Suchergebnisse - "TYMS"

Pleckstrin-2 promotes the progression of colorectal cancer via YTHDF2-mediated TYMS mRNA stability

Autoren: Qian Zhou Yanxia Li Xiaomei Li et al.

Quelle: Cellular and Molecular Life Sciences, Vol 82, Iss 1, Pp 1-15 (2025)

Schlagwörter: Pleckstrin-2, YTHDF2, TYMS, Colorectal cancer, M6A modification, Biology (General), QH301-705.5, Microbiology, QR1-502

Dateibeschreibung: electronic resource

Relation: https://doaj.org/toc/1420-9071

Zugangs-URL: https://doaj.org/article/aee50e0f82294fb1b376d3168698ac07

Computational Analysis of Azadirachta indica plant extracts Targeting Thymidylate Synthetase against Colon cancer

Autoren: Mishra, Sushree Sangita Sahu, Sibani Mishra, Biswajit et al.

Quelle: Research Journal of Pharmacy and Technology 18(4):1640-1648. 2025

Revealing the significance of tissue-resident memory T cells in lung adenocarcinoma through bioinformatic analysis and experimental validation

Autoren: Zhuoqi Li Mei Tian Yuanhui Yang et al.

Quelle: Front Immunol
Frontiers in Immunology, Vol 16 (2025)

Schlagwörter: LUAD, TRM cells, Immunology, immunotherapeutic outcomes, prognostic signature, Immunologic diseases. Allergy, RC581-607, TYMS

Zugangs-URL: https://doaj.org/article/f4863d64dfbd445b8e037e2d3dc40c27

The prognostic value of Ki67 (A), MCM4 (B), and TYMS (C) gene expression levels in the IHC validation cohort.

Autoren: Annette Salomonsson Daniel Ehinger Mats Jönsson et al.

Schlagwörter: Medicine, Cell Biology, Genetics, Biotechnology, Immunology, Developmental Biology, Cancer, Science Policy, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, technique universally applicable, guide treatment choices, independent prognostic ability, concept study demonstrates, six data sets, selected markers could, potential prognostic markers, prognostic potential, data sets, prognostic markers, two independent, six microarray, tyms <, subsequent evaluation, patient surveillance, overall survival, mcm4 <, lung cancer

Relation: https://figshare.com/articles/journal_contribution/The_prognostic_value_of_Ki67_A_MCM4_B_and_TYMS_C_gene_expression_levels_in_the_IHC_validation_cohort_/28948416

Verfügbarkeit: https://doi.org/10.1371/journal.pone.0310232.s010
https://figshare.com/articles/journal_contribution/The_prognostic_value_of_Ki67_A_MCM4_B_and_TYMS_C_gene_expression_levels_in_the_IHC_validation_cohort_/28948416

Prognostic value of Ki67 (A), MCM4 (B), TYMS (C), and combined score (D), on recurrence-free interval (RFI) in the IHC validation cohort.

Autoren: Annette Salomonsson Daniel Ehinger Mats Jönsson et al.

Schlagwörter: Medicine, Cell Biology, Genetics, Biotechnology, Immunology, Developmental Biology, Cancer, Science Policy, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, technique universally applicable, guide treatment choices, independent prognostic ability, concept study demonstrates, six data sets, selected markers could, potential prognostic markers, prognostic potential, data sets, prognostic markers, two independent, six microarray, tyms <, subsequent evaluation, patient surveillance, overall survival, mcm4 <, lung cancer

Verfügbarkeit: https://doi.org/10.1371/journal.pone.0310232.s007
https://figshare.com/articles/journal_contribution/Prognostic_value_of_Ki67_A_MCM4_B_TYMS_C_and_combined_score_D_on_recurrence-free_interval_RFI_in_the_IHC_validation_cohort_/28948407

The association between gene expression levels (y-axis, logFPKM) and immunohistochemical classification (x-axis, low or high expression) for the three markers in the IHC validation cohort.

Autoren: Annette Salomonsson Daniel Ehinger Mats Jönsson et al.

Schlagwörter: Medicine, Cell Biology, Genetics, Biotechnology, Immunology, Developmental Biology, Cancer, Science Policy, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, technique universally applicable, guide treatment choices, independent prognostic ability, concept study demonstrates, six data sets, selected markers could, potential prognostic markers, prognostic potential, data sets, prognostic markers, two independent, six microarray, tyms <, subsequent evaluation, patient surveillance, overall survival, mcm4 <, lung cancer

Verfügbarkeit: https://doi.org/10.1371/journal.pone.0310232.s009
https://figshare.com/articles/journal_contribution/The_association_between_gene_expression_levels_y-axis_logFPKM_and_immunohistochemical_classification_x-axis_low_or_high_expression_for_the_three_markers_in_the_IHC_validation_cohort_/28948413

Prognostic value of Ki67 (A), MCM4 (B), TYMS (C), and combined score (D), on recurrence-free interval (RFI) in the IHC discovery cohort.

Autoren: Annette Salomonsson Daniel Ehinger Mats Jönsson et al.

Schlagwörter: Medicine, Cell Biology, Genetics, Biotechnology, Immunology, Developmental Biology, Cancer, Science Policy, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, technique universally applicable, guide treatment choices, independent prognostic ability, concept study demonstrates, six data sets, selected markers could, potential prognostic markers, prognostic potential, data sets, prognostic markers, two independent, six microarray, tyms <, subsequent evaluation, patient surveillance, overall survival, mcm4 <, lung cancer

Verfügbarkeit: https://doi.org/10.1371/journal.pone.0310232.s006
https://figshare.com/articles/journal_contribution/Prognostic_value_of_Ki67_A_MCM4_B_TYMS_C_and_combined_score_D_on_recurrence-free_interval_RFI_in_the_IHC_discovery_cohort_/28948404

Multivariate Cox regression analysis for 5-year overall survival for Ki67, MCM4, and TYMS protein expression in the IHC validation cohort.

Autoren: Annette Salomonsson Daniel Ehinger Mats Jönsson et al.

Schlagwörter: Medicine, Cell Biology, Genetics, Biotechnology, Immunology, Developmental Biology, Cancer, Science Policy, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, technique universally applicable, guide treatment choices, independent prognostic ability, concept study demonstrates, six data sets, selected markers could, potential prognostic markers, prognostic potential, data sets, prognostic markers, two independent, six microarray, tyms <, subsequent evaluation, patient surveillance, overall survival, mcm4 <, lung cancer

Verfügbarkeit: https://doi.org/10.1371/journal.pone.0310232.s002
https://figshare.com/articles/journal_contribution/Multivariate_Cox_regression_analysis_for_5-year_overall_survival_for_Ki67_MCM4_and_TYMS_protein_expression_in_the_IHC_validation_cohort_/28948392

Prognostic value of Ki67 (A), TYMS (B), GDF10 (C), and CIRBP (D) gene expression levels in one of the validation data set (Tang et al. [14]).

Autoren: Annette Salomonsson Daniel Ehinger Mats Jönsson et al.

Schlagwörter: Medicine, Cell Biology, Genetics, Biotechnology, Immunology, Developmental Biology, Cancer, Science Policy, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, technique universally applicable, guide treatment choices, independent prognostic ability, concept study demonstrates, six data sets, selected markers could, potential prognostic markers, prognostic potential, data sets, prognostic markers, two independent, six microarray, tyms <, subsequent evaluation, patient surveillance, overall survival, mcm4 <, lung cancer

Relation: https://figshare.com/articles/journal_contribution/Prognostic_value_of_i_Ki67_i_A_i_TYMS_i_B_i_GDF10_i_C_and_i_CIRBP_i_D_gene_expression_levels_in_one_of_the_validation_data_set_Tang_et_al_14_/28948395

Verfügbarkeit: https://doi.org/10.1371/journal.pone.0310232.s003
https://figshare.com/articles/journal_contribution/Prognostic_value_of_i_Ki67_i_A_i_TYMS_i_B_i_GDF10_i_C_and_i_CIRBP_i_D_gene_expression_levels_in_one_of_the_validation_data_set_Tang_et_al_14_/28948395

The overlap between cases that were positive for the three markers in the IHC discovery cohort (A) and the IHC validation cohort (B).

Autoren: Annette Salomonsson Daniel Ehinger Mats Jönsson et al.

Schlagwörter: Medicine, Cell Biology, Genetics, Biotechnology, Immunology, Developmental Biology, Cancer, Science Policy, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, technique universally applicable, guide treatment choices, independent prognostic ability, concept study demonstrates, six data sets, selected markers could, potential prognostic markers, prognostic potential, data sets, prognostic markers, two independent, six microarray, tyms <, subsequent evaluation, patient surveillance, overall survival, mcm4 <, lung cancer

Relation: https://figshare.com/articles/journal_contribution/The_overlap_between_cases_that_were_positive_for_the_three_markers_in_the_IHC_discovery_cohort_A_and_the_IHC_validation_cohort_B_/28948410

Verfügbarkeit: https://doi.org/10.1371/journal.pone.0310232.s008
https://figshare.com/articles/journal_contribution/The_overlap_between_cases_that_were_positive_for_the_three_markers_in_the_IHC_discovery_cohort_A_and_the_IHC_validation_cohort_B_/28948410

The overlap between cases with high gene expression levels (cut-off based on the median gene expression values for each gene) of Ki67 , TYMS , and MCM4 in the two validation data sets.

Autoren: Annette Salomonsson Daniel Ehinger Mats Jönsson et al.

Schlagwörter: Medicine, Cell Biology, Genetics, Biotechnology, Immunology, Developmental Biology, Cancer, Science Policy, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, technique universally applicable, guide treatment choices, independent prognostic ability, concept study demonstrates, six data sets, selected markers could, potential prognostic markers, prognostic potential, data sets, prognostic markers, two independent, six microarray, tyms <, subsequent evaluation, patient surveillance, overall survival, mcm4 <, lung cancer

Verfügbarkeit: https://doi.org/10.1371/journal.pone.0310232.s004
https://figshare.com/articles/journal_contribution/The_overlap_between_cases_with_high_gene_expression_levels_cut-off_based_on_the_median_gene_expression_values_for_each_gene_of_i_Ki67_i_i_TYMS_i_and_i_MCM4_i_in_the_two_validation_data_sets_/28948398

Representative microscopic images of the stainings.

Autoren: Annette Salomonsson Daniel Ehinger Mats Jönsson et al.

Schlagwörter: Medicine, Cell Biology, Genetics, Biotechnology, Immunology, Developmental Biology, Cancer, Science Policy, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, technique universally applicable, guide treatment choices, independent prognostic ability, concept study demonstrates, six data sets, selected markers could, potential prognostic markers, prognostic potential, data sets, prognostic markers, two independent, six microarray, tyms <, subsequent evaluation, patient surveillance, overall survival, mcm4 <, lung cancer

Relation: https://figshare.com/articles/journal_contribution/Representative_microscopic_images_of_the_stainings_/28948401

Verfügbarkeit: https://doi.org/10.1371/journal.pone.0310232.s005
https://figshare.com/articles/journal_contribution/Representative_microscopic_images_of_the_stainings_/28948401

Immunohistochemical stainings for Ki67, MCM4 and TYMS.

Autoren: Annette Salomonsson Daniel Ehinger Mats Jönsson et al.

Schlagwörter: Medicine, Cell Biology, Genetics, Biotechnology, Immunology, Developmental Biology, Cancer, Science Policy, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, technique universally applicable, guide treatment choices, independent prognostic ability, concept study demonstrates, six data sets, selected markers could, potential prognostic markers, prognostic potential, data sets, prognostic markers, two independent, six microarray, tyms <, subsequent evaluation, patient surveillance, overall survival, mcm4 <, lung cancer

Relation: https://figshare.com/articles/journal_contribution/Immunohistochemical_stainings_for_Ki67_MCM4_and_TYMS_/28947768

Verfügbarkeit: https://doi.org/10.1371/journal.pone.0310232.s001
https://figshare.com/articles/journal_contribution/Immunohistochemical_stainings_for_Ki67_MCM4_and_TYMS_/28947768

The genetic basis of variation in response to chemotherapy and cancer chemoprevention drugs in Saccharomyces cerevisiae

Autoren: Almayouf, Salwa

Schlagwörter: cancer, chemotherapy, cancer prevention, Anti-cancer agents, Saccharomyces cerevisiae, drug response, drug treatments, yeast, genetics, QTG, Phenotypic variation, human complex traits, drug resistance, yeast genetics, genetic determinants, mTOR, TYMS, Genetic variants, 5-fluorouracil, chemotherapy drugs, human studies, quantitative trait loci mapping, QTL, aspirin, metformin, Pathway enrichment analyses, genetic disease, cancer chemoprevention agents, Thesis

Zugangs-URL: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.850055

Exploring the impact of MiR-92a-3p on FOLFOX chemoresistance biomarker genes in colon cancer cell lines

Autoren: Paula I. Escalante Luis A. Quiñones Héctor R. Contreras

Quelle: Front Pharmacol
Frontiers in Pharmacology, Vol 15 (2024)

Schlagwörter: Pharmacology, 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, DPYD, XRCC1, MTHFR, Therapeutics. Pharmacology, RM1-950, ERCC2, TYMS, miR-92a-3p, 3. Good health

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38659583
https://doaj.org/article/a31bbc1af431457ba87c309b6ee6d65b

Germline thymidylate synthase deficiency impacts nucleotide metabolism and causes dyskeratosis congenita

Autoren: Hemanth Tummala Amanda Walne Roberto Buccafusca et al.

Quelle: Am J Hum Genet

Schlagwörter: 0301 basic medicine, Heterozygote, ENOSF1, dyskeratosis congenita, nucleotide metabolism, TYMS, Article, Dyskeratosis Congenita, Signalling & Oncogenes, 03 medical and health sciences, Medicine and Health Sciences, Humans, 0303 health sciences, JGM, gene epistasis, Nucleotides, Life Sciences, Correction, Thymidylate Synthase, Tumour Biology, 3. Good health, Germ Cells, Genetics & Genomics, Developmental Biology

Dateibeschreibung: 1494 - ?; application/pdf

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/35931051
https://discovery-pp.ucl.ac.uk/id/eprint/10153551/

Investigation of DPYD , MTHFR and TYMS Polymorphisms on 5-Fluorouracil Related Toxicities in Colorectal Cancer

Autoren: Mehtap Cevik Esat Namal Nur Dinc Sener et al.

Weitere Verfasser: Mehtap Cevik Esat Namal Nur Dinc Sener et al.

Quelle: Personalized Medicine. 19:435-444

Schlagwörter: 0301 basic medicine, Efficacy, Genotype, colorectal cancer, fluoropyrimidines, Dpyd-Asterisk-2a, TYMS, 03 medical and health sciences, DPYD, 0302 clinical medicine, Methylenetetrahydrofolate Reductase, Humans, Pharmacokinetics, Predict, Capecitabine, Dihydrouracil Dehydrogenase (NADP), Methylenetetrahydrofolate Reductase (NADPH2), pharmacogenetics, 0303 health sciences, Polymorphism, Genetic, Variants, Thymidylate Synthase, Dihydropyrimidine Dehydrogenase Gene, 3. Good health, Metabolism, MTHFR, Thymidylate-Synthase, adverse effects, Fluorouracil, polymorphisms, Colorectal Neoplasms

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/35880438
https://hdl.handle.net/20.500.12831/8496
https://doi.org/10.2217/pme-2021-0047

Significance of microRNA-330-5p/TYMS Expression Axis in the Pathogenesis of Colorectal Tumorigenesis

Autoren: Leila Karimi Milad Jaberi Milad Asadi et al.

Quelle: Journal of Gastrointestinal Cancer. 53:965-970

Schlagwörter: Carcinogenesis, microRNA 330 5p, cell transformation, 0302 clinical medicine, middle aged, genetics, RNA transcription, microRNA, lymph node metastasis, alternative medicine, adult, MicroRNA, gene expression regulation, Prognosis, cohort analysis, unclassified drug, 3. Good health, Gene Expression Regulation, Neoplastic, female, Cell Transformation, Neoplastic, real time polymerase chain reaction, cancer therapy, diagnostic value, protein RNA binding, Colorectal Neoplasms, carcinogenesis, down regulation, cancer tissue, TYMS protein, human, colorectal cancer, thymidylate synthase, TYMS, Article, MIRN330 microRNA, human, 03 medical and health sciences, male, Cell Line, Tumor, Humans, controlled study, diagnostic test accuracy study, human, protein expression, Cell Proliferation, cancer staging, tumor cell line, Thymidylate Synthase, Colorectal cancer, major clinical study, human tissue, miR-330-5p, MicroRNAs, cell proliferation, gene expression, pathology, computer model, metabolism, upregulation, colorectal tumor

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/34651293
https://pubmed.ncbi.nlm.nih.gov/34651293/
https://hdl.handle.net/11454/79466
https://doi.org/10.1007/s12029-021-00695-x

ARDS and aging: TYMS emerges as a promising biomarker and therapeutic target

Autoren: Gang Li Ke Yan Wanyi Zhang et al.

Quelle: Front Immunol
Frontiers in Immunology, Vol 15 (2024)

Schlagwörter: 0301 basic medicine, Aging, Respiratory Distress Syndrome, 0303 health sciences, WGCNA, immune infiltration, aging, Immunology, Endothelial Cells, Thymidylate Synthase, RC581-607, TYMS, 3. Good health, Mice, 03 medical and health sciences, machine learning, RNA, Small Nuclear, Humans, Animals, ARDS, Immunologic diseases. Allergy, Biomarkers, Aged

Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38558817
https://doaj.org/article/091ecb62e28c4074a08a566cef167b77

Идентификация лиц с мутантными вариантами генов DPYD и TYMS

Schlagwörter: генетически обусловленный дефект DPD, аналоги пиримидинов, ген TYMS, однонуклеотидные полиморфизмы, активные метаболиты, лечение онкологических заболеваний

Dateibeschreibung: application/pdf

Zugangs-URL: https://elib.belstu.by/handle/123456789/63565