Search Results - "Tumor Microenvironment"

The significance of tumor microenvironment for immunotherapy in melanoma and non-melanoma skin cancer.

Authors: Fujimura T; Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Source: Immunological medicine [Immunol Med] 2025 Dec; Vol. 48 (4), pp. 307-317. Date of Electronic Publication: 2025 Aug 25.

Publication Type: Journal Article; Review

Journal Info: Publisher: Informa UK Limited Country of Publication: England NLM ID: 101736847 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2578-5826 (Electronic) Linking ISSN: 25785826 NLM ISO Abbreviation: Immunol Med Subsets: MEDLINE

MeSH Terms: Tumor Microenvironment*/immunology , Tumor Microenvironment*/drug effects , Skin Neoplasms*/immunology , Skin Neoplasms*/therapy , Melanoma*/immunology , Melanoma*/therapy , Immunotherapy*/methods , Immune Checkpoint Inhibitors*/therapeutic use, Humans ; Lymphocytes, Tumor-Infiltrating/immunology ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Programmed Cell Death 1 Receptor/immunology ; Animals

Cancer-associated fibroblast secreted DKK1 promotes the immunosuppressive tumor microenvironment and colorectal cancer resistance to chemotherapy.

Authors: Yin Z Zhou Y Zhu X et al.

Source: Cancer letters [Cancer Lett] 2025 Dec 01; Vol. 634, pp. 218060. Date of Electronic Publication: 2025 Sep 24.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE

MeSH Terms: Colorectal Neoplasms*/drug therapy , Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/immunology , Colorectal Neoplasms*/metabolism , Colorectal Neoplasms*/genetics , Tumor Microenvironment*/drug effects , Tumor Microenvironment*/immunology , Cancer-Associated Fibroblasts*/metabolism , Cancer-Associated Fibroblasts*/drug effects , Cancer-Associated Fibroblasts*/immunology , Cancer-Associated Fibroblasts*/pathology , Intercellular Signaling Peptides and Proteins*/metabolism , Intercellular Signaling Peptides and Proteins*/genetics , Drug Resistance, Neoplasm*, Humans ; Animals ; Fluorouracil/pharmacology ; Mice ; Cell Line, Tumor ; Female ; Xenograft Model Antitumor Assays ; Irinotecan/pharmacology ; Oxaliplatin/pharmacology ; Male

Development and validation of a novel risk stratification signature derived from migrasome and tumor microenvironment-related genes for molecular subtyping and improving clinical outcomes in head and neck squamous cell carcinoma.

Authors: Chai H Zhou C Xue Z et al.

Source: Annals of medicine [Ann Med] 2025 Dec; Vol. 57 (1), pp. 2558121. Date of Electronic Publication: 2025 Sep 09.

Publication Type: Journal Article; Validation Study

Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8906388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2060 (Electronic) Linking ISSN: 07853890 NLM ISO Abbreviation: Ann Med Subsets: MEDLINE

MeSH Terms: Tumor Microenvironment*/genetics , Tumor Microenvironment*/immunology , Squamous Cell Carcinoma of Head and Neck*/genetics , Squamous Cell Carcinoma of Head and Neck*/mortality , Squamous Cell Carcinoma of Head and Neck*/drug therapy , Squamous Cell Carcinoma of Head and Neck*/pathology , Head and Neck Neoplasms*/genetics , Head and Neck Neoplasms*/mortality , Head and Neck Neoplasms*/drug therapy, Humans ; Prognosis ; Male ; Female ; Biomarkers, Tumor/genetics ; Middle Aged ; Risk Assessment/methods ; Nomograms ; Kaplan-Meier Estimate ; Gene Expression Regulation, Neoplastic ; Gene Expression Profiling

Classifying the tumor immune microenvironment in cervical cancer based on nuclear cytoplasmic consistent genes.

Authors: Wang J Chen A Chen Q et al.

Source: Scientific reports [Sci Rep] 2025 Nov 28; Vol. 15 (1), pp. 42703. Date of Electronic Publication: 2025 Nov 28.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Uterine Cervical Neoplasms*/genetics , Uterine Cervical Neoplasms*/immunology , Uterine Cervical Neoplasms*/pathology , Tumor Microenvironment*/genetics , Tumor Microenvironment*/immunology , Cell Nucleus*/genetics , Cytoplasm*/genetics, Humans ; Female ; Biomarkers, Tumor/genetics ; Prognosis ; Gene Expression Regulation, Neoplastic ; Single-Cell Analysis

m6A regulators-based gene expression pattern is associated with immune microenvironment characteristics in hepatocellular carcinoma.

Authors: Wang W Wang E Hong K et al.

Source: Scientific reports [Sci Rep] 2025 Nov 27; Vol. 15 (1), pp. 42530. Date of Electronic Publication: 2025 Nov 27.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Carcinoma, Hepatocellular*/genetics , Carcinoma, Hepatocellular*/immunology , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/mortality , Carcinoma, Hepatocellular*/metabolism , Liver Neoplasms*/genetics , Liver Neoplasms*/immunology , Liver Neoplasms*/pathology , Liver Neoplasms*/mortality , Liver Neoplasms*/metabolism , Tumor Microenvironment*/genetics , Tumor Microenvironment*/immunology , Adenosine*/analogs & derivatives , Adenosine*/metabolism , Adenosine*/genetics , Gene Expression Regulation, Neoplastic*, Humans ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Prognosis ; Male ; Female ; Biomarkers, Tumor/genetics ; B7-H1 Antigen/genetics ; B7-H1 Antigen/metabolism ; RNA Splicing Factors/genetics ; RNA Splicing Factors/metabolism ; Gene Expression Profiling ; Middle Aged

Immune checkpoint inhibitors in melanoma: mechanisms, immune cell interactions, and the tumour microenvironment.

Authors: Liang Y Zheng Y Zeng Y et al.

Source: Frontiers in immunology [Front Immunol] 2025 Nov 19; Vol. 16, pp. 1691608. Date of Electronic Publication: 2025 Nov 19 (Print Publication: 2025).

Publication Type: Journal Article; Review

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH Terms: Tumor Microenvironment*/immunology , Tumor Microenvironment*/drug effects , Immune Checkpoint Inhibitors*/therapeutic use , Immune Checkpoint Inhibitors*/pharmacology , Melanoma*/immunology , Melanoma*/drug therapy , Melanoma*/pathology , Melanoma*/metabolism , Cell Communication*/immunology , Cell Communication*/drug effects , Skin Neoplasms*/immunology , Skin Neoplasms*/drug therapy, Humans ; Animals ; Immunotherapy/methods

Immunomodulatory Role of Propolis in Hypoxia and in the Tumor Microenvironment.

Authors: Kłósek M Kurek-Górecka A Balwierz R et al.

Source: Molecules (Basel, Switzerland) [Molecules] 2025 Nov 19; Vol. 30 (22). Date of Electronic Publication: 2025 Nov 19.

Publication Type: Journal Article; Review

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

MeSH Terms: Propolis*/pharmacology , Propolis*/chemistry , Propolis*/therapeutic use , Tumor Microenvironment*/drug effects , Tumor Microenvironment*/immunology , Neoplasms*/drug therapy , Neoplasms*/immunology , Neoplasms*/pathology , Neoplasms*/metabolism , Immunologic Factors*/pharmacology, Humans ; Animals ; Immunomodulation/drug effects ; Cytokines/metabolism

Deciphering the nexus of aging and pan-cancer: Single-cell sequencing reveals microenvironmental remodeling and cellular drivers.

Authors: Han Y Chen N Wang P et al.

Source: Bioscience trends [Biosci Trends] 2025 Nov 15; Vol. 19 (5), pp. 511-520. Date of Electronic Publication: 2025 Oct 26.

Publication Type: Journal Article; Review

Journal Info: Publisher: International Research and Cooperation Association for Bio & Socio-Sciences Advancement Country of Publication: Japan NLM ID: 101502754 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1881-7823 (Electronic) Linking ISSN: 18817815 NLM ISO Abbreviation: Biosci Trends Subsets: MEDLINE

MeSH Terms: Single-Cell Analysis*/methods , Tumor Microenvironment*/genetics , Tumor Microenvironment*/immunology , Neoplasms*/genetics , Neoplasms*/pathology , Neoplasms*/immunology , Aging*/genetics, Humans ; Animals ; Cellular Senescence/genetics ; Senescence-Associated Secretory Phenotype/genetics

Synergistic gambogic acid/Ga³⁺ remodels the immunosuppressive tumor microenvironment to enhance triple-negative breast cancer therapy.

Authors: Qiu C Guo P Wang C et al.

Source: Journal of nanobiotechnology [J Nanobiotechnology] 2025 Nov 11; Vol. 23 (1), pp. 710. Date of Electronic Publication: 2025 Nov 11.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155 (Electronic) Linking ISSN: 14773155 NLM ISO Abbreviation: J Nanobiotechnology Subsets: MEDLINE

MeSH Terms: Xanthones*/pharmacology , Xanthones*/chemistry , Xanthones*/therapeutic use , Triple Negative Breast Neoplasms*/drug therapy , Triple Negative Breast Neoplasms*/immunology , Triple Negative Breast Neoplasms*/pathology , Tumor Microenvironment*/drug effects , Tumor Microenvironment*/immunology, Humans ; Female ; Animals ; Cell Line, Tumor ; Mice ; Nanoparticles/chemistry ; Immunogenic Cell Death/drug effects ; Antineoplastic Agents/pharmacology ; Drug Synergism ; Apoptosis/drug effects

cGAS-agonistic spherical nucleic acids reprogram the glioblastoma immune microenvironment and promote antitumor immunity.

Authors: Mahajan AS Dussold C Kim S et al.

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Nov 11; Vol. 122 (45), pp. e2409557122. Date of Electronic Publication: 2025 Nov 03.

Publication Type: Journal Article

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH Terms: Glioblastoma*/immunology , Glioblastoma*/drug therapy , Glioblastoma*/pathology , Nucleotidyltransferases*/metabolism , Tumor Microenvironment*/immunology , Tumor Microenvironment*/drug effects , Nucleic Acids*/pharmacology , Brain Neoplasms*/immunology, Animals ; Mice ; Humans ; Cell Line, Tumor ; Membrane Proteins/metabolism ; Metal Nanoparticles/chemistry ; Gold/chemistry ; Mice, Inbred C57BL

Activating Immunogenic Cell Death and Reprogramming the Tumor Microenvironment to Enhance Radiotherapy for Breast Cancer via Low-Frequency Ultrasound-Driven "Artificial T Cells".

Authors: Dong L Li R Liu H et al.

Source: ACS biomaterials science & engineering [ACS Biomater Sci Eng] 2025 Nov 10; Vol. 11 (11), pp. 6605-6620. Date of Electronic Publication: 2025 Oct 23.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101654670 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-9878 (Electronic) Linking ISSN: 23739878 NLM ISO Abbreviation: ACS Biomater Sci Eng Subsets: MEDLINE

MeSH Terms: Tumor Microenvironment*/immunology , Tumor Microenvironment*/radiation effects , Breast Neoplasms*/radiotherapy , Breast Neoplasms*/immunology , Breast Neoplasms*/pathology , Ultrasonic Waves* , Immunogenic Cell Death* , T-Lymphocytes*/immunology, Female ; Humans ; Animals ; Granzymes/chemistry ; Mice ; Microbubbles ; Cell Line, Tumor ; T-Lymphocytes, Cytotoxic/immunology

Metabolic syndrome-related gene signature for prognosis and immune microenvironment prediction in hepatocellular carcinoma.

Authors: Chen L Wang Y Li S et al.

Source: Scientific reports [Sci Rep] 2025 Nov 07; Vol. 15 (1), pp. 39048. Date of Electronic Publication: 2025 Nov 07.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Carcinoma, Hepatocellular*/genetics , Carcinoma, Hepatocellular*/immunology , Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/mortality , Liver Neoplasms*/genetics , Liver Neoplasms*/immunology , Liver Neoplasms*/pathology , Liver Neoplasms*/mortality , Metabolic Syndrome*/genetics , Metabolic Syndrome*/complications , Metabolic Syndrome*/immunology , Tumor Microenvironment*/genetics , Tumor Microenvironment*/immunology, Humans ; Prognosis ; Gene Expression Regulation, Neoplastic ; Male ; Female ; Middle Aged ; Cell Line, Tumor ; Gene Expression Profiling ; Transcriptome

Tumor microenvironment remodeling across thyroid cancer differentiation states revealed by spatial transcriptomics.

Authors: Seok J Choi H Lee EK et al.

Source: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2025 Nov 03; Vol. 74 (12), pp. 357. Date of Electronic Publication: 2025 Nov 03.

Publication Type: Journal Article

Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8605732 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0851 (Electronic) Linking ISSN: 03407004 NLM ISO Abbreviation: Cancer Immunol Immunother Subsets: MEDLINE

MeSH Terms: Thyroid Neoplasms*/pathology , Thyroid Neoplasms*/genetics , Thyroid Neoplasms*/immunology , Tumor Microenvironment*/immunology , Tumor Microenvironment*/genetics , Transcriptome*, Humans ; Male ; Female ; Gene Expression Profiling/methods ; Cell Differentiation ; Middle Aged ; Biomarkers, Tumor/genetics ; Thyroid Cancer, Papillary/pathology ; Thyroid Cancer, Papillary/genetics

Gastric Signet Ring Cell Carcinoma: Tumor Microenvironment Reprogramming and Novel Therapeutic Targets With Emphasis on GRIN2D.

Authors: Raju D Prabhu S Maria A et al.

Source: Clinical and translational science [Clin Transl Sci] 2025 Nov; Vol. 18 (11), pp. e70424.

Publication Type: Journal Article; Review

Journal Info: Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE

MeSH Terms: Tumor Microenvironment*/immunology , Tumor Microenvironment*/drug effects , Tumor Microenvironment*/genetics , Stomach Neoplasms*/pathology , Stomach Neoplasms*/drug therapy , Stomach Neoplasms*/genetics , Stomach Neoplasms*/immunology , Stomach Neoplasms*/therapy , Carcinoma, Signet Ring Cell*/pathology , Carcinoma, Signet Ring Cell*/drug therapy , Carcinoma, Signet Ring Cell*/immunology , Carcinoma, Signet Ring Cell*/genetics , Carcinoma, Signet Ring Cell*/therapy , Receptors, N-Methyl-D-Aspartate*/antagonists & inhibitors , Receptors, N-Methyl-D-Aspartate*/metabolism , Receptors, N-Methyl-D-Aspartate*/genetics, Humans ; Biomarkers, Tumor/metabolism ; Biomarkers, Tumor/antagonists & inhibitors ; Molecular Targeted Therapy/methods ; Prognosis

Spatially Resolved Transcriptomics: Revealing Tumor Microenvironment Heterogeneity to Advance Cancer Immunotherapy.

Authors: Liu D Xiao L Wu Y et al.

Source: Small methods [Small Methods] 2025 Nov; Vol. 9 (11), pp. e00770. Date of Electronic Publication: 2025 Sep 04.

Publication Type: Journal Article; Review

Journal Info: Publisher: WILEY-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 101724536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2366-9608 (Electronic) Linking ISSN: 23669608 NLM ISO Abbreviation: Small Methods Subsets: MEDLINE

MeSH Terms: Tumor Microenvironment*/genetics , Tumor Microenvironment*/immunology , Immunotherapy*/methods , Neoplasms*/therapy , Neoplasms*/genetics , Neoplasms*/immunology , Transcriptome* , Gene Expression Profiling*/methods, Humans ; Computational Biology/methods ; Gene Expression Regulation, Neoplastic

Tumor Microenvironment Metabolism-Modulating Nanomedicines for Enhancing Anti-Tumor Immunity.

Authors: Chen J Fei S Cao Z et al.

Source: Small (Weinheim an der Bergstrasse, Germany) [Small] 2025 Nov; Vol. 21 (47), pp. e09685. Date of Electronic Publication: 2025 Oct 03.

Publication Type: Journal Article; Review

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101235338 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1613-6829 (Electronic) Linking ISSN: 16136810 NLM ISO Abbreviation: Small Subsets: MEDLINE

MeSH Terms: Tumor Microenvironment*/immunology , Tumor Microenvironment*/drug effects , Nanomedicine*/methods , Neoplasms*/immunology , Neoplasms*/metabolism , Neoplasms*/therapy, Humans ; Immunotherapy ; Animals

Transforming the "cold" tumors to "hot" tumors: strategies for immune activation.

Authors: Kong X Ou S Wei Z et al.

Source: Biochemical pharmacology [Biochem Pharmacol] 2025 Nov; Vol. 241, pp. 117194. Date of Electronic Publication: 2025 Jul 26.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH Terms: Neoplasms*/immunology , Neoplasms*/therapy , Immunotherapy*/methods , Immunotherapy*/trends , Tumor Microenvironment*/immunology , Tumor Microenvironment*/drug effects, Humans ; Animals ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/drug effects

A novel oncolytic poxvirus carrying CD47 nanomabs in the treatment of pancreatic cancer by reshaping the immune microenvironment.

Authors: Chen Z Cai Y Zhao K et al.

Source: Cancer letters [Cancer Lett] 2025 Nov 01; Vol. 632, pp. 217934. Date of Electronic Publication: 2025 Aug 05.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE

MeSH Terms: CD47 Antigen*/immunology , CD47 Antigen*/antagonists & inhibitors , Pancreatic Neoplasms*/immunology , Pancreatic Neoplasms*/therapy , Pancreatic Neoplasms*/pathology , Tumor Microenvironment*/immunology , Tumor Microenvironment*/drug effects , Oncolytic Virotherapy*/methods , Oncolytic Viruses*/genetics , Oncolytic Viruses*/immunology , Vaccinia virus*/genetics , Vaccinia virus*/immunology , Single-Domain Antibodies*/genetics , Single-Domain Antibodies*/immunology, Animals ; Humans ; Mice ; Cell Line, Tumor ; Xenograft Model Antitumor Assays ; Female

Targeting the tumor microenvironment in triple-negative breast cancer: Biological insights and therapeutic opportunities.

Authors: Martorana TM Ricciardi G Tralongo P et al.

Source: Pathology, research and practice [Pathol Res Pract] 2025 Nov; Vol. 275, pp. 156226. Date of Electronic Publication: 2025 Sep 10.

Publication Type: Journal Article; Review

Journal Info: Publisher: Gustav Fischer Verlag Country of Publication: Germany NLM ID: 7806109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-0631 (Electronic) Linking ISSN: 03440338 NLM ISO Abbreviation: Pathol Res Pract Subsets: MEDLINE

MeSH Terms: Tumor Microenvironment*/drug effects , Tumor Microenvironment*/immunology , Triple Negative Breast Neoplasms*/pathology , Triple Negative Breast Neoplasms*/immunology , Triple Negative Breast Neoplasms*/drug therapy , Triple Negative Breast Neoplasms*/therapy, Humans ; Female ; Biomarkers, Tumor/metabolism

Emerging mechanisms of triple-negative breast cancer radioresistance: Interplay between cancer cell mechanisms and the tumor immune microenvironment.

Authors: Canha-Borges A Nunes B Quintas ST et al.

Source: Cancer treatment reviews [Cancer Treat Rev] 2025 Nov; Vol. 140, pp. 103026. Date of Electronic Publication: 2025 Sep 28.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7502030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1967 (Electronic) Linking ISSN: 03057372 NLM ISO Abbreviation: Cancer Treat Rev Subsets: MEDLINE

MeSH Terms: Triple Negative Breast Neoplasms*/radiotherapy , Triple Negative Breast Neoplasms*/immunology , Triple Negative Breast Neoplasms*/pathology , Tumor Microenvironment*/immunology , Tumor Microenvironment*/radiation effects , Radiation Tolerance*/immunology, Humans ; Female