Suchergebnisse - "Ubiquitin Thiolesterase"

PARP1 cooperates with ASXL1 to stimulate BAP1 deubiquitinase activity through its DNA-binding domain.

Autoren: Lee B Lee J Kwon J

Quelle: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2025 Dec 15; Vol. 792, pp. 152982. Date of Electronic Publication: 2025 Nov 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

MeSH-Schlagworte: Ubiquitin Thiolesterase*/metabolism , Ubiquitin Thiolesterase*/chemistry , Poly (ADP-Ribose) Polymerase-1*/metabolism , Poly (ADP-Ribose) Polymerase-1*/chemistry , Tumor Suppressor Proteins*/metabolism , Tumor Suppressor Proteins*/chemistry , Repressor Proteins*/metabolism , Repressor Proteins*/chemistry , DNA*/metabolism, Humans ; Protein Domains ; Protein Binding ; Nucleosomes/metabolism

UCH-L1 regulates eye differentiation-related genes and modulates EGFR signalling in Drosophila melanogaster .

Autoren: Tuan NA Thuoc TL Thao DTP

Quelle: Fly [Fly (Austin)] 2025 Dec; Vol. 19 (1), pp. 2580003. Date of Electronic Publication: 2025 Nov 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101470897 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1933-6942 (Electronic) Linking ISSN: 19336934 NLM ISO Abbreviation: Fly (Austin) Subsets: MEDLINE

MeSH-Schlagworte: Drosophila Proteins*/metabolism , Drosophila Proteins*/genetics , Drosophila melanogaster*/genetics , Drosophila melanogaster*/growth & development , Drosophila melanogaster*/metabolism , ErbB Receptors*/metabolism , ErbB Receptors*/genetics , Ubiquitin Thiolesterase*/metabolism , Ubiquitin Thiolesterase*/genetics , Receptors, Invertebrate Peptide*/metabolism , Receptors, Invertebrate Peptide*/genetics , Eye*/growth & development , Eye*/metabolism, Animals ; Signal Transduction ; Cell Differentiation/genetics ; Gene Expression Regulation, Developmental

Use of UCHL1 Gene Expression to Estimate Adipocyte Size.

Autoren: Schormair K Zhong J Rico LDM et al.

Quelle: Diabetes [Diabetes] 2025 Dec 01; Vol. 74 (12), pp. 2291-2300.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE

MeSH-Schlagworte: Ubiquitin Thiolesterase*/genetics , Ubiquitin Thiolesterase*/metabolism , Adipocytes*/metabolism , Adipocytes*/cytology, Humans ; Male ; Insulin Resistance/genetics ; Female ; Middle Aged ; Adult ; Cell Size ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/genetics ; Real-Time Polymerase Chain Reaction ; Gene Expression

USP9X suppresses ferroptosis in diabetic kidney disease by deubiquitinating Nrf2 in vitro .

Autoren: Shao N Cai K Hong Y et al.

Quelle: Renal failure [Ren Fail] 2025 Dec; Vol. 47 (1), pp. 2458761. Date of Electronic Publication: 2025 Feb 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE

MeSH-Schlagworte: NF-E2-Related Factor 2*/metabolism , Ferroptosis*/drug effects , Ubiquitin Thiolesterase*/metabolism , Ubiquitin Thiolesterase*/genetics , Diabetic Nephropathies*/metabolism , Diabetic Nephropathies*/pathology, Humans ; Cell Survival/drug effects ; Ubiquitination ; Cell Line ; Glucose ; Apoptosis ; Reactive Oxygen Species/metabolism ; Iron/metabolism

Identification of AKOS, a Chikungunya virus inhibitor, as a USP14 inhibitor for colorectal cancer treatment.

Autoren: Lu B Sun YY Zhou JH et al.

Quelle: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2025 Dec; Vol. 46 (12), pp. 3302-3313. Date of Electronic Publication: 2025 Jul 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE

MeSH-Schlagworte: Colorectal Neoplasms*/drug therapy , Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/metabolism , Ubiquitin Thiolesterase*/antagonists & inhibitors , Ubiquitin Thiolesterase*/metabolism , Chikungunya virus*/drug effects , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use , Antineoplastic Agents*/chemistry , Antiviral Agents*/pharmacology , Antiviral Agents*/therapeutic use , Antiviral Agents*/chemistry, Humans ; Animals ; Cell Proliferation/drug effects ; Mice, Nude ; Mice ; Mice, Inbred BALB C ; Cell Line, Tumor ; Xenograft Model Antitumor Assays ; HCT116 Cells

USP8-mediated CDH3 drives the malignant progression of lung adenocarcinoma by regulating ferroptosis.

Autoren: Qv R Fang Y Wang N et al.

Quelle: Tissue & cell [Tissue Cell] 2025 Dec; Vol. 97, pp. 103040. Date of Electronic Publication: 2025 Jul 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 0214745 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3072 (Electronic) Linking ISSN: 00408166 NLM ISO Abbreviation: Tissue Cell Subsets: MEDLINE

MeSH-Schlagworte: Ferroptosis*/genetics , Cadherins*/metabolism , Cadherins*/genetics , Adenocarcinoma of Lung*/pathology , Adenocarcinoma of Lung*/genetics , Adenocarcinoma of Lung*/metabolism , Lung Neoplasms*/pathology , Lung Neoplasms*/genetics , Lung Neoplasms*/metabolism , Ubiquitin Thiolesterase*/metabolism , Ubiquitin Thiolesterase*/genetics , Disease Progression* , Endopeptidases*/metabolism, Humans ; Animals ; Cell Proliferation/genetics ; Cell Movement/genetics ; Mice ; Cell Line, Tumor ; Female ; Gene Expression Regulation, Neoplastic ; Male

USP36 suppresses breast cancer cell ferroptosis by regulating the ubiquitination and stability of KIF2C.

Autoren: Chen Y Hong S Wu F et al.

Quelle: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 2), pp. 117196. Date of Electronic Publication: 2025 Jul 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Ferroptosis*/physiology , Ferroptosis*/drug effects , Breast Neoplasms*/metabolism , Breast Neoplasms*/pathology , Breast Neoplasms*/genetics , Kinesins*/metabolism , Kinesins*/genetics , Ubiquitination*/physiology , Ubiquitin Thiolesterase*/metabolism , Ubiquitin Thiolesterase*/genetics, Humans ; Female ; Animals ; Mice ; Cell Line, Tumor ; Mice, Nude ; Protein Stability ; MCF-7 Cells ; Mice, Inbred BALB C ; Xenograft Model Antitumor Assays/methods

METTL3-Mediated m6A Methylation of USP21 Contributes to Hepatocellular Carcinoma Progression by Stabilizing H2BFS Through Deubiquitination.

Autoren: Yao P Li X Chai J et al.

Quelle: Biochemical genetics [Biochem Genet] 2025 Dec; Vol. 63 (6), pp. 5462-5479. Date of Electronic Publication: 2024 Dec 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 0126611 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4927 (Electronic) Linking ISSN: 00062928 NLM ISO Abbreviation: Biochem Genet Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/genetics , Liver Neoplasms*/metabolism , Liver Neoplasms*/pathology , Liver Neoplasms*/genetics , Methyltransferases*/metabolism , Methyltransferases*/genetics , Ubiquitin Thiolesterase*/genetics , Ubiquitin Thiolesterase*/metabolism, Humans ; Mice ; Animals ; Ubiquitination ; Disease Progression ; Cell Proliferation ; Cell Line, Tumor ; Male ; Methylation ; Gene Expression Regulation, Neoplastic ; Mice, Nude ; Cell Movement ; Cadherins/metabolism

USP18 inhibits CVB3-induced pyroptosis and fibrosis of mouse cardiomyocytes through the IRF7/NF-κB signaling pathway.

Autoren: Zhang Y Yang L Mu H et al.

Quelle: Molecular immunology [Mol Immunol] 2025 Dec; Vol. 188, pp. 62-72. Date of Electronic Publication: 2025 Nov 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Pergamon Press Country of Publication: England NLM ID: 7905289 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9142 (Electronic) Linking ISSN: 01615890 NLM ISO Abbreviation: Mol Immunol Subsets: MEDLINE

MeSH-Schlagworte: Myocytes, Cardiac*/pathology , Myocytes, Cardiac*/metabolism , Myocytes, Cardiac*/virology , NF-kappa B*/metabolism , Ubiquitin Thiolesterase*/metabolism , Ubiquitin Thiolesterase*/genetics , Myocarditis*/virology , Myocarditis*/pathology , Myocarditis*/metabolism , Enterovirus B, Human* , Pyroptosis* , Interferon Regulatory Factor-7*/metabolism , Coxsackievirus Infections*/metabolism , Coxsackievirus Infections*/pathology , Coxsackievirus Infections*/virology, Animals ; Mice ; Signal Transduction ; Fibrosis ; Male ; Cell Line

Isoginkgetin as a novel USP8 inhibitor discovered by structure-based virtual screening exerts anticancer effects in ovarian cancer.

Autoren: Hu B Liu Y Zhao Z et al.

Quelle: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2025 Nov 28; Vol. 791, pp. 152924. Date of Electronic Publication: 2025 Nov 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

MeSH-Schlagworte: Ovarian Neoplasms*/drug therapy , Ovarian Neoplasms*/pathology , Ovarian Neoplasms*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Ubiquitin Thiolesterase*/antagonists & inhibitors , Ubiquitin Thiolesterase*/metabolism , Ubiquitin Thiolesterase*/chemistry , Endopeptidases*/metabolism , Endopeptidases*/chemistry, Humans ; Female ; Cell Proliferation/drug effects ; Cell Line, Tumor ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Drug Screening Assays, Antitumor

Characterization of BRCA1-Associated Protein-1 (BAP1) Aggregation Properties Induced by Cancer-Associated Mutations.

Autoren: Hsiao LC Puri S Sriramoju MK et al.

Quelle: Chembiochem : a European journal of chemical biology [Chembiochem] 2025 Nov 27; Vol. 26 (23), pp. e202500372. Date of Electronic Publication: 2025 Oct 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE

MeSH-Schlagworte: Ubiquitin Thiolesterase*/genetics , Ubiquitin Thiolesterase*/metabolism , Ubiquitin Thiolesterase*/chemistry , Tumor Suppressor Proteins*/genetics , Tumor Suppressor Proteins*/metabolism , Tumor Suppressor Proteins*/chemistry , Neoplasms*/genetics , Neoplasms*/metabolism, Humans ; Protein Aggregates ; Mutation ; Benzothiazoles/chemistry

Protective effects of mouse bone marrow mesenchymal stem cell-derived extracellular vesicles on radiation-induced epididymal cells damage via USP44/RBM14 axis.

Autoren: Zhu L Zhang J Liang Y et al.

Quelle: Stem cell research & therapy [Stem Cell Res Ther] 2025 Nov 26; Vol. 16 (1), pp. 662. Date of Electronic Publication: 2025 Nov 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE

MeSH-Schlagworte: Mesenchymal Stem Cells*/metabolism , Mesenchymal Stem Cells*/cytology , Extracellular Vesicles*/metabolism , RNA-Binding Proteins*/metabolism , RNA-Binding Proteins*/genetics , Ubiquitin Thiolesterase*/metabolism , Ubiquitin Thiolesterase*/genetics , Epididymis*/metabolism , Epididymis*/radiation effects , Epididymis*/pathology , Epididymis*/cytology, Animals ; Male ; Mice ; Oxidative Stress ; Apoptosis/radiation effects ; DNA Damage ; Cell Survival/radiation effects

Oxidative stress reactivates androgen receptor signaling via USP36 to drive castration resistance in prostate cancer.

Autoren: Fan C Huang Z Gao J et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 26; Vol. 15 (1), pp. 42185. Date of Electronic Publication: 2025 Nov 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Receptors, Androgen*/metabolism , Receptors, Androgen*/genetics , Oxidative Stress* , Prostatic Neoplasms, Castration-Resistant*/metabolism , Prostatic Neoplasms, Castration-Resistant*/pathology , Prostatic Neoplasms, Castration-Resistant*/genetics , Signal Transduction* , Ubiquitin Thiolesterase*/metabolism , Ubiquitin Thiolesterase*/genetics, Male ; Humans ; Cell Line, Tumor ; Hydrogen Peroxide/pharmacology ; Prostate-Specific Antigen/genetics ; Prostate-Specific Antigen/metabolism ; Gene Expression Regulation, Neoplastic

USP14-mediated stabilization of ACTN1 maintains mesenchymal characteristics in glioblastoma.

Autoren: Qiu W Shi X Wei R et al.

Quelle: Communications biology [Commun Biol] 2025 Nov 25; Vol. 8 (1), pp. 1680. Date of Electronic Publication: 2025 Nov 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE

MeSH-Schlagworte: Actinin*/metabolism , Actinin*/genetics , Glioblastoma*/pathology , Glioblastoma*/metabolism , Glioblastoma*/genetics , Brain Neoplasms*/pathology , Brain Neoplasms*/metabolism , Brain Neoplasms*/genetics , Ubiquitin Thiolesterase*/metabolism , Ubiquitin Thiolesterase*/genetics , Epithelial-Mesenchymal Transition*, Humans ; Cell Line, Tumor ; Animals ; Mice ; Gene Expression Regulation, Neoplastic ; Cell Proliferation ; Female

The Small Molecule Compound Eupalinolide B Alleviates Neuropathic Pain by Regulating the USP7/Keap1/Nrf2 Pathway.

Autoren: Yang X Jiang F Li J et al.

Quelle: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology [J Neuroimmune Pharmacol] 2025 Nov 25; Vol. 20 (1), pp. 106. Date of Electronic Publication: 2025 Nov 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 101256586 Publication Model: Electronic Cited Medium: Internet ISSN: 1557-1904 (Electronic) Linking ISSN: 15571890 NLM ISO Abbreviation: J Neuroimmune Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: NF-E2-Related Factor 2*/metabolism , NF-E2-Related Factor 2*/biosynthesis , Kelch-Like ECH-Associated Protein 1*/metabolism , Kelch-Like ECH-Associated Protein 1*/biosynthesis , Neuralgia*/drug therapy , Neuralgia*/metabolism , Ubiquitin Thiolesterase*/metabolism , Ubiquitin Thiolesterase*/biosynthesis , Sesquiterpenes*/pharmacology , Sesquiterpenes*/therapeutic use, Animals ; Mice ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Male ; Mice, Inbred C57BL

UCHL3 depletion inhibits gastric cancer progression and enhances palbociclib sensitivity by regulating the AKT/CCND1 signaling axis via ENO1 ubiquitination.

Autoren: Liu W Zhou L Le Y et al.

Quelle: Cell death & disease [Cell Death Dis] 2025 Nov 21; Vol. 16 (1), pp. 850. Date of Electronic Publication: 2025 Nov 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE

MeSH-Schlagworte: Ubiquitin Thiolesterase*/metabolism , Ubiquitin Thiolesterase*/genetics , Stomach Neoplasms*/pathology , Stomach Neoplasms*/genetics , Stomach Neoplasms*/drug therapy , Stomach Neoplasms*/metabolism , Proto-Oncogene Proteins c-akt*/metabolism , Cyclin D1*/metabolism , Piperazines*/pharmacology , Piperazines*/therapeutic use , Tumor Suppressor Proteins*/metabolism , Tumor Suppressor Proteins*/genetics , Phosphopyruvate Hydratase*/metabolism , Phosphopyruvate Hydratase*/genetics , Pyridines*/pharmacology , Pyridines*/therapeutic use , DNA-Binding Proteins*/metabolism, Humans ; Animals ; Ubiquitination/drug effects ; Signal Transduction/drug effects ; Mice ; Disease Progression ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Epithelial-Mesenchymal Transition/drug effects ; Mice, Nude ; Female ; Male ; Cell Movement/drug effects ; Gene Expression Regulation, Neoplastic ; Biomarkers, Tumor

Ubiquitin-specific protease 24: a potential anti-cancer target.

Autoren: Ye L Du Y Mai Y et al.

Quelle: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2025 Nov 19; Vol. 790, pp. 152895. Date of Electronic Publication: 2025 Nov 01.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

MeSH-Schlagworte: Neoplasms*/drug therapy , Neoplasms*/enzymology , Ubiquitin Thiolesterase*/antagonists & inhibitors , Ubiquitin Thiolesterase*/metabolism , Ubiquitin Thiolesterase*/chemistry , Ubiquitin Thiolesterase*/genetics , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use, Humans ; Animals ; Autophagy ; Molecular Targeted Therapy ; DNA Repair

Knockdown of PATZ1 alleviates chronic heart failure through the USP22/HIF-1α axis.

Autoren: Luo Y Zhou F Chen Q et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 18; Vol. 15 (1), pp. 40566. Date of Electronic Publication: 2025 Nov 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism , Hypoxia-Inducible Factor 1, alpha Subunit*/genetics , Heart Failure*/genetics , Heart Failure*/metabolism , Heart Failure*/pathology , Ubiquitin Thiolesterase*/metabolism , Ubiquitin Thiolesterase*/genetics, Animals ; Humans ; Rats ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Male ; Rats, Sprague-Dawley ; Disease Models, Animal ; Apoptosis ; Gene Knockdown Techniques ; Cell Line ; Chronic Disease ; Signal Transduction

Deubiquitinating Enzymes Ubiquitin-Specific Proteases 7 and 10 Regulate TAU Aggregation.

Autoren: Volbracht C Fog K

Quelle: International journal of molecular sciences [Int J Mol Sci] 2025 Nov 15; Vol. 26 (22). Date of Electronic Publication: 2025 Nov 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: tau Proteins*/metabolism , Ubiquitin Thiolesterase*/metabolism , Ubiquitin Thiolesterase*/genetics , Ubiquitin Thiolesterase*/antagonists & inhibitors , Ubiquitin-Specific Peptidase 7*/metabolism , Ubiquitin-Specific Peptidase 7*/genetics , Ubiquitin-Specific Peptidase 7*/antagonists & inhibitors , Protein Aggregation, Pathological*/metabolism, Animals ; Mice ; Ubiquitination ; Neurons/metabolism ; Hippocampus/metabolism ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Humans ; Protein Aggregates

A rare variant of USP9X associated with female-restricted X-linked syndromic intellectual disability.

Autoren: Xue S Shi W Hao L

Quelle: Molecular biology reports [Mol Biol Rep] 2025 Nov 15; Vol. 53 (1), pp. 88. Date of Electronic Publication: 2025 Nov 15.

Publikationsart: Journal Article; Case Reports

Info zur Zeitschrift: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE

MeSH-Schlagworte: Intellectual Disability*/genetics , Ubiquitin Thiolesterase*/genetics , Ubiquitin Thiolesterase*/metabolism, Humans ; Female ; Phenotype ; Infant, Newborn ; Whole Genome Sequencing ; Mutation ; Syndrome