Suchergebnisse - "TUMOR suppressor genes"

AKR1B1 is Required for Maintaining Acute Leukemia Cell Survival by Epigenetic Silencing of Tumor Suppressor Genes.

Autoren: Chen, Jingyu Xu, Lu Li, Wangshi et al.

Quelle: Biochemical Genetics. Dec2025, Vol. 63 Issue 6, p5273-5293. 21p.

Schlagwörter: *ACUTE leukemia, *TUMOR suppressor genes, *GENE silencing, *DRUG target, *RNA sequencing, *CARCINOGENESIS, *CELL survival, *CARBONYL reductase

Prevalence of SPOP and IDH Gene Mutations in Prostate Cancer in a Jordanian Population.

Autoren: Alorjani, Mohammed S. Al Bashir, Samir Al-Zaareer, Basmah et al.

Quelle: Biochemical Genetics. Dec2025, Vol. 63 Issue 6, p5258-5272. 15p.

Schlagwörter: *PROSTATE cancer, *TUMOR suppressor genes, *GLEASON grading system, *PROSTATE-specific antigen, *GENETIC mutation, *ISOCITRATE dehydrogenase

Genomic characterization of host gene alterations in Theileria annulata-transformed leukocytes.

Autoren: Dandasena, Debabrata Suresh, Akash Budhwar, Roli et al.

Quelle: Communications Biology. 11/20/2025, Vol. 8 Issue 1, p1-17. 17p.

Schlagwörter: *ONCOGENES, *TUMOR suppressor genes, *SOMATIC mutation, *LEUKOCYTES, *GENOMICS, *CANCER cells, *THEILERIA

SORCS2 serves as a tumor suppressor and associates with immune infiltration in ovarian cancer.

Autoren: Qiu, Yiling Chen, Zhijing Chen, Xiaoqin et al.

Quelle: Journal of Ovarian Research. 11/20/2025, Vol. 18 Issue 1, p1-14. 14p.

Schlagwörter: *OVARIAN cancer, *TUMOR suppressor genes, *PROGNOSIS, *APOPTOSIS, *TUMOR-infiltrating immune cells, *BIOMARKERS, *CELL proliferation

Nonsense-mediated mRNA decay: a key regulatory system engaged in cancer.

Autoren: Pan, Hongyu Wu, Xinyu Hu, Bingshuang et al.

Quelle: Cell Communication & Signaling. 11/11/2025, Vol. 23 Issue 1, p1-18. 18p.

Schlagwörter: *TUMORS, *TUMOR suppressor genes, *CANCER genes, *NEOPLASTIC cell transformation, *IMMUNITY, *REGULATOR genes, TUMOR genetics

Clinical and mechanistic insights into the expression of SP100 family proteins in various cancers: a systematic review.

Autoren: Azami, Mehrnoosh Sadeghi, Fatemeh Mohammadi, Nazanin et al.

Quelle: BMC Cancer. 11/4/2025, Vol. 25 Issue 1, p1-26. 26p.

Schlagwörter: *TUMOR suppressor genes, *PROGNOSIS, *DRUG target, *CARCINOGENICITY, *IMMUNE system, *TUMORS

FOXS1, frequently inactivated by promoter methylation, inhibited colorectal cancer cell growth by promoting TGFBI degradation through autophagy-lysosome pathway.

Autoren: Kuang, Yeye Yu, Yijian Wang, Chan et al.

Quelle: Journal of Advanced Research. Nov2025, Vol. 77, p623-636. 14p.

Schlagwörter: *COLORECTAL cancer, *TUMOR suppressor genes, *PROTEOLYSIS, *AUTOPHAGY, *PI3K/AKT pathway, *DNA methylation, *BIOMARKERS

SCARB1 links cholesterol metabolism-mediated ferroptosis inhibition to radioresistance in tumor cells.

Autoren: Mao, Xiaojuan Xiong, Jingwen Cai, Mengjiao et al.

Quelle: Journal of Advanced Research. Nov2025, Vol. 77, p207-219. 13p.

Schlagwörter: *CHOLESTEROL metabolism, *TUMOR suppressor genes, *CANCER treatment, *LIPID peroxidation (Biology), *CELL death, *CANCER cells, *RADIATION tolerance, *UBIQUINONES

Villin like suppresses nasopharyngeal carcinoma proliferation by downregulating MYC.

Autoren: Wen, Yueting Zhou, Ziying Zhou, Yibo et al.

Quelle: Scientific Reports. 10/28/2025, Vol. 15 Issue 1, p1-13. 13p.

Schlagwörter: *NASOPHARYNX cancer, *TUMOR suppressor genes, *PHYSIOLOGY, *INTERPHASE, *GENETIC engineering, *THERAPEUTICS, *ONCOGENES

SorCS3 suppresses adrenocortical carcinoma progression by enhancing IGF2R-mediated endocytic trafficking and signaling attenuation.

Autoren: Zhang, Yanqiu Cao, Shihui Nie, Jingqi et al.

Quelle: Journal of Translational Medicine. 10/21/2025, Vol. 23 Issue 1, p1-15. 15p.

Schlagwörter: *TUMOR suppressor genes, *INSULIN-like growth factor receptors, *ENDOSOMES, *ADRENAL tumors, *DRUG target, *OVERALL survival, *ATTENUATION (Physics), *CELL communication

Prognostic and predictive implications of tumor suppressor gene alterations in non-small cell lung cancer.

Autoren: Sposito, Marco Belluomini, Lorenzo Nocini, Riccardo et al.

Quelle: Scientific Reports. 10/6/2025, Vol. 15 Issue 1, p1-11. 11p.

Schlagwörter: *TUMOR suppressor genes, *NON-small-cell lung carcinoma, *INDIVIDUALIZED medicine, *PROGNOSIS, *NUCLEOTIDE sequencing, *TREATMENT effectiveness

LAG3 as a Tumor Suppressor and Immune Regulator in Cervical Cancer: From Functional Validation to Therapeutic Strategy.

Autoren: Yao, Shijie Chen, Siming Wan, Shimeng et al.

Quelle: Cancer Medicine. Oct2025, Vol. 14 Issue 19, p1-16. 16p.

Schlagwörter: *CERVICAL cancer, *TUMOR suppressor genes, *PYROPTOSIS, *DRUG target, *IMMUNOREGULATION, *IMMUNOTHERAPY, *PROGNOSTIC models

Blastic Plasmacytoid Dendritic Cell Neoplasm: A Case Report.

Autoren: Nayeri, Farzaneh Nematolahi, Pardis Mohamadi, Behnoosh

Quelle: Iranian Journal of Pathology. Fall2025, Vol. 20 Issue 4, p495-505. 11p.

Schlagwörter: *ACUTE myeloid leukemia, *TUMOR suppressor genes, *CD antigens, *STEM cell transplantation, *SKIN tumors, *TUMORS, BONE marrow examination

Identification of BCL2L11 as a Candidate Gene for Hereditary Predisposition to Non‐Medullary Thyroid Cancer Using Familial Whole‐Exome‐Sequencing.

Autoren: Abbasoglu, Duygu Lepage, Mathis Sonnier, Nicolas et al.

Quelle: Clinical Genetics. Sep2025, p1. 12p. 6 Illustrations.

Schlagwörter: *THYROID cancer, *TUMOR suppressor genes, *NUCLEOTIDE sequencing, *CELL communication, *HEREDITARY cancer syndromes

Elucidating PTEN conformational dynamics and phosphatase regulation via integrative modeling and mutation prediction.

Autoren: Dawson, Jennifer Erin Smith, Iris Nira Tushar, Ann Marie et al.

Quelle: Structure. Sep2025, Vol. 33 Issue 9, p1533-15154. 13622p.

Schlagwörter: *TUMOR suppressor genes, *MOLECULAR conformation, *PHOSPHOPROTEIN phosphatases, *CELL membranes, *PHOSPHATASES, *MULTISCALE modeling, *PHOSPHATIDYLINOSITOL 3-kinases

The Dual Role of RASSF4 in Tumorigenesis: Mechanisms and Epigenetic Targeting Strategies.

Autoren: Tian, Rui Wu, Yixin Yuan, Wenbin et al.

Quelle: Biology (2079-7737). Sep2025, Vol. 14 Issue 9, p1289. 26p.

Schlagwörter: *EPIGENETICS, *TUMOR suppressor genes, *TUMORS, *BIOMARKERS, *NEOPLASTIC cell transformation, *THERAPEUTICS

TFAP2E acts as a tumor suppressor by regulating cell cycle progression in oral squamous cell carcinoma cells.

Autoren: Sakai, Ryo Inagaki, Yoshinori Tsurumi, Haruno et al.

Quelle: Cancer Genetics. Sep2025, Vol. 296, p111-116. 6p.

Schlagwörter: *TUMOR suppressor genes, *CELL cycle, *DOWNREGULATION, *TRANSCRIPTION factors, *CANCER prognosis, *ORAL cancer, *CHROMOSOMES

Inherited Susceptibility to Cancer: Past, Present and Future.

Autoren: Hodgson, Shirley V. Foulkes, William D. Maher, Eamonn R et al.

Quelle: Annals of Human Genetics. Sep2025, Vol. 89 Issue 5, p354-365. 12p.

Schlagwörter: *HEREDITARY cancer syndromes, *TUMOR suppressor genes, *GENETIC risk score, *PROTO-oncogenes, *TUMOR susceptibility gene 101, *GENOMICS, *EARLY detection of cancer

Mini and enhanced CRISPR activators for cancer therapies.

Autoren: Huang, Meiyu Wang, Keshan Li, Anshu et al.

Quelle: Journal of Advanced Research. Sep2025, Vol. 75, p151-161. 11p.

Schlagwörter: *CANCER treatment, *TUMOR suppressor genes, *GENETIC transcription regulation, *GENOME editing, *CRISPRS

A distinct mechanism of epigenetic reprogramming silences PAX2 and initiates endometrial carcinogenesis.

Autoren: Sahoo, Subhransu S. Ramanand, Susmita G. Cuevas, Ileana C. et al.

Quelle: Journal of Clinical Investigation. Aug2025, Vol. 135 Issue 16, p1-17. 18p.

Schlagwörter: *TUMOR suppressor genes, *ENDOMETRIAL tumors, *ENDOMETRIAL cancer, *EPIGENETICS, *DELETION mutation