Výsledky vyhledávání - "Toxicity Tests methods"

Application of a high-density microelectrode array assay using a 3D human iPSC-derived brain microphysiological system model for in vitro neurotoxicity screening of environmental compounds

Autoři: Kelly E. Carstens Elena Gronskaya David Jäckel a další

Zdroj: Arch Toxicol
Archives of toxicology, vol. 99, no. 7, pp. 2917-2935

Témata: In Vitro Systems, Humans, Induced Pluripotent Stem Cells/drug effects, Microelectrodes, Neurons/drug effects, Brain/drug effects, Brain/cytology, Toxicity Tests/methods, Astrocytes/drug effects, Environmental Pollutants/toxicity, Neurotoxicity Syndromes/etiology, Oligodendroglia/drug effects, Cells, Cultured, Microphysiological Systems, 3D cultures, BrainSphere, High-density electrode array, MEA, MPS, Microelectrode array, Neuronal electrical activity, Neurotoxicology, iPSC

Popis souboru: application/pdf

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/40293475
https://serval.unil.ch/notice/serval:BIB_76A6E3083DBE
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_76A6E3083DBE7
https://serval.unil.ch/resource/serval:BIB_76A6E3083DBE.P001/REF.pdf

Design of optimal concentrations for in vitro cytotoxicity experiments

Autoři: Leonie Schürmeyer Chen Peng Wiebke Albrecht a další

Zdroj: Arch Toxicol

Témata: 0301 basic medicine, In Vitro Systems, 0303 health sciences, 03 medical and health sciences, Dose-Response Relationship, Drug [MeSH], Optimal design, Humans [MeSH], Concentration-response experiments, Valproic Acid/administration, Cell Survival/drug effects [MeSH], Bayesian optimal design, Valproic Acid/toxicity [MeSH], Bayes Theorem [MeSH], Research Design [MeSH], Toxicity Tests/methods [MeSH]

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39547999
https://repository.publisso.de/resource/frl:6499161

Establishment of a human 3D in vitro liver-bone model as a potential system for drug toxicity screening

Autoři: Guanqiao Chen Yuxuan Xin Mohammad Majd Hammour a další

Zdroj: Arch Toxicol

Témata: 0301 basic medicine, 0303 health sciences, Diclofenac, Cell Survival, Anti-Inflammatory Agents, Non-Steroidal, Drug Evaluation, Preclinical, Models, Biological, Coculture Techniques, Bone and Bones, Cell Line, In Vitro Systems, 03 medical and health sciences, Liver/pathology [MeSH], Diclofenac/toxicity [MeSH], Humans [MeSH], Liver/metabolism [MeSH], Cell Line [MeSH], Liver/drug effects [MeSH], Cell Survival/drug effects [MeSH], Bone and Bones/drug effects [MeSH], 3D in vitro liver-bone co-culture model, Drug affect bone homeostasis, Liver-bone axis, Culture Media [MeSH], Spheroids, Cellular/drug effects [MeSH], Reactive Oxygen Species, Drug Evaluation, Preclinical/methods [MeSH], Interleukin-6, Coculture Techniques [MeSH], Tissue Scaffolds [MeSH], Anti-Inflammatory Agents, Non-Steroidal/toxicity [MeSH], Bone and Bones/metabolism [MeSH], Toxicity Tests/methods [MeSH], Liver, Spheroids, Cellular, Toxicity Tests, Humans

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39503877
https://repository.publisso.de/resource/frl:6513662

Evaluating the performance of multi-omics integration: a thyroid toxicity case study

Autoři: Sebastian Canzler Kristin Schubert Ulrike E. Rolle-Kampczyk a další

Zdroj: Arch Toxicol

Témata: Proteomics, Male, Thyroid Gland/metabolism [MeSH], Proteomics/methods [MeSH], Thyroid Gland/drug effects [MeSH], Risk Assessment [MeSH], Humans [MeSH], Risk assessment, Rats [MeSH], Thyroid Gland/pathology [MeSH], Transcriptome/drug effects [MeSH], Genomics/methods [MeSH], Data integration, Animals [MeSH], Chemical exposure, Toxicogenomics and Omics Technologies, Multi-omics, Multiomics [MeSH], Toxicology, Male [MeSH], Metabolomics/methods [MeSH], Toxicity Tests/methods [MeSH], Thyroid Gland, Genomics, Multiomics, Risk Assessment, Rats, Toxicity Tests, Animals, Metabolomics, Humans, Transcriptome

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39441382
https://repository.publisso.de/resource/frl:6502259

Methodological steps forward in toxicological in vitro screening of mineral wools in primary rat alveolar macrophages and normal rat mesothelial NRM2 cells

Autoři: Christina Ziemann Florian Schulz Christoph Koch a další

Zdroj: Arch Toxicol

Témata: Mineral Fibers, Male, Dose-Response Relationship, Drug [MeSH], Genotoxicity, Rat alveolar macrophages, Cell Line [MeSH], In vitro, Mineral Fibers/toxicity [MeSH], Rats [MeSH], Animals [MeSH], Inorganic Compounds, Rats, Wistar [MeSH], DNA Damage/drug effects [MeSH], Epithelial Cells/drug effects [MeSH], Asbestos, Amosite/toxicity [MeSH], Male [MeSH], Macrophages, Alveolar/drug effects [MeSH], Cytotoxicity, Rat mesothelial cells, Cells, Cultured [MeSH], Mineral wools, Toxicity Tests/methods [MeSH], Dose-Response Relationship, Drug, Epithelial Cells, Rats, Cell Line, Macrophages, Alveolar, Toxicity Tests, Animals, Rats, Wistar, Asbestos, Amosite, Cells, Cultured, DNA Damage

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39261308
https://repository.publisso.de/resource/frl:6508068

Comparative case study on NAMs: towards enhancing specific target organ toxicity analysis

Autoři: Jochum, Kristina Miccoli, Andrea Sommersdorf, Cornelia a další

Zdroj: Arch Toxicol

Témata: Kidney/drug effects [MeSH], Omics, Liver/metabolism [MeSH], Cell Line [MeSH], Cytochrome P-450 CYP1A2/genetics [MeSH], Liver/drug effects [MeSH], Pesticides, Risk Assessment/methods [MeSH], Computational Biology [MeSH], RPTEC, Regulatory Toxicology, Pathway analysis, Toxicity Tests/methods [MeSH], Proteomics/methods [MeSH], Cytochrome P-450 CYP1A2/metabolism [MeSH], Gene enrichment, Kidney/metabolism [MeSH], HepaRG, Humans [MeSH], Transcriptome/drug effects [MeSH], Cytochrome P-450 CYP1A1/genetics [MeSH], Reproducibility of Results [MeSH], Cytochrome P-450 CYP1A1/metabolism [MeSH], Proteome/drug effects [MeSH], Pesticides/toxicity [MeSH], Proteomics, 0301 basic medicine, 0303 health sciences, Proteome, Computational Biology, Reproducibility of Results, HepaRG, RPTEC, Omics, Pathway analysis, Gene enrichment, Pesticides, Kidney, Risk Assessment, Cell Line, 03 medical and health sciences, Liver, Cytochrome P-450 CYP1A2, Toxicity Tests, Cytochrome P-450 CYP1A1, Humans, Transcriptome

Popis souboru: application/pdf

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39207506
https://hdl.handle.net/20.500.14243/494026
https://doi.org/10.1007/s00204-024-03839-7
https://repository.publisso.de/resource/frl:6505978

Avoiding a reproducibility crisis in regulatory toxicology—on the fundamental role of ring trials

Autoři: Miriam N. Jacobs Sebastian Hoffmann Heli M. Hollnagel a další

Zdroj: Arch Toxicol

Témata: Reproducibility of Results, Research Design/standards [MeSH], Animal Testing Alternatives/methods [MeSH], Humans [MeSH], Toxicology/methods [MeSH], Animals [MeSH], Robustness, Ring trials, Reproducibility of Results [MeSH], Validation, Validation Studies as Topic [MeSH], Toxicology/standards [MeSH], OECD Test Guidelines, Risk Assessment/methods [MeSH], Regulatory Toxicology, Reliability, Toxicity Tests/methods [MeSH], Validation Studies as Topic, Toxicology, Animal Testing Alternatives, Risk Assessment, 3. Good health, Research Design, Toxicity Tests, Animals, Humans, 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38689008
https://repository.publisso.de/resource/frl:6493103

1 H NMR spectroscopic characterisation of HepG2 cells as a model metabolic system for toxicology studies

Autoři: Jinks, Maren Davies, Emily C Boughton, Berin A a další

Témata: Hep G2 Cells, Humans, Hydrogen Peroxide - toxicity, Magnetic Resonance Spectroscopy, Metabolome - drug effects, Proton Magnetic Resonance Spectroscopy, Toxicity Tests - methods

Popis souboru: pdf

Relation: ispartof: Toxicology in vitro vol 99; WOS:001325356000001; 991005707062507891; https://researchportal.murdoch.edu.au/view/delivery/61MUN_INST/12168315150007891/13168677600007891; alma:61MUN_INST/bibs/991005707062507891

Dostupnost: https://doi.org/10.1016/j.tiv.2024.105881
https://researchportal.murdoch.edu.au/esploro/outputs/journalArticle/1-H-NMR-spectroscopic-characterisation-of/991005707062507891
https://researchportal.murdoch.edu.au/view/delivery/61MUN_INST/12168315150007891/13168677600007891

Plant cell cultures as food—aspects of sustainability and safety

Autoři: Rischer Heiko Nygren Heli Nohynek Liisa a další

Zdroj: Plant Cell Rep

Témata: 0301 basic medicine, Sucrose, Toxicity Tests/methods, Food Safety, Plant growth regulators, Sucrose/metabolism, Plant Cells/chemistry, Carbohydrates, Cell Culture Techniques, Cell Culture Techniques/methods, Lactose, Amino Acids/analysis, Plant Growth Regulators/analysis, 12. Responsible consumption, Dairy side stream, 03 medical and health sciences, Carbohydrates/analysis, Plant Growth Regulators, Plant Cells, Toxicity Tests, Plant cell cultures, Animals, Humans, Amino Acids, SDG 2 - Zero Hunger, Betula, 2. Zero hunger, 0303 health sciences, Daphnia/drug effects, Betula/cytology, Sustainable Development, 6. Clean water, Culture Media, Daphnia, Food, Odorants, Original Article, Rubus/cytology, Cellular agriculture, Rubus, Culture Media/chemistry

Přístupová URL adresa: https://link.springer.com/content/pdf/10.1007/s00299-020-02592-2.pdf
https://pubmed.ncbi.nlm.nih.gov/32892290
https://cris.vtt.fi/en/publications/bd5b73fe-7327-460d-9487-e39471562f65
https://doi.org/10.1007/s00299-020-02592-2
https://link.springer.com/content/pdf/10.1007/s00299-020-02592-2.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644541
https://europepmc.org/article/MED/32892290
https://www.ncbi.nlm.nih.gov/pubmed/32892290
https://www.scilit.net/article/1ab4ea2249d4921b5b249a2b5562ee7b
https://cris.vtt.fi/en/publications/plant-cell-cultures-as-foodaspects-of-sustainability-and-safety

In vitro prediction of organ toxicity: the challenges of scaling and secondary mechanisms of toxicity

Autoři: Hengstler, Jan G. Sjögren, Anna-Karin Zink, Daniele a další

Zdroj: Arch Toxicol

Témata: 0301 basic medicine, 2. Zero hunger, 0303 health sciences, Dose-Response Relationship, Drug, 16. Peace & justice, Cell Line, 3. Good health, 03 medical and health sciences, Editorial, Drug Discovery, Toxicity Tests, Hepatocytes, Humans, Dose-Response Relationship, Drug [MeSH], Pharmacology/Toxicology, Environmental Health, Drug Discovery [MeSH], Occupational Medicine/Industrial Medicine, Humans [MeSH], Cell Line [MeSH], Biomedicine, general, Hepatocytes/drug effects [MeSH], Toxicity Tests/methods [MeSH]

Přístupová URL adresa: https://link.springer.com/content/pdf/10.1007/s00204-020-02669-7.pdf
https://pubmed.ncbi.nlm.nih.gov/32067068
https://link.springer.com/10.1007/s00204-020-02669-7
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211595
https://pubmed.ncbi.nlm.nih.gov/32067068/
https://link.springer.com/article/10.1007/s00204-020-02669-7
https://link.springer.com/content/pdf/10.1007/s00204-020-02669-7.pdf
https://www.ncbi.nlm.nih.gov/pubmed/32067068
https://repository.publisso.de/resource/frl:6466300

Neuronal in vitro models for the estimation of acute systemic toxicity.

Autoři: Forsby, A. Bal-Price, A.K. Camins, A. a další

Témata: Acute Toxicity Tests/methods, Animals, Blood-Brain Barrier, Cell Line, Humans, Lethal Dose 50, Membrane Potentials/drug effects, Mice, Neurons/drug effects, Rats, Receptors, GABA-A/drug effects, GABA-A/physiology

Relation: Toxicology in Vitro; 1879-3177[electronic], 0887-2333[linking]; https://iris.unil.ch/handle/iris/37994; serval:BIB_48DC6DF28660; 000272276600021

Dostupnost: https://iris.unil.ch/handle/iris/37994
https://doi.org/10.1016/j.gyobfe.2005.03.026

Model-based estimation of lowest observed effect concentration from replicate experiments to identify potential biomarkers of in vitro neurotoxicity.

Autoři: Calderazzo, S. Tavel, D. Zurich, M.G. a další

Témata: Animal Testing Alternatives/methods, Biomarkers/metabolism, Brain/drug effects, Brain/metabolism, Computer Simulation, Dose-Response Relationship, Drug, Humans, In Vitro Techniques, Models, Biological, Neurotoxicity Syndromes/metabolism, No-Observed-Adverse-Effect Level, Toxicity Tests/methods, 3D cultures, Box–Cox transform both sides, Dose–response modeling, Log-logistic model, Neurotoxicity

Relation: Archives of Toxicology; https://iris.unil.ch/handle/iris/241723; serval:BIB_F8E7E90B5212; 000487647300014

Dostupnost: https://iris.unil.ch/handle/iris/241723
https://doi.org/10.1007/s00204-019-02520-8

Workgroup report: incorporating in vitro alternative methods for developmental neurotoxicity into international hazard and risk assessment strategies.

Autoři: Coecke, S. Goldberg, A.M. Allen, S. a další

Témata: Animal Testing Alternatives/legislation & jurisprudence, Animal Testing Alternatives/standards, Animals, Humans, Models, Biological, Nervous System/drug effects, Nervous System/embryology, Toxicity Tests/methods, Validation Studies as Topic, Xenobiotics/toxicity

Popis souboru: application/pdf

Relation: Environmental Health Perspectives; https://iris.unil.ch/handle/iris/138714; serval:BIB_8AEAA8429053; 000247280200039

Dostupnost: https://iris.unil.ch/handle/iris/138714
https://doi.org/10.1289/ehp.9427

Estrogenic activity assessment of environmental chemicals using in vitro assays: identification of two new estrogenic compounds.

Autoři: Lascombe, I. Beffa, D. Rüegg, U. a další

Témata: Breast Neoplasms/pathology, Cell Culture Techniques/methods, Environmental Pollutants/toxicity, Female, Histone Acetyltransferases, Humans, Nuclear Receptor Coactivator 1, Receptors, Estrogen/drug effects, Estrogen/physiology, Toxicity Tests/methods, Transcription Factors/drug effects, Transcription Factors/physiology, Transcriptional Activation, Xenobiotics/toxicity, Yeasts

Popis souboru: application/pdf

Relation: Environmental Health Perspectives; 0091-6765[print], 0091-6765[linking]; https://iris.unil.ch/handle/iris/124256; serval:BIB_5C4456D885DE; 000088529700033

Dostupnost: https://iris.unil.ch/handle/iris/124256
https://doi.org/10.2307/3434882

Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity.

Autoři: Bal-Price, A. Hogberg, H.T. Crofton, K.M. a další

Témata: Animal Testing Alternatives, Animals, Education, Guidelines as Topic, Humans, Neurotoxicity Syndromes/etiology, Risk Assessment, Toxicity Tests/methods, Toxicity Tests/trends, developmental in vitro neurotoxicity testing, quality assurance, regulatory toxicology, toxicity screening

Relation: Alternatives to Animal Experimentation; https://iris.unil.ch/handle/iris/208525; serval:BIB_866FEC6DF239; 000438331200003

Dostupnost: https://iris.unil.ch/handle/iris/208525
https://doi.org/10.14573/altex.1712081

The urgency for optimization and harmonization of thyroid hormone analyses and their interpretation in developmental and reproductive toxicology studies

Autoři: Manon Beekhuijzen Steffen Schneider Narinder Barraclough a další

Přispěvatelé: Manon Beekhuijzen Steffen Schneider Narinder Barraclough a další

Zdroj: Reproductive Toxicology. 80:126-130

Témata: Male, 0301 basic medicine, Thyroid Hormones, 0303 health sciences, Clinical Laboratory Techniques/methods, Thyroid Gland/drug effects, Toxicity Tests/methods, Clinical Laboratory Techniques, Reproduction, Thyroid Gland, Guidelines as Topic/standards, Guidelines as Topic, Endocrine Disruptors, Reference Standards, Thyroid Function Tests, Endocrine Disruptors/toxicity, Thyroid Hormones/blood, 3. Good health, 03 medical and health sciences, Taverne, Toxicity Tests, Animals, Female, Reproduction/drug effects

Popis souboru: application/pdf

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/29729334
https://dspace.library.uu.nl/handle/1874/374722
https://www.sciencedirect.com/science/article/pii/S0890623817305737
https://europepmc.org/abstract/MED/29729334
https://rivm.openrepository.com/handle/10029/621948
https://pubmed.ncbi.nlm.nih.gov/29729334/
https://www.ncbi.nlm.nih.gov/pubmed/29729334
https://dspace.library.uu.nl/handle/1874/374722
https://hdl.handle.net/10029/621948
https://rivm.openrepository.com/handle/10029/651327

Workshop on acceleration of the validation and regulatory acceptance of alternative methods and implementation of testing strategies

Autoři: Piersma, A H Burgdorf, T Louekari, K a další

Přispěvatelé: Piersma, A H Burgdorf, T Louekari, K a další

Zdroj: Piersma, A H, Burgdorf, T, Louekari, K, Desprez, B, Taalman, R, Landsiedel, R, Barroso, J, Rogiers, V, Eskes, C, Oelgeschläger, M, Whelan, M, Braeuning, A, Vinggaard, A M, Kienhuis, A, van Benthem, J & Ezendam, J 2018, ' Workshop on acceleration of the validation and regulatory acceptance of alternative methods and implementation of testing strategies ', Toxicology in Vitro, vol. 50, pp. 62-74 . https://doi.org/10.1016/j.tiv.2018.02.018

Témata: 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, Government Agencies, Toxicity Tests/methods, Taverne, Animal Testing Alternatives/methods, Animals, Humans, Reproducibility of Results, Risk Assessment/methods, 3. Good health

Popis souboru: application/pdf

Přístupová URL adresa: https://backend.orbit.dtu.dk/ws/files/144915145/1_s2.0_S0887233318300651_main.pdf
https://research-portal.uu.nl/en/publications/babbbf89-0b63-4914-99c7-c37f3671a25d
https://doi.org/10.1016/j.tiv.2018.02.018
https://rivm.openrepository.com/handle/10029/621605
https://www.ncbi.nlm.nih.gov/pubmed/29501630
https://orbit.dtu.dk/files/144915145/1_s2.0_S0887233318300651_main.pdf
https://pubmed.ncbi.nlm.nih.gov/29501630/
https://europepmc.org/abstract/MED/29501630
http://dspace.library.uu.nl/handle/1874/374766
https://orbit.dtu.dk/en/publications/ef6de13d-2b0a-4a57-920c-be3784973ac8
https://biblio.vub.ac.be/vubir/workshop-on-acceleration-of-the-validation-and-regulatory-acceptance-of-alternative-methods-and-implementation-of-testing-strategies(b3e08d79-ac99-44c3-a4a2-f64e357d9b1f).html
https://dspace.library.uu.nl/handle/1874/374766
https://hdl.handle.net/10029/621605

A comparison of the embryonic stem cell test and whole embryo culture assay combined with the BeWo placental passage model for predicting the embryotoxicity of azoles

Autoři: Dimopoulou, Myrto Verhoef, Aart Gomes, Caroline A. a další

Přispěvatelé: Dimopoulou, Myrto Verhoef, Aart Gomes, Caroline A. a další

Zdroj: Toxicology Letters. 286:10-21

Témata: Azoles, 0301 basic medicine, Placenta, Mammalian/drug effects, Developmental/drug effects, Mixed Function Oxygenases, Embryo Culture Techniques, Alcohol Oxidoreductases/genetics, Mice, Pregnancy, Myocytes, Cardiac, Sterol 14-Demethylase/genetics, 0303 health sciences, Placenta/drug effects, Gene Expression Regulation, Developmental, Cell Differentiation, Mouse Embryonic Stem Cells, Embryo, Mouse Embryonic Stem Cells/drug effects, Whole embryo culture, Embryotoxicity, Mixed Function Oxygenases/genetics, Biological Assay, Female, Drug, Myocytes, Cardiac/drug effects, Toxicity Tests/methods, Azoles/toxicity, Embryo, Mammalian/drug effects, Placental transfer, Risk Assessment, Cell Line, Dose-Response Relationship, 03 medical and health sciences, Stem cell test, Animals, Humans, Myocytes, Gene Expression Regulation, Developmental/drug effects, Dose-Response Relationship, Drug, Retinoic Acid 4-Hydroxylase/genetics, Reproducibility of Results, Biological Transport, Embryo, Mammalian, Teratogens/toxicity, Alcohol Oxidoreductases, Kinetics, Cardiac/drug effects, Gene Expression Regulation, Cell Differentiation/drug effects, Biomarkers

Popis souboru: image/pdf

Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/29337257
https://research-portal.uu.nl/en/publications/47b1d035-d465-4c93-b521-38843d1860f2
https://doi.org/10.1016/j.toxlet.2018.01.009
https://europepmc.org/abstract/MED/29337257
https://www.narcis.nl/publication/RecordID/oai%3Alibrary.wur.nl%3Awurpubs%2F534090
https://www.sciencedirect.com/science/article/pii/S0378427418300092
https://core.ac.uk/display/151741490
https://pubmed.ncbi.nlm.nih.gov/29337257/
https://dspace.library.uu.nl/bitstream/1874/374738/1/dimopoulou2.pdf
https://research.wur.nl/en/publications/a-comparison-of-the-embryonic-stem-cell-test-and-whole-embryo-cul
https://doi.org/10.1016/j.toxlet.2018.01.009
https://dspace.library.uu.nl/handle/1874/374738
https://hdl.handle.net/10029/621212
https://rivm.openrepository.com/handle/10029/650692

Current limitations and recommendations to improve testing for the environmental assessment of endocrine active substances

Autoři: Coady, Katherine K Biever, Ronald C Denslow, Nancy D a další

Zdroj: Coady, K K, Biever, R C, Denslow, N D, Gross, M, Guiney, P D, Holbech, H, Karouna-Renier, N K, Katsiadaki, I, Krueger, H, Levine, S L, Maack, G, Williams, M, Wolf, J C & Ankley, G T 2017, ' Current Limitations and Recommendations to Improve Testing for the Environmental Assessment of Endocrine Active Substances ', Integrated Environmental Assessment and Management, vol. 13, no. 2, pp. 302–316 . https://doi.org/10.1002/ieam.1862

Témata: High-throughput assays, Toxicity Tests/methods, Environmental Pollutants/analysis, Endocrine disruption, Endocrine Disruptors, Ecotoxicology, Risk Assessment, 01 natural sciences, Endocrine Disruptors/analysis, 3. Good health, Regulatory tests, 13. Climate action, Toxicity Tests, Animals, Humans, Risk and hazard assessment, Biological Assay, Environmental Pollutants, Environmental Monitoring/methods, Environmental Monitoring, 0105 earth and related environmental sciences

Popis souboru: application/pdf

Přístupová URL adresa: https://setac.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ieam.1862
https://pubmed.ncbi.nlm.nih.gov/27791330
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059567
https://europepmc.org/article/MED/27791330
https://setac.onlinelibrary.wiley.com/doi/full/10.1002/ieam.1862
http://onlinelibrary.wiley.com/doi/10.1002/ieam.1862/abstract
https://pubs.er.usgs.gov/publication/70194267
https://onlinelibrary.wiley.com/doi/abs/10.1002/ieam.1862
https://findresearcher.sdu.dk:8443/ws/files/135785653/Coady_et_al_2017_Integrated_Environmental_Assessment_and_Management.pdf
https://portal.findresearcher.sdu.dk/da/publications/845fc38d-c44c-4f1b-84b1-e90795810577
https://doi.org/10.1002/ieam.1862

Adverse outcome pathway development from protein alkylation to liver fibrosis

Autoři: Horvat, Tomislav Landesmann, Brigitte Lostia, Alfonso a další

Přispěvatelé: Horvat, Tomislav Landesmann, Brigitte Lostia, Alfonso a další

Zdroj: Arch Toxicol

Témata: Liver Cirrhosis, 0301 basic medicine, Toxicity Tests/methods, Alkylation, Drug-Related Side Effects and Adverse Reactions, Liver Cirrhosis/chemically induced, Chemical and Drug Induced Liver Injury/etiology, Health, Toxicology and Mutagenesis, Review Article, Animal Testing Alternatives, Toxicology, Risk Assessment, 03 medical and health sciences, Toxicity Tests, Animals, Humans, Alternatives to animal testing, Risk Assessment/methods, liver fibrosis, 0303 health sciences, Toxicology/methods, risk assessment, Proteins, Adverse outcome pathway (AOP), Systems toxicology, 3. Good health, Alkylation/drug effects, Proteins/metabolism, Chemical and Drug Induced Liver Injury, Drug-Related Side Effects and Adverse Reactions/physiopathology

Přístupová URL adresa: https://link.springer.com/content/pdf/10.1007%2Fs00204-016-1814-8.pdf
https://pubmed.ncbi.nlm.nih.gov/27542122
https://link.springer.com/content/pdf/10.1007%2Fs00204-016-1814-8.pdf
https://rd.springer.com/article/10.1007/s00204-016-1814-8
https://paperity.org/p/77780041/adverse-outcome-pathway-development-from-protein-alkylation-to-liver-fibrosis
https://core.ac.uk/display/81818181
https://europepmc.org/article/MED/27542122
https://researchportal.vub.be/en/publications/adverse-outcome-pathway-development-from-protein-alkylation-to-li
https://biblio.vub.ac.be/vubir/adverse-outcome-pathway-development-from-protein-alkylation-to-liver-fibrosis(80ce383c-d9db-44a6-a688-b34b17e0a2da).html