Suchergebnisse - "Transforming Growth Factor beta1"

Stathmin-mediated autophagy drives the differentiation of dermal fibroblast into myofibroblast under TGFβ1 stimulation.

Autoren: Tang H Yang L Feng Y et al.

Quelle: Molecular biology reports [Mol Biol Rep] 2025 Dec 06; Vol. 53 (1), pp. 166. Date of Electronic Publication: 2025 Dec 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE

MeSH-Schlagworte: Autophagy*/drug effects , Myofibroblasts*/metabolism , Myofibroblasts*/cytology , Myofibroblasts*/drug effects , Transforming Growth Factor beta1*/metabolism , Transforming Growth Factor beta1*/pharmacology , Stathmin*/metabolism , Stathmin*/genetics , Fibroblasts*/metabolism , Fibroblasts*/cytology , Fibroblasts*/drug effects, Cell Differentiation/drug effects ; Humans ; Skin/cytology ; Skin/metabolism ; Wound Healing ; p38 Mitogen-Activated Protein Kinases/metabolism ; Dermis/cytology ; Dermis/metabolism ; Cells, Cultured

Transforming growth factor-β1 triggers the proliferation of human cholangiocyte spheroids via interleukin-6-mediated STAT3 signaling.

Autoren: Yi J Jeon BY Jeong JH et al.

Quelle: Molecular biology reports [Mol Biol Rep] 2025 Dec 06; Vol. 53 (1), pp. 168. Date of Electronic Publication: 2025 Dec 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE

MeSH-Schlagworte: Interleukin-6*/metabolism , Transforming Growth Factor beta1*/metabolism , Transforming Growth Factor beta1*/pharmacology , STAT3 Transcription Factor*/metabolism, Humans ; Cell Proliferation/drug effects ; Spheroids, Cellular/metabolism ; Spheroids, Cellular/drug effects ; Signal Transduction/drug effects ; Epithelial-Mesenchymal Transition/drug effects ; Cholangiocarcinoma/metabolism ; Cholangiocarcinoma/pathology ; Bile Ducts/cytology ; Bile Ducts/metabolism ; Epithelial Cells/metabolism ; Cell Line

Unravelling the therapeutic potential of dual TGFβ-1 and CXCR4 inhibition in breast cancer using computational strategies.

Autoren: Haq BU Sofi S Qayoom H et al.

Quelle: PloS one [PLoS One] 2025 Dec 05; Vol. 20 (12), pp. e0323665. Date of Electronic Publication: 2025 Dec 05 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

MeSH-Schlagworte: Receptors, CXCR4*/antagonists & inhibitors , Receptors, CXCR4*/metabolism , Receptors, CXCR4*/genetics , Receptors, CXCR4*/chemistry , Breast Neoplasms*/drug therapy , Breast Neoplasms*/metabolism , Breast Neoplasms*/genetics , Breast Neoplasms*/pathology , Transforming Growth Factor beta1*/antagonists & inhibitors , Transforming Growth Factor beta1*/metabolism , Transforming Growth Factor beta1*/genetics , Transforming Growth Factor beta1*/chemistry, Humans ; Female ; Molecular Docking Simulation ; Computational Biology/methods ; Gene Expression Regulation, Neoplastic/drug effects ; Protein Interaction Maps ; Signal Transduction/drug effects

Chlorogenic acid-rich Morus alba leaf alleviated renal fibrosis through the regulation of transforming growth factor-beta 1 (TGF-β1) and fibroblast growth factor-2 (FGF-2), and extracellular matrix deposition.

Autoren: Fauzi A Atho'illah MF Titisari N et al.

Quelle: Molecular biology reports [Mol Biol Rep] 2025 Dec 04; Vol. 53 (1), pp. 160. Date of Electronic Publication: 2025 Dec 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE

MeSH-Schlagworte: Chlorogenic Acid*/pharmacology , Transforming Growth Factor beta1*/metabolism , Transforming Growth Factor beta1*/genetics , Morus*/chemistry , Morus*/metabolism , Fibroblast Growth Factor 2*/metabolism , Fibroblast Growth Factor 2*/genetics, Animals ; Fibrosis/drug therapy ; Male ; Mice ; Plant Leaves/chemistry ; Plant Leaves/metabolism ; Plant Extracts/pharmacology ; Extracellular Matrix/metabolism ; Extracellular Matrix/drug effects ; Mice, Inbred BALB C ; Disease Models, Animal ; Molecular Docking Simulation ; Kidney/pathology ; Kidney/drug effects ; Kidney/metabolism ; Renal Insufficiency, Chronic/drug therapy ; Renal Insufficiency, Chronic/metabolism ; Renal Insufficiency, Chronic/pathology ; Signal Transduction/drug effects ; Kidney Diseases/drug therapy

TGF-β1-based restoration of sodium iodide symporter expression in radioiodine-refractory differentiated thyroid cancer via engineered MSCs.

Autoren: Han Y Koehler VF Nagarajah J et al.

Quelle: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2025 Dec 03; Vol. 33 (12), pp. 6130-6145. Date of Electronic Publication: 2025 Oct 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

MeSH-Schlagworte: Symporters*/genetics , Symporters*/metabolism , Iodine Radioisotopes*/therapeutic use , Transforming Growth Factor beta1*/metabolism , Transforming Growth Factor beta1*/genetics , Mesenchymal Stem Cells*/metabolism , Thyroid Neoplasms*/genetics , Thyroid Neoplasms*/therapy , Thyroid Neoplasms*/metabolism , Thyroid Neoplasms*/pathology, Humans ; Animals ; Mice ; Cell Line, Tumor ; Xenograft Model Antitumor Assays ; Proto-Oncogene Proteins B-raf/genetics ; Cell Differentiation ; Thyroid Cancer, Papillary/genetics ; Promoter Regions, Genetic

Mechanism by which 24-week different-volume high-intensity interval training ameliorates renal fibrosis in naturally aging rats via regulating the TGF-β1/Smad pathway.

Autoren: Zhang J Cui K Wei H et al.

Quelle: Experimental gerontology [Exp Gerontol] 2025 Dec; Vol. 212, pp. 112977. Date of Electronic Publication: 2025 Nov 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 0047061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6815 (Electronic) Linking ISSN: 05315565 NLM ISO Abbreviation: Exp Gerontol Subsets: MEDLINE

MeSH-Schlagworte: Transforming Growth Factor beta1*/metabolism , Transforming Growth Factor beta1*/genetics , Aging*/physiology , High-Intensity Interval Training*/methods , Kidney*/pathology , Kidney*/metabolism , Physical Conditioning, Animal*/methods , Smad Proteins*/metabolism , Kidney Diseases*/pathology , Kidney Diseases*/prevention & control , Kidney Diseases*/metabolism, Animals ; Male ; Fibrosis ; Rats, Wistar ; Signal Transduction/physiology ; Rats ; Smad2 Protein/metabolism

[Expression of Concern] TGF‑β1 mediates epithelial to mesenchymal transition via the TGF‑β/Smad pathway in squamous cell carcinoma of the head and neck.

Autoren: Yu C Liu Y Huang D et al.

Quelle: Oncology reports [Oncol Rep] 2025 Dec; Vol. 54 (6). Date of Electronic Publication: 2025 Oct 03.

Publikationsart: Journal Article; Expression of Concern

Info zur Zeitschrift: Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9422756 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-2431 (Electronic) Linking ISSN: 1021335X NLM ISO Abbreviation: Oncol Rep Subsets: MEDLINE

MeSH-Schlagworte: Epithelial-Mesenchymal Transition*/genetics , Head and Neck Neoplasms*/pathology , Head and Neck Neoplasms*/metabolism , Head and Neck Neoplasms*/genetics , Carcinoma, Squamous Cell*/pathology , Carcinoma, Squamous Cell*/metabolism , Carcinoma, Squamous Cell*/genetics , Transforming Growth Factor beta1*/metabolism , Transforming Growth Factor beta1*/genetics , Smad Proteins*/metabolism, Humans ; Signal Transduction ; Squamous Cell Carcinoma of Head and Neck ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic

TGFβ1‑induced epithelial‑mesenchymal transition is associated with stathmin downregulation and increased microtubule stability in bronchial epithelial cells.

Autoren: Mohamad Hasan NAH Lee YZ Tham CL et al.

Quelle: Molecular medicine reports [Mol Med Rep] 2025 Dec; Vol. 32 (6). Date of Electronic Publication: 2025 Sep 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-3004 (Electronic) Linking ISSN: 17912997 NLM ISO Abbreviation: Mol Med Rep Subsets: MEDLINE

MeSH-Schlagworte: Epithelial-Mesenchymal Transition*/drug effects , Stathmin*/metabolism , Stathmin*/genetics , Transforming Growth Factor beta1*/pharmacology , Transforming Growth Factor beta1*/metabolism , Microtubules*/metabolism , Microtubules*/drug effects , Epithelial Cells*/metabolism , Epithelial Cells*/drug effects , Epithelial Cells*/cytology , Bronchi*/cytology , Bronchi*/metabolism, Humans ; Cell Line ; Cell Movement/drug effects ; Down-Regulation ; Cadherins/metabolism ; Benzamides ; Dioxoles

Chi-miR-146a promotes the propagation of Neospora caninum by targeting the TGF-β1/SMAD2 pathway.

Autoren: Chen JM Li JY Jin JY et al.

Quelle: Veterinary parasitology [Vet Parasitol] 2025 Dec; Vol. 340, pp. 110632. Date of Electronic Publication: 2025 Oct 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7602745 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2550 (Electronic) Linking ISSN: 03044017 NLM ISO Abbreviation: Vet Parasitol Subsets: MEDLINE

MeSH-Schlagworte: Neospora*/physiology , Neospora*/growth & development , Neospora*/genetics , MicroRNAs*/genetics , MicroRNAs*/metabolism , Transforming Growth Factor beta1*/metabolism , Transforming Growth Factor beta1*/genetics , Smad2 Protein*/metabolism , Smad2 Protein*/genetics , Coccidiosis*/veterinary , Coccidiosis*/parasitology, Animals ; Signal Transduction ; Goats ; Female ; Gene Expression Regulation ; Epithelial Cells/parasitology ; Goat Diseases/parasitology

Impact of IL-6 and TGF-β1 on equine mesenchymal stromal cell homing gene expression.

Autoren: Parker JL Berghaus LJ Gordon J et al.

Quelle: Research in veterinary science [Res Vet Sci] 2025 Dec; Vol. 197, pp. 105969. Date of Electronic Publication: 2025 Nov 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: British Veterinary Association Country of Publication: England NLM ID: 0401300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2661 (Electronic) Linking ISSN: 00345288 NLM ISO Abbreviation: Res Vet Sci Subsets: MEDLINE

MeSH-Schlagworte: Mesenchymal Stem Cells*/drug effects , Mesenchymal Stem Cells*/physiology , Mesenchymal Stem Cells*/metabolism , Transforming Growth Factor beta1*/pharmacology , Transforming Growth Factor beta1*/metabolism , Interleukin-6*/pharmacology , Interleukin-6*/metabolism , Gene Expression Regulation*/drug effects, Animals ; Horses ; Wound Healing

PAX9 and Col1A1 may regulate the progression of colon cancer through interactions with the TGF-β1/Smad pathway.

Autoren: Huang C Liang B Shen W

Quelle: Cytokine [Cytokine] 2025 Dec; Vol. 196, pp. 157051. Date of Electronic Publication: 2025 Oct 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005353 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0023 (Electronic) Linking ISSN: 10434666 NLM ISO Abbreviation: Cytokine Subsets: MEDLINE

MeSH-Schlagworte: Colonic Neoplasms*/metabolism , Colonic Neoplasms*/genetics , Colonic Neoplasms*/pathology , Transforming Growth Factor beta1*/metabolism , Transforming Growth Factor beta1*/genetics , Signal Transduction* , Smad Proteins*/metabolism , Smad Proteins*/genetics , Collagen Type I*/metabolism , Collagen Type I*/genetics, Humans ; Disease Progression ; Gene Expression Regulation, Neoplastic ; Collagen Type I, alpha 1 Chain ; Male ; Female ; Prognosis ; Middle Aged

Disrupting BMP/TGF-β Signaling: Modulation of AQP1 and TGFB1 in Human Pulmonary Microvascular Endothelial Cells.

Autoren: Keskinidou C Lotsios NS Papavassiliou KA et al.

Quelle: Comprehensive Physiology [Compr Physiol] 2025 Dec; Vol. 15 (6), pp. e70066.

Publikationsart: Journal Article

Info zur Zeitschrift: Country of Publication: United States NLM ID: 101574442 Publication Model: Print Cited Medium: Internet ISSN: 2040-4603 (Electronic) Linking ISSN: 20404603 NLM ISO Abbreviation: Compr Physiol Subsets: MEDLINE

MeSH-Schlagworte: Aquaporin 1*/metabolism , Aquaporin 1*/genetics , Endothelial Cells*/metabolism , Endothelial Cells*/drug effects , Transforming Growth Factor beta1*/metabolism , Transforming Growth Factor beta1*/genetics , Lung*/blood supply , Lung*/metabolism, Humans ; Signal Transduction/physiology ; Cells, Cultured ; Microvessels/metabolism ; Microvessels/cytology ; Bone Morphogenetic Protein Receptors, Type II/metabolism ; Bone Morphogenetic Protein Receptors, Type II/genetics ; Receptor, Transforming Growth Factor-beta Type I/metabolism ; Receptor, Transforming Growth Factor-beta Type I/genetics

Increased expression of membrane-bound TGF-β1, GITR, and GITR ligand in patients with autoimmune thyroid disease.

Autoren: Hayashi F Inoue N Iwatani Y et al.

Quelle: Immunology letters [Immunol Lett] 2025 Dec; Vol. 276, pp. 107036. Date of Electronic Publication: 2025 May 22.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7910006 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0542 (Electronic) Linking ISSN: 01652478 NLM ISO Abbreviation: Immunol Lett Subsets: MEDLINE

MeSH-Schlagworte: Transforming Growth Factor beta1*/metabolism , Transforming Growth Factor beta1*/genetics , Glucocorticoid-Induced TNFR-Related Protein*/metabolism , Glucocorticoid-Induced TNFR-Related Protein*/genetics , T-Lymphocytes, Regulatory*/immunology , T-Lymphocytes, Regulatory*/metabolism , Tumor Necrosis Factors*/metabolism , Tumor Necrosis Factors*/genetics , Thyroiditis, Autoimmune*/immunology , Thyroiditis, Autoimmune*/metabolism, Humans ; Female ; Male ; Adult ; Middle Aged

[Medicinal cake-separated moxibustion inhibits ectopic endometrium remodeling by regulating TGF-β/Smad signaling in rats with endometriosis].

Autoren: Wang Y Guo HW Xiong J et al.

Quelle: Zhen ci yan jiu = Acupuncture research [Zhen Ci Yan Jiu] 2025 Nov 25; Vol. 50 (11), pp. 1257-1265.

Publikationsart: English Abstract; Journal Article

Info zur Zeitschrift: Publisher: Institute Of Acupuncture And Moxibustion Country of Publication: China NLM ID: 8507710 Publication Model: Print Cited Medium: Print ISSN: 1000-0607 (Print) Linking ISSN: 10000607 NLM ISO Abbreviation: Zhen Ci Yan Jiu Subsets: MEDLINE

MeSH-Schlagworte: Moxibustion* , Endometriosis*/therapy , Endometriosis*/genetics , Endometriosis*/metabolism , Endometrium*/metabolism , Smad Proteins*/metabolism , Smad Proteins*/genetics , Transforming Growth Factor beta1*/metabolism , Transforming Growth Factor beta1*/genetics , Transforming Growth Factor beta*/metabolism , Transforming Growth Factor beta*/genetics, Animals ; Female ; Rats ; Rats, Sprague-Dawley ; Signal Transduction ; Humans ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism

Regulatory role of vitamin D 3 on myogenesis and fibrogenesis under Vdr gene silencing and TGF-β1 stimulation in skeletal muscle cells.

Autoren: Watcharanapapan W Hirunsai M Srikuea R

Quelle: Scientific reports [Sci Rep] 2025 Nov 24; Vol. 15 (1), pp. 41599. Date of Electronic Publication: 2025 Nov 24.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Receptors, Calcitriol*/genetics , Receptors, Calcitriol*/metabolism , Muscle Development*/drug effects , Cholecalciferol*/pharmacology , Cholecalciferol*/metabolism , Transforming Growth Factor beta1*/pharmacology , Transforming Growth Factor beta1*/metabolism , Muscle, Skeletal*/metabolism , Muscle, Skeletal*/cytology , Muscle, Skeletal*/drug effects , Muscle Fibers, Skeletal*/metabolism , Muscle Fibers, Skeletal*/drug effects, Animals ; Mice ; Cell Line ; Gene Silencing ; Calcitriol/pharmacology ; Fibrosis

Cannabidiol inhibits TGF-β1-induced epithelial-mesenchymal transition in human conjunctival epithelial cells by interrupting TGF-β/Smad signaling.

Autoren: Baskan A Awad EM Elahi A et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 21; Vol. 15 (1), pp. 41229. Date of Electronic Publication: 2025 Nov 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Epithelial-Mesenchymal Transition*/drug effects , Cannabidiol*/pharmacology , Signal Transduction*/drug effects , Transforming Growth Factor beta1*/metabolism , Transforming Growth Factor beta1*/pharmacology , Epithelial Cells*/drug effects , Epithelial Cells*/metabolism , Conjunctiva*/cytology , Conjunctiva*/metabolism , Conjunctiva*/drug effects , Conjunctiva*/pathology , Smad Proteins*/metabolism, Humans ; Cell Movement/drug effects ; Smad2 Protein/metabolism ; Cadherins/metabolism

Regulation of the mechanoresponsive Neat1 and PSPC1 by substrate stiffness in TGF-β1-induced renal progenitor cell fate.

Autoren: Huang HN Lee LW Kuo CH et al.

Quelle: Journal of biomedical science [J Biomed Sci] 2025 Nov 17; Vol. 32 (1), pp. 99. Date of Electronic Publication: 2025 Nov 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 9421567 Publication Model: Electronic Cited Medium: Internet ISSN: 1423-0127 (Electronic) Linking ISSN: 10217770 NLM ISO Abbreviation: J Biomed Sci Subsets: MEDLINE

MeSH-Schlagworte: Transforming Growth Factor beta1*/metabolism , Transforming Growth Factor beta1*/genetics , RNA, Long Noncoding*/metabolism , RNA, Long Noncoding*/genetics , Kidney*/cytology , Stem Cells* , RNA-Binding Proteins*/metabolism , RNA-Binding Proteins*/genetics, Animals ; Mice ; Cell Differentiation ; Mesenchymal Stem Cells ; Cells, Cultured

TGF-β1 mediates epithelial-mesenchymal transition in interstitial cystitis through the regulation of ROCK.

Autoren: Long X Yu B Chen M et al.

Quelle: European journal of pharmacology [Eur J Pharmacol] 2025 Nov 05; Vol. 1006, pp. 178184. Date of Electronic Publication: 2025 Sep 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: rho-Associated Kinases*/metabolism , rho-Associated Kinases*/antagonists & inhibitors , Transforming Growth Factor beta1*/metabolism , Transforming Growth Factor beta1*/pharmacology , Transforming Growth Factor beta1*/blood , Epithelial-Mesenchymal Transition*/drug effects , Cystitis, Interstitial*/pathology , Cystitis, Interstitial*/chemically induced , Cystitis, Interstitial*/metabolism , Cystitis, Interstitial*/enzymology, Animals ; Rats ; Rats, Sprague-Dawley ; Urinary Bladder/pathology ; Urinary Bladder/drug effects ; Humans ; Female ; Fibrosis ; Cell Line ; Disease Models, Animal ; Cyclophosphamide ; Male

A New Approach for Achieving Earlier and More Accurate Diagnosis of Connective Tissue Disease-Related Interstitial Lung Disease: TGFB and PDGFA as Novel Promising Biomarkers.

Autoren: Pulito-Cueto V Atienza-Mateo B Batista-Liz JC et al.

Quelle: International journal of molecular sciences [Int J Mol Sci] 2025 Nov 04; Vol. 26 (21). Date of Electronic Publication: 2025 Nov 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: Lung Diseases, Interstitial*/diagnosis , Lung Diseases, Interstitial*/blood , Lung Diseases, Interstitial*/etiology , Platelet-Derived Growth Factor*/metabolism , Platelet-Derived Growth Factor*/genetics , Connective Tissue Diseases*/complications , Connective Tissue Diseases*/diagnosis , Connective Tissue Diseases*/blood , Transforming Growth Factor beta1*/blood , Transforming Growth Factor beta1*/genetics , Transforming Growth Factor beta2*/blood , Transforming Growth Factor beta2*/genetics, Humans ; Biomarkers/blood ; Female ; Male ; Middle Aged ; Aged ; Adult ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/blood ; Transforming Growth Factor beta3/blood ; Early Diagnosis ; Scleroderma, Systemic/complications

Targeted Delivery of Anti-TGF-β 1 -siRNA Using PDGFR-β Peptide-Modified Chitosan Nanoparticles for the Treatment of Liver Fibrosis.

Autoren: Mostafa S Shetab Boushehri MA Ezzat AA et al.

Quelle: Molecular pharmaceutics [Mol Pharm] 2025 Nov 03; Vol. 22 (11), pp. 6741-6758. Date of Electronic Publication: 2025 Sep 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE

MeSH-Schlagworte: Chitosan*/chemistry , RNA, Small Interfering*/administration & dosage , RNA, Small Interfering*/genetics , Nanoparticles*/chemistry , Liver Cirrhosis*/drug therapy , Liver Cirrhosis*/therapy , Liver Cirrhosis*/metabolism , Receptor, Platelet-Derived Growth Factor beta*/chemistry , Receptor, Platelet-Derived Growth Factor beta*/metabolism , Transforming Growth Factor beta1*/genetics , Transforming Growth Factor beta1*/antagonists & inhibitors , Transforming Growth Factor beta1*/metabolism , Peptides*/chemistry, Animals ; Mice ; Hepatic Stellate Cells/metabolism ; Hepatic Stellate Cells/drug effects ; Male ; Drug Delivery Systems/methods ; Humans ; Liver/metabolism