Výsledky vyhľadávania - "TRPA1 Cation Channel"

Synthesis and biological evaluation of N-O heterobicyclic ring systems derived from 1,2-dihydropyridines as novel TRPA1 activators: implication in GLP-1 release and neuroprotection.

Autori: Comparini LM Citi V Ortore G a ďalší

Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118115. Date of Electronic Publication: 2025 Aug 30.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: TRPA1 Cation Channel*/agonists , TRPA1 Cation Channel*/metabolism , Glucagon-Like Peptide 1*/metabolism , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/chemical synthesis , Neuroprotective Agents*/chemistry , Dihydropyridines*/chemistry , Dihydropyridines*/pharmacology , Dihydropyridines*/chemical synthesis, Humans ; Structure-Activity Relationship ; Molecular Structure ; Apoptosis/drug effects ; Dose-Response Relationship, Drug

PPARγ ligands activate the ion channel TRPA1.

Autori: Guenther F Kibria Mumu M Gentry C a ďalší

Zdroj: European journal of pharmacology [Eur J Pharmacol] 2025 Dec 05; Vol. 1008, pp. 178343. Date of Electronic Publication: 2025 Nov 13.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: TRPA1 Cation Channel*/metabolism , TRPA1 Cation Channel*/genetics , TRPA1 Cation Channel*/agonists , PPAR gamma*/metabolism , PPAR gamma*/agonists, Animals ; CHO Cells ; Ligands ; Cricetulus ; Mice ; Cricetinae ; Calcium/metabolism ; Male ; Ganglia, Spinal/cytology ; Ganglia, Spinal/drug effects ; Ganglia, Spinal/metabolism ; Troglitazone/pharmacology ; Humans ; Nociception/drug effects ; Molecular Docking Simulation ; Mice, Inbred C57BL ; Prostaglandin D2/pharmacology ; Prostaglandin D2/analogs & derivatives

Purine-2,6-dione-based multitarget-directed ligands inhibiting PDE/TRPA1/CHIT1 as a new approach for the treatment of COPD.

Autori: Chłoń-Rzepa G Wójcik-Pszczoła K Ślusarczyk M a ďalší

Zdroj: Bioorganic chemistry [Bioorg Chem] 2025 Dec; Vol. 167, pp. 109209. Date of Electronic Publication: 2025 Nov 05.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Pulmonary Disease, Chronic Obstructive*/drug therapy , Pulmonary Disease, Chronic Obstructive*/metabolism , TRPA1 Cation Channel*/antagonists & inhibitors , TRPA1 Cation Channel*/metabolism , Purines*/pharmacology , Purines*/chemistry , Purines*/chemical synthesis , Phosphodiesterase Inhibitors*/pharmacology , Phosphodiesterase Inhibitors*/chemistry , Phosphodiesterase Inhibitors*/chemical synthesis, Humans ; Animals ; Ligands ; Molecular Structure ; Structure-Activity Relationship ; Mice ; Dose-Response Relationship, Drug ; Phosphoric Diester Hydrolases/metabolism ; Male ; Molecular Docking Simulation ; Purinones

NCX1 interacts with TRPA1 to promote cell proliferation and tumor growth of colon cancer via disruption of calcium homeostasis.

Autori: Zhou L Zhou G Li J a ďalší

Zdroj: Journal of advanced research [J Adv Res] 2025 Dec; Vol. 78, pp. 573-587. Date of Electronic Publication: 2025 Feb 24.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Cairo University, production and hosting by Elsevier B. V Country of Publication: Egypt NLM ID: 101546952 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2090-1224 (Electronic) Linking ISSN: 20901224 NLM ISO Abbreviation: J Adv Res Subsets: MEDLINE

Výrazy zo slovníka MeSH: Sodium-Calcium Exchanger*/metabolism , Sodium-Calcium Exchanger*/genetics , Colonic Neoplasms*/metabolism , Colonic Neoplasms*/pathology , Colonic Neoplasms*/genetics , TRPA1 Cation Channel*/metabolism , TRPA1 Cation Channel*/genetics , Calcium*/metabolism, Humans ; Cell Proliferation ; Animals ; Mice ; Homeostasis ; Cell Line, Tumor ; Mice, Nude ; Calcium Signaling

Nav1.8, TRPV1 and TRPA1 as possible targets of ambroxol when used for topical treatment of neuropathic pain.

Autori: Hefner S Oprita G Pantke S a ďalší

Zdroj: The journal of pain [J Pain] 2025 Dec; Vol. 37, pp. 105563. Date of Electronic Publication: 2025 Sep 16.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Churchill Livingstone Country of Publication: United States NLM ID: 100898657 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-8447 (Electronic) Linking ISSN: 15265900 NLM ISO Abbreviation: J Pain Subsets: MEDLINE

Výrazy zo slovníka MeSH: Ambroxol*/pharmacology , Ambroxol*/administration & dosage , TRPA1 Cation Channel*/metabolism , TRPA1 Cation Channel*/drug effects , TRPA1 Cation Channel*/antagonists & inhibitors , TRPV Cation Channels*/metabolism , TRPV Cation Channels*/drug effects , TRPV Cation Channels*/antagonists & inhibitors , TRPV Cation Channels*/genetics , Neuralgia*/drug therapy , Neuralgia*/metabolism , NAV1.8 Voltage-Gated Sodium Channel*/metabolism , NAV1.8 Voltage-Gated Sodium Channel*/drug effects , NAV1.8 Voltage-Gated Sodium Channel*/genetics, Animals ; Humans ; Rats ; HEK293 Cells ; Patch-Clamp Techniques ; Administration, Topical ; Dose-Response Relationship, Drug

TRPA1 ion channel activation context-dependently regulates gene expression in normal and psoriatic human skin.

Autori: Kemény Á Horváth S Szebényi J a ďalší

Zdroj: British journal of pharmacology [Br J Pharmacol] 2025 Dec; Vol. 182 (23), pp. 5814-5825. Date of Electronic Publication: 2025 Aug 06.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: TRPA1 Cation Channel*/agonists , TRPA1 Cation Channel*/metabolism , TRPA1 Cation Channel*/antagonists & inhibitors , TRPA1 Cation Channel*/genetics , Skin*/metabolism , Skin*/drug effects , Skin*/pathology , Psoriasis*/genetics , Psoriasis*/metabolism , Psoriasis*/pathology, Humans ; Male ; Adult ; Female ; Middle Aged ; Plant Oils/pharmacology ; Gene Expression Regulation/drug effects ; Acetanilides/pharmacology ; Mustard Plant ; Purines

The ameliorative effect of inhibiting transient receptor potential ankyrin 1 on sepsis-induced kidney injury via the toll-like receptor 4/nuclear factor-kappa B pathway.

Autori: Fırat S Çakır M Aydın A a ďalší

Zdroj: European journal of pharmacology [Eur J Pharmacol] 2025 Nov 15; Vol. 1007, pp. 178285. Date of Electronic Publication: 2025 Oct 24.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Sepsis*/complications , Sepsis*/metabolism , Sepsis*/pathology , Sepsis*/drug therapy , Toll-Like Receptor 4*/metabolism , NF-kappa B*/metabolism , TRPA1 Cation Channel*/antagonists & inhibitors , TRPA1 Cation Channel*/metabolism , TRPA1 Cation Channel*/agonists , Acute Kidney Injury*/metabolism , Acute Kidney Injury*/etiology , Acute Kidney Injury*/pathology , Acute Kidney Injury*/drug therapy, Animals ; Male ; Rats ; Signal Transduction/drug effects ; Kidney/drug effects ; Kidney/pathology ; Kidney/metabolism ; Rats, Sprague-Dawley ; Apoptosis/drug effects ; Disease Models, Animal ; Cytokines/blood ; Sulfonamides

Cold temperature enhances innate eosinophilic airway inflammation via transient receptor potential ankyrin1.

Autori: Dotake Y Matsuyama T Machida K a ďalší

Zdroj: Frontiers in immunology [Front Immunol] 2025 Nov 13; Vol. 16, pp. 1655919. Date of Electronic Publication: 2025 Nov 13 (Print Publication: 2025).

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

Výrazy zo slovníka MeSH: TRPA1 Cation Channel*/genetics , TRPA1 Cation Channel*/metabolism , Cold Temperature*/adverse effects , Eosinophils*/immunology , Eosinophils*/metabolism , Immunity, Innate* , Asthma*/immunology , Asthma*/metabolism, Animals ; Mice, Knockout ; Mice ; Humans ; Papain ; Bronchoalveolar Lavage Fluid/immunology ; Cytokines/metabolism ; Mice, Inbred C57BL ; Disease Models, Animal ; Inflammation/immunology ; Isothiocyanates/pharmacology

TRPA1 inhibition reduces ocular pain and corneal neurogenic inflammation in a mouse model of dry eye disease.

Autori: Migeon T Cordovilla A Potey A a ďalší

Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2025 Nov; Vol. 192, pp. 118625. Date of Electronic Publication: 2025 Oct 07.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE

Výrazy zo slovníka MeSH: TRPA1 Cation Channel*/antagonists & inhibitors , TRPA1 Cation Channel*/metabolism , Dry Eye Syndromes*/drug therapy , Dry Eye Syndromes*/metabolism , Dry Eye Syndromes*/physiopathology , Cornea*/drug effects , Cornea*/innervation , Cornea*/metabolism , Neurogenic Inflammation*/drug therapy , Neurogenic Inflammation*/metabolism , Eye Pain*/drug therapy , Eye Pain*/metabolism , Acetanilides*/pharmacology , Purines*/pharmacology, Animals ; Disease Models, Animal ; Mice ; Mice, Inbred C57BL ; Male

Prevention of fatty acid-induced maladaptation in secretin tumor cell-1 enteroendocrine cells by allicin, a transient receptor potential ankyrin 1 agonist.

Autori: Mahajan N Lal R Kumar V a ďalší

Zdroj: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2025 Nov; Vol. 392 (11), pp. 103728. Date of Electronic Publication: 2025 Sep 29.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

Výrazy zo slovníka MeSH: TRPA1 Cation Channel*/agonists , TRPA1 Cation Channel*/metabolism , Enteroendocrine Cells*/drug effects , Enteroendocrine Cells*/metabolism , Sulfinic Acids*/pharmacology , Fatty Acids*/pharmacology , Secretin*/metabolism, Mice ; Animals ; Cell Line, Tumor ; Disulfides/pharmacology ; Diet, High-Fat/adverse effects ; Mice, Inbred C57BL

LC-MS-Guided Isolation of Triterpene Glycosides from Holothuria atra : Structural Features Governing TRPA1 Inhibition.

Autori: Bawkar C To LH Oh C a ďalší

Zdroj: Journal of agricultural and food chemistry [J Agric Food Chem] 2025 Oct 08; Vol. 73 (40), pp. 25469-25478. Date of Electronic Publication: 2025 Sep 30.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: Glycosides*/chemistry , Glycosides*/isolation & purification , TRPA1 Cation Channel*/antagonists & inhibitors , TRPA1 Cation Channel*/chemistry , Triterpenes*/chemistry , Triterpenes*/isolation & purification , Holothuria*/chemistry, Animals ; Molecular Structure ; Humans ; Chromatography, High Pressure Liquid ; Chromatography, Liquid ; Mass Spectrometry ; Liquid Chromatography-Mass Spectrometry

Hot breath, quick exit: aphids flee mammalian heat via TRPA1.

Autori: Wang B Yang L Wei J a ďalší

Zdroj: Science China. Life sciences [Sci China Life Sci] 2025 Oct; Vol. 68 (10), pp. 3088-3101. Date of Electronic Publication: 2025 Jun 19.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Science China Press, co-published with Springer Country of Publication: China NLM ID: 101529880 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1869-1889 (Electronic) Linking ISSN: 16747305 NLM ISO Abbreviation: Sci China Life Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Aphids*/physiology , Hot Temperature* , TRPA1 Cation Channel*/metabolism , TRPA1 Cation Channel*/genetics , Insect Proteins*/metabolism , Insect Proteins*/genetics, Animals ; Neurons/metabolism

Oxidation of the Unsaturated Fatty Acid Linoleic Acid Generates Highly Potent TRPA1 Agonists.

Autori: Kaneko A Terada Y Yamamoto H a ďalší

Zdroj: Journal of food science [J Food Sci] 2025 Oct; Vol. 90 (10), pp. e70605.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley on behalf of the Institute of Food Technologists Country of Publication: United States NLM ID: 0014052 Publication Model: Print Cited Medium: Internet ISSN: 1750-3841 (Electronic) Linking ISSN: 00221147 NLM ISO Abbreviation: J Food Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: TRPA1 Cation Channel*/agonists , TRPA1 Cation Channel*/metabolism , Linoleic Acid*/chemistry , Linoleic Acid*/metabolism , Linoleic Acid*/pharmacology , Fatty Acids, Unsaturated*/chemistry, Oxidation-Reduction ; Humans ; Taste ; TRPV Cation Channels/metabolism ; HEK293 Cells

The cation channel Trpa1 and chemokine Cxcl1 mediate axonal degeneration in spared nerve injury-induced neuropathic pain.

Autori: Ye LQ Huang XX Liu HF a ďalší

Zdroj: The Journal of biological chemistry [J Biol Chem] 2025 Oct; Vol. 301 (10), pp. 110654. Date of Electronic Publication: 2025 Aug 30.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: TRPA1 Cation Channel*/metabolism , TRPA1 Cation Channel*/genetics , TRPA1 Cation Channel*/antagonists & inhibitors , Neuralgia*/metabolism , Neuralgia*/pathology , Neuralgia*/etiology , Axons*/metabolism , Axons*/pathology , Chemokine CXCL1*/metabolism , Chemokine CXCL1*/genetics , Peripheral Nerve Injuries*/metabolism , Peripheral Nerve Injuries*/pathology , Peripheral Nerve Injuries*/complications, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Schwann Cells/metabolism ; Schwann Cells/pathology ; Hyperalgesia/metabolism ; Hyperalgesia/pathology ; Macrophages/metabolism

Reversibly and repeatedly controlling pain sensation through photo-dependent activation and deactivation of TRPA1 channels induced by Photoswitches.

Autori: Li C Luan K Jiang Q a ďalší

Zdroj: Bioorganic chemistry [Bioorg Chem] 2025 Dec; Vol. 167, pp. 109259. Date of Electronic Publication: 2025 Nov 17.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

Výrazy zo slovníka MeSH: TRPA1 Cation Channel*/metabolism , Azo Compounds*/pharmacology , Azo Compounds*/chemistry , Azo Compounds*/chemical synthesis , Pain*/drug therapy , Pain*/metabolism, Humans ; Molecular Structure ; Structure-Activity Relationship ; HEK293 Cells ; Dose-Response Relationship, Drug ; Ultraviolet Rays ; Light

Anti-nociceptive action of leonurine through TRPA1 and TRPV4 channels modulation.

Autori: Marini M Landini L Coppi E a ďalší

Zdroj: British journal of pharmacology [Br J Pharmacol] 2025 Nov; Vol. 182 (22), pp. 5469-5488. Date of Electronic Publication: 2025 Jul 21.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: TRPV Cation Channels*/metabolism , TRPA1 Cation Channel*/metabolism , Analgesics*/pharmacology , Analgesics*/therapeutic use , Gallic Acid*/analogs & derivatives , Gallic Acid*/pharmacology , Gallic Acid*/therapeutic use, Animals ; Humans ; Mice ; Male ; Mice, Inbred C57BL ; HEK293 Cells ; Ganglia, Spinal/drug effects ; Ganglia, Spinal/metabolism

Transient receptor potential channels TRPA1 and TRPV1 are involved in chronic pain relief via Pulsed Radiofrequency in Rheumatoid Arthritis rat.

Autori: Wang YD Xu Y Zhu CM a ďalší

Zdroj: Neuropharmacology [Neuropharmacology] 2025 Nov 01; Vol. 278, pp. 110548. Date of Electronic Publication: 2025 Jun 06.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

Výrazy zo slovníka MeSH: TRPV Cation Channels*/metabolism , TRPA1 Cation Channel*/metabolism , Chronic Pain*/therapy , Chronic Pain*/metabolism , Chronic Pain*/etiology , Arthritis, Rheumatoid*/metabolism , Arthritis, Rheumatoid*/complications , Arthritis, Rheumatoid*/therapy , Pulsed Radiofrequency Treatment*/methods, Animals ; Ganglia, Spinal/metabolism ; Male ; Rats, Sprague-Dawley ; Rats ; Arthritis, Experimental/metabolism ; Arthritis, Experimental/complications ; Arthritis, Experimental/therapy ; Hyperalgesia/therapy ; Hyperalgesia/metabolism

Activation of TRPA1 and TRPM3 triggers Ca ²⁺ waves in central terminals of sensory neurons and facilitates synaptic activity in the spinal dorsal horn.

Autori: Andrianov YE Keyes AL Warwick CA a ďalší

Zdroj: The Journal of physiology [J Physiol] 2025 Oct; Vol. 603 (20), pp. 6365-6389. Date of Electronic Publication: 2025 Apr 02.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Cambridge Univ. Press Country of Publication: England NLM ID: 0266262 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-7793 (Electronic) Linking ISSN: 00223751 NLM ISO Abbreviation: J Physiol Subsets: MEDLINE

Výrazy zo slovníka MeSH: TRPA1 Cation Channel*/metabolism , TRPM Cation Channels*/metabolism , Calcium Signaling* , Sensory Receptor Cells*/physiology , Sensory Receptor Cells*/metabolism , Spinal Cord Dorsal Horn*/physiology , Spinal Cord Dorsal Horn*/metabolism , Posterior Horn Cells*/physiology , Posterior Horn Cells*/metabolism, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Calcium/metabolism

TRPA1 modulates urocortin 1 turnover in the centrally projecting Edinger-Westphal nucleus in a CGRP-induced migraine model.

Autori: Al-Omari A Poszovácz P Berta G a ďalší

Zdroj: Neuropharmacology [Neuropharmacology] 2026 Feb 01; Vol. 283, pp. 110753. Date of Electronic Publication: 2025 Oct 28.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

Výrazy zo slovníka MeSH: TRPA1 Cation Channel*/metabolism , TRPA1 Cation Channel*/genetics , Migraine Disorders*/metabolism , Migraine Disorders*/chemically induced , Urocortins*/metabolism, Animals ; Calcitonin Gene-Related Peptide ; Male ; Mice, Knockout ; Disease Models, Animal ; Mice ; Mice, Inbred C57BL ; Neurons/metabolism ; Hyperalgesia/metabolism

Calmodulin binding is required for calcium mediated TRPA1 desensitization.

Autori: Sanders JH Garcia C Taiwo KM a ďalší

Zdroj: Nature communications [Nat Commun] 2025 Sep 30; Vol. 16 (1), pp. 8640. Date of Electronic Publication: 2025 Sep 30.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Výrazy zo slovníka MeSH: Calmodulin*/metabolism , Calmodulin*/genetics , TRPA1 Cation Channel*/metabolism , TRPA1 Cation Channel*/genetics , TRPA1 Cation Channel*/chemistry , Calcium*/metabolism, Humans ; HEK293 Cells ; Protein Binding ; Animals ; Binding Sites ; Mice