaging, Humans ; Infant ; Adult ; Female ; Male ; Diffusion Tensor Imaging/methods ; Infant, Newborn ; Young Adult ; Diffusion Magnetic Resonance Imaging/methods ; Neural Pathways/growth & development ; Neural Pathways/diagnostic imaging ; Magnetic Resonance Imaging ; Fetus ; Postmortem Imaging

Effect of ninjin'yoeito on age-related decline in responsiveness of the brain reward system in mice.

Autoren: Miyazaki S Mizuno K Ikeda Y

Quelle: Experimental gerontology [Exp Gerontol] 2025 Dec; Vol. 212, pp. 112967. Date of Electronic Publication: 2025 Nov 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 0047061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6815 (Electronic) Linking ISSN: 05315565 NLM ISO Abbreviation: Exp Gerontol Subsets: MEDLINE

MeSH-Schlagworte: Reward* , Ventral Tegmental Area*/drug effects , Ventral Tegmental Area*/metabolism , Aging*/drug effects , Aging*/physiology , Drugs, Chinese Herbal*/pharmacology, Animals ; Nucleus Accumbens/drug effects ; Nucleus Accumbens/metabolism ; Mice ; Dopamine/metabolism ; Microglia/drug effects ; Microglia/metabolism ; Male ; Dopaminergic Neurons/drug effects ; Dopaminergic Neurons/metabolism ; Mice, Inbred C57BL ; Behavior, Animal/drug effects ; Interleukin-1beta/metabolism

Naringenin prevents ethanol-induced reward behavior in adolescent rats through inhibition of TRPM3-dependent inflammation in the pVTA.

Autoren: Awathale SN Shirasath KR More BR et al.

Quelle: The Journal of nutritional biochemistry [J Nutr Biochem] 2025 Dec; Vol. 146, pp. 110078. Date of Electronic Publication: 2025 Aug 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: United States NLM ID: 9010081 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4847 (Electronic) Linking ISSN: 09552863 NLM ISO Abbreviation: J Nutr Biochem Subsets: MEDLINE

MeSH-Schlagworte: Flavanones*/pharmacology , Reward* , TRPM Cation Channels*/metabolism , TRPM Cation Channels*/genetics , Ethanol*/adverse effects , Ventral Tegmental Area*/drug effects , Ventral Tegmental Area*/metabolism , Inflammation*/metabolism, Animals ; Male ; Rats ; Rats, Sprague-Dawley ; Nucleus Accumbens/drug effects ; Nucleus Accumbens/metabolism

Cannabidiol attenuates behavioral and electrophysiological changes in the MAM model of schizophrenia in male and female rats.

Autoren: Fabris D Andrade LM Freitas ÍS et al.

Quelle: Schizophrenia research [Schizophr Res] 2025 Dec; Vol. 286, pp. 63-73. Date of Electronic Publication: 2025 Oct 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Publisher B. V Country of Publication: Netherlands NLM ID: 8804207 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2509 (Electronic) Linking ISSN: 09209964 NLM ISO Abbreviation: Schizophr Res Subsets: MEDLINE

MeSH-Schlagworte: Cannabidiol*/pharmacology , Cannabidiol*/administration & dosage , Cannabidiol*/therapeutic use , Schizophrenia*/drug therapy , Schizophrenia*/chemically induced , Schizophrenia*/physiopathology , Ventral Tegmental Area*/drug effects , Ventral Tegmental Area*/physiopathology , Behavior, Animal*/drug effects , Prenatal Exposure Delayed Effects*/chemically induced , Prenatal Exposure Delayed Effects*/physiopathology , Prenatal Exposure Delayed Effects*/drug therapy , Antipsychotic Agents*/pharmacology, Animals ; Female ; Male ; Methylazoxymethanol Acetate ; Disease Models, Animal ; Rats ; Pregnancy ; Dopaminergic Neurons/drug effects ; Dopaminergic Neurons/physiology ; Dizocilpine Maleate/pharmacology ; Rats, Sprague-Dawley

The psychoactive compound ibogaine sex-dependently alters the firing rate and afterhyperpolarization of I h -negative neurons in the mouse ventral tegmental area.

Autoren: Eliasen JN Rezagholizadeh A Jacobsen HP et al.

Quelle: Neuroscience [Neuroscience] 2025 Nov 28; Vol. 589, pp. 308-321. Date of Electronic Publication: 2025 Oct 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7544 (Electronic) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE

MeSH-Schlagworte: Ventral Tegmental Area*/drug effects , Ventral Tegmental Area*/physiology , Ibogaine*/pharmacology , Action Potentials*/drug effects , GABAergic Neurons*/drug effects , GABAergic Neurons*/physiology , Sex Characteristics* , Hallucinogens*/pharmacology , Neurons*/drug effects , Neurons*/physiology, Animals ; Male ; Female ; Mice ; Mice, Inbred C57BL ; Excitatory Postsynaptic Potentials/drug effects ; Membrane Potentials/drug effects

Ventral tegmental area GABA neurons integrate positive and negative valence.

Autoren: Stelzner ME Wolff AR Saunders BT

Quelle: Nature communications [Nat Commun] 2025 Nov 24; Vol. 16 (1), pp. 10357. Date of Electronic Publication: 2025 Nov 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Ventral Tegmental Area*/physiology , Ventral Tegmental Area*/cytology , GABAergic Neurons*/physiology , GABAergic Neurons*/metabolism, Animals ; Reward ; Dopaminergic Neurons/physiology ; Dopaminergic Neurons/metabolism ; Male ; Rats ; Optogenetics ; Motivation/physiology ; Dopamine/metabolism ; Behavior, Animal/physiology ; Decision Making/physiology ; Rats, Long-Evans

Adolescent isolation disrupts medial amygdala and ventral tegmental area maturation and sex-specifically dysregulates transcriptional responses to cocaine and stress.

Autoren: Andrus MD Vu T Juarez B et al.

Quelle: Neuropharmacology [Neuropharmacology] 2025 Nov 15; Vol. 279, pp. 110629. Date of Electronic Publication: 2025 Aug 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

MeSH-Schlagworte: Ventral Tegmental Area*/drug effects , Ventral Tegmental Area*/growth & development , Ventral Tegmental Area*/metabolism , Cocaine*/pharmacology , Sex Characteristics* , Stress, Psychological*/metabolism , Social Isolation*/psychology , Corticomedial Nuclear Complex*/drug effects , Corticomedial Nuclear Complex*/metabolism , Corticomedial Nuclear Complex*/growth & development , Dopamine Uptake Inhibitors*/pharmacology, Animals ; Male ; Female ; Mice, Inbred C57BL ; Mice ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/genetics ; Receptors, Dopamine D2/metabolism ; Receptors, N-Methyl-D-Aspartate/metabolism