Suchergebnisse - "Thrombospondins"

Integration of RASSF1A and TSPYL5 methylation and AFP protein as plasma biomarker for hepatocellular carcinoma diagnosis.

Autoren: Chen H Luo Y Li L et al.

Quelle: Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2025 Nov 18; Vol. 151 (12), pp. 324. Date of Electronic Publication: 2025 Nov 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7902060 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1335 (Electronic) Linking ISSN: 01715216 NLM ISO Abbreviation: J Cancer Res Clin Oncol Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Hepatocellular*/diagnosis , Carcinoma, Hepatocellular*/blood , Carcinoma, Hepatocellular*/genetics , Liver Neoplasms*/diagnosis , Liver Neoplasms*/blood , Liver Neoplasms*/genetics , Tumor Suppressor Proteins*/genetics , Tumor Suppressor Proteins*/blood , DNA Methylation* , Biomarkers, Tumor*/blood , Biomarkers, Tumor*/genetics , alpha-Fetoproteins*/metabolism , alpha-Fetoproteins*/analysis , Thrombospondins*/genetics , Thrombospondins*/blood, Humans ; Male ; Female ; Middle Aged ; CpG Islands ; Computational Biology

Integrative multi-omics and Mendelian randomization identify WWOX and THBS2 as potential therapeutic targets in mature T/NK-cell lymphoma.

Autoren: Qin Y Wei J He Y et al.

Quelle: Journal of translational medicine [J Transl Med] 2025 Nov 18; Vol. 23 (1), pp. 1306. Date of Electronic Publication: 2025 Nov 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE

MeSH-Schlagworte: Mendelian Randomization Analysis* , WW Domain-Containing Oxidoreductase*/genetics , WW Domain-Containing Oxidoreductase*/metabolism , Tumor Suppressor Proteins*/genetics , Tumor Suppressor Proteins*/metabolism , Thrombospondins*/genetics , Thrombospondins*/metabolism , Thrombospondins*/chemistry , Molecular Targeted Therapy* , Lymphoma, Extranodal NK-T-Cell*/genetics , Lymphoma, Extranodal NK-T-Cell*/drug therapy, Humans ; Quantitative Trait Loci/genetics ; Genome-Wide Association Study ; Gene Expression Regulation, Neoplastic ; DNA Methylation/genetics ; Molecular Docking Simulation ; Bayes Theorem ; Multiomics

Cancer-associated fibroblasts drive lung adenocarcinoma progression via THBS2-mediated epithelial-mesenchymal transition.

Autoren: Ren Y Ming R Zuo A et al.

Quelle: Oncogene [Oncogene] 2025 Nov; Vol. 44 (44), pp. 4284-4297. Date of Electronic Publication: 2025 Sep 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE

MeSH-Schlagworte: Cancer-Associated Fibroblasts*/metabolism , Cancer-Associated Fibroblasts*/pathology , Epithelial-Mesenchymal Transition*/genetics , Thrombospondins*/metabolism , Thrombospondins*/genetics , Adenocarcinoma of Lung*/pathology , Adenocarcinoma of Lung*/genetics , Adenocarcinoma of Lung*/metabolism , Lung Neoplasms*/pathology , Lung Neoplasms*/genetics , Lung Neoplasms*/metabolism, Humans ; Disease Progression ; Animals ; Mice ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Female ; Male

Exosomal ALPPL2 and THBS2 as biomarkers for early detection and disease monitoring of pancreatic ductal adenocarcinoma.

Autoren: Halder K Borazanci EH Jameson GS et al.

Quelle: British journal of cancer [Br J Cancer] 2025 Nov; Vol. 133 (9), pp. 1335-1343. Date of Electronic Publication: 2025 Sep 03.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE

MeSH-Schlagworte: Exosomes*/metabolism , Carcinoma, Pancreatic Ductal*/blood , Carcinoma, Pancreatic Ductal*/diagnosis , Carcinoma, Pancreatic Ductal*/pathology , Biomarkers, Tumor*/blood , Thrombospondins*/blood , Thrombospondins*/metabolism , Pancreatic Neoplasms*/blood , Pancreatic Neoplasms*/diagnosis , Pancreatic Neoplasms*/pathology, Humans ; Female ; Male ; Middle Aged ; Aged ; Early Detection of Cancer/methods ; Prognosis ; Adult ; Case-Control Studies

Restricted mating windows and thrombospondin 2 gene deletion improve the precision of parturition timing in mice†.

Autoren: Rogers JH Martin-Fairey C Boatwright N et al.

Quelle: Biology of reproduction [Biol Reprod] 2025 Oct 14; Vol. 113 (4), pp. 886-893.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0207224 Publication Model: Print Cited Medium: Internet ISSN: 1529-7268 (Electronic) Linking ISSN: 00063363 NLM ISO Abbreviation: Biol Reprod Subsets: MEDLINE

MeSH-Schlagworte: Parturition*/genetics , Parturition*/physiology , Thrombospondins*/genetics , Thrombospondins*/metabolism , Sexual Behavior, Animal*/physiology, Animals ; Female ; Mice ; Pregnancy ; Mice, Knockout ; Mice, Inbred C57BL ; Gene Deletion ; Male

Dual-ligand engineered exosome regulates WNT signaling activation to promote liver repair and regeneration.

Autoren: Yang L Wang S Qiao Z et al.

Quelle: Nature communications [Nat Commun] 2025 Oct 10; Vol. 16 (1), pp. 9019. Date of Electronic Publication: 2025 Oct 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Exosomes*/metabolism , Liver Regeneration*/physiology , Wnt Signaling Pathway*/drug effects , Wnt Signaling Pathway*/physiology , Liver*/metabolism , Wnt3A Protein*/metabolism , Wnt3A Protein*/genetics , Thrombospondins*/metabolism , Thrombospondins*/genetics, Animals ; Ligands ; Mice ; Humans ; Organoids/metabolism ; Mice, Inbred C57BL ; Hepatocytes/metabolism ; Male ; Pyridines/pharmacology ; Pyrimidines/pharmacology

R-spondin 3 is a myokine that mediates type I fiber determination during skeletal muscle regeneration.

Autoren: Hu T Mita Y Zhu X et al.

Quelle: Molecular biology reports [Mol Biol Rep] 2025 Oct 09; Vol. 52 (1), pp. 995. Date of Electronic Publication: 2025 Oct 09.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE

MeSH-Schlagworte: Regeneration*/physiology , Regeneration*/genetics , Thrombospondins*/metabolism , Thrombospondins*/genetics , Muscle, Skeletal*/physiology , Muscle, Skeletal*/metabolism , Muscle Fibers, Slow-Twitch*/metabolism , Muscle Fibers, Slow-Twitch*/physiology, Animals ; Mice ; Cell Differentiation ; Muscle Fibers, Skeletal/metabolism ; Myoblasts/metabolism ; Muscle Development ; Mice, Knockout ; Myokines

Phenotype-dependent heterogeneity of THSD7A expression in gastric cancer tissue in a patient with THSD7A-associated membranous nephropathy.

Autoren: Minezaki C Azegami T Hashiguchi A et al.

Quelle: CEN case reports [CEN Case Rep] 2025 Oct; Vol. 14 (5), pp. 693-699. Date of Electronic Publication: 2025 Jun 09.

Publikationsart: Journal Article; Case Reports

Info zur Zeitschrift: Publisher: Springer Japan Country of Publication: Japan NLM ID: 101636244 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-4449 (Electronic) Linking ISSN: 21924449 NLM ISO Abbreviation: CEN Case Rep Subsets: MEDLINE

MeSH-Schlagworte: Stomach Neoplasms*/complications , Stomach Neoplasms*/pathology , Stomach Neoplasms*/diagnosis , Stomach Neoplasms*/surgery , Glomerulonephritis, Membranous*/diagnosis , Glomerulonephritis, Membranous*/pathology , Glomerulonephritis, Membranous*/etiology , Thrombospondins*/metabolism , Thrombospondins*/genetics, Humans ; Male ; Aged, 80 and over ; Nephrotic Syndrome/etiology ; Nephrotic Syndrome/diagnosis ; Phenotype ; Kidney/pathology

Optimizing thrombospondin function through repositioning: Implications for injury and diabetic foot ulcer management.

Autoren: Trujillo-Paez JV Jacobo-Delgado YM Felix-Arellano C et al.

Quelle: Tissue & cell [Tissue Cell] 2025 Oct; Vol. 96, pp. 102987. Date of Electronic Publication: 2025 May 20.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 0214745 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3072 (Electronic) Linking ISSN: 00408166 NLM ISO Abbreviation: Tissue Cell Subsets: MEDLINE

MeSH-Schlagworte: Thrombospondins*/metabolism , Thrombospondins*/genetics , Diabetic Foot*/pathology , Diabetic Foot*/metabolism , Diabetic Foot*/drug therapy , Diabetic Foot*/genetics , Wound Healing*/drug effects , Thrombospondin 1*/metabolism , Thrombospondin 1*/genetics, Humans ; Male ; Middle Aged ; Female ; Aged ; Superoxide Dismutase/metabolism ; Superoxide Dismutase/genetics

Ubiquitination-Dependent LLGL2 Degradation Drives Colorectal Cancer Progression via THBS3 mRNA Stabilization.

Autoren: Huang J Zhang T Li H et al.

Quelle: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Oct; Vol. 12 (39), pp. e01656. Date of Electronic Publication: 2025 Jul 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

MeSH-Schlagworte: Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/metabolism , Colorectal Neoplasms*/pathology , RNA Stability*/genetics , Thrombospondins*/genetics , Thrombospondins*/metabolism, Humans ; Disease Progression ; Ubiquitination/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Cell Line, Tumor ; Signal Transduction ; Gene Expression Regulation, Neoplastic/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Animals ; Proto-Oncogene Proteins c-akt/metabolism

Thrombospondin 2 drives liver metastasis in skin cutaneous melanoma via regulation of angiogenesis and extracellular matrix remodeling.

Autoren: Zhang LP Zhang ZG Guan J et al.

Quelle: Melanoma research [Melanoma Res] 2025 Oct 01; Vol. 35 (5), pp. 306-316. Date of Electronic Publication: 2025 Jul 16.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 9109623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5636 (Electronic) Linking ISSN: 09608931 NLM ISO Abbreviation: Melanoma Res Subsets: MEDLINE

MeSH-Schlagworte: Skin Neoplasms*/pathology , Skin Neoplasms*/metabolism , Skin Neoplasms*/genetics , Melanoma*/pathology , Melanoma*/metabolism , Melanoma*/genetics , Thrombospondins*/metabolism , Thrombospondins*/genetics , Extracellular Matrix*/metabolism , Extracellular Matrix*/pathology , Neovascularization, Pathologic*/pathology , Neovascularization, Pathologic*/metabolism , Neovascularization, Pathologic*/genetics , Liver Neoplasms*/secondary , Liver Neoplasms*/metabolism , Liver Neoplasms*/genetics, Animals ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Male ; Female ; Angiogenesis

Structural insights into Wnt/β-catenin signaling regulation by LGR4, R-spondin, and ZNRF3.

Autoren: Peng Y Fujimura A Asami J et al.

Quelle: Nature communications [Nat Commun] 2025 Oct 01; Vol. 16 (1), pp. 8337. Date of Electronic Publication: 2025 Oct 01.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Receptors, G-Protein-Coupled*/metabolism , Receptors, G-Protein-Coupled*/chemistry , Receptors, G-Protein-Coupled*/genetics , Receptors, G-Protein-Coupled*/ultrastructure , Thrombospondins*/metabolism , Thrombospondins*/chemistry , Thrombospondins*/genetics , Wnt Signaling Pathway* , Ubiquitin-Protein Ligases*/metabolism , Ubiquitin-Protein Ligases*/chemistry , Ubiquitin-Protein Ligases*/genetics , Ubiquitin-Protein Ligases*/ultrastructure, Humans ; Cryoelectron Microscopy ; beta Catenin/metabolism ; Protein Binding ; HEK293 Cells ; Models, Molecular ; R-Spondins

Descendants of hypertrophic chondrocytes promote angiogenesis by secreting THBS4 during bone growth and injury repair.

Autoren: Song S Fan J Ding G et al.

Quelle: Bone research [Bone Res] 2025 Nov 10; Vol. 13 (1), pp. 92. Date of Electronic Publication: 2025 Nov 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: West China School of Stomatology, Sichuan University Country of Publication: China NLM ID: 101608652 Publication Model: Electronic Cited Medium: Print ISSN: 2095-4700 (Print) Linking ISSN: 20954700 NLM ISO Abbreviation: Bone Res Subsets: MEDLINE

MeSH-Schlagworte: Thrombospondins*/metabolism , Chondrocytes*/metabolism , Chondrocytes*/pathology , Neovascularization, Physiologic* , Bone Development*/physiology , Wound Healing*, Animals ; Mice ; Mice, Transgenic ; Angiogenesis

Anti-tumor activity of camptothecin analog conjugate of an RSPO4-based peptibody targeting LGR4/5/6 in preclinical models of colorectal cancer.

Autoren: Toh Y Wu L Tu J et al.

Quelle: British journal of cancer [Br J Cancer] 2025 Nov; Vol. 133 (8), pp. 1218-1228. Date of Electronic Publication: 2025 Aug 18.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE

MeSH-Schlagworte: Colorectal Neoplasms*/drug therapy , Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/metabolism , Colorectal Neoplasms*/genetics , Receptors, G-Protein-Coupled*/antagonists & inhibitors , Receptors, G-Protein-Coupled*/metabolism , Camptothecin*/analogs & derivatives , Camptothecin*/pharmacology , Camptothecin*/chemistry , Thrombospondins*/chemistry, Humans ; Animals ; Mice ; Xenograft Model Antitumor Assays ; Cell Line, Tumor ; Female

Wnt induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL.

Autoren: Luo D Zheng J Lv S et al.

Quelle: ELife [Elife] 2025 Oct 10; Vol. 14. Date of Electronic Publication: 2025 Oct 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

MeSH-Schlagworte: Endocytosis* , Frizzled Receptors*/metabolism , Ubiquitin-Protein Ligases*/metabolism , Dishevelled Proteins*/metabolism , Wnt Proteins*/metabolism , Thrombospondins*/metabolism , DNA-Binding Proteins*/metabolism, Humans ; Proteolysis ; Wnt Signaling Pathway ; HEK293 Cells ; R-Spondins

Diagnostic and prognostic role of thrombospondin-4 levels in pre-eclampsia: Association with onset type, severity, and perinatal outcome.

Autoren: Dayanan R Bulan DD Yucel KY

Quelle: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics [Int J Gynaecol Obstet] 2025 Oct; Vol. 171 (1), pp. 345-352. Date of Electronic Publication: 2025 Aug 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley Country of Publication: United States NLM ID: 0210174 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3479 (Electronic) Linking ISSN: 00207292 NLM ISO Abbreviation: Int J Gynaecol Obstet Subsets: MEDLINE

MeSH-Schlagworte: Pre-Eclampsia*/blood , Pre-Eclampsia*/diagnosis , Thrombospondins*/blood, Humans ; Female ; Pregnancy ; Adult ; Prospective Studies ; Prognosis ; Biomarkers/blood ; Pregnancy Outcome ; ROC Curve ; Severity of Illness Index ; Case-Control Studies ; Infant, Newborn ; Sensitivity and Specificity ; Gestational Age

Thrombospondin-4 from cancer-associated fibroblasts downregulates ERBB2 expression in gastric cancer cells.

Autoren: Tsujio G Yashiro M Sakuma T et al.

Quelle: Carcinogenesis [Carcinogenesis] 2025 Sep 04; Vol. 46 (3).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Irl Press At Oxford University Press Country of Publication: England NLM ID: 8008055 Publication Model: Print Cited Medium: Internet ISSN: 1460-2180 (Electronic) Linking ISSN: 01433334 NLM ISO Abbreviation: Carcinogenesis Subsets: MEDLINE

MeSH-Schlagworte: Stomach Neoplasms*/pathology , Stomach Neoplasms*/genetics , Stomach Neoplasms*/drug therapy , Stomach Neoplasms*/metabolism , Receptor, ErbB-2*/genetics , Receptor, ErbB-2*/metabolism , Cancer-Associated Fibroblasts*/metabolism , Cancer-Associated Fibroblasts*/pathology , Cancer-Associated Fibroblasts*/drug effects , Thrombospondins*/genetics , Thrombospondins*/metabolism, Humans ; Animals ; Mice ; Down-Regulation ; Gene Expression Regulation, Neoplastic/drug effects ; Cell Line, Tumor ; Mice, Nude ; Trastuzumab/pharmacology ; Drug Resistance, Neoplasm/genetics ; Female ; Xenograft Model Antitumor Assays ; Tumor Microenvironment ; RNA, Small Interfering/genetics

Single cell RNA seq reveals the pro-regenerative phenotype of thrombospondin-2 deficient dermal fibroblasts.

Autoren: Huang Y Wang N Xing H et al.

Quelle: Scientific reports [Sci Rep] 2025 Sep 02; Vol. 15 (1), pp. 32304. Date of Electronic Publication: 2025 Sep 02.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Fibroblasts*/metabolism , Fibroblasts*/cytology , Thrombospondins*/genetics , Thrombospondins*/deficiency , Thrombospondins*/metabolism , Single-Cell Analysis*/methods , Dermis*/cytology , Dermis*/metabolism , Regeneration*/genetics, Animals ; Mice ; Mice, Knockout ; RNA-Seq ; Skin/metabolism ; Skin/cytology ; Wound Healing/genetics ; Phenotype ; Cell Differentiation ; Signal Transduction ; Single-Cell Gene Expression Analysis

Carbon black induced pulmonary fibrosis through piR-713551/PIWIL4 targeting THBS2 signal pathway.

Autoren: Wang M Niu Y Liu Q et al.

Quelle: Journal of environmental sciences (China) [J Environ Sci (China)] 2025 Sep; Vol. 155, pp. 409-422. Date of Electronic Publication: 2024 May 19.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: IOS Press Country of Publication: Netherlands NLM ID: 100967627 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1001-0742 (Print) Linking ISSN: 10010742 NLM ISO Abbreviation: J Environ Sci (China) Subsets: MEDLINE

MeSH-Schlagworte: Pulmonary Fibrosis*/chemically induced , Soot*/toxicity , Air Pollutants*/toxicity , Thrombospondins*/metabolism , Thrombospondins*/genetics, Animals ; Mice ; Signal Transduction/drug effects ; Mice, Inbred C57BL ; Humans ; Cell Line

H3K4me3 regulates the transcription of RSPO3 in dermal papilla cells to influence hair follicle morphogenesis and development.

Autoren: Zhong Z Bai K Song Z et al.

Quelle: Epigenetics & chromatin [Epigenetics Chromatin] 2025 Aug 08; Vol. 18 (1), pp. 52. Date of Electronic Publication: 2025 Aug 08.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: BioMed Central Country of Publication: England NLM ID: 101471619 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-8935 (Electronic) Linking ISSN: 17568935 NLM ISO Abbreviation: Epigenetics Chromatin Subsets: MEDLINE

MeSH-Schlagworte: Hair Follicle*/metabolism , Hair Follicle*/growth & development , Hair Follicle*/cytology , Thrombospondins*/genetics , Thrombospondins*/metabolism , Histones*/metabolism , Histones*/genetics , Dermis*/metabolism , Dermis*/cytology, Animals ; Morphogenesis ; Cell Proliferation ; Wnt Signaling Pathway