Výsledky vyhledávání - "Tissue Distribution"

Identification of In Vivo Components in Shiduqing Capsule Using High-Resolution Mass Spectrometry and Network Pharmacology-Based Analysis of Its Therapeutic Mechanisms Against Eczema.

Autoři: Li S Liu Z Sun P a další

Zdroj: Rapid communications in mass spectrometry : RCM [Rapid Commun Mass Spectrom] 2025 Dec 15; Vol. 39 (23), pp. e10128.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: John Wiley And Sons Ltd Country of Publication: England NLM ID: 8802365 Publication Model: Print Cited Medium: Internet ISSN: 1097-0231 (Electronic) Linking ISSN: 09514198 NLM ISO Abbreviation: Rapid Commun Mass Spectrom Subsets: MEDLINE

Výrazy ze slovníku MeSH: Drugs, Chinese Herbal*/chemistry , Drugs, Chinese Herbal*/pharmacokinetics , Drugs, Chinese Herbal*/pharmacology , Eczema*/drug therapy , Eczema*/metabolism , Mass Spectrometry*/methods, Animals ; Network Pharmacology/methods ; Mice ; Capsules/chemistry ; Tissue Distribution ; Female ; Male ; Humans ; Skin/drug effects

Pharmacokinetics and tissue distribution of tripchlorolide in rodents using liquid chromatography tandem mass spectrometry.

Autoři: Deng Y Zhou L Gu Z a další

Zdroj: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2025 Dec 15; Vol. 1267, pp. 124805. Date of Electronic Publication: 2025 Oct 02.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101139554 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-376X (Electronic) Linking ISSN: 15700232 NLM ISO Abbreviation: J Chromatogr B Analyt Technol Biomed Life Sci Subsets: MEDLINE

Výrazy ze slovníku MeSH: Tandem Mass Spectrometry*/methods , Diterpenes*/pharmacokinetics , Diterpenes*/chemistry , Diterpenes*/blood , Diterpenes*/analysis , Phenanthrenes*/pharmacokinetics , Phenanthrenes*/chemistry , Phenanthrenes*/analysis , Phenanthrenes*/blood, Animals ; Tissue Distribution ; Mice ; Rats ; Male ; Reproducibility of Results ; Rats, Sprague-Dawley ; Linear Models ; Chromatography, Liquid/methods ; Female ; Limit of Detection ; Epoxy Compounds/pharmacokinetics

Preclinical Development of GT-14, a Novel Inhibitor of Gα i 2 Protein: Comprehensive Evaluation of Physicochemical, Metabolic Characteristics and Tissue Distribution.

Autoři: Sarkar M Du T Chen Y a další

Zdroj: The AAPS journal [AAPS J] 2025 Dec 01; Vol. 28 (1), pp. 23. Date of Electronic Publication: 2025 Dec 01.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication Model: Electronic Cited Medium: Internet ISSN: 1550-7416 (Electronic) Linking ISSN: 15507416 NLM ISO Abbreviation: AAPS J Subsets: MEDLINE

Výrazy ze slovníku MeSH: Indoles*/pharmacokinetics , Indoles*/chemistry , Indoles*/pharmacology , Indoles*/administration & dosage, Animals ; Humans ; Male ; Caco-2 Cells ; Rats ; Tissue Distribution ; Solubility ; Rats, Sprague-Dawley ; Microsomes, Liver/metabolism ; Hydrogen-Ion Concentration ; Drug Evaluation, Preclinical/methods ; Drug Development/methods

Tissue distribution of endogenously formed and orally administered low molecular mass advanced glycation end-products in rats.

Autoři: Li X Sang Y Liu X a další

Zdroj: Food research international (Ottawa, Ont.) [Food Res Int] 2025 Dec; Vol. 222 (Pt 2), pp. 117672. Date of Electronic Publication: 2025 Oct 21.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Published on behalf of the Canadian Institute of Food Science and Technology by Elsevier Applied Science Country of Publication: Canada NLM ID: 9210143 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7145 (Electronic) Linking ISSN: 09639969 NLM ISO Abbreviation: Food Res Int Subsets: MEDLINE

Výrazy ze slovníku MeSH: Glycation End Products, Advanced*/administration & dosage , Glycation End Products, Advanced*/pharmacokinetics , Glycation End Products, Advanced*/metabolism , Glycation End Products, Advanced*/chemistry, Animals ; Tissue Distribution ; Male ; Administration, Oral ; Rats ; Kidney/metabolism ; Molecular Weight ; Biological Availability ; Lysine/analogs & derivatives ; Lysine/pharmacokinetics ; Lysine/administration & dosage ; Rats, Sprague-Dawley

Profiling the Preclinical Pharmacokinetics and Biodistribution of a Platinum(IV)-Based Oxaliplatin Prodrug OxaliTEX and Their Significance to Antitumor Response.

Autoři: He G Thiabaud GD Shelton KA a další

Zdroj: Molecular pharmaceutics [Mol Pharm] 2025 Dec 01; Vol. 22 (12), pp. 7590-7599. Date of Electronic Publication: 2025 Oct 29.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE

Výrazy ze slovníku MeSH: Oxaliplatin*/pharmacokinetics , Prodrugs*/pharmacokinetics , Prodrugs*/chemistry , Antineoplastic Agents*/pharmacokinetics , Antineoplastic Agents*/pharmacology , Organoplatinum Compounds*/pharmacokinetics , Organoplatinum Compounds*/chemistry , Platinum*/chemistry, Animals ; Mice ; Humans ; Tissue Distribution ; Mice, Nude ; Xenograft Model Antitumor Assays ; Female ; HCT116 Cells ; Male ; Tumor Suppressor Protein p53/metabolism

Pharmacokinetics, Excretion, and Organ Distribution of the Novel Gadolinium-Based MRI Contrast Agent Gadoquatrane in Female Cynomolgus Monkeys.

Autoři: Guenther C Frenzel T Rottmann A a další

Zdroj: Investigative radiology [Invest Radiol] 2025 Dec 01; Vol. 60 (12), pp. 831-839. Date of Electronic Publication: 2025 Dec 01.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0045377 Publication Model: Electronic Cited Medium: Internet ISSN: 1536-0210 (Electronic) Linking ISSN: 00209996 NLM ISO Abbreviation: Invest Radiol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Contrast Media*/pharmacokinetics , Organometallic Compounds*/pharmacokinetics , Magnetic Resonance Imaging*/methods , Gadolinium*/pharmacokinetics, Animals ; Female ; Macaca fascicularis ; Tissue Distribution ; Metabolic Clearance Rate

Species- and sex-specific bioaccumulation, tissue-specific distribution, and maternal transfer of per- and polyfluoroalkyl substances in tiger frogs (Hoplobatrachus chinensis) and forest frogs (Rana chensinensis).

Autoři: Zhu CH Luo XJ Chen X a další

Zdroj: Environmental research [Environ Res] 2025 Nov 15; Vol. 285 (Pt 5), pp. 122633. Date of Electronic Publication: 2025 Aug 19.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0147621 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0953 (Electronic) Linking ISSN: 00139351 NLM ISO Abbreviation: Environ Res Subsets: MEDLINE

Výrazy ze slovníku MeSH: Ranidae*/metabolism , Anura*/metabolism , Fluorocarbons*/metabolism , Environmental Pollutants*/metabolism, Animals ; Female ; Male ; Tissue Distribution ; China ; Species Specificity ; Environmental Monitoring ; Bioaccumulation

Pharmacokinetics, tissue distribution and metabolism study of 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside in a rat model of ischemic stroke using UHPLC‑Q‑TOF-MS/MS.

Autoři: Ruan L Liu W Lin H a další

Zdroj: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2025 Nov 15; Vol. 265, pp. 117028. Date of Electronic Publication: 2025 Jun 12.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Science Country of Publication: England NLM ID: 8309336 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-264X (Electronic) Linking ISSN: 07317085 NLM ISO Abbreviation: J Pharm Biomed Anal Subsets: MEDLINE

Výrazy ze slovníku MeSH: Glucosides*/pharmacokinetics , Glucosides*/metabolism , Stilbenes*/pharmacokinetics , Stilbenes*/metabolism , Ischemic Stroke*/drug therapy , Ischemic Stroke*/metabolism, Animals ; Rats ; Male ; Tandem Mass Spectrometry/methods ; Chromatography, High Pressure Liquid/methods ; Tissue Distribution ; Rats, Sprague-Dawley ; Infarction, Middle Cerebral Artery/drug therapy ; Infarction, Middle Cerebral Artery/metabolism ; Disease Models, Animal ; Fallopia multiflora/chemistry

Tissue distribution of morphine and levetiracetam in a forensic autopsy case of a terminal cancer patient.

Autoři: Waters B Kashiwagi M Matsusue A a další

Zdroj: Legal medicine (Tokyo, Japan) [Leg Med (Tokyo)] 2025 Nov; Vol. 79, pp. 102736. Date of Electronic Publication: 2025 Oct 14.

Způsob vydávání: Journal Article; Case Reports

Informace o časopise: Publisher: Elsevier Science Ireland Ltd Country of Publication: Ireland NLM ID: 100889186 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4162 (Electronic) Linking ISSN: 13446223 NLM ISO Abbreviation: Leg Med (Tokyo) Subsets: MEDLINE

Výrazy ze slovníku MeSH: Levetiracetam*/pharmacokinetics , Morphine*/pharmacokinetics , Morphine*/blood , Analgesics, Opioid*/pharmacokinetics , Neoplasms*, Humans ; Autopsy ; Tissue Distribution ; Male ; Tandem Mass Spectrometry ; Morphine Derivatives ; Forensic Toxicology ; Chromatography, Liquid ; Middle Aged ; Female

Embryo-fetal developmental toxicity and toxicokinetics studies of YWS20045 orally administered to pregnant rats.

Autoři: Li H Yue P Shao Q a další

Zdroj: Toxicology letters [Toxicol Lett] 2025 Nov; Vol. 413, pp. 111749. Date of Electronic Publication: 2025 Oct 17.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7709027 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3169 (Electronic) Linking ISSN: 03784274 NLM ISO Abbreviation: Toxicol Lett Subsets: MEDLINE

Výrazy ze slovníku MeSH: Fetal Development*/drug effects , Embryonic Development*/drug effects, Animals ; Female ; Pregnancy ; Administration, Oral ; Toxicokinetics ; Rats, Sprague-Dawley ; Rats ; Dose-Response Relationship, Drug ; Maternal-Fetal Exchange ; Tissue Distribution ; Male ; Gestational Age

Pharmacokinetics, Tissue Distribution, and Metabolic Profile of Cyanidin 3-O-β-Galactoside Purified From Black Chokeberry.

Autoři: Liu X Fan Z Lu W a další

Zdroj: Molecular nutrition & food research [Mol Nutr Food Res] 2025 Nov; Vol. 69 (21), pp. e70219. Date of Electronic Publication: 2025 Aug 21.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101231818 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1613-4133 (Electronic) Linking ISSN: 16134125 NLM ISO Abbreviation: Mol Nutr Food Res Subsets: MEDLINE

Výrazy ze slovníku MeSH: Anthocyanins*/pharmacokinetics , Anthocyanins*/isolation & purification , Anthocyanins*/metabolism, Animals ; Male ; Rats, Sprague-Dawley ; Tissue Distribution ; Rats ; Brain/metabolism ; Neuroprotective Agents/pharmacokinetics ; Galactosides

Toxicity assessment of VX in zebrafish: multi-organ toxicity evaluation and tissue distribution visualization using DESI-MSI.

Autoři: Cao M Zhang Y Dong M a další

Zdroj: Archives of toxicology [Arch Toxicol] 2025 Nov; Vol. 99 (11), pp. 4555-4573. Date of Electronic Publication: 2025 Aug 19.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Zebrafish* , Chemical Warfare Agents*/toxicity , Chemical Warfare Agents*/pharmacokinetics , Organothiophosphorus Compounds*/toxicity , Organothiophosphorus Compounds*/pharmacokinetics , Water Pollutants, Chemical*/toxicity , Water Pollutants, Chemical*/pharmacokinetics, Animals ; Tissue Distribution ; Male ; Female ; Lethal Dose 50 ; Larva/drug effects ; Dose-Response Relationship, Drug ; Toxicity Tests/methods

Cyp3a4-Mediated in vitro Metabolism and in vivo Disposition of Lorlatinib in Rats.

Autoři: Xie C Guan T Huang J a další

Zdroj: Drug design, development and therapy [Drug Des Devel Ther] 2025 Oct 25; Vol. 19, pp. 9627-9645. Date of Electronic Publication: 2025 Oct 25 (Print Publication: 2025).

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN: 1177-8881 (Electronic) Linking ISSN: 11778881 NLM ISO Abbreviation: Drug Des Devel Ther Subsets: MEDLINE

Výrazy ze slovníku MeSH: Cytochrome P-450 CYP3A*/metabolism , Lactams, Macrocyclic*/pharmacokinetics , Lactams, Macrocyclic*/metabolism , Lactams, Macrocyclic*/administration & dosage , Lactams*/pharmacokinetics , Lactams*/metabolism , Lactams*/administration & dosage, Animals ; Rats, Sprague-Dawley ; Rats ; Humans ; Male ; Microsomes, Liver/metabolism ; Aminopyridines ; Tissue Distribution ; Administration, Oral ; Cytochrome P-450 CYP3A Inhibitors/pharmacology ; Drug Interactions ; Tandem Mass Spectrometry ; Pyrazoles

Effects of hibernation on the bioaccumulation and tissue distribution of per- and polyfluoroalkyl substances in frogs (Rana tigrina cantor) via skin exposure.

Autoři: Zhu CH Luo XJ Guan KL a další

Zdroj: Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2025 Oct 15; Vol. 383, pp. 126842. Date of Electronic Publication: 2025 Jul 16.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8804476 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6424 (Electronic) Linking ISSN: 02697491 NLM ISO Abbreviation: Environ Pollut Subsets: MEDLINE

Výrazy ze slovníku MeSH: Fluorocarbons*/metabolism , Hibernation* , Ranidae*/metabolism , Ranidae*/physiology , Environmental Pollutants*/metabolism, Animals ; Skin/metabolism ; Tissue Distribution ; Female ; Bioaccumulation ; Environmental Monitoring

A Novel Felbinac Transdermal Patch with High Permeability: Design, Development and Evaluation.

Autoři: Qin L Liu C Bai R a další

Zdroj: AAPS PharmSciTech [AAPS PharmSciTech] 2025 Oct 04; Vol. 26 (8), pp. 234. Date of Electronic Publication: 2025 Oct 04.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Springer Country of Publication: United States NLM ID: 100960111 Publication Model: Electronic Cited Medium: Internet ISSN: 1530-9932 (Electronic) Linking ISSN: 15309932 NLM ISO Abbreviation: AAPS PharmSciTech Subsets: MEDLINE

Výrazy ze slovníku MeSH: Transdermal Patch*, Administration, Cutaneous ; Animals ; Skin Absorption/drug effects ; Permeability ; Skin/metabolism ; Skin/drug effects ; Drug Delivery Systems/methods ; Tissue Distribution ; Propylene Glycol/chemistry ; Drug Liberation ; Drug Stability ; Male ; Chemistry, Pharmaceutical/methods ; Rats

Assessment of metal distribution patterns in loggerhead sea turtles: A comparative analysis based on sex and tissue type.

Autoři: Simsek I Kuzukiran O Filazi İ a další

Zdroj: Marine pollution bulletin [Mar Pollut Bull] 2025 Oct; Vol. 219, pp. 118339. Date of Electronic Publication: 2025 Jun 24.

Způsob vydávání: Journal Article; Comparative Study

Informace o časopise: Publisher: Elsevier Country of Publication: England NLM ID: 0260231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3363 (Electronic) Linking ISSN: 0025326X NLM ISO Abbreviation: Mar Pollut Bull Subsets: MEDLINE

Výrazy ze slovníku MeSH: Turtles*/metabolism , Water Pollutants, Chemical*/metabolism , Environmental Monitoring* , Metals*/metabolism, Animals ; Male ; Female ; Turkey ; Tissue Distribution ; Liver ; Sex Factors ; Bioaccumulation

Oral pharmacokinetics and tissue distribution of a homogeneous polysaccharide from Auricularia auricula-judae: dual-method validation of absorption and distribution.

Autoři: Zhou L Wei Z Wang N a další

Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2025 Oct; Vol. 327 (Pt 2), pp. 147518. Date of Electronic Publication: 2025 Sep 08.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

Výrazy ze slovníku MeSH: Auricularia*/chemistry , Polysaccharides*/pharmacokinetics , Polysaccharides*/administration & dosage , Polysaccharides*/chemistry , Fungal Polysaccharides*/pharmacokinetics , Fungal Polysaccharides*/administration & dosage , Fungal Polysaccharides*/chemistry, Animals ; Administration, Oral ; Tissue Distribution ; Male ; Rats ; Biological Availability ; Rats, Sprague-Dawley

Deciphering the Pharmacodynamic Basis of Biyan Qingdu Granules: Integrated key Pharmacodynamic Components Identification, Multi-Tissue Distribution, and Metabolic Profiling.

Autoři: Zhang N Fan X Lv F a další

Zdroj: Journal of mass spectrometry : JMS [J Mass Spectrom] 2025 Oct; Vol. 60 (10), pp. e5179.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Wiley Country of Publication: England NLM ID: 9504818 Publication Model: Print Cited Medium: Internet ISSN: 1096-9888 (Electronic) Linking ISSN: 10765174 NLM ISO Abbreviation: J Mass Spectrom Subsets: MEDLINE

Výrazy ze slovníku MeSH: Drugs, Chinese Herbal*/pharmacokinetics , Drugs, Chinese Herbal*/pharmacology , Drugs, Chinese Herbal*/chemistry , Drugs, Chinese Herbal*/analysis , Drugs, Chinese Herbal*/metabolism , Metabolome*/drug effects, Chromatography, High Pressure Liquid/methods ; Animals ; Tissue Distribution ; Tandem Mass Spectrometry/methods ; Male ; Molecular Docking Simulation ; Mice ; Network Pharmacology ; Metabolomics/methods ; Humans

Epirubicin-loaded porous wollastonite nanoparticles for colorectal cancer therapy: synthesis, characterization, and in vivo study.

Autoři: Mahmoudi A Sadi KS Charmforoushan A a další

Zdroj: International journal of pharmaceutics [Int J Pharm] 2025 Dec 25; Vol. 686, pp. 126318. Date of Electronic Publication: 2025 Oct 30.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE

Výrazy ze slovníku MeSH: Silicates*/chemistry , Silicates*/administration & dosage , Calcium Compounds*/chemistry , Calcium Compounds*/administration & dosage , Nanoparticles*/chemistry , Nanoparticles*/administration & dosage , Colorectal Neoplasms*/drug therapy , Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/metabolism , Epirubicin*/administration & dosage , Epirubicin*/pharmacokinetics , Epirubicin*/chemistry , Epirubicin*/pharmacology , Antibiotics, Antineoplastic*/administration & dosage , Antibiotics, Antineoplastic*/pharmacokinetics , Antibiotics, Antineoplastic*/chemistry , Drug Carriers*/chemistry, Animals ; Mice, Inbred BALB C ; Cell Line, Tumor ; Drug Liberation ; Tissue Distribution ; Porosity ; Mice ; Particle Size ; Humans ; Cell Survival/drug effects ; Female

High-Throughput in vivo and in vitro screening of lipid nanoparticles for nucleic acid delivery to the brain.

Autoři: Rodrigues Alves MT Aluotto Scalzo Júnior SR Nunes da Silva W a další

Zdroj: International journal of pharmaceutics [Int J Pharm] 2025 Dec 25; Vol. 686, pp. 126278. Date of Electronic Publication: 2025 Oct 23.

Způsob vydávání: Journal Article

Informace o časopise: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE

Výrazy ze slovníku MeSH: Nanoparticles*/administration & dosage , Nanoparticles*/chemistry , Lipids*/chemistry , Lipids*/administration & dosage , Brain*/metabolism , DNA*/administration & dosage , Nucleic Acids*/administration & dosage , Gene Transfer Techniques*, Animals ; Mice, Inbred C57BL ; Neurons/metabolism ; Tissue Distribution ; Mice ; High-Throughput Screening Assays ; Cell Survival/drug effects ; Transfection/methods ; Male ; Genetic Therapy/methods ; Cells, Cultured ; Liposomes