Suchergebnisse - "Timing"

Dynamic association of H3K36me3 with pericentromeric heterochromatin regulates its replication time.

Autoren: Pradhan SK Zhang H Kolobynina KG et al.

Quelle: EMBO reports [EMBO Rep] 2025 Oct; Vol. 26 (20), pp. 4950-4976. Date of Electronic Publication: 2025 Sep 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE

MeSH-Schlagworte: Heterochromatin*/metabolism , Heterochromatin*/genetics , Histones*/metabolism , Histones*/genetics , DNA Replication Timing* , DNA Replication* , Centromere*/metabolism , Centromere*/genetics, Animals ; Mice ; Mouse Embryonic Stem Cells/metabolism ; Methylation ; DNA, Satellite/genetics ; DNA, Satellite/metabolism ; Histone-Lysine N-Methyltransferase/metabolism ; Histone-Lysine N-Methyltransferase/genetics ; RNA Polymerase II/metabolism ; Protein Processing, Post-Translational ; Phosphorylation

Regulated TRESLIN-MTBP loading governs initiation zones and replication timing in human DNA replication.

Autoren: Zhu X Bektash A Hatoyama Y et al.

Quelle: Nature communications [Nat Commun] 2025 Dec 02; Vol. 16 (1), pp. 10069. Date of Electronic Publication: 2025 Dec 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Cell Cycle Proteins*/metabolism , Cell Cycle Proteins*/genetics , DNA Replication Timing* , DNA Replication*, Humans ; Phosphorylation ; Replication Origin/genetics ; Minichromosome Maintenance Proteins/metabolism ; Telomere-Binding Proteins/metabolism ; Protein Phosphatase 1/metabolism ; Minichromosome Maintenance Complex Component 7/metabolism ; HeLa Cells ; Minichromosome Maintenance Complex Component 2/metabolism

Interplay of replication timing, DNA repair, and translesion synthesis in UV mutagenesis in yeast.

Autoren: Sewell A Wyrick JJ

Quelle: Nucleus (Austin, Tex.) [Nucleus] 2025 Dec; Vol. 16 (1), pp. 2476935. Date of Electronic Publication: 2025 Mar 13.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101518322 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1949-1042 (Electronic) Linking ISSN: 19491034 NLM ISO Abbreviation: Nucleus Subsets: MEDLINE

MeSH-Schlagworte: DNA Repair*/radiation effects , DNA Repair*/genetics , Ultraviolet Rays* , Saccharomyces cerevisiae*/genetics , Saccharomyces cerevisiae*/radiation effects , Saccharomyces cerevisiae*/metabolism , Mutagenesis*/radiation effects , DNA Replication*/radiation effects , DNA Replication Timing*/radiation effects, DNA Damage ; Pyrimidine Dimers/metabolism ; Mutation ; Translesion DNA Synthesis

ATR, a DNA damage kinase, modulates DNA replication timing in Leishmania major.

Autoren: da Silva GLA Damasceno JD Black JA et al.

Quelle: PLoS genetics [PLoS Genet] 2025 Nov 24; Vol. 21 (11), pp. e1011899. Date of Electronic Publication: 2025 Nov 24 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7404 (Electronic) Linking ISSN: 15537390 NLM ISO Abbreviation: PLoS Genet Subsets: MEDLINE

MeSH-Schlagworte: Leishmania major*/genetics , Ataxia Telangiectasia Mutated Proteins*/genetics , Ataxia Telangiectasia Mutated Proteins*/metabolism , DNA Replication*/genetics , DNA Replication Timing*/genetics , Protozoan Proteins*/genetics , Protozoan Proteins*/metabolism, DNA Damage/genetics ; CRISPR-Cas Systems

Unveiling Replication Timing-Dependent Mutational Biases: Mechanistic Insights from Gene Knockouts and Genotoxins Exposures.

Autoren: Gross-Samuels H Koren A Simon I

Quelle: International journal of molecular sciences [Int J Mol Sci] 2025 Jul 29; Vol. 26 (15). Date of Electronic Publication: 2025 Jul 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: Mutagens*/toxicity , Mutagens*/pharmacology , Mutation* , DNA Replication Timing*/genetics , DNA Replication Timing*/drug effects , DNA Replication*/drug effects , DNA Replication*/genetics, Humans ; DNA Repair/genetics ; DNA Repair/drug effects ; Gene Knockout Techniques ; Genomic Instability ; Mutagenesis ; DNA Mismatch Repair/genetics

A single-cell multiomics approach for simultaneous analysis of replication timing and gene expression.

Autoren: Shetty AV Steer CJ Low WC

Quelle: The Journal of biological chemistry [J Biol Chem] 2025 Sep; Vol. 301 (9), pp. 110581. Date of Electronic Publication: 2025 Aug 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

MeSH-Schlagworte: Single-Cell Analysis*/methods , DNA Replication Timing* , DNA Replication*, Humans ; Hep G2 Cells ; S Phase ; Gene Expression Profiling/methods ; Multiomics

RIF1 controls replication timing in early mouse embryos independently of lamina-associated nuclear organization.

Autoren: Nakatani T Schauer T Pal M et al.

Quelle: Developmental cell [Dev Cell] 2025 Aug 18; Vol. 60 (16), pp. 2149-2162.e7. Date of Electronic Publication: 2025 Apr 21.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 101120028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1551 (Electronic) Linking ISSN: 15345807 NLM ISO Abbreviation: Dev Cell Subsets: MEDLINE

MeSH-Schlagworte: Telomere-Binding Proteins*/metabolism , Telomere-Binding Proteins*/genetics , Embryo, Mammalian*/metabolism , Embryo, Mammalian*/cytology , DNA Replication Timing* , Nuclear Lamina*/metabolism , Nuclear Lamina*/genetics , DNA Replication*, Animals ; Mice ; Embryonic Development/genetics ; Gene Expression Regulation, Developmental ; Cell Nucleus/metabolism ; Female

Master transcription-factor binding sites constitute the core of early replication control elements.

Autoren: Turner JL Hinojosa-Gonzalez L Sasaki T et al.

Quelle: The EMBO journal [EMBO J] 2025 Aug; Vol. 44 (16), pp. 4499-4524. Date of Electronic Publication: 2025 Jul 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE

MeSH-Schlagworte: Transcription Factors*/metabolism , Transcription Factors*/genetics , Mouse Embryonic Stem Cells*/metabolism , DNA Replication Timing* , DNA Replication*, Animals ; Mice ; Binding Sites ; Chromatin/metabolism ; Chromatin/genetics ; Transcription, Genetic

Dynamics of replication timing during mammalian development.

Autoren: Nakatani T; Institute of Epigenetics and Stem Cells (IES), Helmholtz Zentrum München, D-81377, München, Germany. Electronic address: tsunetoshi.nakatani@helmholtz-muenchen.de.

Quelle: Trends in genetics : TIG [Trends Genet] 2025 Jul; Vol. 41 (7), pp. 568-576. Date of Electronic Publication: 2025 Mar 12.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Trends Journals Country of Publication: England NLM ID: 8507085 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0168-9525 (Print) Linking ISSN: 01689525 NLM ISO Abbreviation: Trends Genet Subsets: MEDLINE

MeSH-Schlagworte: Embryonic Development*/genetics , DNA Replication Timing*/genetics , Mammals*/genetics , Mammals*/embryology , DNA Replication*, Animals ; Humans ; Chromatin/genetics ; Gene Expression Regulation, Developmental ; Cell Differentiation/genetics

Protocol for genome-wide DNA replication timing analysis using click chemistry-based biotinylation.

Autoren: Gökbuget D Lenshoek K Blelloch R

Quelle: STAR protocols [STAR Protoc] 2025 Sep 19; Vol. 6 (3), pp. 104058. Date of Electronic Publication: 2025 Sep 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 101769501 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-1667 (Electronic) Linking ISSN: 26661667 NLM ISO Abbreviation: STAR Protoc Subsets: MEDLINE

MeSH-Schlagworte: Click Chemistry*/methods , Biotinylation*/methods , DNA Replication Timing*/genetics, Humans ; High-Throughput Nucleotide Sequencing/methods ; DNA/genetics

Single cell multiomics approach to analyze replication timing and gene expression in mouse preimplantation embryos.

Autoren: Shetty AV Steer CJ Low WC

Quelle: Communications biology [Commun Biol] 2025 Aug 19; Vol. 8 (1), pp. 1245. Date of Electronic Publication: 2025 Aug 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE

MeSH-Schlagworte: Single-Cell Analysis*/methods , Blastocyst*/metabolism , Blastocyst*/cytology , Gene Expression Regulation, Developmental* , DNA Replication Timing*, Animals ; Mice ; Female ; Zygote/metabolism ; Embryonic Development/genetics ; Multiomics

Soffritto: a deep learning model for predicting high-resolution replication timing.

Autoren: Bolzan D Ay F

Quelle: Bioinformatics (Oxford, England) [Bioinformatics] 2025 Jul 01; Vol. 41 (Supplement_1), pp. i580-i589.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: England NLM ID: 9808944 Publication Model: Print Cited Medium: Internet ISSN: 1367-4811 (Electronic) Linking ISSN: 13674803 NLM ISO Abbreviation: Bioinformatics Subsets: MEDLINE

MeSH-Schlagworte: Deep Learning* , DNA Replication Timing* , Software*, Humans ; Sequence Analysis, DNA/methods ; Computational Biology/methods ; Animals

Regulation of replication timing in Saccharomyces cerevisiae.

Autoren: Berners-Lee R Gilmore E Berkemeier F et al.

Quelle: PLoS computational biology [PLoS Comput Biol] 2025 Jun 02; Vol. 21 (6), pp. e1013066. Date of Electronic Publication: 2025 Jun 02 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7358 (Electronic) Linking ISSN: 1553734X NLM ISO Abbreviation: PLoS Comput Biol Subsets: MEDLINE

MeSH-Schlagworte: Saccharomyces cerevisiae*/genetics , DNA Replication*/genetics , DNA Replication Timing*/genetics , DNA Replication Timing*/physiology , Models, Genetic*, Algorithms ; Replication Origin/genetics ; DNA, Fungal/genetics ; Computational Biology ; Genome, Fungal

A comparison of genomic methods to assess DNA replication timing.

Autoren: Wheeler E Mickelson-Young L Wear EE et al.

Quelle: Scientific reports [Sci Rep] 2025 May 22; Vol. 15 (1), pp. 17761. Date of Electronic Publication: 2025 May 22.

Publikationsart: Journal Article; Comparative Study

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: DNA Replication Timing* , Genomics*/methods , DNA Replication*, Humans ; S Phase/genetics ; Deoxyuridine/analogs & derivatives ; G1 Phase/genetics ; Cell Nucleus/genetics

DNA replication timing reveals genome-wide features of transcription and fragility.

Autoren: Berkemeier F Cook PR Boemo MA

Quelle: Nature communications [Nat Commun] 2025 May 19; Vol. 16 (1), pp. 4658. Date of Electronic Publication: 2025 May 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: DNA Replication Timing*/genetics , Transcription, Genetic* , Genome, Human* , DNA Replication*, Humans ; Chromatin/metabolism ; Chromatin/genetics ; Genomic Instability ; Replication Origin ; Promoter Regions, Genetic ; Cell Line

KMT2C/KMT2D-dependent H3K4me1 mediates changes in DNA replication timing and origin activity during a cell fate transition.

Autoren: Gökbuget D Goehring L Boileau RM et al.

Quelle: Cell reports [Cell Rep] 2025 Feb 25; Vol. 44 (2), pp. 115272. Date of Electronic Publication: 2025 Feb 04.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

MeSH-Schlagworte: Histones*/metabolism , DNA Replication Timing* , DNA Replication* , DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/genetics , Replication Origin* , Histone-Lysine N-Methyltransferase*/metabolism, Cell Differentiation ; Animals ; Mice ; Chromatin/metabolism ; Humans ; Methylation ; Cell Lineage ; Embryonic Stem Cells/metabolism ; Embryonic Stem Cells/cytology ; Lysine/analogs & derivatives ; Myeloid-Lymphoid Leukemia Protein

Unravelling single-cell DNA replication timing dynamics using machine learning reveals heterogeneity in cancer progression.

Autoren: Josephides JM Chen CL

Quelle: Nature communications [Nat Commun] 2025 Feb 08; Vol. 16 (1), pp. 1472. Date of Electronic Publication: 2025 Feb 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Machine Learning* , Single-Cell Analysis*/methods , Neoplasms*/genetics , Neoplasms*/pathology , DNA Replication Timing*/genetics , DNA Replication*, Humans ; Disease Progression ; DNA Copy Number Variations ; Cell Line, Tumor ; Genetic Heterogeneity ; Animals ; Mice ; Genomic Instability

R-loops acted on by RNase H1 influence DNA replication timing and genome stability in Leishmania.

Autoren: Damasceno JD Briggs EM Krasilnikova M et al.

Quelle: Nature communications [Nat Commun] 2025 Feb 08; Vol. 16 (1), pp. 1470. Date of Electronic Publication: 2025 Feb 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Ribonuclease H*/metabolism , Ribonuclease H*/genetics , Genomic Instability* , R-Loop Structures*/genetics , Leishmania major*/genetics , Leishmania major*/metabolism , DNA Replication Timing*/genetics , DNA Replication*, Genome, Protozoan ; Chromatin/metabolism ; DNA, Protozoan/genetics ; Chromosomes/genetics ; Chromosomes/metabolism ; Protozoan Proteins/metabolism ; Protozoan Proteins/genetics ; G-Quadruplexes ; Humans

Sir2 and Fun30 regulate ribosomal DNA replication timing via MCM helicase positioning and nucleosome occupancy.

Autoren: Lichauco C Foss EJ Gatbonton-Schwager T et al.

Quelle: ELife [Elife] 2025 Jan 20; Vol. 13. Date of Electronic Publication: 2025 Jan 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

MeSH-Schlagworte: Nucleosomes*/metabolism , Sirtuin 2*/metabolism , Sirtuin 2*/genetics , Saccharomyces cerevisiae*/genetics , Saccharomyces cerevisiae*/metabolism , Silent Information Regulator Proteins, Saccharomyces cerevisiae*/metabolism , Silent Information Regulator Proteins, Saccharomyces cerevisiae*/genetics , Saccharomyces cerevisiae Proteins*/metabolism , Saccharomyces cerevisiae Proteins*/genetics , DNA, Ribosomal*/metabolism , DNA, Ribosomal*/genetics , Transcription Factors*/metabolism , DNA Replication Timing* , DNA Replication* , Minichromosome Maintenance Proteins*/metabolism, Replication Origin

Telomere-to-telomere DNA replication timing profiling using single-molecule sequencing with Nanotiming.

Autoren: Theulot B Tourancheau A Simonin Chavignier E et al.

Quelle: Nature communications [Nat Commun] 2025 Jan 02; Vol. 16 (1), pp. 242. Date of Electronic Publication: 2025 Jan 02.

Publikationsart: Journal Article; Research Support, Non-U.S. Gov't

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Telomere*/genetics , Telomere*/metabolism , Saccharomyces cerevisiae*/genetics , DNA Replication Timing* , Telomere-Binding Proteins*/metabolism , Telomere-Binding Proteins*/genetics, Saccharomyces cerevisiae Proteins/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; DNA Replication ; DNA, Fungal/genetics ; DNA, Fungal/metabolism ; S Phase/genetics ; Single Molecule Imaging/methods ; Bromodeoxyuridine/metabolism ; Nanopore Sequencing/methods ; Repressor Proteins