Search Results - "Type 1 Diabetes: Pathophysiology and Prevention"

Insulin resistance relates to DKA severity and affects insulin requirement in children with type 1 diabetes at onset

Authors: Mastromauro, Concetta Polidori, Nella Blasetti, Annalisa et al.

Source: Pediatr Diabetes

Subject Terms: 03 medical and health sciences, Diabetes Mellitus, Type 1, Glucose, 0302 clinical medicine, Type 1 Diabetes: Pathophysiology and Prevention, Humans, Insulin, DKA, children, insulin administration, insulin resistance, type 1 diabetes, Insulin Resistance, Child, Retrospective Studies, Diabetic Ketoacidosis, 3. Good health

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Access URL: https://pubmed.ncbi.nlm.nih.gov/36183171
https://onlinelibrary.wiley.com/doi/10.1111/pedi.13424
https://doi.org/10.1111/pedi.13424
https://hdl.handle.net/11564/790951

HbA1c as a time predictive biomarker for an additional islet autoantibody and type 1 diabetes in seroconverted TEDDY children

Authors: Falastin Salami Roy Tamura Lu You et al.

Source: Pediatr Diabetes
Pediatr. Diabetes 23, 1586-1593 (2022)

Subject Terms: Glycated Hemoglobin, 0301 basic medicine, Glutamate Decarboxylase, Type 1 Diabetes: Pathophysiology and Prevention, Children, Gada, Hba1c, Ia-2a, Iaa, Islet Autoantibodies, Type 1 Diabetes, Znt8a, ta3121, ta3111, ta3123, ddc, 3. Good health, 03 medical and health sciences, Diabetes Mellitus, Type 1, 0302 clinical medicine, Humans, Insulin, Child, Biomarkers, Autoantibodies

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Access URL: https://pubmed.ncbi.nlm.nih.gov/36082496
http://juuli.fi/Record/0394434222
https://doi.org/10.1111/pedi.13413
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=66154
https://mediatum.ub.tum.de/1771275

Viral infection‐related gene upregulation in monocytes in children with signs of β‐cell autoimmunity

Authors: Milla Valta Masahito Yoshihara Elisabet Einarsdottir et al.

Contributors: Milla Valta Masahito Yoshihara Elisabet Einarsdottir et al.

Source: Pediatr Diabetes

Subject Terms: EXPRESSION, 0301 basic medicine, YOUNG-CHILDREN, β-cell autoimmunity, type 1 diabetes, PREDICTION, Autoimmunity, 3121 Internal medicine, BLOOD MONONUCLEAR-CELLS, ta3111, Monocytes, 03 medical and health sciences, 3123 Gynaecology and paediatrics, SEROCONVERSION, Humans, TRANSCRIPTOME, beta-cell autoimmunity, Autoantibodies, 0303 health sciences, TYPE-1 DIABETES-MELLITUS, SIGNATURE, Type 1 Diabetes: Pathophysiology and Prevention, DISEASE RISK, ta3121, viral response, General medicine, internal medicine and other clinical medicine, Up-Regulation, 3. Good health, Diabetes Mellitus, Type 1, Virus Diseases, Asymptomatic Diseases, Leukocytes, Mononuclear, AUTOANTIBODIES, monocytes

File Description: application/pdf; fulltext

Access URL: https://pubmed.ncbi.nlm.nih.gov/35419920
http://hdl.handle.net/10138/347026
http://urn.fi/urn:nbn:fi-fe2022100561190
https://trepo.tuni.fi/handle/10024/140855

Associations between deduced first islet specific autoantibody with sex, age at diagnosis and genetic risk factors in young children with type 1 diabetes

Authors: Ilonen, Jorma Laine, Antti Pekka Kiviniemi, Minna et al.

Contributors: Ilonen, Jorma Laine, Antti Pekka Kiviniemi, Minna et al.

Source: Pediatr Diabetes

Subject Terms: Male, 0301 basic medicine, demography, Genotype, autoantibodies, Insulin Antibodies, AUTOIMMUNE, SUSCEPTIBILITY, 3121 Internal medicine, PHENOTYPE, ta3111, DISEASE, Islets of Langerhans, 03 medical and health sciences, 0302 clinical medicine, MARKERS, 3123 Gynaecology and paediatrics, Risk Factors, Humans, CELL-ANTIBODIES, HLA antigens, genes, Child, Gynaecology and paediatrics, Autoantibodies, GENERAL-POPULATION, Glutamate Decarboxylase, Type 1 Diabetes: Pathophysiology and Prevention, HUMAN THYMUS, Protein Tyrosine Phosphatase, Non-Receptor Type 22, ta3121, ta3123, General medicine, internal medicine and other clinical medicine, 3. Good health, Diabetes Mellitus, Type 1, Child, Preschool, ONSET, Female, INSULIN AUTOANTIBODIES

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Access URL: https://pubmed.ncbi.nlm.nih.gov/35403376
http://juuli.fi/Record/0399692222
http://juuli.fi/Record/0390747322
https://doi.org/10.1111/pedi.13340
http://hdl.handle.net/10138/347206
https://trepo.tuni.fi/handle/10024/141790

Human plasma‐derived alpha 1 ‐proteinase inhibitor in patients with new‐onset type 1 diabetes mellitus: A randomized, placebo‐controlled proof‐of‐concept study

Authors: William H. Lagarde Kecia L. Courtney Barry Reiner et al.

Source: Pediatr Diabetes

Subject Terms: Adult, Male, 0301 basic medicine, 0303 health sciences, Serine Proteinase Inhibitors, Adolescent, C-Peptide, Interleukin-6, Type 1 Diabetes: Pathophysiology and Prevention, 16. Peace & justice, Proof of Concept Study, Drug Administration Schedule, 3. Good health, Young Adult, 03 medical and health sciences, Diabetes Mellitus, Type 1, Treatment Outcome, alpha 1-Antitrypsin, Humans, Female, Child, Infusions, Intravenous

Access URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/pedi.13162
https://pubmed.ncbi.nlm.nih.gov/33244872
https://pubmed.ncbi.nlm.nih.gov/33244872/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984376
https://onlinelibrary.wiley.com/doi/full/10.1111/pedi.13162
https://www.ncbi.nlm.nih.gov/pubmed/33244872
https://europepmc.org/article/MED/33244872

Celiac disease can be predicted by high levels of tissue transglutaminase antibodies in children and adolescents with type 1 diabetes

Authors: Ulf Samuelsson Elin Udén Auste Pundziute Lyckå et al.

Source: Pediatr Diabetes

Subject Terms: Male, Sweden, Transglutaminases, Adolescent, Type 1 Diabetes: Pathophysiology and Prevention, Age Factors, Endocrinology and Diabetes, 3. Good health, Cohort Studies, Celiac Disease, 03 medical and health sciences, biopsy, celiac disease, screening, tissue transglutaminase antibodies, type 1 diabetes, Diabetes Mellitus, Type 1, 0302 clinical medicine, Predictive Value of Tests, Child, Preschool, Endokrinologi och diabetes, Humans, Female, Child, Autoantibodies

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Access URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/pedi.13165
https://pubmed.ncbi.nlm.nih.gov/33259121
https://pubmed.ncbi.nlm.nih.gov/33259121/
https://lup.lub.lu.se/search/publication/985b0854-9285-4cdf-8ae7-f162870f8db3
http://pubmed.ncbi.nlm.nih.gov/33259121/
https://onlinelibrary.wiley.com/doi/full/10.1111/pedi.13165
https://www.ncbi.nlm.nih.gov/pubmed/33259121
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048786
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-172234

Antibiotic treatment during early childhood and risk of type 1 diabetes in children: A national birth cohort study: A national birth cohort study

Authors: Karsten Buschard Kristine H. Allin Camilla Schmidt Morgen et al.

Source: Pediatr Diabetes
Antvorskov, J C, Morgen, C S, Buschard, K, Jess, T, Allin, K H & Josefsen, K 2020, ' Antibiotic treatment during early childhood and risk of type 1 diabetes in children : A national birth cohort study ', Pediatric Diabetes, vol. 21, no. 8, pp. 1457-1464 . https://doi.org/10.1111/pedi.13111

Subject Terms: Adult, Male, type 1 diabetes, Type 1 Diabetes: Pathophysiology and Prevention, Infant, Newborn, Infant, early childhood, antibiotics, Anti-Bacterial Agents, Gastrointestinal Microbiome, 3. Good health, 03 medical and health sciences, Child Development, Diabetes Mellitus, Type 1, 0302 clinical medicine, children, Risk Factors, Child, Preschool, Humans, postnatal exposure, Female, Registries

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Access URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/pedi.13111
https://pubmed.ncbi.nlm.nih.gov/32902076
https://www.ncbi.nlm.nih.gov/pubmed/32902076
https://portal.findresearcher.sdu.dk/da/publications/antibiotic-treatment-during-early-childhood-and-risk-of-type-1-di
https://pubmed.ncbi.nlm.nih.gov/32902076/
https://findresearcher.sdu.dk:8443/ws/files/174330520/pedi.13111.pdf
https://onlinelibrary.wiley.com/doi/10.1111/pedi.13111
https://jglobal.jst.go.jp/detail?JGLOBAL_ID=202002214171242252
https://curis.ku.dk/ws/files/251585400/pedi.13111.pdf
https://portal.findresearcher.sdu.dk/da/publications/8bdfd8cd-a343-4546-b203-149227406818
https://doi.org/10.1111/pedi.13111
https://findresearcher.sdu.dk:8443/ws/files/174330520/pedi.13111.pdf

Increased tissue factor activity promotes thrombin generation at type 1 diabetes onset in children

Authors: Hildegard Jasser‐Nitsche Harald Haidl Gerhard Cvirn et al.

Source: Pediatr Diabetes

Subject Terms: Male, 0301 basic medicine, Time Factors, Adolescent, Lipoproteins, Type 1 Diabetes: Pathophysiology and Prevention, Age Factors, Thrombin, Thromboplastin, 03 medical and health sciences, Diabetes Mellitus, Type 1, 0302 clinical medicine, Child, Preschool, Humans, Hypoglycemic Agents, Insulin, Female, Longitudinal Studies, Child

Access URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/pedi.13086
https://pubmed.ncbi.nlm.nih.gov/32691481
https://onlinelibrary.wiley.com/doi/10.1111/pedi.13086
https://www.ncbi.nlm.nih.gov/pubmed/32691481
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589270
http://europepmc.org/abstract/MED/32691481

Identification of infants with increased type 1 diabetes genetic risk for enrollment into Primary Prevention Trials—GPPAD‐02 study design and first results

Authors: Winkler, Christiane Haupt, Florian Heigermoser, Martin et al.

Source: Pediatr Diabetes
Pediatr. Diabetes 20, 720-727 (2019)

Subject Terms: Male, 0301 basic medicine, type 1 diabetes, CHILDREN, Autoimmunity, Pediatrics, Polymorphism, Single Nucleotide, Endocrinology & Metabolism, Islets of Langerhans, 03 medical and health sciences, Neonatal Screening, Risk Factors, Humans, Genetic Predisposition to Disease, Genetic Testing, Autoantibodies, Beta-cell Autoantibodies, Genetic Risk For Type 1 Diabetes, Type 1 Diabetes, 0303 health sciences, Science & Technology, genetic risk for type 1 diabetes, Patient Selection, Type 1 Diabetes: Pathophysiology and Prevention, 3202 Clinical sciences, Infant, Newborn, Infant, 3213 Paediatrics, ddc, 3. Good health, GPPAD Study Group, Europe, Primary Prevention, Diabetes Mellitus, Type 1, Research Design, beta-cell autoantibodies, 1114 Paediatrics and Reproductive Medicine, AUTOANTIBODIES, Female, Life Sciences & Biomedicine, Preliminary Data

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Access URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/pedi.12870
https://pubmed.ncbi.nlm.nih.gov/31192505
https://onlinelibrary.wiley.com/doi/pdf/10.1111/pedi.12870
https://portal.research.lu.se/sv/publications/identification-of-infants-with-increased-type-1-diabetes-genetic-
https://onlinelibrary.wiley.com/doi/full/10.1111/pedi.12870
https://www.jenner.ac.uk/publications/1015618
https://researchportal.vub.be/en/publications/identification-of-infants-with-increased-type-1-diabetes-genetic-
https://europepmc.org/article/MED/31192505
https://ora.ox.ac.uk/objects/uuid:05c9e083-f1db-406f-b4ba-bb2f245cb4b8
https://doi.org/10.1111/pedi.12870
https://lirias.kuleuven.be/handle/123456789/640384
https://doi.org/10.1111/pedi.12870
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=56327
https://mediatum.ub.tum.de/1539819

Mixed‐meal tolerance test to assess residual beta‐cell secretion: Beyond the area‐under‐curve of plasma C‐peptide concentration

Authors: Ruben H. Willemsen Malgorzata E. Wilinska David B. Dunger et al.

Contributors: Ruben H. Willemsen Malgorzata E. Wilinska David B. Dunger et al.

Source: Pediatr Diabetes
Pediatric Diabetes

Subject Terms: Blood Glucose, Glycated Hemoglobin, Male, Adolescent, C-Peptide, type 1 diabetes, Type 1 Diabetes: Pathophysiology and Prevention, Postprandial Period, Diagnostic Techniques, Endocrine, 03 medical and health sciences, Diabetes Mellitus, Type 1, 0302 clinical medicine, mixed-meal tolerance test, Area Under Curve, Insulin-Secreting Cells, Insulin Secretion, Feasibility Studies, Humans, Female, beta-cell secretion, C-peptide, Child, Meals

File Description: application/msword

Access URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/pedi.12816
https://pubmed.ncbi.nlm.nih.gov/30652426
https://www.ncbi.nlm.nih.gov/pubmed/30652426
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487945
https://onlinelibrary.wiley.com/doi/full/10.1111/pedi.12816
https://europepmc.org/article/MED/30652426
https://www.repository.cam.ac.uk/handle/1810/288800
https://pubmed.ncbi.nlm.nih.gov/30652426/

Extended family history of type 1 diabetes in HLA-predisposed children with and without islet autoantibodies

Authors: Jorma Ilonen Salla Kuusela Paula Vähäsalo et al.

Contributors: Jorma Ilonen Salla Kuusela Paula Vähäsalo et al.

Source: Pediatr Diabetes

Subject Terms: Male, 0301 basic medicine, GENETIC SUSCEPTIBILITY, type 1 diabetes, Autoimmunity, genetic risk, MELLITUS, Islets of Langerhans, 03 medical and health sciences, 0302 clinical medicine, children, Humans, Family, Genetic Predisposition to Disease, Prospective Studies, Child, POPULATION, Finland, Gynaecology and paediatrics, Autoantibodies, RISK, family history, MOTHERS, Incidence, Type 1 Diabetes: Pathophysiology and Prevention, ta3121, ta3123, General medicine, internal medicine and other clinical medicine, 3. Good health, HLA, Diabetes Mellitus, Type 1, Child, Preschool, Disease Progression, BETA-CELL AUTOIMMUNITY, Female, islet autoimmunity, Follow-Up Studies

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Access URL: http://jultika.oulu.fi/files/nbnfi-fe202101222348.pdf
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/pedi.13122
https://pubmed.ncbi.nlm.nih.gov/32939969
http://juuli.fi/Record/0371456020
https://doi.org/10.1111/pedi.13122
https://onlinelibrary.wiley.com/doi/10.1111/pedi.13122
https://pubmed.ncbi.nlm.nih.gov/32939969/
https://onlinelibrary.wiley.com/doi/epdf/10.1111/pedi.13122
https://researchportal.helsinki.fi/en/publications/extended-family-history-of-type-1-diabetes-inhla-predisposed-chil
https://www.ncbi.nlm.nih.gov/pubmed/32939969
http://hdl.handle.net/10138/325878
http://urn.fi/urn:nbn:fi-fe202101222348