Suchergebnisse - "UK Biobank"

Associations between sweetened beverage consumption, degenerative valvular heart disease, and related events: a prospective study from UK Biobank.

Autoren: Wei C Gong W Xu B et al.

Quelle: European journal of preventive cardiology [Eur J Prev Cardiol] 2025 Dec 04; Vol. 32 (17), pp. 1763-1775.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 101564430 Publication Model: Print Cited Medium: Internet ISSN: 2047-4881 (Electronic) Linking ISSN: 20474873 NLM ISO Abbreviation: Eur J Prev Cardiol Subsets: MEDLINE

MeSH-Schlagworte: Heart Valve Diseases*/epidemiology , Heart Valve Diseases*/diagnosis , Artificially Sweetened Beverages*/adverse effects , Sugar-Sweetened Beverages*/adverse effects , Aortic Valve Stenosis*/epidemiology , Aortic Valve Stenosis*/diagnosis, Humans ; Prospective Studies ; Male ; Female ; United Kingdom/epidemiology ; Middle Aged ; Aged ; Risk Factors ; Risk Assessment ; Biological Specimen Banks ; Incidence ; Time Factors ; UK Biobank

Physical activity and Alzheimer's disease risk across genetic susceptibility: a prospective UK Biobank study using accelerometer data.

Autoren: Na S Muir K Lophatananon A et al.

Quelle: Journal of neurology [J Neurol] 2025 Dec 02; Vol. 273 (1), pp. 1. Date of Electronic Publication: 2025 Dec 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0423161 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1459 (Electronic) Linking ISSN: 03405354 NLM ISO Abbreviation: J Neurol Subsets: MEDLINE

MeSH-Schlagworte: Alzheimer Disease*/genetics , Alzheimer Disease*/epidemiology , Alzheimer Disease*/prevention & control , Exercise*/physiology , Genetic Predisposition to Disease*, Humans ; Male ; Female ; Middle Aged ; Aged ; United Kingdom/epidemiology ; Accelerometry ; Biological Specimen Banks ; Adult ; Prospective Studies ; Genome-Wide Association Study ; Apolipoprotein E4/genetics ; Multifactorial Inheritance ; Risk Factors ; UK Biobank

Intake of one-carbon metabolism nutrients and risk of rheumatoid arthritis: a prospective UK biobank cohort study.

Autoren: Zhang S Xia B Kang Y et al.

Quelle: European journal of nutrition [Eur J Nutr] 2025 Dec 01; Vol. 64 (8), pp. 325. Date of Electronic Publication: 2025 Dec 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Steinkopff Country of Publication: Germany NLM ID: 100888704 Publication Model: Electronic Cited Medium: Internet ISSN: 1436-6215 (Electronic) Linking ISSN: 14366207 NLM ISO Abbreviation: Eur J Nutr Subsets: MEDLINE

MeSH-Schlagworte: Arthritis, Rheumatoid*/epidemiology , Arthritis, Rheumatoid*/genetics , Diet*/methods , Diet*/statistics & numerical data , Nutrients*/administration & dosage , Carbon*/metabolism, Humans ; Female ; Male ; Prospective Studies ; Middle Aged ; United Kingdom/epidemiology ; Risk Factors ; Biological Specimen Banks ; Folic Acid/administration & dosage ; Aged ; Methionine/administration & dosage ; Proportional Hazards Models ; Adult ; Vitamin B 6/administration & dosage ; Cohort Studies ; Vitamin B 12/administration & dosage ; UK Biobank

Genetic Susceptibility to Cardio-Cerebrovascular Diseases and White Matter Integrity in Asymptomatic Older Adults: A UK Biobank Observational Cohort Study.

Autoren: Liu J Wang C Zhang Y et al.

Quelle: Journal of magnetic resonance imaging : JMRI [J Magn Reson Imaging] 2025 Dec; Vol. 62 (6), pp. 1770-1779. Date of Electronic Publication: 2025 Jul 12.

Publikationsart: Journal Article; Observational Study

Info zur Zeitschrift: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 9105850 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-2586 (Electronic) Linking ISSN: 10531807 NLM ISO Abbreviation: J Magn Reson Imaging Subsets: MEDLINE

MeSH-Schlagworte: White Matter*/diagnostic imaging , Genetic Predisposition to Disease* , Cerebrovascular Disorders*/genetics , Cerebrovascular Disorders*/diagnostic imaging , Cardiovascular Diseases*/genetics , Cardiovascular Diseases*/diagnostic imaging, Humans ; Male ; Female ; Middle Aged ; United Kingdom ; Cohort Studies ; Aged ; Biological Specimen Banks ; Magnetic Resonance Imaging ; Brain/diagnostic imaging ; Diffusion Tensor Imaging ; Risk Factors ; UK Biobank

Polygenic risk of refractory celiac disease type II and its association with autoimmune diseases: a phenome-wide association study in the UK Biobank.

Autoren: Tsali L Tsilidis K Katsanos K et al.

Quelle: European journal of gastroenterology & hepatology [Eur J Gastroenterol Hepatol] 2025 Dec 01; Vol. 37 (12), pp. 1344-1349. Date of Electronic Publication: 2025 Jul 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Lippincott Williams And Wilkins Country of Publication: England NLM ID: 9000874 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5687 (Electronic) Linking ISSN: 0954691X NLM ISO Abbreviation: Eur J Gastroenterol Hepatol Subsets: MEDLINE

MeSH-Schlagworte: Celiac Disease*/genetics , Celiac Disease*/immunology , Celiac Disease*/diagnosis , Celiac Disease*/epidemiology , Multifactorial Inheritance* , Autoimmune Diseases*/genetics , Autoimmune Diseases*/epidemiology, Humans ; Female ; Male ; Middle Aged ; Genome-Wide Association Study ; United Kingdom/epidemiology ; Genetic Predisposition to Disease ; Phenotype ; Biological Specimen Banks ; Risk Factors ; Polymorphism, Single Nucleotide ; Aged ; Adult ; UK Biobank

Alzheimer's disease polygenic risk's association with all-cause dementia through the plasma metabolome in the UK Biobank study.

Autoren: Beydoun MA Hu YH Li Z et al.

Quelle: GeroScience [Geroscience] 2025 Dec; Vol. 47 (6), pp. 7023-7042. Date of Electronic Publication: 2025 Jul 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE

MeSH-Schlagworte: Alzheimer Disease*/genetics , Alzheimer Disease*/blood , Alzheimer Disease*/epidemiology , Metabolome* , Dementia*/genetics , Dementia*/epidemiology , Dementia*/blood, Humans ; Female ; Male ; United Kingdom/epidemiology ; Aged ; Genome-Wide Association Study ; Biomarkers/blood ; Middle Aged ; Biological Specimen Banks ; Multifactorial Inheritance ; Risk Factors ; Metabolomics ; Genetic Predisposition to Disease ; UK Biobank

Sleep Health and White Matter Integrity in the UK Biobank.

Autoren: Petri R Holub F Schiel JE et al.

Quelle: Journal of sleep research [J Sleep Res] 2025 Dec; Vol. 34 (6), pp. e70034. Date of Electronic Publication: 2025 Mar 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Published on behalf of the European Sleep Research Society by Blackwell Scientific Publications Country of Publication: England NLM ID: 9214441 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2869 (Electronic) Linking ISSN: 09621105 NLM ISO Abbreviation: J Sleep Res Subsets: MEDLINE

MeSH-Schlagworte: White Matter*/diagnostic imaging , White Matter*/pathology , Sleep*/physiology , Sleep Initiation and Maintenance Disorders*/pathology , Sleep Initiation and Maintenance Disorders*/diagnostic imaging, Humans ; Male ; Female ; United Kingdom ; Middle Aged ; Aged ; Biological Specimen Banks ; Diffusion Magnetic Resonance Imaging ; UK Biobank

Investigating multimorbidity trajectories in people living with MASLD diagnosis: A trajectory analysis using the UK Biobank.

Autoren: Lu F Yang H She B et al.

Quelle: Diabetes, obesity & metabolism [Diabetes Obes Metab] 2025 Dec; Vol. 27 (12), pp. 6968-6978. Date of Electronic Publication: 2025 Sep 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 100883645 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1463-1326 (Electronic) Linking ISSN: 14628902 NLM ISO Abbreviation: Diabetes Obes Metab Subsets: MEDLINE

MeSH-Schlagworte: Multimorbidity* , Non-alcoholic Fatty Liver Disease*/epidemiology, Humans ; Male ; Female ; Middle Aged ; United Kingdom/epidemiology ; Biological Specimen Banks/statistics & numerical data ; Risk Factors ; Aged ; UK Biobank

Association between the atherogenic index of plasma and major adverse cardiovascular events in individuals with metabolic syndrome: findings from the UK biobank.

Autoren: Hu Y Li W Nie J et al.

Quelle: Cardiovascular diabetology [Cardiovasc Diabetol] 2025 Nov 21; Vol. 24 (1), pp. 444. Date of Electronic Publication: 2025 Nov 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101147637 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2840 (Electronic) Linking ISSN: 14752840 NLM ISO Abbreviation: Cardiovasc Diabetol Subsets: MEDLINE

MeSH-Schlagworte: Metabolic Syndrome*/diagnosis , Metabolic Syndrome*/blood , Metabolic Syndrome*/mortality , Metabolic Syndrome*/epidemiology , Cardiovascular Diseases*/diagnosis , Cardiovascular Diseases*/mortality , Cardiovascular Diseases*/epidemiology , Cardiovascular Diseases*/blood , Atherosclerosis*/diagnosis , Atherosclerosis*/blood , Atherosclerosis*/mortality , Atherosclerosis*/epidemiology, Humans ; Male ; Female ; Middle Aged ; United Kingdom/epidemiology ; Risk Assessment ; Aged ; Biomarkers/blood ; Incidence ; Biological Specimen Banks ; Time Factors ; Prognosis ; Predictive Value of Tests ; Risk Factors ; Adult ; Heart Disease Risk Factors ; Databases, Factual ; UK Biobank

Elevated triglyceride-glucose index and risk of thymoma-associated myasthenia gravis: a prospective analysis from the UK Biobank.

Autoren: Zhu K Shi J Zhao J et al.

Quelle: Cardiovascular diabetology [Cardiovasc Diabetol] 2025 Nov 19; Vol. 24 (1), pp. 439. Date of Electronic Publication: 2025 Nov 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101147637 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2840 (Electronic) Linking ISSN: 14752840 NLM ISO Abbreviation: Cardiovasc Diabetol Subsets: MEDLINE

MeSH-Schlagworte: Myasthenia Gravis*/epidemiology , Myasthenia Gravis*/diagnosis , Myasthenia Gravis*/blood , Thymoma*/epidemiology , Thymoma*/blood , Thymoma*/diagnosis , Triglycerides*/blood , Thymus Neoplasms*/epidemiology , Thymus Neoplasms*/blood , Thymus Neoplasms*/diagnosis , Thymus Neoplasms*/complications , Blood Glucose*/metabolism , Blood Glucose*/analysis , Cholesterol, HDL*/blood, Humans ; Male ; Female ; Middle Aged ; United Kingdom/epidemiology ; Prospective Studies ; Risk Factors ; Risk Assessment ; Biomarkers/blood ; Aged ; Biological Specimen Banks ; Adult ; Up-Regulation ; Prognosis ; UK Biobank

Dietary patterns, polygenic risk, and kidney cancer incidence: a UK Biobank cohort study.

Autoren: Zou M Deng R Qiu J et al.

Quelle: Journal of translational medicine [J Transl Med] 2025 Nov 19; Vol. 23 (1), pp. 1318. Date of Electronic Publication: 2025 Nov 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE

MeSH-Schlagworte: Kidney Neoplasms*/epidemiology , Kidney Neoplasms*/genetics , Biological Specimen Banks* , Diet* , Multifactorial Inheritance*/genetics , Genetic Predisposition to Disease*, Humans ; Female ; Male ; United Kingdom/epidemiology ; Middle Aged ; Risk Factors ; Incidence ; Proportional Hazards Models ; Cohort Studies ; Aged ; Prospective Studies ; UK Biobank

Genetic variants associated with gout identified through a genome-wide study in the UK biobank (N = 150 542).

Autoren: Tao Y Cai T Pan Q et al.

Quelle: Human molecular genetics [Hum Mol Genet] 2025 Nov 18; Vol. 34 (23), pp. 1951-1963.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE

MeSH-Schlagworte: Gout*/genetics , Gout*/epidemiology , Gout*/pathology , Genetic Predisposition to Disease*, Humans ; Genome-Wide Association Study ; Male ; United Kingdom/epidemiology ; Female ; Polymorphism, Single Nucleotide/genetics ; Biological Specimen Banks ; Middle Aged ; Aged ; Hyperuricemia/genetics ; Uric Acid ; UK Biobank

Blood pressure, hypertension, and the risk of aortic aneurysm in the UK Biobank.

Autoren: Naqvi REZ Baroom G Zheng L et al.

Quelle: BMC cardiovascular disorders [BMC Cardiovasc Disord] 2025 Nov 10; Vol. 25 (1), pp. 799. Date of Electronic Publication: 2025 Nov 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 100968539 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2261 (Electronic) Linking ISSN: 14712261 NLM ISO Abbreviation: BMC Cardiovasc Disord Subsets: MEDLINE

MeSH-Schlagworte: Hypertension*/physiopathology , Hypertension*/diagnosis , Hypertension*/epidemiology , Hypertension*/mortality , Blood Pressure* , Aortic Aneurysm, Abdominal*/epidemiology , Aortic Aneurysm, Abdominal*/physiopathology , Aortic Aneurysm, Abdominal*/diagnosis , Biological Specimen Banks* , Aortic Aneurysm*/epidemiology , Aortic Aneurysm*/diagnosis , Aortic Aneurysm*/physiopathology , Aortic Aneurysm, Thoracic*/epidemiology , Aortic Aneurysm, Thoracic*/physiopathology , Aortic Aneurysm, Thoracic*/diagnosis, Humans ; Female ; Male ; Middle Aged ; Aged ; United Kingdom/epidemiology ; Risk Factors ; Adult ; Risk Assessment ; Time Factors ; Incidence ; UK Biobank

Plasma NfL and GFAP in the preclinical stages of neurodegenerative diseases: insights from the UK Biobank.

Autoren: Buonocore J Fratto E Arcuri F et al.

Quelle: Journal of neurology [J Neurol] 2025 Nov 09; Vol. 272 (12), pp. 755. Date of Electronic Publication: 2025 Nov 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0423161 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1459 (Electronic) Linking ISSN: 03405354 NLM ISO Abbreviation: J Neurol Subsets: MEDLINE

MeSH-Schlagworte: Glial Fibrillary Acidic Protein*/blood , Neurofilament Proteins*/blood , Neurodegenerative Diseases*/blood , Neurodegenerative Diseases*/epidemiology , Neurodegenerative Diseases*/diagnosis , Prodromal Symptoms*, Humans ; Male ; Female ; United Kingdom/epidemiology ; Aged ; Middle Aged ; Biomarkers/blood ; Biological Specimen Banks ; Amyotrophic Lateral Sclerosis/blood ; Amyotrophic Lateral Sclerosis/epidemiology ; Alzheimer Disease/blood ; Alzheimer Disease/epidemiology ; UK Biobank

Malnutrition and age-related macular degeneration: mechanistic insights from UK Biobank metabolomic and imaging data.

Autoren: Zhou J He Y Wang J et al.

Quelle: The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2025 Nov 06; Vol. 80 (12).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: published on behalf of the Gerontological Society of America by Oxford University Press Country of Publication: United States NLM ID: 9502837 Publication Model: Print Cited Medium: Internet ISSN: 1758-535X (Electronic) Linking ISSN: 10795006 NLM ISO Abbreviation: J Gerontol A Biol Sci Med Sci Subsets: MEDLINE

MeSH-Schlagworte: Macular Degeneration*/epidemiology , Macular Degeneration*/etiology , Macular Degeneration*/metabolism , Macular Degeneration*/diagnostic imaging , Malnutrition*/complications , Malnutrition*/metabolism , Malnutrition*/epidemiology, Humans ; Male ; Female ; Middle Aged ; United Kingdom/epidemiology ; Metabolomics ; Biological Specimen Banks ; Aged ; Risk Factors ; Cohort Studies ; Tomography, Optical Coherence ; UK Biobank

A simulation study comparing anticholinergic drug use with polypharmacy for risk of death, dementia, and delirium in UK Biobank.

Autoren: Mur J Stirland LE Muniz-Terrera G et al.

Quelle: The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2025 Nov 06; Vol. 80 (12).

Publikationsart: Journal Article; Comparative Study

Info zur Zeitschrift: Publisher: published on behalf of the Gerontological Society of America by Oxford University Press Country of Publication: United States NLM ID: 9502837 Publication Model: Print Cited Medium: Internet ISSN: 1758-535X (Electronic) Linking ISSN: 10795006 NLM ISO Abbreviation: J Gerontol A Biol Sci Med Sci Subsets: MEDLINE

MeSH-Schlagworte: Cholinergic Antagonists*/adverse effects , Polypharmacy* , Dementia*/epidemiology , Dementia*/chemically induced , Delirium*/epidemiology , Delirium*/chemically induced, Humans ; Aged ; United Kingdom/epidemiology ; Male ; Female ; Prospective Studies ; Middle Aged ; Aged, 80 and over ; Biological Specimen Banks ; Risk Factors ; UK Biobank

Rheumatoid arthritis and cardiovascular disease associations in the UK Biobank.

Autoren: Salatzki J Condurache DG D'Angelo S et al.

Quelle: BMC medicine [BMC Med] 2025 Nov 03; Vol. 23 (1), pp. 605. Date of Electronic Publication: 2025 Nov 03.

Publikationsart: Journal Article; Observational Study

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE

MeSH-Schlagworte: Arthritis, Rheumatoid*/epidemiology , Arthritis, Rheumatoid*/complications , Cardiovascular Diseases*/epidemiology , Cardiovascular Diseases*/diagnostic imaging, Humans ; Female ; Male ; United Kingdom/epidemiology ; Middle Aged ; Biological Specimen Banks ; Aged ; Prospective Studies ; Magnetic Resonance Imaging ; Risk Factors ; Case-Control Studies ; UK Biobank

Body mass index, metabolically abnormal status, and incident Parkinson's disease: Data from the UK Biobank.

Autoren: Yun HR Son NH Koh HB et al.

Quelle: Journal of Parkinson's disease [J Parkinsons Dis] 2025 Nov; Vol. 15 (7), pp. 1275-1286. Date of Electronic Publication: 2025 Aug 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101567362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1877-718X (Electronic) Linking ISSN: 18777171 NLM ISO Abbreviation: J Parkinsons Dis Subsets: MEDLINE

MeSH-Schlagworte: Parkinson Disease*/epidemiology , Parkinson Disease*/metabolism , Body Mass Index* , Obesity*/epidemiology , Obesity*/metabolism , Overweight*/epidemiology , Overweight*/metabolism, Humans ; Male ; Female ; United Kingdom/epidemiology ; Middle Aged ; Aged ; Incidence ; Biological Specimen Banks/statistics & numerical data ; Risk Factors ; Adult ; UK Biobank

Lymphoma and Long-Term cardiovascular disease risk: A comprehensive analysis from the UK biobank.

Autoren: Ge C He Y Huang F et al.

Quelle: Annals of hematology [Ann Hematol] 2025 Nov; Vol. 104 (11), pp. 5797-5808. Date of Electronic Publication: 2025 Aug 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9107334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0584 (Electronic) Linking ISSN: 09395555 NLM ISO Abbreviation: Ann Hematol Subsets: MEDLINE

MeSH-Schlagworte: Cardiovascular Diseases*/epidemiology , Cardiovascular Diseases*/etiology , Cardiovascular Diseases*/diagnosis , Lymphoma*/epidemiology , Lymphoma*/complications , Biological Specimen Banks*, Humans ; Male ; Female ; Middle Aged ; United Kingdom/epidemiology ; Retrospective Studies ; Aged ; Adult ; Risk Factors ; UK Biobank

Development of a risk prediction model for Alzheimer's disease based on the UK Biobank prospective study.

Autoren: Li H Wu Y Huang T et al.

Quelle: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2025 Nov; Vol. 108 (1), pp. 142-156. Date of Electronic Publication: 2025 Sep 15.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: SAGE Publications Country of Publication: United States NLM ID: 9814863 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-8908 (Electronic) Linking ISSN: 13872877 NLM ISO Abbreviation: J Alzheimers Dis Subsets: MEDLINE

MeSH-Schlagworte: Alzheimer Disease*/genetics , Alzheimer Disease*/epidemiology , Alzheimer Disease*/diagnosis , Biological Specimen Banks*, Humans ; United Kingdom/epidemiology ; Male ; Female ; Risk Factors ; Prospective Studies ; Aged ; Proportional Hazards Models ; Middle Aged ; Risk Assessment ; Polymorphism, Single Nucleotide ; Multifactorial Inheritance ; Genetic Predisposition to Disease ; UK Biobank