Výsledky vyhledávání - "Tumor Microenvironment/immunology"

HPV16-Expressing Tumors Release Multiple IL1 Ligands to Orchestrate Systemic Immunosuppression Whose Disruption Enables Efficacy of a Therapeutic Vaccine

Autoři: Morgane Lecointre Jérémy Guillot Rachel Marcone a další

Zdroj: Cancer Discov
Cancer discovery, vol. 15, no. 7, pp. 1458-1483

Témata: Animals, Female, Mice, Humans, Human papillomavirus 16/immunology, Uterine Cervical Neoplasms/immunology, Uterine Cervical Neoplasms/virology, Uterine Cervical Neoplasms/therapy, Cancer Vaccines/immunology, Papillomavirus Infections/immunology, Papillomavirus Infections/virology, Interleukin-1/metabolism, Papillomavirus E7 Proteins/immunology, Tumor Microenvironment/immunology, Mice, Inbred C57BL, Research Articles

Popis souboru: application/pdf

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40287949
https://serval.unil.ch/resource/serval:BIB_7EEDFD7BF1B3.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_7EEDFD7BF1B33
https://serval.unil.ch/notice/serval:BIB_7EEDFD7BF1B3

Tumor-Infiltrating Clonal Hematopoiesis

Autoři: Oriol Pich Elsa Bernard Maria Zagorulya a další

Zdroj: N Engl J Med
The New England journal of medicine, vol. 392, no. 16, pp. 1594-1608

Témata: Male, Lung Neoplasms, Middle Aged, Article, Monocytes, Dioxygenases, DNA-Binding Proteins, Mice, Observational Studies as Topic, Cell Movement, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Mutation, Tumor Microenvironment, Animals, Humans, Female, Prospective Studies, Clonal Hematopoiesis, Neoplasm Recurrence, Local, Aged, Carcinoma, Non-Small-Cell Lung/genetics, Carcinoma, Non-Small-Cell Lung/immunology, Carcinoma, Non-Small-Cell Lung/mortality, Carcinoma, Non-Small-Cell Lung/pathology, Clonal Hematopoiesis/genetics, Clonal Hematopoiesis/immunology, Dioxygenases/genetics, DNA-Binding Proteins/genetics, Lung Neoplasms/genetics, Lung Neoplasms/mortality, Lung Neoplasms/pathology, Neoplasm Recurrence, Local/epidemiology, Neoplasm Recurrence, Local/genetics, Neoplasm Recurrence, Local/pathology, Tumor Microenvironment/immunology, Monocytes/immunology, Monocytes/pathology, Cell Movement/genetics, Cell Movement/immunology, Neoplasm Transplantation

Popis souboru: application/pdf

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40267425
https://ora.ox.ac.uk/objects/uuid:e20d5bce-3d87-4ac2-9e89-b887ca4cc72b
https://doi.org/10.1056/nejmoa2413361
https://serval.unil.ch/notice/serval:BIB_435B0ABCF518
https://serval.unil.ch/resource/serval:BIB_435B0ABCF518.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_435B0ABCF5187

Primary and Acquired Resistance to Immunotherapy with Checkpoint Inhibitors in NSCLC: From Bedside to Bench and Back

Autoři: Mariniello, Annapaola Borgeaud, Maxime Weiner, Marc a další

Zdroj: BioDrugs

Témata: Tumor Microenvironment / drug effects, Immune Checkpoint Inhibitors / pharmacology, Lung Neoplasms / immunology, Immune Checkpoint Inhibitors / therapeutic use, Review Article, Carcinoma, Non-Small-Cell Lung / immunology, Tumor Microenvironment / immunology, Lung Neoplasms / drug therapy, Programmed Cell Death 1 Receptor / antagonists & inhibitors, Immunotherapy / methods, Drug Resistance, Neoplasm, Animals, Humans, Carcinoma, Non-Small-Cell Lung / drug therapy

Popis souboru: application/pdf

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39954220
https://archive-ouverte.unige.ch/unige:183990
https://doi.org/10.1007/s40259-024-00700-2

Second Breath (Preclinical Hypothesis, in silico validated): Biomarker-Guided Local Immune Sequencing for Desmoplastic Tumors

Autoři: Novruzov, Murad Raval, Keval Shiraliyeva, Ulkar

Témata: Cytokine therapy, Cancer immunotherapy, Leukemia, Experimental/therapy, Immunomodulation/immunology, Medical Oncology, Sarcoma, Experimental/therapy, Neoplasms, Experimental/therapy, Immunomodulation, Preclinical strategy, Oncology, Tumor-targeted therapy, Cell-based immunotherapy, Melanoma, Experimental/therapy, Tumor Microenvironment, Tumor Microenvironment/immunology, Cytokine Release Syndrome/therapy, T cell engineering, Late-stage cancer, Experimental therapy, Novel cancer treatment, Cancer

STING and Nonnecroptotic MLKL‐Mediated Mechanisms Improve Dendritic Cell Maturation and Killing of Cancer Cells

Autoři: Trine S. Jensen Marlene F. Laursen Lea Schort a další

Zdroj: Jensen, T S, Laursen, M F, Schort, L, Banasik, A J, Agger, R, Jakobsen, M R & Kofod-Olsen, E 2025, 'STING and Nonnecroptotic MLKL-Mediated Mechanisms Improve Dendritic Cell Maturation and Killing of Cancer Cells', European Journal of Immunology, vol. 55, no. 9, e70044, pp. e70044. https://doi.org/10.1002/eji.70044

Témata: Tumor Necrosis Factor-alpha/metabolism, Signal Transduction/immunology, Receptor-Interacting Protein Serine-Threonine Kinases/metabolism, Necroptosis/immunology, necroptosis, Apoptosis, Coculture Techniques, Cell Differentiation/immunology, Mice, caspases, Dendritic Cells/immunology, Cell Line, Tumor, Neoplasms/immunology, Humans, Animals, Tumor Microenvironment/immunology, Protein Kinases/metabolism, Membrane Proteins/metabolism, dendritic cells, STING, MLKL

Popis souboru: application/pdf

Přístupová URL adresa: https://vbn.aau.dk/ws/files/794949944/Eur_J_Immunol_-_2025_-_Jensen_-_STING_and_Nonnecroptotic_MLKL_Mediated_Mechanisms_Improve_Dendritic_Cell_Maturation_and.pdf
http://www.scopus.com/inward/record.url?scp=105015208892&partnerID=8YFLogxK
https://vbn.aau.dk/da/publications/0718a2ae-f3b5-4a4c-b6a1-83bf10fd7840
https://doi.org/10.1002/eji.70044

HIV infection is associated with compromised tumor microenvironment adaptive immune reactivity in Hodgkin lymphoma

Autoři: Amanda Chantziou Cloe Brenna Kalliopi Ioannidou a další

Zdroj: Blood Adv
Blood advances, vol. 8, no. 24, pp. 6215-6231

Témata: Male, 0301 basic medicine, Epstein-Barr Virus Infections, 0303 health sciences, Lymphoid Neoplasia, HIV Infections, Humans, Tumor Microenvironment/immunology, Hodgkin Disease/immunology, Hodgkin Disease/virology, HIV Infections/immunology, HIV Infections/complications, Adaptive Immunity, CD8-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/metabolism, Epstein-Barr Virus Infections/complications, Epstein-Barr Virus Infections/immunology, CD8-Positive T-Lymphocytes, Hodgkin Disease, 3. Good health, 03 medical and health sciences, Tumor Microenvironment

Popis souboru: application/pdf

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39116294
https://serval.unil.ch/resource/serval:BIB_D343689440C2.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_D343689440C2
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_D343689440C24
https://pergamos.lib.uoa.gr/uoa/dl/object/3482214

Cancer cells impair monocyte-mediated T cell stimulation to evade immunity

Autoři: Anais Elewaut Guillem Estivill Felix Bayerl a další

Přispěvatelé: Anais Elewaut Guillem Estivill Felix Bayerl a další

Zdroj: Nature, vol. 637, no. 8046, pp. 716-725
Nature

Témata: 0301 basic medicine, 0303 health sciences, Reveals, Resistance, Activation, Cdc1, Network, Dendritic cells, Biomedicine, 03 medical and health sciences, Monocytes/immunology, Monocytes/metabolism, Mice, Dinoprostone/metabolism, Animals, Humans, Tumor Microenvironment/immunology, CD8-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/cytology, CD8-Positive T-Lymphocytes/metabolism, Female, Interferon Type I/metabolism, Interferon Type I/immunology, Dendritic Cells/immunology, Dendritic Cells/metabolism, Tumor Escape/immunology, Cell Line, Tumor, Lymphocyte Activation/immunology, Neoplasms/immunology, Neoplasms/pathology, Neoplasms/therapy, MAP Kinase Signaling System/immunology, Male, Cross-Priming/immunology, Antigen Presentation/immunology, Interleukin-15/metabolism, Interleukin-15/immunology, Mice, Inbred C57BL, Histocompatibility Antigens Class I/immunology, Histocompatibility Antigens Class I/metabolism, Chemokine CXCL9/metabolism, Evasion, Programs, Responses, Cancers, Melanoma

Popis souboru: application/pdf

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39604727
http://hdl.handle.net/10138/590687
https://serval.unil.ch/resource/serval:BIB_6B66C99B58FA.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_6B66C99B58FA
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_6B66C99B58FA0

Targeting of TAMs: can we be more clever than cancer cells?

Autoři: Julia Kzhyshkowska Jiaxin Shen Irina Larionova

Zdroj: Cell Mol Immunol

Témata: 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, Neoplasms, Macrophages, Tumor-Associated Macrophages, Tumor Microenvironment, Biomarkers, Tumor, Humans, Animals, Review Article, Epigenetic, 692/4028/67/580, Tumor-Associated Macrophages/metabolism [MeSH], Humans [MeSH], Neoplasms/immunology [MeSH], Tumor-Associated Macrophages/immunology [MeSH], Macrophages/metabolism [MeSH], 631/250/2504/342, Animals [MeSH], Scavenger receptor, Tumor Microenvironment/immunology [MeSH], Epigenesis, Genetic [MeSH], Macrophages/immunology [MeSH], Biomarkers, Tumor/metabolism [MeSH], Neoplasms/pathology [MeSH], Immunotherapy, review-article, Neoplasms/therapy [MeSH], Cytokine, Metabolism, Growth factor, Angiogenesis, Epigenesis, Genetic

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39516356
https://repository.publisso.de/resource/frl:6495856

Combination CXCR4 and PD-1 Blockade Enhances Intratumoral Dendritic Cell Activation and Immune Responses Against Hepatocellular Carcinoma

Autoři: Satoru Morita Pin-Ji Lei Kohei Shigeta a další

Zdroj: Cancer Immunol Res
Cancer immunology research, vol. 13, no. 2, pp. 162-170

Témata: 0301 basic medicine, 03 medical and health sciences, 0302 clinical medicine, Priority Brief, Animals, Dendritic Cells/immunology, Dendritic Cells/drug effects, Dendritic Cells/metabolism, Receptors, CXCR4/antagonists & inhibitors, Receptors, CXCR4/immunology, Carcinoma, Hepatocellular/immunology, Carcinoma, Hepatocellular/drug therapy, Carcinoma, Hepatocellular/pathology, Mice, Programmed Cell Death 1 Receptor/antagonists & inhibitors, Liver Neoplasms/immunology, Liver Neoplasms/drug therapy, Liver Neoplasms/pathology, Humans, Immune Checkpoint Inhibitors/pharmacology, Tumor Microenvironment/immunology, Mice, Inbred C57BL, Cell Line, Tumor, CD8-Positive T-Lymphocytes/immunology, Immunotherapy/methods

Popis souboru: application/pdf

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39514263
https://serval.unil.ch/resource/serval:BIB_CD3850EE9E31.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_CD3850EE9E31
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_CD3850EE9E318

The Immune Microenvironment in Prostate Cancer: A Comprehensive Review

Autoři: Rene Novysedlak Miray Guney Majd Al Khouri a další

Zdroj: Oncology
Oncology, vol. 103, no. 6, pp. 521-545

Témata: Humans, Prostatic Neoplasms/immunology, Prostatic Neoplasms/pathology, Prostatic Neoplasms/therapy, Tumor Microenvironment/immunology, Male, T-Lymphocytes, Regulatory/immunology, Tumor-Associated Macrophages/immunology, Immunotherapy/methods, CD4, CD8, Immunology, Immunotherapy, Metastatic, Myeloid-derived suppressor cells, Neutrophils, Prostate tumor, T cells, Tertiary lymphoid structures, Tumor-associated macrophages, Review

Popis souboru: application/pdf

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39380471
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_F33B7BC8896A2
https://serval.unil.ch/resource/serval:BIB_F33B7BC8896A.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_F33B7BC8896A

Five latent factors underlie response to immunotherapy

Autoři: Joseph Usset Axel Rosendahl Huber Maria A. Andrianova a další

Přispěvatelé: Joseph Usset Axel Rosendahl Huber Maria A. Andrianova a další

Zdroj: Nat Genet
Scientia
Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
Dipòsit Digital de la UB
Nature Genetics

Témata: CHEMICALS AND DRUGS::Biological Factors::Biomarkers::Biomarkers, Tumor, Cancer therapy, Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia, COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores::marcadores tumorales, Immunoteràpia, Medicaments antineoplàstics - Ús terapèutic, Therapeutics, Immunotheraphy, Article, Cohort Studies, DISEASES::Neoplasms, COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antineoplásicos::inmunoterapia antineoplásica, Transforming Growth Factor beta, Neoplasms, Neoplasms/immunology, CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents::Antineoplastic Agents, Immunological, Genetics, Journal Article, Tumor Microenvironment, Biomarkers, Tumor, Tumor Microenvironment/immunology, Humans, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy, Immune Checkpoint Inhibitors, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::inmunomodulación::inmunoterapia, Other subheadings::Other subheadings::Other subheadings::/drug therapy, Biochemical markers, Terapèutica, Immune Checkpoint Inhibitors/therapeutic use, Treatment Outcome, ENFERMEDADES::neoplasias, Marcadors bioquímics, Mutation, Immunotherapy/methods, Càncer - Immunoteràpia, Immunotherapy, Biomarkers, Tumor/genetics, Transforming Growth Factor beta/metabolism

Popis souboru: application/pdf

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39266764
https://hdl.handle.net/11351/12234
https://hdl.handle.net/2445/217272
https://dspace.library.uu.nl/handle/1874/458268

Prospects of Synergy: Local Interventions and CAR T Cell Therapy in Solid Tumors

Autoři: Anne Holtermann Mila Gislon Martin Angele a další

Zdroj: BioDrugs

Témata: Receptors, Chimeric Antigen, Neoplasms, T-Lymphocytes, Tumor Microenvironment, Humans, Animals, Review Article, Combined Modality Therapy/methods [MeSH], T-Lymphocytes/immunology [MeSH], Humans [MeSH], Neoplasms/immunology [MeSH], Receptors, Chimeric Antigen/immunology [MeSH], Neoplasms/therapy [MeSH], T-Lymphocytes/transplantation [MeSH], Animals [MeSH], Immunotherapy, Adoptive/methods [MeSH], Tumor Microenvironment/immunology [MeSH], Receptors, Chimeric Antigen/therapeutic use [MeSH], Immunotherapy, Adoptive, Combined Modality Therapy

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39080180
https://repository.publisso.de/resource/frl:6517186

Tumor-associated tertiary lymphoid structures in cancer: implications for immunotherapy

Autoři: Langouo Fontsa, Mireille Padonou, Francine Willard-Gallo, Karen

Zdroj: Expert Review of Clinical Immunology. 20:839-847

Témata: biomarkers, Sciences bio-médicales et agricoles, Tertiary Lymphoid Structures -- immunology, Neoplasms -- immunology -- therapy, Immune Checkpoint Inhibitors -- therapeutic use, Cancer Vaccines, Cancer Vaccines -- therapeutic use -- immunology, Tumor infiltrating lymphocytes, Tumor Microenvironment -- immunology, Tertiary Lymphoid Structures, Neoplasms, Immunotherapy -- methods, Tumor Microenvironment, cancer, Humans, Animals, immunotherapy, Immunotherapy, Immune Checkpoint Inhibitors, tertiary lymphoid structures

Popis souboru: 1 full-text file(s): application/pdf

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39007892

Treatment of patients with pMMR GI cancers with tumor-infiltrating lymphocytes (TIL): a reality?

Autoři: John B. Haanen

Zdroj: Trends in cancer, vol. 11, no. 7, pp. 614-615

Témata: Humans, Lymphocytes, Tumor-Infiltrating/immunology, Lymphocytes, Tumor-Infiltrating/transplantation, Lymphocytes, Tumor-Infiltrating/drug effects, Gastrointestinal Neoplasms/immunology, Gastrointestinal Neoplasms/therapy, Gastrointestinal Neoplasms/pathology, Gastrointestinal Neoplasms/genetics, Tumor Microenvironment/immunology, Tumor Microenvironment/drug effects, Immunotherapy, Adoptive/methods, Immune Checkpoint Inhibitors/therapeutic use, Immune Checkpoint Inhibitors/pharmacology, Antigens, Neoplasm/immunology, Treatment Outcome, Drug Resistance, Neoplasm/genetics, Mutation, Programmed Cell Death 1 Receptor/antagonists & inhibitors, Programmed Cell Death 1 Receptor/immunology

Popis souboru: application/pdf

Přístupová URL adresa: https://serval.unil.ch/notice/serval:BIB_BBE36ACAE635
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_BBE36ACAE6354
https://serval.unil.ch/resource/serval:BIB_BBE36ACAE635.P001/REF.pdf

A Luminescence-Based Method for In Vitro Screening of Immunomodulatory Checkpoints and Therapeutics

Autoři: Álvarez Freile, Jimena Bremer, Edwin

Zdroj: Methods in Molecular Biology ISBN: 9781071645574

Témata: Papillomavirus E7 Proteins/immunology, Luminescence, Papillomavirus E7 Proteins, T-Lymphocytes, Receptors, Antigen, T-Cell, Luminescent Measurements/methods, T-Lymphocytes/immunology, Jurkat Cells, Antigen, Receptors, Luminescent Measurements, Tumor Microenvironment, Tumor Microenvironment/immunology, Humans, Immune Checkpoint Inhibitors/pharmacology, Immune Checkpoint Inhibitors, T-Cell/immunology

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40402459

A temporal perspective for tumor-associated macrophage identities and functions

Autoři: Blériot, Camille Dunsmore, Garett Alonso-Curbelo, Direna a další

Přispěvatelé: Blériot, Camille Dunsmore, Garett Alonso-Curbelo, Direna a další

Zdroj: Cancer Cell. 42:747-758

Témata: Inflammation, Neoplasms / pathology, Neoplasms / immunology, Macrophages, Tumor-Associated Macrophages / immunology, Inflammation / immunology, Tumor Microenvironment / immunology, Tumor-Associated Macrophages / metabolism, Inflammation / pathology, Macrophages / immunology, 3. Good health, [SDV] Life Sciences [q-bio], Neoplasms, Tumor-Associated Macrophages, Tumor Microenvironment, Animals, Humans

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38670090
https://u-paris.hal.science/hal-04589077v1
https://doi.org/10.1016/j.ccell.2024.04.002

Phosphatidylserine externalization as immune checkpoint in cancer

Autoři: Ivan-Maximiliano Kur Andreas Weigert

Zdroj: Pflugers Arch

Témata: 0301 basic medicine, ddc:610, 0303 health sciences, Macrophages, Invited Review, Cancer, Humans [MeSH], Inflammation, Neoplasms/immunology [MeSH], Animals [MeSH], Tumor Microenvironment/immunology [MeSH], Neoplasms/metabolism [MeSH], Immune checkpoint, Immunotherapy/methods [MeSH], Phosphatidylserines/immunology [MeSH], Phosphatidylserines/metabolism [MeSH], Phospholipids, Phosphatidylserines, 3. Good health, 03 medical and health sciences, Neoplasms, Tumor Microenvironment, Humans, Animals, Immunotherapy

Popis souboru: application/pdf

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38573347
https://repository.publisso.de/resource/frl:6491972

GcMAF, Nagalase Suppression & Fibrin Reduction – A Quantum Oncology OS Expansion

Autoři: Mohamed, Anwar

Témata: Tumor Microenvironment/genetics, Clinical Integrative Medicine, Tumor Microenvironment/physiology, Sublingual Immunotherapy/trends, GcMAF, Immunotherapy/standards, Exosomes, Medical Oncology, Tumour Microenvironment, Immunotherapy, Adoptive, Clinical Trial Protocols as Topic, Fibrin/standards, Clinical Protocols, Molecular Chaperones/immunology, Fibrin/immunology, Tumor Microenvironment, Immune Evasion/drug effects, Vision, Monocular/immunology, PEMF, Heparin, Low-Molecular-Weight/immunology, Systems Biology, Clinical Protocols/standards, Nagalase, Redox Medicine, Immunotherapy/classification, Exosomes/immunology, Tumor Microenvironment/drug effects, Fibrin/chemistry, EZ Water, Biofield Science, Exposome, Scalar Fields, CD68 Molecule/immunology, Tumour Holography, Oncology, Quantum Oncology, Cardio-Oncology, Structured Water, Systems Biology/standards, Immunotherapy, Fibrin/pharmacokinetics, Exosomes/physiology, Kininogen, Low-Molecular-Weight/immunology, Molecular Immunology, Integrative Oncology/standards, Systems Biology/methods, Psycho-Oncology, Immunotherapy/psychology, TRPV Cation Channels, Fourth Phase Water, Fibrin/metabolism, Fibrin/physiology, Immunotherapy/ethics, ECS Therapeutics, Tumor Microenvironment/immunology, Integrative Oncology, Cancer Stealth, Systems Biology/education, Immune Evasion/immunology, Exosomes/genetics, Exosomes/classification, Bioelectric Medicine, Systems Biology/ethics, Immune Evasion, Fibrin, Immune Evasion/genetics, Sublingual Immunotherapy, Fibrin/classification, Exosomes/chemistry, Pathogen-Associated Molecular Pattern Molecules/immunology, Fibrin/agonists, Fibrin/genetics, ECS, Immune Reprogramming, Immunotherapy, Active, Systems Biology/trends, Immune Evasion/physiology, Sublingual Immunotherapy/economics, TRPV1, Immunotherapy/trends, Clinical Protocols/classification, AI in Healthcare

Advanced Metabolic Reprogramming

Autoři: Mohamed, Anwar

Témata: Mesenchymal Stem Cells/metabolism, Tumor Microenvironment/genetics, Tumor Microenvironment/physiology, Glutamine addiction, Systems Biology/economics, Tumour vulnerability, Medical Oncology, Clinical oncology, Tumor Microenvironment/radiation effects, Glycolysis inhibition, Bioenergetic collapse, Tumor Microenvironment, Integrative Oncology/ethics, Hematopoietic Stem Cells/metabolism, ECS modulation, Cancer Biology, Stem Cells/metabolism, Artificial Intelligence in Healthcare, Cancer stem cells, Systems Biology, Multipotent Stem Cells/metabolism, Mitochondrial targeting, Precision oncology, Cancer metabolism, Tumor Microenvironment/drug effects, Oncology, Cardio-Oncology, Cancer Pain/etiology, Neural Stem Cells/metabolism, Oncology protocol design, Functional medicine, Metabolic kill-switch, Psycho-Oncology, Embryonic Stem Cells/metabolism, Metabolic escape, Cancer Pain/metabolism, Stem Cell Factor/metabolism, Mitochondrial Medicine, Neoplastic Stem Cells/metabolism, Tumor Microenvironment/immunology, Integrative Oncology, Stem cell metabolism, AI-driven therapy, Systems Biology/education, Cancer-Associated Fibroblasts/metabolism, Systems Biology/ethics, Tumour microenvironment, Systems Biology/classification, Systems Biology/trends, Induced Pluripotent Stem Cells/metabolism, Pluripotent Stem Cells/metabolism, Therapeutic stacking

Targeting HIF-2α in glioblastoma reshapes the immune infiltrate and enhances response to immune checkpoint blockade

Autoři: Espinoza Rojas, Felipe Ignacio Tankov, Stoyan Chliate, Sylvie a další

Zdroj: Cell Mol Life Sci

Témata: Tumor Microenvironment / drug effects, Basic Helix-Loop-Helix Transcription Factors / genetics, Brain Neoplasms / metabolism, T-Lymphocytes, Regulatory / immunology, Glioblastoma / drug therapy, T-Lymphocytes, Regulatory, Macrophages / immunology, Hypoxia inducible factor, Mice, Tumor-associated macrophage, Basic Helix-Loop-Helix Transcription Factors / antagonists & inhibitors, Brain Neoplasms / pathology, Basic Helix-Loop-Helix Transcription Factors, Tumor Microenvironment, Sulfones, Microglia / immunology, Immune Checkpoint Inhibitors, Glioblastoma / metabolism, Immune Checkpoint Inhibitors / pharmacology, Brain Neoplasms, Glioma, Immune Checkpoint Inhibitors / therapeutic use, Tumor Microenvironment / immunology, Treg, Tumor microenvironment, Brain Neoplasms / drug therapy, Microglia / metabolism, Indans, Original Article, Immunotherapy, Microglia, Macrophages / drug effects, Brain Neoplasms / immunology, Brain tumors, Glioblastoma / pathology, Immune checkpoint inhibitors, Macrophages / metabolism, Cell Line, Tumor, Animals, Humans, Basic Helix-Loop-Helix Transcription Factors / immunology, Glioblastoma / immunology, Macrophages, HIF-2, T-Lymphocytes, Regulatory / metabolism, Microglia / drug effects, Mice, Inbred C57BL, Glioblastoma, Basic Helix-Loop-Helix Transcription Factors / metabolism

Popis souboru: application/pdf

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40095115
https://archive-ouverte.unige.ch/unige:184525
https://doi.org/10.1007/s00018-025-05642-8