Výsledky vyhľadávania - "TOLL-like receptor agonists"

Efficient bovine sex selection via Toll-like receptors 7/8 agonist 24e through the GSK3α/β-hexokinase pathway.

Autori: Wang D Di A Zhang X a ďalší

Zdroj: Theriogenology [Theriogenology] 2025 Dec; Vol. 248, pp. 117590. Date of Electronic Publication: 2025 Jul 16.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: United States NLM ID: 0421510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3231 (Electronic) Linking ISSN: 0093691X NLM ISO Abbreviation: Theriogenology Subsets: MEDLINE

Výrazy zo slovníka MeSH: Sex Preselection*/methods , Sex Preselection*/veterinary , Toll-Like Receptors*/agonists , Toll-Like Receptors*/genetics , Toll-Like Receptors*/physiology , Toll-Like Receptor Agonists*, Animals ; Cattle ; Toll-Like Receptor 7/agonists ; Toll-Like Receptor 7/genetics ; Toll-Like Receptor 7/metabolism ; Toll-Like Receptor 8/agonists ; Toll-Like Receptor 8/genetics ; Toll-Like Receptor 8/metabolism ; Glycogen Synthase Kinases/genetics ; Glycogen Synthase Kinases/metabolism ; Hexokinase/genetics ; Hexokinase/metabolism ; Signal Transduction/physiology ; Male ; Female ; Dairying ; Flow Cytometry/economics ; Flow Cytometry/methods ; Flow Cytometry/veterinary ; X Chromosome/physiology ; NF-kappa B/metabolism ; Spermatozoa/metabolism ; Spermatozoa/physiology ; Sex Chromosomes

In vitro characterization of cellular responses elicited by endosomal TLR agonists encapsulated in Qβ virus-like particles.

Autori: Hasibuzzaman MM Ibarra B Khan IN a ďalší

Zdroj: BMC immunology [BMC Immunol] 2025 Nov 17; Vol. 26 (1), pp. 93. Date of Electronic Publication: 2025 Nov 17.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 100966980 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2172 (Electronic) Linking ISSN: 14712172 NLM ISO Abbreviation: BMC Immunol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Endosomes*/metabolism , Endosomes*/immunology , Dendritic Cells*/immunology , Toll-Like Receptor 9*/agonists , Vaccines, Virus-Like Particle*/immunology , Toll-Like Receptors*/agonists, Humans ; Toll-Like Receptor 7/agonists ; Lymphocyte Activation/drug effects ; Toll-Like Receptor 8/agonists ; Cytokines/metabolism ; Cells, Cultured ; Killer Cells, Natural/immunology ; Toll-Like Receptor Agonists

Triple-TLR agonists' adjuvanted inactivated Newcastle disease virus vaccine promotes effective Th1/Th2 immune responses and affords protective efficacy in chickens.

Autori: Kaliappan A Ramakrishnan S Panwar K a ďalší

Zdroj: Vaccine [Vaccine] 2025 Nov 14; Vol. 66, pp. 127846. Date of Electronic Publication: 2025 Oct 11.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2518 (Electronic) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE

Výrazy zo slovníka MeSH: Newcastle disease virus*/immunology , Newcastle Disease*/prevention & control , Newcastle Disease*/immunology , Th1 Cells*/immunology , Viral Vaccines*/immunology , Viral Vaccines*/administration & dosage , Adjuvants, Immunologic*/administration & dosage , Toll-Like Receptors*/agonists , Th2 Cells*/immunology , Poultry Diseases*/prevention & control , Poultry Diseases*/immunology, Animals ; Chickens/immunology ; Vaccines, Inactivated/immunology ; Vaccines, Inactivated/administration & dosage ; Immunity, Cellular ; Immunity, Humoral ; Antibodies, Viral/blood ; Cytokines ; Leukocytes, Mononuclear/immunology ; Oligodeoxyribonucleotides/administration & dosage ; Toll-Like Receptor Agonists

Dermal fibroblast cultures recapitulate differences between deermice and mice in their responses to a Toll-like receptor agonist.

Autori: Duong JV Motiwala A Hotz WJ a ďalší

Zdroj: Frontiers in immunology [Front Immunol] 2025 Nov 04; Vol. 16, pp. 1666789. Date of Electronic Publication: 2025 Nov 04 (Print Publication: 2025).

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Fibroblasts*/immunology , Fibroblasts*/metabolism , Fibroblasts*/drug effects , Toll-Like Receptor 2*/agonists , Toll-Like Receptors*/agonists , Skin*/cytology , Skin*/immunology, Animals ; Mice ; Cells, Cultured ; Lipopeptides/pharmacology ; Species Specificity ; Toll-Like Receptor Agonists

Toll-like receptor agonists as cancer therapeutics: a patent review (2014-2024).

Autori: Kumar P Zargar ZB Chopra K a ďalší

Zdroj: Expert opinion on therapeutic patents [Expert Opin Ther Pat] 2025 Nov; Vol. 35 (11), pp. 1099-1139. Date of Electronic Publication: 2025 Sep 18.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: Informa Healthcare Country of Publication: England NLM ID: 9516419 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-7674 (Electronic) Linking ISSN: 13543776 NLM ISO Abbreviation: Expert Opin Ther Pat Subsets: MEDLINE

Výrazy zo slovníka MeSH: Neoplasms*/immunology , Neoplasms*/pathology , Neoplasms*/drug therapy , Neoplasms*/therapy , Toll-Like Receptors*/agonists , Toll-Like Receptors*/metabolism , Toll-Like Receptors*/immunology , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/adverse effects , Antineoplastic Agents*/administration & dosage, Humans ; Patents as Topic ; Animals ; Immunotherapy/methods ; Drug Delivery Systems ; Immunity, Innate/drug effects ; Immunity, Innate/immunology ; Adaptive Immunity/drug effects ; Adaptive Immunity/immunology ; Cytokines/metabolism ; Cytokines/immunology ; Toll-Like Receptor Agonists

Saponin nanoparticle adjuvants incorporating Toll-like receptor agonists drive distinct immune signatures and potent vaccine responses.

Autori: Ou BS Baillet J Filsinger Interrante MV a ďalší

Zdroj: Science advances [Sci Adv] 2024 Aug 09; Vol. 10 (32), pp. eadn7187. Date of Electronic Publication: 2024 Aug 07.

Spôsob vydávania: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

Informácie o časopise: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

Výrazy zo slovníka MeSH: Adjuvants, Immunologic*/pharmacology , COVID-19 Vaccines*/immunology , Nanoparticles*/chemistry , Saponins*/pharmacology , Saponins*/chemistry , Saponins*/immunology , SARS-CoV-2*/immunology , Toll-Like Receptor Agonists*, Animals ; Humans ; Mice ; Adjuvants, Vaccine/chemistry ; AIDS Vaccines/immunology ; COVID-19/prevention & control ; COVID-19/immunology ; COVID-19/virology ; Cytokines/metabolism

Non-conjugated TLR agonists increase the quantity of antibodies but not their quality in a murine immunization model.

Autori: Aymerich N Bucheli OTM Portmann K a ďalší

Zdroj: Vaccine [Vaccine] 2025 Aug 30; Vol. 62, pp. 127518. Date of Electronic Publication: 2025 Jul 22.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2518 (Electronic) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE

Výrazy zo slovníka MeSH: Toll-Like Receptors*/agonists , Adjuvants, Immunologic*/administration & dosage , Adjuvants, Immunologic*/pharmacology , Antibodies, Bacterial*/blood, Animals ; Mice ; Female ; Immunization ; B-Lymphocytes/immunology ; B-Lymphocytes/drug effects ; Mice, Inbred BALB C ; Alum Compounds/administration & dosage ; Toll-Like Receptor 2/agonists ; Toll-Like Receptor Agonists

TLR agonists polarize interferon responses in conjunction with dendritic cell vaccination in malignant glioma: a randomized phase II Trial.

Autori: Everson RG Hugo W Sun L a ďalší

Zdroj: Nature communications [Nat Commun] 2024 May 08; Vol. 15 (1), pp. 3882. Date of Electronic Publication: 2024 May 08.

Spôsob vydávania: Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

Informácie o časopise: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Výrazy zo slovníka MeSH: Cancer Vaccines*/immunology , Cancer Vaccines*/administration & dosage , Cancer Vaccines*/therapeutic use , Dendritic Cells*/immunology , Dendritic Cells*/drug effects , Glioma*/immunology , Glioma*/therapy , Interferons* , Toll-Like Receptor Agonists*, Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Brain Neoplasms/immunology ; Brain Neoplasms/therapy ; Brain Neoplasms/drug therapy ; Carboxymethylcellulose Sodium/analogs & derivatives ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/drug effects ; Imidazoles/pharmacology ; Imidazoles/therapeutic use ; Immunotherapy/methods ; Monocytes/immunology ; Monocytes/drug effects ; Poly I-C/administration & dosage ; Poly I-C/pharmacology ; Polylysine/analogs & derivatives ; Vaccination

Combining toll-like receptor agonists with immune checkpoint blockade affects antitumor vaccine efficacy.

Autori: Jeon D Hill E Moseman JE a ďalší

Zdroj: Journal for immunotherapy of cancer [J Immunother Cancer] 2024 May 03; Vol. 12 (5). Date of Electronic Publication: 2024 May 03.

Spôsob vydávania: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

Informácie o časopise: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE

Výrazy zo slovníka MeSH: Cancer Vaccines*/immunology , Cancer Vaccines*/therapeutic use , Immune Checkpoint Inhibitors*/pharmacology , Immune Checkpoint Inhibitors*/therapeutic use , Toll-Like Receptor Agonists*, Animals ; Female ; Humans ; Mice ; Cell Line, Tumor

Reprogramming tumor-associated macrophages using STING or TLR agonists: a promising strategy to enhance immunotherapy in hormone-dependent cancers.

Autori: Sacristan Santos V Pensado-López A García-Campelo R a ďalší

Zdroj: Journal for immunotherapy of cancer [J Immunother Cancer] 2025 May 15; Vol. 13 (5). Date of Electronic Publication: 2025 May 15.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE

Výrazy zo slovníka MeSH: Tumor-Associated Macrophages*/metabolism , Tumor-Associated Macrophages*/drug effects , Tumor-Associated Macrophages*/immunology , Immunotherapy*/methods , Toll-Like Receptors*/agonists , Membrane Proteins*/agonists , Membrane Proteins*/metabolism , Neoplasms, Hormone-Dependent*/drug therapy , Neoplasms, Hormone-Dependent*/immunology, Humans ; Animals ; Tumor Microenvironment ; Male ; Mice ; Toll-Like Receptor Agonists

Exploring TLR agonists as adjuvants for COVID-19 oral vaccines.

Autori: Félix P Melo AA Costa JP a ďalší

Zdroj: Vaccine [Vaccine] 2025 Apr 19; Vol. 53, pp. 127078. Date of Electronic Publication: 2025 Apr 03.

Spôsob vydávania: Journal Article; Research Support, Non-U.S. Gov't

Informácie o časopise: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2518 (Electronic) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE

Výrazy zo slovníka MeSH: COVID-19 Vaccines*/immunology , COVID-19 Vaccines*/administration & dosage , Adjuvants, Immunologic*/administration & dosage , Adjuvants, Immunologic*/pharmacology , COVID-19*/prevention & control , COVID-19*/immunology , Adjuvants, Vaccine*/administration & dosage , Toll-Like Receptors*/agonists, Animals ; Mice ; Humans ; Administration, Oral ; SARS-CoV-2/immunology ; RAW 264.7 Cells ; Spike Glycoprotein, Coronavirus/immunology ; Spike Glycoprotein, Coronavirus/administration & dosage ; Immunity, Mucosal ; Female ; Immunoglobulin A, Secretory ; Toll-Like Receptor Agonists

Co-Delivery of Multiple Toll-Like Receptor Agonists and Avian Influenza Hemagglutinin on Protein Nanoparticles Enhances Vaccine Immunogenicity and Efficacy.

Autori: Ramirez A Hernandez-Davies JE Jain A a ďalší

Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2025 Apr; Vol. 14 (10), pp. e2404335. Date of Electronic Publication: 2025 Feb 09.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101581613 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-2659 (Electronic) Linking ISSN: 21922640 NLM ISO Abbreviation: Adv Healthc Mater Subsets: MEDLINE

Výrazy zo slovníka MeSH: Influenza Vaccines*/immunology , Influenza Vaccines*/chemistry , Influenza Vaccines*/pharmacology , Nanoparticles*/chemistry , Hemagglutinin Glycoproteins, Influenza Virus*/immunology , Hemagglutinin Glycoproteins, Influenza Virus*/chemistry , Toll-Like Receptors*/agonists , Immunogenicity, Vaccine*, Animals ; Flagellin/chemistry ; Flagellin/pharmacology ; Flagellin/immunology ; Oligodeoxyribonucleotides/pharmacology ; Oligodeoxyribonucleotides/chemistry ; Mice ; Antibodies, Viral/immunology ; Female ; Adjuvants, Immunologic ; Immunoglobulin G/immunology ; Mice, Inbred BALB C ; Influenza A Virus, H5N1 Subtype/immunology ; Toll-Like Receptor Agonists

An in vitro model for osteoarthritis using long-cultured inflammatory human macrophages repeatedly stimulated with TLR agonists.

Autori: Ummarino A Pensado-López A Migliore R a ďalší

Zdroj: European journal of immunology [Eur J Immunol] 2023 Dec; Vol. 53 (12), pp. e2350507. Date of Electronic Publication: 2023 Oct 06.

Spôsob vydávania: Journal Article; Research Support, Non-U.S. Gov't

Informácie o časopise: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 1273201 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4141 (Electronic) Linking ISSN: 00142980 NLM ISO Abbreviation: Eur J Immunol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Toll-Like Receptor Agonists* , Osteoarthritis*/drug therapy , Osteoarthritis*/metabolism, Humans ; Macrophages/metabolism ; Inflammation/metabolism ; Inflammation Mediators/metabolism

Toll-like receptor agonists promote the formation of tertiary lymphoid structure and improve anti-glioma immunity.

Autori: Shen S Cui Y Li M a ďalší

Zdroj: Neuro-oncology [Neuro Oncol] 2025 Jan 12; Vol. 27 (1), pp. 140-154.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Oxford University Press Country of Publication: England NLM ID: 100887420 Publication Model: Print Cited Medium: Internet ISSN: 1523-5866 (Electronic) Linking ISSN: 15228517 NLM ISO Abbreviation: Neuro Oncol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Glioma*/immunology , Glioma*/pathology , Glioma*/drug therapy , Tertiary Lymphoid Structures*/immunology , Tertiary Lymphoid Structures*/pathology , Tumor Microenvironment*/immunology , Tumor Microenvironment*/drug effects , Brain Neoplasms*/immunology , Brain Neoplasms*/pathology , Brain Neoplasms*/drug therapy , Toll-Like Receptors*/agonists , Lymphocytes, Tumor-Infiltrating*/immunology , Lymphocytes, Tumor-Infiltrating*/drug effects, Animals ; Mice ; Humans ; Prognosis ; Female ; Mice, Inbred C57BL ; Male ; Toll-Like Receptor Agonists

Rational Design and In Silico Evaluation of a Multiepitope Vaccine Targeting the uPAR for Cancer Immunotherapy.

Autori: Baghaei, Fahimeh Hemmat, Zahra Taherkhani, Amir a ďalší

Zdroj: Journal of Immunology Research. 10/16/2025, Vol. 2025, p1-18. 18p.

Predmety: *IMMUNOTHERAPY, *TOLL-like receptor agonists, *MOLECULAR docking, *IMMUNITY, *CYTOTOXIC T cells, *COMBINED vaccines, *BIOINFORMATICS

A TLR7/8 agonist–chitosan conjugate as an adjuvant for carbohydrate-based anticancer vaccine development.

Autori: Yin, Xu-Guang Tong, Guo-Zuo Huang, Si-Qi a ďalší

Zdroj: Chemical Communications. 10/4/2025, Vol. 61 Issue 77, p14951-14954. 4p.

Predmety: *TOLL-like receptor agonists, *CHITOSAN, *TUMOR antigens, *SALTS, *VACCINES, *IMMUNOMODULATORS, *ANTINEOPLASTIC agents

Toll-like receptor agonists as cancer vaccine adjuvants.

Autori: Jeon D Hill E McNeel DG

Zdroj: Human vaccines & immunotherapeutics [Hum Vaccin Immunother] 2024 Dec 31; Vol. 20 (1), pp. 2297453. Date of Electronic Publication: 2023 Dec 28.

Spôsob vydávania: Journal Article; Review; Research Support, N.I.H., Extramural

Informácie o časopise: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101572652 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2164-554X (Electronic) Linking ISSN: 21645515 NLM ISO Abbreviation: Hum Vaccin Immunother Subsets: MEDLINE

Výrazy zo slovníka MeSH: Cancer Vaccines*/therapeutic use , Neoplasms*/drug therapy, Humans ; Adjuvants, Vaccine ; Toll-Like Receptor Agonists ; Adjuvants, Immunologic ; Antigens ; Tumor Microenvironment

Micellization of Lipopeptides Containing Toll-like Receptor Agonist and Integrin Binding Sequences.

Autori: Castelletto V de Mello LR Seitsonen J a ďalší

Zdroj: ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2024 Dec 18; Vol. 16 (50), pp. 68713-68723. Date of Electronic Publication: 2024 Dec 09.

Spôsob vydávania: Journal Article; Review

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-8252 (Electronic) Linking ISSN: 19448244 NLM ISO Abbreviation: ACS Appl Mater Interfaces Subsets: MEDLINE

Výrazy zo slovníka MeSH: Lipopeptides*/chemistry , Lipopeptides*/pharmacology , Integrins*/metabolism , Integrins*/chemistry , Integrins*/agonists , Micelles* , Toll-Like Receptors*/agonists , Toll-Like Receptors*/metabolism , Toll-Like Receptors*/chemistry, Molecular Dynamics Simulation ; Humans ; Oligopeptides/chemistry ; Oligopeptides/pharmacology ; Animals ; Toll-Like Receptor Agonists

Adjuvant activity of a small molecule TLR4 agonist discovered via structure-based virtual screening.

Autori: Kadivella, Mohammad Varma, Vivek P. CP, Jusail a ďalší

Zdroj: Communications Biology. 9/29/2025, Vol. 8 Issue 1, p1-17. 17p.

Predmety: *TOLL-like receptor agonists, *IMMUNOLOGICAL adjuvants, *DRUG discovery, *CYTOKINES, *IMMUNOREGULATION, *TOLL-like receptors, *SMALL molecules

黏膜免疫佐剂研究进展.

Alternate Title: Recent progress in research on mucosal immune adjuvants.

Autori: 张 芹 丁步坚 张 标

Zdroj: Chinese Journal of Immunology. Aug2025, Vol. 41 Issue 8, p2038-2045. 8p.

Predmety: *TOLL-like receptor agonists, *VACCINE effectiveness, *BACTERIAL toxins, *VACCINE development, *IMMUNE response