Výsledky vyhľadávania - "Tumor-initiating cells"

CDK4/6 inhibitor PD-0332991 suppresses hepatocarcinogenesis by inducing senescence of hepatic tumor-initiating cells

Autori: Miaomiao Chen Wenjian Chen Shiwen Sun a ďalší

Zdroj: J Adv Res
Journal of Advanced Research, Vol 73, Iss, Pp 357-373 (2025)

Predmety: CDK4/6 inhibitors, Medicine (General), Q1-390, R5-920, Science (General), Basic and Biological Science, Tumor-initiating cells, HCC, Cellular senescence, Cyclin D-CDK4/6-INK4-Rb pathway

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39218249
https://doaj.org/article/cec1cfb0284f4ffba1081f3d78698005

The rise of RAS: how gradual oncogene activation shapes the OIS spectrum

Autori: Zhu, Haoran Chan, Adelyne Sue Li Narita, Masashi a ďalší

Prispievatelia: Zhu, Haoran Chan, Adelyne Sue Li Narita, Masashi a ďalší

Zdroj: Genes & Development. 39:936-947

Predmety: liver cancer, Genes, ras, Neoplasms, oncogene-induced senescence, ras Proteins, Humans, Animals, Oncogenes, tumor-initiating cells, Cellular Senescence, RAS

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40324881
https://www.repository.cam.ac.uk/handle/1810/381803
https://doi.org/10.1101/gad.352761.125
https://doi.org/10.17863/cam.116861

PLA2 driven lipid signaling drives ARMS tumorigenic cell properties

Autori: Amogh Gupta Bharathi Ramanathan Dipanwita Das a ďalší

Zdroj: Cell Communication and Signaling, Vol 23, Iss 1, Pp 1-17 (2025)

Predmety: Alveolar rhabdomyosarcoma, Tumor-initiating cells, Lipid metabolism, PLA2 signalling, Metabolic plasticity, Medicine, Cytology, QH573-671

Popis súboru: electronic resource

Relation: https://doaj.org/toc/1478-811X

Prístupová URL adresa: https://doaj.org/article/50e1ffb34eac494f996b213f2363aea7

The DRP1 receptor FIS1 is critical to the expansion of triple-negative breast cancer tumor-initiating cells

Autori: Tetiana Katrii Tanya Freywald Malkon G. Estrada a ďalší

Zdroj: Cancer Cell International, Vol 25, Iss 1, Pp 1-14 (2025)

Predmety: Breast cancer, Tumor initiating cells, Mitochondria, Fission, FIS1 therapeutic targeting, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

Popis súboru: electronic resource

Relation: https://doaj.org/toc/1475-2867

Prístupová URL adresa: https://doaj.org/article/5a30590bb2914e7a9a2841fb1a23aca6

The immunomodulatory role of tumor-initiating cells in digestive system tumors: from mechanisms to therapy

Autori: Zun-yue Zhang Xin-feng Zhang Cong-hui Xu a ďalší

Zdroj: Frontiers in Immunology, Vol 16 (2025)

Predmety: tumor-initiating cells (TICs), tumor microenvironment, immunotherapy, immune checkpoints, Immunologic diseases. Allergy, RC581-607, digestive system tumors, combination therapy

Prístupová URL adresa: https://doaj.org/article/d7eaab4ccc554fb7907b182b4f8a97de

Bmi-1 inhibition sensitizes head and neck cancer stem cells to cytotoxic chemotherapy

Autori: Alexandra E. Herzog Shirley Zheng Kristy A. Warner a ďalší

Zdroj: Translational Oncology, Vol 63, Iss , Pp 102603- (2026)

Predmety: Chemoresistance, Tumor initiating cells, Cancer stemness, Self-renewal, Head neck squamous cell carcinoma, Oral cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

Popis súboru: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1936523325003341; https://doaj.org/toc/1936-5233

Prístupová URL adresa: https://doaj.org/article/b7503c3603024705ae7f43985ce8b577

Immunotherapy targeting liver cancer tumor-initiating cells: challenges, mechanisms, and emerging therapeutic horizons

Autori: Yinying Chai Tinghui Xu Xin Chen a ďalší

Zdroj: Front Immunol
Frontiers in Immunology, Vol 16 (2025)

Predmety: liver cancer, therapeutic resistance, nanotechnology, Immunology, tumor microenvironment, immunotherapy, Immunologic diseases. Allergy, RC581-607, tumor-initiating cells

Prístupová URL adresa: https://doaj.org/article/4c88a33e45344471977eaeb7357d7840

Characterization of uniquely tumorigenic cancer stem cells in salivary gland adenoid cystic carcinoma

Autori: Kristy A. Warner Sosuke Sahara Alexandra E. Herzog a ďalší

Zdroj: Front Oral Health
Frontiers in Oral Health, Vol 6 (2025)

Predmety: salivary gland cancer, cancer stemness, aldehyde dehydrogenase, Dentistry, RK1-715, Oral Health, tumor-initiating cells, tumor cell heterogeneity

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40371051
https://doaj.org/article/b1842a4a7bcd4fa499cdfc2af32339fb

SIRT4 Promotes Pancreatic Cancer Stemness by Enhancing Histone Lactylation and Epigenetic Reprogramming Stimulated by Calcium Signaling

Autori: Mengzhu Lv Xiaodan Yang Congcong Xu a ďalší

Zdroj: Adv Sci (Weinh)
Advanced Science, Vol 12, Iss 20, Pp n/a-n/a (2025)

Predmety: SIRT4, tumor‐initiating cells, Science, glycolysis, histones lactylation, Research Article

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40298941
https://doaj.org/article/cc82d3c4da074d67b66713d1ab767073

Tumor-initiating and metastasis-initiating cells of clear-cell renal cell carcinoma

Autori: Dinh-Xuan Pham Tien Hsu

Zdroj: Journal of Biomedical Science, Vol 32, Iss 1, Pp 1-20 (2025)

Predmety: Clear-cell renal cell carcinoma, Cancer stem cells, Tumor-initiating cells, Metastasis-initiating cells, Kidney progenitor cells, VHL tumor suppressor gene, Medicine

Popis súboru: electronic resource

Relation: https://doaj.org/toc/1423-0127

Prístupová URL adresa: https://doaj.org/article/935130c121c94571a8de65b1c1880d49

NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells

Autori: Hye Yeon Choi Yicheng Zhu Xuyao Zhao a ďalší

Prispievatelia: Hye Yeon Choi Yicheng Zhu Xuyao Zhao a ďalší

Zdroj: Exp Mol Med
Experimental and Molecular Medicine, Vol 56, Iss 2, Pp 461-477 (2024)

Predmety: 0301 basic medicine, Chromatin Immunoprecipitation, cancer, tumor-initiating cells, NOTCH, prolyl isomerase Pin1, Ubiquitin-Protein Ligases, QD415-436, Biochemistry, Article, tumor-initiating cell, Mitochondrial Proteins, Mice, 03 medical and health sciences, Humans, Animals, Phosphorylation, 0303 health sciences, GTPase-Activating Proteins, Membrane Proteins, Cyclin-Dependent Kinase 8, Cyclin-Dependent Kinases, Mitochondria, Disease Models, Animal, Mitochondrial Membranes, Medicine

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38409448
https://doaj.org/article/cce91a31632d430a830e45249520ef25
https://www.nature.com/articles/s12276-024-01174-6
https://hdl.handle.net/11368/3100044
https://pmc.ncbi.nlm.nih.gov/articles/pmid/38409448/
https://www.nature.com/articles/s12276-024-01174-6
https://doi.org/10.1038/s12276-024-01174-6
https://hdl.handle.net/11368/3100044

Interpretation of the Transcriptome-Based Signature of Tumor-Initiating Cells, the Core of Cancer Development, and the Construction of a Machine Learning-Based Classifier

Autori: Seung-Hyun Jeong Jong-Jin Kim Ji-Hun Jang a ďalší

Zdroj: Cells, Vol 14, Iss 16, p 1255 (2025)

Predmety: tumor-initiating cells, transcriptome profiling, differential gene expression, metabolic reprogramming, non-coding RNA, machine learning classifier, Cytology, QH573-671

Popis súboru: electronic resource

Relation: https://www.mdpi.com/2073-4409/14/16/1255; https://doaj.org/toc/2073-4409

Prístupová URL adresa: https://doaj.org/article/4b7efbe1186544bfba10b763d1e585df

Streptomycin targets tumor-initiating cells by disrupting oxidative phosphorylation

Autori: Guillorit, Hélène Relier, Sébastien Zagiel, Benjamin a ďalší

Prispievatelia: Guillorit, Hélène Relier, Sébastien Zagiel, Benjamin a ďalší

Zdroj: ISSN: 2451-9456.

Predmety: mitochondria, OXPHOS activity, RSL3, sphere-forming ability, streptomycin, tumor initiating cells, Cytochrome C oxidase, aminoglycoside, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.BC]Life Sciences [q-bio]/Cellular Biology

Relation: info:eu-repo/semantics/altIdentifier/pmid/40209702; PUBMED: 40209702; WOS: 001474811900001

Dostupnosť: https://hal.inrae.fr/hal-05036262
https://hal.inrae.fr/hal-05036262v1/document
https://hal.inrae.fr/hal-05036262v1/file/2025-Bonafos-mmc3.pdf
https://doi.org/10.1016/j.chembiol.2025.03.008

PIWIL2/PDK1 Axis Promotes the Progression of Cervical Epithelial Lesions via Metabolic Reprogramming to Maintain Tumor‐Initiating Cell Stemness

Autori: Yuebo Li Wenhui Wang Dongkui Xu a ďalší

Zdroj: Adv Sci (Weinh)
Advanced Science, Vol 11, Iss 48, Pp n/a-n/a (2024)

Predmety: 0301 basic medicine, 0303 health sciences, cervical lesion, Metabolic Reprogramming, Science, Uterine Cervical Neoplasms, Pyruvate Dehydrogenase Acetyl-Transferring Kinase, Cellular Reprogramming, pyruvate dehydrogenase kinase 1, stemness, Mice, Disease Models, Animal, 03 medical and health sciences, tumor‐initiating cells, Neoplastic Stem Cells, Disease Progression, Humans, Animals, Female, Research Article, Signal Transduction

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39499767
https://doaj.org/article/3ad9855b6c0a4d3d88f84f6f736fc239

Therapeutic targeting of differentiation-state dependent metabolic vulnerabilities in diffuse midline glioma

Autori: Nneka E. Mbah Amy L. Myers Peter Sajjakulnukit a ďalší

Zdroj: Nat Commun
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)

Predmety: EXPRESSION, Science, BRAIN CHOLESTEROL, Article, Oxidative Phosphorylation, Mice, Cell Line, Tumor, INTRINSIC PONTINE GLIOMA, MANAGEMENT, SUBGROUPS, Humans, Animals, Brain Stem Neoplasms, MUTATIONS, Brain Neoplasms, Diffuse Intrinsic Pontine Glioma, Cell Differentiation, Glioma, CANCER, Xenograft Model Antitumor Assays, TUMOR-INITIATING CELLS, Mitochondria, Oligodendroglia, Astrocytes, Hydroxymethylglutaryl-CoA Reductase Inhibitors, HISTONE H3.3, PEDIATRIC HIGH-GRADE

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39419964
https://doaj.org/article/b60128e341cf4e8c9deb69669f6c0187

Oncofetal MCB1 Is a Functional Biomarker for HCC Personalized Therapy

Autori: Daimin Xiang Junyu Liu Yichuan Wang a ďalší

Zdroj: Adv Sci (Weinh)
Advanced Science, Vol 11, Iss 45, Pp n/a-n/a (2024)

Predmety: drug resistance, Carcinoma, Hepatocellular, Science, Liver Neoplasms, hepatocellular carcinoma, Mice, Disease Models, Animal, tumor‐initiating cells, Cell Line, Tumor, Biomarkers, Tumor, MCB1, Humans, Animals, Precision Medicine, early diagnosis, Research Article

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39402741
https://doaj.org/article/8d6b4560753241ef86f48b9bcd5983ae

Ex vivo drug sensitivity screening predicts response to temozolomide in glioblastoma patients and identifies candidate biomarkers

Autori: Ioannis Ntafoulis Anne Kleijn Jie Ju a ďalší

Zdroj: Br J Cancer

Predmety: EXPRESSION, Drug Evaluation, Preclinical, PHENOTYPE, Article, 1117 Public Health and Health Services, CULTURE, SDG 3 - Good Health and Well-being, CONCOMITANT, 3211 Oncology and carcinogenesis, Cell Line, Tumor, Temozolomide, Tumor Microenvironment, Humans, 1112 Oncology and Carcinogenesis, Oncology & Carcinogenesis, MGMT GENE, Antineoplastic Agents, Alkylating, Science & Technology, Brain Neoplasms, GLIOTRAIN consortium, SET ENRICHMENT ANALYSIS, SIGNATURE, Glioma, DNA, TUMOR-INITIATING CELLS, 3. Good health, Dacarbazine, Oncology, Drug Resistance, Neoplasm, Glioblastoma, Life Sciences & Biomedicine, STEM-CELLS, RESISTANCE, Biomarkers

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/37620410

Cancer‐associated fibroblasts nurture LGR5 marked liver tumor‐initiating cells and promote their tumor formation, growth, and metastasis

Autori: Mingna Zhang Yiqiao Fang Xia Fu a ďalší

Zdroj: Cancer Med
Cancer Medicine, Vol 12, Iss 17, Pp 18032-18049 (2023)

Predmety: liver cancer, cancer‐associated fibroblasts, SDG 3 - Good Health and Well-being, tumor‐initiating cells, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, leucine‐rich repeat‐containing G‐protein coupled receptor 5, RC254-282, 3. Good health, diphtheria toxin receptor, RESEARCH ARTICLES

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/37578396
https://doaj.org/article/6dca15fe43bb4954acd3cd23f077e098

Characterization of EpCAM in thyroid cancer biology by three-dimensional spheroids in vitro model

Autori: Viola Ghiandai Elisa Stellaria Grassi Giacomo Gazzano a ďalší

Zdroj: Cancer Cell International, Vol 24, Iss 1, Pp 1-14 (2024)

Predmety: Thyroid cancer, Tumor-initiating cells, EpCAM, Spheroid cultures, Regulated intramembrane proteolysis, Drug resistance, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

Popis súboru: electronic resource

Relation: https://doaj.org/toc/1475-2867

Prístupová URL adresa: https://doaj.org/article/a5b84c9754e34fd5abe25fc05a072b92

Cellular plasticity in the breast cancer ecosystem

Autori: Kristian Pietras Jonas Sjölund

Zdroj: Upsala Journal of Medical Sciences, Vol 129, Pp 1-5 (2024)

Predmety: tumor microenvironment, tumor-initiating cells, cancer-associated fibroblasts, macrophages, Medicine

Popis súboru: electronic resource

Relation: https://ujms.net/index.php/ujms/article/view/10629; https://doaj.org/toc/0300-9734; https://doaj.org/toc/2000-1967

Prístupová URL adresa: https://doaj.org/article/b15f6782c06b4255a8bbb5f0c9f2d1fc