Suchergebnisse - "TRANSCRIPTION factors"

Targeting TAZ-TEAD in minimal residual disease enhances the duration of targeted therapy in melanoma models.

Autoren: Ott CA Purwin TJ Chen PY et al.

Quelle: Nature communications [Nat Commun] 2025 Nov 05; Vol. 16 (1), pp. 9655. Date of Electronic Publication: 2025 Nov 05.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Melanoma*/drug therapy , Melanoma*/genetics , Melanoma*/metabolism , Melanoma*/pathology , Transcription Factors*/metabolism , Transcription Factors*/genetics , Transcription Factors*/antagonists & inhibitors , Neoplasm, Residual*/drug therapy, Humans ; SOXE Transcription Factors/genetics ; SOXE Transcription Factors/metabolism ; Animals ; Cell Line, Tumor ; Mice ; Proto-Oncogene Proteins B-raf/antagonists & inhibitors ; Proto-Oncogene Proteins B-raf/metabolism ; Drug Resistance, Neoplasm/drug effects ; Xenograft Model Antitumor Assays ; Protein Kinase Inhibitors/pharmacology ; Transcriptional Coactivator with PDZ-Binding Motif Proteins ; Molecular Targeted Therapy ; Connective Tissue Growth Factor/metabolism ; Connective Tissue Growth Factor/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; TEA Domain Transcription Factors ; Female ; Trans-Activators

CD4+ T-cell transcription factors as early predictors of phenoconversion in idiopathic rapid eye movement sleep behaviour disorder.

Autoren: Pinoli M Terzaghi M Marino F et al.

Quelle: F1000Research [F1000Res] 2025 Oct 06; Vol. 14, pp. 683. Date of Electronic Publication: 2025 Oct 06 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: F1000 Research Ltd Country of Publication: England NLM ID: 101594320 Publication Model: eCollection Cited Medium: Internet ISSN: 2046-1402 (Electronic) Linking ISSN: 20461402 NLM ISO Abbreviation: F1000Res Subsets: MEDLINE

MeSH-Schlagworte: CD4-Positive T-Lymphocytes*/metabolism , REM Sleep Behavior Disorder*/metabolism , REM Sleep Behavior Disorder*/genetics , REM Sleep Behavior Disorder*/diagnosis , Transcription Factors*/metabolism , Transcription Factors*/genetics, Humans ; Male ; Female ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; Middle Aged ; Aged ; RNA, Messenger/metabolism ; RNA, Messenger/genetics ; Parkinson Disease ; GATA3 Transcription Factor/genetics ; GATA3 Transcription Factor/metabolism ; Biomarkers/metabolism ; STAT1 Transcription Factor/genetics ; STAT1 Transcription Factor/metabolism ; Adult

Pleiotropic function of Dlx5/6 in the development of mammalian vocal and auditory organs.

Autoren: Sánchez-Garrido F Bouzerand V Kaiser M et al.

Quelle: PloS one [PLoS One] 2025 Dec 02; Vol. 20 (12), pp. e0337426. Date of Electronic Publication: 2025 Dec 02 (Print Publication: 2025).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

MeSH-Schlagworte: Homeodomain Proteins*/genetics , Homeodomain Proteins*/metabolism , Vocalization, Animal*/physiology , Transcription Factors*/genetics , Transcription Factors*/metabolism , Ear*/embryology, Animals ; Mice ; Signal Transduction ; SOXE Transcription Factors/metabolism ; SOXE Transcription Factors/genetics ; Gene Expression Regulation, Developmental ; Morphogenesis

Water shortage reduces PHYTOCHROME INTERACTING FACTOR 4, 5 and 3 expression and shade avoidance in Arabidopsis.

Autoren: Semmoloni M Costigliolo Rojas C Escudero C et al.

Quelle: The Plant journal : for cell and molecular biology [Plant J] 2025 Dec; Vol. 124 (5), pp. e70610.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Blackwell Scientific Publishers and BIOS Scientific Publishers in association with the Society for Experimental Biology Country of Publication: England NLM ID: 9207397 Publication Model: Print Cited Medium: Internet ISSN: 1365-313X (Electronic) Linking ISSN: 09607412 NLM ISO Abbreviation: Plant J Subsets: MEDLINE

MeSH-Schlagworte: Arabidopsis*/genetics , Arabidopsis*/physiology , Arabidopsis*/metabolism , Arabidopsis*/growth & development , Arabidopsis*/radiation effects , Arabidopsis Proteins*/metabolism , Arabidopsis Proteins*/genetics , Basic Helix-Loop-Helix Transcription Factors*/metabolism , Basic Helix-Loop-Helix Transcription Factors*/genetics , Water*/metabolism, Gene Expression Regulation, Plant ; Hypocotyl/growth & development ; Hypocotyl/genetics ; Hypocotyl/metabolism ; Hypocotyl/physiology ; Hypocotyl/radiation effects ; Seedlings/genetics ; Seedlings/growth & development ; Seedlings/physiology ; Light ; Promoter Regions, Genetic ; Indoleacetic Acids/metabolism ; Transcription Factors/metabolism ; Transcription Factors/genetics ; Signal Transduction

HSF-1 regulates FoxO expression to induce diapause in the cotton bollworm, Helicoverpa armigera via upstream HIF-1α and MNK signaling.

Autoren: Su ZR Su XL Jiang SS et al.

Quelle: Insect biochemistry and molecular biology [Insect Biochem Mol Biol] 2025 Dec; Vol. 185, pp. 104429. Date of Electronic Publication: 2025 Oct 27.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 9207282 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0240 (Electronic) Linking ISSN: 09651748 NLM ISO Abbreviation: Insect Biochem Mol Biol Subsets: MEDLINE

MeSH-Schlagworte: Moths*/metabolism , Moths*/genetics , Moths*/growth & development , Moths*/physiology , Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism , Hypoxia-Inducible Factor 1, alpha Subunit*/genetics , Insect Proteins*/metabolism , Insect Proteins*/genetics , Forkhead Transcription Factors*/metabolism , Forkhead Transcription Factors*/genetics , Transcription Factors*/metabolism , Transcription Factors*/genetics , Diapause, Insect*/genetics, Animals ; Signal Transduction ; Pupa/metabolism ; Pupa/growth & development ; Pupa/genetics ; Heat Shock Transcription Factors/metabolism ; Helicoverpa armigera

SOX2 is a dispensable modulator of NUT carcinoma oncogenesis in mice.

Autoren: Luo C Zheng D Elnegiry A et al.

Quelle: Life science alliance [Life Sci Alliance] 2025 Nov 20; Vol. 9 (2). Date of Electronic Publication: 2025 Nov 20 (Print Publication: 2026).

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Life Science Alliance, LLC Country of Publication: United States NLM ID: 101728869 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2575-1077 (Electronic) Linking ISSN: 25751077 NLM ISO Abbreviation: Life Sci Alliance Subsets: MEDLINE

MeSH-Schlagworte: SOXB1 Transcription Factors*/metabolism , SOXB1 Transcription Factors*/genetics , Carcinogenesis*/genetics , Carcinogenesis*/metabolism , Nuclear Proteins*/genetics , Nuclear Proteins*/metabolism , Carcinoma, Squamous Cell*/genetics , Carcinoma, Squamous Cell*/metabolism , Carcinoma, Squamous Cell*/pathology, Animals ; Mice ; Transcription Factors/metabolism ; Transcription Factors/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Disease Models, Animal ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism

DAF-16/FOXO and HLH-30/TFEB comprise a cooperative regulatory axis controlling tubular lysosome induction in C. elegans.

Autoren: Ricaurte-Perez C Gill JP Wall PK et al.

Quelle: Nature communications [Nat Commun] 2025 Nov 10; Vol. 16 (1), pp. 9878. Date of Electronic Publication: 2025 Nov 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH-Schlagworte: Caenorhabditis elegans Proteins*/metabolism , Caenorhabditis elegans Proteins*/genetics , Caenorhabditis elegans*/metabolism , Caenorhabditis elegans*/genetics , Lysosomes*/metabolism , Lysosomes*/genetics , Forkhead Transcription Factors*/metabolism , Forkhead Transcription Factors*/genetics , Basic Helix-Loop-Helix Leucine Zipper Transcription Factors*/metabolism , Basic Helix-Loop-Helix Leucine Zipper Transcription Factors*/genetics, Animals ; Longevity/genetics ; Aging/genetics ; Aging/metabolism ; Gene Expression Regulation ; Basic Helix-Loop-Helix Transcription Factors

Single cis-elements in brassinosteroid-induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA-binding domain.

Autoren: Nosaki S Ohtsuka M Nakano T et al.

Quelle: FEBS letters [FEBS Lett] 2025 Nov; Vol. 599 (22), pp. 3369-3380. Date of Electronic Publication: 2025 Aug 29.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 0155157 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3468 (Electronic) Linking ISSN: 00145793 NLM ISO Abbreviation: FEBS Lett Subsets: MEDLINE

MeSH-Schlagworte: Arabidopsis Proteins*/metabolism , Arabidopsis Proteins*/genetics , Arabidopsis Proteins*/chemistry , Brassinosteroids*/pharmacology , Brassinosteroids*/metabolism , Arabidopsis*/genetics , Arabidopsis*/metabolism , Arabidopsis*/drug effects , Gene Expression Regulation, Plant*/drug effects , DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/genetics , DNA-Binding Proteins*/chemistry , Nuclear Proteins*/metabolism , Nuclear Proteins*/genetics , Nuclear Proteins*/chemistry , Transcription Factors*/metabolism , Transcription Factors*/genetics , Transcription Factors*/chemistry, Oxidation-Reduction ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Up-Regulation/drug effects ; Protein Domains ; Protein Binding

MdHSFA2 enhances heat stress tolerance through promoting the MdGolS4 transcription in apple.

Autoren: Li M Zhang X Zuo D et al.

Quelle: Scientific reports [Sci Rep] 2025 Oct 10; Vol. 15 (1), pp. 35436. Date of Electronic Publication: 2025 Oct 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Malus*/genetics , Malus*/physiology , Malus*/metabolism , Plant Proteins*/genetics , Plant Proteins*/metabolism , Heat-Shock Response*/genetics , Heat Shock Transcription Factors*/genetics , Heat Shock Transcription Factors*/metabolism , Thermotolerance*/genetics , Transcription, Genetic*, Gene Expression Regulation, Plant ; Arabidopsis/genetics ; Plants, Genetically Modified ; Promoter Regions, Genetic ; Transcription Factors/genetics ; Transcription Factors/metabolism

Transcription factors ERF74/77/108/125 enhance thermotolerance in rice by regulating common and distinct heat-responsive gene expression.

Autoren: Luo A Yang C Yao ZW et al.

Quelle: Plant biotechnology journal [Plant Biotechnol J] 2025 Oct; Vol. 23 (10), pp. 4539-4551. Date of Electronic Publication: 2025 Jul 11.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley on behalf of the Society for Experimental Biology, Association of Applied Biologists Country of Publication: England NLM ID: 101201889 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1467-7652 (Electronic) Linking ISSN: 14677644 NLM ISO Abbreviation: Plant Biotechnol J Subsets: MEDLINE

MeSH-Schlagworte: Oryza*/genetics , Oryza*/physiology , Oryza*/metabolism , Gene Expression Regulation, Plant*/genetics , Thermotolerance*/genetics , Plant Proteins*/metabolism , Plant Proteins*/genetics , Transcription Factors*/metabolism , Transcription Factors*/genetics, Heat-Shock Response/genetics ; Plants, Genetically Modified ; Hot Temperature ; Heat Shock Transcription Factors/genetics ; Heat Shock Transcription Factors/metabolism ; Promoter Regions, Genetic

Identification of pyrazolo-piperidinone derivatives targeting YAP-TEAD interface 3 as anticancer agents through integrated virtual screening and mass spectrometry proteomics.

Autoren: Scalvini L Tagliazucchi L Elisi GM et al.

Quelle: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118056. Date of Electronic Publication: 2025 Aug 12.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Pyrazoles*/chemistry , Pyrazoles*/pharmacology , Pyrazoles*/chemical synthesis , Proteomics* , Transcription Factors*/metabolism , Transcription Factors*/antagonists & inhibitors , DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/antagonists & inhibitors , Adaptor Proteins, Signal Transducing*/metabolism , Adaptor Proteins, Signal Transducing*/antagonists & inhibitors , Muscle Proteins*/metabolism , Muscle Proteins*/antagonists & inhibitors, Humans ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; TEA Domain Transcription Factors ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Mass Spectrometry ; YAP-Signaling Proteins ; Cell Line, Tumor

Overexpression of Nuclear Factor of Activated T-cells (NFAT) Transcription Factors Drives Chemoresistance and Poor Outcomes in Pancreatic Cancer.

Autoren: Kamioka Y Hiroshima Y Kawase W et al.

Quelle: Annals of surgical oncology [Ann Surg Oncol] 2025 Dec; Vol. 32 (13), pp. 10179-10192. Date of Electronic Publication: 2025 Aug 28.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Springer Country of Publication: United States NLM ID: 9420840 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-4681 (Electronic) Linking ISSN: 10689265 NLM ISO Abbreviation: Ann Surg Oncol Subsets: MEDLINE

MeSH-Schlagworte: Pancreatic Neoplasms*/pathology , Pancreatic Neoplasms*/metabolism , Pancreatic Neoplasms*/drug therapy , Pancreatic Neoplasms*/genetics , NFATC Transcription Factors*/metabolism , NFATC Transcription Factors*/genetics , Drug Resistance, Neoplasm* , Carcinoma, Pancreatic Ductal*/metabolism , Carcinoma, Pancreatic Ductal*/drug therapy , Carcinoma, Pancreatic Ductal*/pathology , Carcinoma, Pancreatic Ductal*/genetics , Biomarkers, Tumor*/metabolism , Biomarkers, Tumor*/genetics , Neoplasm Recurrence, Local*/pathology , Neoplasm Recurrence, Local*/metabolism , Neoplasm Recurrence, Local*/drug therapy , Neoplasm Recurrence, Local*/genetics, Humans ; Male ; Female ; Animals ; Survival Rate ; Prognosis ; Mice ; Middle Aged ; Follow-Up Studies ; Tumor Cells, Cultured ; Gene Expression Regulation, Neoplastic ; Signal Transduction ; Xenograft Model Antitumor Assays ; Aged ; Cell Proliferation ; Transcription Factors

Depalmitoylation of TEAD1 facilitates lipid droplet accumulation and resistance to oxidative stress by transactivating PP2Acα.

Autoren: Sun X Xu S Ni Y et al.

Quelle: Free radical biology & medicine [Free Radic Biol Med] 2025 Dec 01; Vol. 240, pp. 532-545. Date of Electronic Publication: 2025 Aug 30.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

MeSH-Schlagworte: Transcription Factors*/genetics , Transcription Factors*/metabolism , DNA-Binding Proteins*/genetics , DNA-Binding Proteins*/metabolism , Lipid Droplets*/metabolism , Lipid Droplets*/drug effects , Protein Phosphatase 2*/genetics , Protein Phosphatase 2*/metabolism , Chemical and Drug Induced Liver Injury*/metabolism , Chemical and Drug Induced Liver Injury*/pathology , Chemical and Drug Induced Liver Injury*/genetics , Nuclear Proteins*/genetics , Nuclear Proteins*/metabolism, Animals ; Mice ; TEA Domain Transcription Factors ; Oxidative Stress/drug effects ; Mice, Knockout ; Acetaminophen/toxicity ; Acetaminophen/adverse effects ; Hepatocytes/metabolism ; Hepatocytes/drug effects ; Hepatocytes/pathology ; Liver/metabolism ; Liver/pathology ; Liver/drug effects ; Humans ; Lipid Metabolism ; Male ; Transcriptional Activation ; Signal Transduction ; Reactive Oxygen Species/metabolism

Exosomes derived from human umbilical cord mesenchymal stem cells ameliorate AKI after cardiac surgery by facilitating miR-21-5p targeting TEAD1.

Autoren: Li Z He F Dai S et al.

Quelle: Renal failure [Ren Fail] 2025 Dec; Vol. 47 (1), pp. 2537797. Date of Electronic Publication: 2025 Aug 07.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE

MeSH-Schlagworte: Exosomes*/metabolism , Acute Kidney Injury*/etiology , Acute Kidney Injury*/therapy , MicroRNAs*/metabolism , MicroRNAs*/genetics , Mesenchymal Stem Cells*/metabolism , Mesenchymal Stem Cells*/cytology , Transcription Factors*/metabolism , Transcription Factors*/genetics , Cardiac Surgical Procedures*/adverse effects , DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/genetics , Nuclear Proteins*/metabolism , Nuclear Proteins*/genetics, Humans ; Animals ; TEA Domain Transcription Factors ; Male ; Umbilical Cord/cytology ; Apoptosis ; Hepatitis A Virus Cellular Receptor 1/metabolism ; Mice ; Disease Models, Animal

TEA domain transcription factor 3 suppresses aortic and left ventricular remodeling via transcriptional activation of PDZ domain containing 1.

Autoren: Wang L Bai Y Ma D et al.

Quelle: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 2), pp. 117329. Date of Electronic Publication: 2025 Sep 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH-Schlagworte: Ventricular Remodeling*/physiology , Transcription Factors*/genetics , Transcription Factors*/biosynthesis , Transcription Factors*/metabolism , DNA-Binding Proteins*/genetics , DNA-Binding Proteins*/biosynthesis , DNA-Binding Proteins*/metabolism , Transcriptional Activation*/physiology , Aorta*/metabolism , Aorta*/pathology, Animals ; Rats, Inbred SHR ; Rats ; Male ; TEA Domain Transcription Factors ; Muscle, Smooth, Vascular/metabolism ; Rats, Inbred WKY ; Cells, Cultured

Insights and trends in development of TEAD-YAP/TAZ inhibitors: a review of PCT patents (2022 to June 2025).

Autoren: Fan T Yu Z Xiao A et al.

Quelle: Expert opinion on therapeutic patents [Expert Opin Ther Pat] 2025 Dec; Vol. 35 (12), pp. 1209-1239. Date of Electronic Publication: 2025 Nov 07.

Publikationsart: Journal Article; Review

Info zur Zeitschrift: Publisher: Informa Healthcare Country of Publication: England NLM ID: 9516419 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-7674 (Electronic) Linking ISSN: 13543776 NLM ISO Abbreviation: Expert Opin Ther Pat Subsets: MEDLINE

MeSH-Schlagworte: Drug Development* , Transcription Factors*/antagonists & inhibitors , Transcription Factors*/metabolism , Neoplasms*/drug therapy , Neoplasms*/pathology , Antineoplastic Agents*/pharmacology, Patents as Topic ; Humans ; Animals ; Drug Design ; YAP-Signaling Proteins ; Molecular Targeted Therapy ; TEA Domain Transcription Factors/antagonists & inhibitors

AlphaFold-Guided Discovery of an Overlapping MYC/Miz-1 Interface Enables Peptidomimetic Disruption of MYC/MAX.

Autoren: Ellenbroek BD Tirtosentono ASS Pomplun SJ

Quelle: ChemMedChem [ChemMedChem] 2025 Nov 28; Vol. 20 (23), pp. e202500740. Date of Electronic Publication: 2025 Oct 26.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

MeSH-Schlagworte: Peptidomimetics*/chemistry , Peptidomimetics*/pharmacology , Peptidomimetics*/chemical synthesis , Proto-Oncogene Proteins c-myc*/metabolism , Proto-Oncogene Proteins c-myc*/chemistry , Proto-Oncogene Proteins c-myc*/antagonists & inhibitors , Basic Helix-Loop-Helix Leucine Zipper Transcription Factors*/metabolism , Basic Helix-Loop-Helix Leucine Zipper Transcription Factors*/chemistry , Basic Helix-Loop-Helix Leucine Zipper Transcription Factors*/antagonists & inhibitors, Humans ; Protein Binding/drug effects ; Binding Sites ; Kruppel-Like Transcription Factors

Phenotypic Hit Identification and Optimization of Novel Pan-TEAD and Subtype-Selective Inhibitors.

Autoren: Heinrich T Gambardella A Schwarz D et al.

Quelle: Journal of medicinal chemistry [J Med Chem] 2025 Nov 27; Vol. 68 (22), pp. 24603-24623. Date of Electronic Publication: 2025 Nov 10.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

MeSH-Schlagworte: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacokinetics , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/therapeutic use , Transcription Factors*/antagonists & inhibitors , Transcription Factors*/metabolism, Humans ; Animals ; Structure-Activity Relationship ; Cell Line, Tumor ; Mice ; Lung Neoplasms/drug therapy ; Lung Neoplasms/pathology ; Xenograft Model Antitumor Assays ; TEA Domain Transcription Factors ; Mice, Nude

The ratio of Wnt signaling activity to Sox2 transcription factor levels predicts neuromesodermal fate potential.

Autoren: Morabito RM Tatarakis D Swick R et al.

Quelle: Development (Cambridge, England) [Development] 2025 Nov 15; Vol. 152 (22). Date of Electronic Publication: 2025 Nov 17.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Company Of Biologists Limited Country of Publication: England NLM ID: 8701744 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-9129 (Electronic) Linking ISSN: 09501991 NLM ISO Abbreviation: Development Subsets: MEDLINE

MeSH-Schlagworte: Zebrafish*/embryology , Zebrafish*/metabolism , Zebrafish*/genetics , SOXB1 Transcription Factors*/metabolism , SOXB1 Transcription Factors*/genetics , Zebrafish Proteins*/metabolism , Zebrafish Proteins*/genetics , Wnt Signaling Pathway*/physiology , Mesoderm*/cytology , Mesoderm*/metabolism , Mesoderm*/embryology, Animals ; Animals, Genetically Modified ; Cell Differentiation ; Gene Expression Regulation, Developmental ; Spinal Cord/embryology ; Spinal Cord/metabolism ; Spinal Cord/cytology ; Notochord/metabolism ; Notochord/cytology ; Notochord/embryology ; SOX Transcription Factors

Clinicopathological significance of Kruppel-like factor 15 and epithelial-to-mesenchymal transition related factors in bladder cancer.

Autoren: Li W Lv R Su H et al.

Quelle: Scientific reports [Sci Rep] 2025 Nov 06; Vol. 15 (1), pp. 38862. Date of Electronic Publication: 2025 Nov 06.

Publikationsart: Journal Article

Info zur Zeitschrift: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH-Schlagworte: Urinary Bladder Neoplasms*/pathology , Urinary Bladder Neoplasms*/metabolism , Urinary Bladder Neoplasms*/mortality , Urinary Bladder Neoplasms*/genetics , Epithelial-Mesenchymal Transition* , Kruppel-Like Transcription Factors*/metabolism , Kruppel-Like Transcription Factors*/genetics, Humans ; Male ; Female ; Middle Aged ; Aged ; Prognosis ; Zinc Finger E-box-Binding Homeobox 1/metabolism ; Zinc Finger E-box-Binding Homeobox 1/genetics ; Snail Family Transcription Factors/metabolism ; Biomarkers, Tumor/metabolism ; Gene Expression Regulation, Neoplastic ; Cadherins/metabolism ; Adult ; beta Catenin/metabolism