Suchergebnisse - "Therapeutics"

A Double-Blind, Placebo-Controlled, Single-Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of HT-101, an RNAi Therapeutic Targeting HBV Infection.

Autoren: Zhang J Li J Wu L et al.

Quelle: Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2025 Oct; Vol. 14 (10), pp. 754-763. Date of Electronic Publication: 2025 Jul 03.

Publikationsart: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I

Info zur Zeitschrift: Publisher: Wiley Country of Publication: United States NLM ID: 101572899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2160-7648 (Electronic) Linking ISSN: 2160763X NLM ISO Abbreviation: Clin Pharmacol Drug Dev Subsets: MEDLINE

MeSH-Schlagworte: Acetylgalactosamine*/administration & dosage , Acetylgalactosamine*/pharmacokinetics , Acetylgalactosamine*/adverse effects , Acetylgalactosamine*/analogs & derivatives , Hepatitis B, Chronic*/drug therapy , Antiviral Agents*/pharmacokinetics , Antiviral Agents*/adverse effects , Antiviral Agents*/administration & dosage , RNAi Therapeutics*/methods , RNAi Therapeutics*/adverse effects, Humans ; Double-Blind Method ; Male ; Adult ; Female ; Young Adult ; Healthy Volunteers ; Middle Aged ; Dose-Response Relationship, Drug ; Half-Life ; Injections, Subcutaneous ; Hepatitis B virus/drug effects

Phase I randomized double-blind study of an RNA interference therapeutic targeting HSD17B13 for metabolic dysfunction-associated steatohepatitis.

Autoren: Sanyal AJ Taubel J Badri P et al.

Quelle: Journal of hepatology [J Hepatol] 2025 Oct; Vol. 83 (4), pp. 838-848. Date of Electronic Publication: 2025 Jun 27.

Publikationsart: Journal Article; Clinical Trial, Phase I; Randomized Controlled Trial; Multicenter Study

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE

MeSH-Schlagworte: 17-Hydroxysteroid Dehydrogenases*/genetics , 17-Hydroxysteroid Dehydrogenases*/antagonists & inhibitors , 17-Hydroxysteroid Dehydrogenases*/metabolism , RNA, Small Interfering*/administration & dosage , RNA, Small Interfering*/pharmacokinetics , Fatty Liver*/drug therapy , Fatty Liver*/therapy , Fatty Liver*/genetics , RNA Interference* , Acetylgalactosamine*/analogs & derivatives , Acetylgalactosamine*/administration & dosage , Acetylgalactosamine*/pharmacokinetics , RNAi Therapeutics*/methods, Humans ; Male ; Female ; Double-Blind Method ; Middle Aged ; Adult ; Aged ; Liver/pathology

Multigene RNAi Technology to Treat Cancer: Harnessing Synergistic Gene Regulation to Combat Evolving Cancer.

Autoren: Vaishnavi S Bhatt CS Ellipilli S

Quelle: Molecular pharmaceutics [Mol Pharm] 2025 Nov 03; Vol. 22 (11), pp. 6472-6498. Date of Electronic Publication: 2025 Oct 23.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE

MeSH-Schlagworte: Neoplasms*/genetics , Neoplasms*/therapy , RNA Interference* , RNAi Therapeutics*/methods, Humans ; RNA, Small Interfering/genetics ; RNA, Small Interfering/therapeutic use ; Animals ; MicroRNAs/genetics ; Gene Expression Regulation, Neoplastic ; Genetic Therapy/methods

A review of host and pathogen gene targets for RNAi therapeutics in shrimp disease mitigation.

Autoren: Tare MVR Almazan DJDN Saquilayan KMDL et al.

Quelle: Developmental and comparative immunology [Dev Comp Immunol] 2025 Nov; Vol. 172, pp. 105482. Date of Electronic Publication: 2025 Sep 30.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7708205 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0089 (Electronic) Linking ISSN: 0145305X NLM ISO Abbreviation: Dev Comp Immunol Subsets: MEDLINE

MeSH-Schlagworte: Penaeidae*/immunology , Penaeidae*/genetics , RNA Interference* , RNAi Therapeutics*/methods, Animals ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Aquaculture/methods ; Immunity, Innate/genetics ; RNA, Small Interfering/genetics

Lumasiran at birth changes the trajectory of primary hyperoxaluria type 1: same disease, different outcomes in two affected siblings.

Autoren: Peruzzi L Leporati M

Körperschaften: Peruzzi L Leporati M

Quelle: Journal of nephrology [J Nephrol] 2025 Nov; Vol. 38 (8), pp. 2417-2422. Date of Electronic Publication: 2025 Jul 09.

Publikationsart: Journal Article; Case Reports

Info zur Zeitschrift: Publisher: Springer Country of Publication: Italy NLM ID: 9012268 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1724-6059 (Electronic) Linking ISSN: 11218428 NLM ISO Abbreviation: J Nephrol Subsets: MEDLINE

MeSH-Schlagworte: Hyperoxaluria, Primary*/therapy , Hyperoxaluria, Primary*/diagnosis , Hyperoxaluria, Primary*/genetics , Hyperoxaluria, Primary*/drug therapy , RNAi Therapeutics*, Humans ; Male ; Infant, Newborn ; Oxalates/urine ; Oxalates/blood ; Treatment Outcome ; Siblings ; Disease Progression ; Pyridoxine/therapeutic use ; Pyridoxine/administration & dosage ; Glycolates/metabolism

SCR Disease Name: Primary hyperoxaluria type 1

RNA interference-based therapeutics against aquatic viral diseases: Recent advances in fish and crustaceans (2010-2025).

Autoren: Zhong C Jin N Liu M et al.

Quelle: Fish & shellfish immunology [Fish Shellfish Immunol] 2026 Jan; Vol. 168, pp. 110913. Date of Electronic Publication: 2025 Oct 07.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: England NLM ID: 9505220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9947 (Electronic) Linking ISSN: 10504648 NLM ISO Abbreviation: Fish Shellfish Immunol Subsets: MEDLINE

MeSH-Schlagworte: Fish Diseases*/therapy , Fish Diseases*/virology , Fish Diseases*/immunology , RNA Interference* , Virus Diseases*/veterinary , Virus Diseases*/therapy , Crustacea*/virology , RNAi Therapeutics*/veterinary, Animals ; Fishes ; Aquaculture

RNAi therapeutics targeting Japanese encephalitis virus: Gene targets, delivery platforms, and translational barriers.

Autoren: Kumar M Gupta P Kumar S et al.

Quelle: Virology [Virology] 2026 Jan; Vol. 613, pp. 110713. Date of Electronic Publication: 2025 Oct 10.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Academic Press Country of Publication: United States NLM ID: 0110674 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0341 (Electronic) Linking ISSN: 00426822 NLM ISO Abbreviation: Virology Subsets: MEDLINE

MeSH-Schlagworte: Encephalitis Virus, Japanese*/genetics , Encephalitis Virus, Japanese*/physiology , Encephalitis Virus, Japanese*/drug effects , Encephalitis, Japanese*/therapy , Encephalitis, Japanese*/virology , RNAi Therapeutics*/methods , RNA Interference*, Humans ; Animals ; Virus Replication

Development of a Modular Ribonucleoprotein Complex as a General Strategy to Deliver RNAi Therapeutics.

Autoren: Tam NY Wang X Chan GCY et al.

Quelle: Advanced healthcare materials [Adv Healthc Mater] 2025 Sep; Vol. 14 (25), pp. e03281. Date of Electronic Publication: 2025 Jul 23.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101581613 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-2659 (Electronic) Linking ISSN: 21922640 NLM ISO Abbreviation: Adv Healthc Mater Subsets: MEDLINE

MeSH-Schlagworte: RNA, Small Interfering*/genetics , RNA, Small Interfering*/metabolism , RNA, Small Interfering*/chemistry , RNAi Therapeutics*/methods , Ribonucleoproteins*/chemistry , Ribonucleoproteins, Small Nuclear*/chemistry , Ribonucleoproteins, Small Nuclear*/metabolism, Humans ; Animals ; Cell Line, Tumor ; RNA Interference ; Mice ; Proto-Oncogene Proteins p21(ras)/genetics ; Proto-Oncogene Proteins p21(ras)/metabolism

Molecular dynamics simulations based siRNA design against GPR10 reveals stable RNAi therapeutics for hormone-dependent uterine fibroids.

Autoren: Sriram S Palanichamy C Subash PT et al.

Quelle: Scientific reports [Sci Rep] 2025 Aug 28; Vol. 15 (1), pp. 31708. Date of Electronic Publication: 2025 Aug 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Receptors, G-Protein-Coupled*/genetics , Receptors, G-Protein-Coupled*/metabolism , Receptors, G-Protein-Coupled*/antagonists & inhibitors , Receptors, G-Protein-Coupled*/chemistry , Molecular Dynamics Simulation* , Leiomyoma*/genetics , Leiomyoma*/therapy , Leiomyoma*/metabolism , Leiomyoma*/pathology , RNA, Small Interfering*/genetics , RNA, Small Interfering*/chemistry , RNAi Therapeutics*/methods , Uterine Neoplasms*/genetics , Uterine Neoplasms*/therapy, Humans ; Female ; RNA Interference ; Molecular Docking Simulation

Efficacy and safety of RNA interference therapeutics in transthyretin cardiac amyloidosis: A systematic review and meta-analysis.

Autoren: Tabassum S Naeem F Rakab MS et al.

Quelle: European journal of clinical investigation [Eur J Clin Invest] 2025 Jul; Vol. 55 (7), pp. e70049. Date of Electronic Publication: 2025 Apr 17.

Publikationsart: Systematic Review; Journal Article; Meta-Analysis

Info zur Zeitschrift: Publisher: Wiley Country of Publication: England NLM ID: 0245331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2362 (Electronic) Linking ISSN: 00142972 NLM ISO Abbreviation: Eur J Clin Invest Subsets: MEDLINE

MeSH-Schlagworte: Amyloid Neuropathies, Familial*/therapy , RNAi Therapeutics*/methods , Cardiomyopathies*/therapy, Humans ; Quality of Life ; Natriuretic Peptide, Brain/metabolism ; Treatment Outcome

SCR Disease Name: Amyloidosis, Hereditary, Transthyretin-Related

An RNAi Therapy That Attenuates Multi-Organ Viremia and Improves Animal Survival in a Lethal EMCV Challenge Model.

Autoren: Zhang Y Yue J Wu B et al.

Quelle: Viruses [Viruses] 2025 Sep 14; Vol. 17 (9). Date of Electronic Publication: 2025 Sep 14.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

MeSH-Schlagworte: RNA, Small Interfering*/genetics , RNA, Small Interfering*/administration & dosage , Viremia*/therapy , Viremia*/virology , Encephalomyocarditis virus*/genetics , Encephalomyocarditis virus*/physiology , Encephalomyocarditis virus*/drug effects , Cardiovirus Infections*/therapy , Cardiovirus Infections*/virology , RNAi Therapeutics*/methods, Animals ; Disease Models, Animal ; Mice ; Virus Replication/drug effects ; Liposomes ; Swine ; Antiviral Agents/administration & dosage ; RNA Interference

siRNA Therapeutics for the Treatment of Hereditary Diseases and Other Conditions: A Review.

Autoren: Shevelev A Pozdniakova N Generalov E et al.

Quelle: International journal of molecular sciences [Int J Mol Sci] 2025 Sep 05; Vol. 26 (17). Date of Electronic Publication: 2025 Sep 05.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

MeSH-Schlagworte: RNA, Small Interfering*/therapeutic use , RNA, Small Interfering*/genetics , Genetic Diseases, Inborn*/therapy , Genetic Diseases, Inborn*/genetics , RNAi Therapeutics*/methods , Amyloid Neuropathies, Familial*/genetics , Amyloid Neuropathies, Familial*/therapy, Humans ; Animals ; Nanoparticles/chemistry ; RNA Interference ; Genetic Therapy/methods

Effect of inclisiran on lipid and mechanical vascular profiles in familial hypercholesterolemia subjects: results from a single lipid center real-world experience.

Autoren: Bosco G Di Giacomo Barbagallo F Di Marco M et al.

Quelle: Progress in cardiovascular diseases [Prog Cardiovasc Dis] 2025 Sep-Oct; Vol. 92, pp. 108-117. Date of Electronic Publication: 2025 May 26.

Publikationsart: Journal Article; Observational Study

Info zur Zeitschrift: Publisher: W.B. Saunders Co. [etc.] Country of Publication: United States NLM ID: 0376442 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1740 (Electronic) Linking ISSN: 00330620 NLM ISO Abbreviation: Prog Cardiovasc Dis Subsets: MEDLINE

MeSH-Schlagworte: Hyperlipoproteinemia Type II*/blood , Hyperlipoproteinemia Type II*/diagnosis , Hyperlipoproteinemia Type II*/genetics , Hyperlipoproteinemia Type II*/therapy , Hyperlipoproteinemia Type II*/drug therapy , Hyperlipoproteinemia Type II*/physiopathology , Cholesterol, LDL*/blood , Vascular Stiffness*/drug effects , RNAi Therapeutics*/adverse effects , PCSK9 Inhibitors*, Humans ; Male ; Female ; Middle Aged ; Prospective Studies ; Adult ; Treatment Outcome ; Biomarkers/blood ; Time Factors ; Pulse Wave Analysis ; Proprotein Convertase 9/genetics ; Proprotein Convertase 9/metabolism ; Anticholesteremic Agents/therapeutic use ; Anticholesteremic Agents/adverse effects ; RNA, Small Interfering

EFTX-G12V: a novel KRAS ^G12V -selective RNAi therapeutic.

Autoren: Papavassiliou KA Vassiliou AG Papavassiliou AG

Quelle: Trends in pharmacological sciences [Trends Pharmacol Sci] 2025 Sep; Vol. 46 (9), pp. 820-822. Date of Electronic Publication: 2025 Jul 25.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Published By Elsevier In Association With The International Union Of Pharmacology Country of Publication: England NLM ID: 7906158 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3735 (Electronic) Linking ISSN: 01656147 NLM ISO Abbreviation: Trends Pharmacol Sci Subsets: MEDLINE

MeSH-Schlagworte: Proto-Oncogene Proteins p21(ras)*/genetics , RNA, Small Interfering*/genetics , RNA, Small Interfering*/administration & dosage , Neoplasms*/genetics , Neoplasms*/therapy , RNAi Therapeutics*/methods, Humans ; Animals ; RNA Interference ; Mutation

Advances in Lipid-Based Nanomedicine: Pathway Specific siRNA Therapy and Optimizing Delivery for Hepatocellular Carcinoma.

Autoren: Thalij KM You HW Aher KB et al.

Quelle: International journal of nanomedicine [Int J Nanomedicine] 2025 Aug 30; Vol. 20, pp. 10541-10566. Date of Electronic Publication: 2025 Aug 30 (Print Publication: 2025).

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: DOVE Medical Press Country of Publication: New Zealand NLM ID: 101263847 Publication Model: eCollection Cited Medium: Internet ISSN: 1178-2013 (Electronic) Linking ISSN: 11769114 NLM ISO Abbreviation: Int J Nanomedicine Subsets: MEDLINE

MeSH-Schlagworte: Carcinoma, Hepatocellular*/epidemiology , Carcinoma, Hepatocellular*/genetics , Carcinoma, Hepatocellular*/therapy , Liver Neoplasms*/epidemiology , Liver Neoplasms*/genetics , Liver Neoplasms*/therapy , RNA, Small Interfering*/administration & dosage , RNA, Small Interfering*/genetics , Nanoparticle Drug Delivery System*/adverse effects , Nanoparticle Drug Delivery System*/pharmacokinetics , Nanoparticle Drug Delivery System*/therapeutic use , RNAi Therapeutics*/methods, Risk Factors ; Carcinogenesis/genetics ; Liposomes ; Biological Availability ; Tissue Distribution ; Precision Medicine/methods ; Humans ; Animals ; Treatment Outcome ; Cell Survival/genetics ; Signal Transduction/genetics ; Cell Proliferation/genetics ; Xenograft Model Antitumor Assays

Impact of Vutrisiran on Cardiac Biomarkers in Patients With Transthyretin Amyloidosis With Cardiomyopathy From HELIOS-B.

Autoren: Maurer MS Berk JL Damy T et al.

Quelle: Journal of the American College of Cardiology [J Am Coll Cardiol] 2025 Aug 12; Vol. 86 (6), pp. 459-475.

Publikationsart: Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial

Info zur Zeitschrift: Publisher: Elsevier Biomedical Country of Publication: United States NLM ID: 8301365 Publication Model: Print Cited Medium: Internet ISSN: 1558-3597 (Electronic) Linking ISSN: 07351097 NLM ISO Abbreviation: J Am Coll Cardiol Subsets: MEDLINE

MeSH-Schlagworte: Amyloid Neuropathies, Familial*/blood , Amyloid Neuropathies, Familial*/drug therapy , Amyloid Neuropathies, Familial*/mortality , Amyloid Neuropathies, Familial*/complications , Cardiomyopathies*/blood , Cardiomyopathies*/drug therapy , Cardiomyopathies*/mortality , Cardiomyopathies*/etiology , Natriuretic Peptide, Brain*/blood , Peptide Fragments*/blood , RNAi Therapeutics*/methods , Troponin I*/blood, Aged ; Female ; Humans ; Male ; Middle Aged ; Biomarkers/blood ; Double-Blind Method ; Prealbumin ; Prognosis ; Troponin T/blood

SCR Disease Name: Amyloidosis, Hereditary, Transthyretin-Related

RNA Therapies in Cardio-Kidney-Metabolic Syndrome: Advancing Disease Management.

Autoren: Mohammadi A Karimian A Shokri K et al.

Quelle: Journal of cardiovascular translational research [J Cardiovasc Transl Res] 2025 Aug; Vol. 18 (4), pp. 703-722. Date of Electronic Publication: 2025 Mar 13.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Springer Country of Publication: United States NLM ID: 101468585 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-5395 (Electronic) Linking ISSN: 19375387 NLM ISO Abbreviation: J Cardiovasc Transl Res Subsets: MEDLINE

MeSH-Schlagworte: Cardio-Renal Syndrome*/therapy , Cardio-Renal Syndrome*/genetics , Cardio-Renal Syndrome*/physiopathology , Cardio-Renal Syndrome*/metabolism , Cardio-Renal Syndrome*/diagnosis , Metabolic Syndrome*/therapy , Metabolic Syndrome*/genetics , Metabolic Syndrome*/physiopathology , Metabolic Syndrome*/diagnosis , RNAi Therapeutics*/adverse effects , RNA, Small Interfering*/therapeutic use , RNA, Small Interfering*/adverse effects , Genetic Therapy*/methods , Genetic Therapy*/adverse effects , Oligonucleotides, Antisense*/therapeutic use , Oligonucleotides, Antisense*/adverse effects, Humans ; Animals ; Treatment Outcome

RNA interference versus antibody-based PCSK9 inhibition for the prevention of cardiovascular disease: a drug-target Mendelian randomization study.

Autoren: Gagnon E Gill D Bourgault J et al.

Quelle: Cardiovascular research [Cardiovasc Res] 2025 Jul 08; Vol. 121 (7), pp. 1066-1075.

Publikationsart: Journal Article; Comparative Study

Info zur Zeitschrift: Publisher: Oxford Journals Country of Publication: England NLM ID: 0077427 Publication Model: Print Cited Medium: Internet ISSN: 1755-3245 (Electronic) Linking ISSN: 00086363 NLM ISO Abbreviation: Cardiovasc Res Subsets: MEDLINE

MeSH-Schlagworte: Proprotein Convertase 9*/genetics , Proprotein Convertase 9*/metabolism , Proprotein Convertase 9*/immunology , PCSK9 Inhibitors* , Cardiovascular Diseases*/prevention & control , Cardiovascular Diseases*/genetics , Cardiovascular Diseases*/enzymology , Serine Proteinase Inhibitors*/adverse effects , Serine Proteinase Inhibitors*/therapeutic use , RNAi Therapeutics* , RNA Interference* , Dyslipidemias*/genetics , Dyslipidemias*/enzymology , Dyslipidemias*/blood , Dyslipidemias*/diagnosis, Humans ; Mendelian Randomization Analysis ; Cholesterol, LDL/blood ; Liver/enzymology ; Liver/drug effects ; Phenotype ; Biomarkers/blood ; Treatment Outcome ; Genetic Predisposition to Disease ; Apolipoprotein B-100/blood ; Male ; Risk Assessment ; Female

RNA-targeting therapies for amyloid transthyretin cardiomyopathy: A systematic review and meta-analysis.

Autoren: Ramos JVO Fernandes JVA Formiga YGA et al.

Quelle: Current problems in cardiology [Curr Probl Cardiol] 2025 Jul; Vol. 50 (7), pp. 103057. Date of Electronic Publication: 2025 Apr 15.

Publikationsart: Journal Article; Systematic Review; Meta-Analysis

Info zur Zeitschrift: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7701802 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-6280 (Electronic) Linking ISSN: 01462806 NLM ISO Abbreviation: Curr Probl Cardiol Subsets: MEDLINE

MeSH-Schlagworte: Amyloid Neuropathies, Familial*/therapy , Amyloid Neuropathies, Familial*/genetics , Amyloid Neuropathies, Familial*/metabolism , Amyloid Neuropathies, Familial*/complications , Prealbumin*/genetics , Prealbumin*/metabolism , RNAi Therapeutics*/methods , Cardiomyopathies*/therapy , Cardiomyopathies*/genetics , RNA Interference*, Humans

SCR Disease Name: Amyloidosis, Hereditary, Transthyretin-Related

Harnessing antiviral RNAi therapeutics for pandemic viruses: SARS-CoV-2 and HIV.

Autoren: Bowden-Reid E Moles E Kelleher A et al.

Quelle: Drug delivery and translational research [Drug Deliv Transl Res] 2025 Jul; Vol. 15 (7), pp. 2301-2322. Date of Electronic Publication: 2025 Jan 20.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Springer Country of Publication: United States NLM ID: 101540061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2190-3948 (Electronic) Linking ISSN: 2190393X NLM ISO Abbreviation: Drug Deliv Transl Res Subsets: MEDLINE

MeSH-Schlagworte: SARS-CoV-2*/genetics , SARS-CoV-2*/drug effects , HIV Infections*/therapy , HIV Infections*/drug therapy , HIV Infections*/genetics , COVID-19*/therapy , RNA, Small Interfering*/administration & dosage , RNAi Therapeutics*/methods , Antiviral Agents*/administration & dosage , COVID-19 Drug Treatment* , HIV*/genetics , HIV*/drug effects, Humans ; Nanoparticles/chemistry ; Animals ; RNA Interference