Výsledky vyhľadávania - "THIOREDOXIN GLUTATHIONE-REDUCTASE"

Screening Novel Furoxan Derivatives as Potential Inhibitors Targeting Thioredoxin Glutathione Reductase of Fasciola gigantica

Autori: Yanhui Han Yuting He Qingqing Guo a ďalší

Zdroj: Pharmaceuticals, Vol 18, Iss 11, p 1603 (2025)

Predmety: Fasciola gigantica, thioredoxin glutathione reductase, enzymatic activity, furoxan, Medicine, Pharmacy and materia medica, RS1-441

Popis súboru: electronic resource

Relation: https://www.mdpi.com/1424-8247/18/11/1603; https://doaj.org/toc/1424-8247

Prístupová URL adresa: https://doaj.org/article/924b0f7163d74117a5a5aa7b344b38ec

Novel Antischistosomal Drug Targets: Identification of Alkaloid Inhibitors of SmTGR via Integrated In Silico Methods

Autori: Valéria V. M. Paixão Yria J. A. Santos Adriana O. Fernandes a ďalší

Zdroj: Pathogens, Vol 14, Iss 6, p 591 (2025)

Predmety: Schistosoma mansoni, schistosomiasis, thioredoxin glutathione reductase, QSAR, molecular docking, alkaloids, Medicine

Popis súboru: electronic resource

Relation: https://www.mdpi.com/2076-0817/14/6/591; https://doaj.org/toc/2076-0817

Prístupová URL adresa: https://doaj.org/article/faf0626ce00e403ea9e277d331e1c140

A Physiological Approach to Explore How Thioredoxin–Glutathione Reductase (TGR) and Peroxiredoxin (Prx) Eliminate H 2 O 2 in Cysticerci of Taenia

Autori: Alberto Guevara-Flores Gabriela Nava-Balderas José de Jesús Martínez-González a ďalší

Zdroj: Antioxidants, Vol 13, Iss 4, p 444 (2024)

Predmety: peroxiredoxins, Taenia crassiceps, thioredoxin–glutathione reductase, hydrogen peroxide, Therapeutics. Pharmacology, RM1-950

Relation: https://www.mdpi.com/2076-3921/13/4/444; https://doaj.org/toc/2076-3921; https://doaj.org/article/ccf32f17457941b59af05ae78023893d

Dostupnosť: https://doi.org/10.3390/antiox13040444
https://doaj.org/article/ccf32f17457941b59af05ae78023893d

A genome-scale metabolic model of parasitic whipworm

Autori: Ömer F. Bay Kelly S. Hayes Jean-Marc Schwartz a ďalší

Prispievatelia: Ömer F. Bay Kelly S. Hayes Jean-Marc Schwartz a ďalší

Zdroj: Nat Commun
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Bay, O, Hayes, K, Schwartz, J-M, Grencis, R & Roberts, I 2023, 'A genome-scale metabolic model of parasitic whipworm', Nature Communications, vol. 14, no. 1, 6937. https://doi.org/10.1038/s41467-023-42552-4

Predmety: KNOWLEDGEBASE, THIOREDOXIN GLUTATHIONE-REDUCTASE, Science, MANSONI, Glutathione, Article, Glutathione Reductase/metabolism, Mice, Trichuris, Glutathione Reductase, Trichuris/genetics, Auranofin, Host-Pathogen Interactions, Animals, DRUG

Popis súboru: application/pdf

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/37907472
https://doaj.org/article/cec17c831ff347c7b75d0ae58cfd6235

A Novel Diagnostic Strategy for Schistosomiasis Using SmTGR as a Biosensor Target

Autori: Ramesh, Vondhana

Predmety: Schistosomiasis, SmTGR, Schistosoma mansoni, drug resistance, host-parasite interaction, thioredoxin glutathione reductase, diagnostic biomarker, biosensor, synthetic biology

First In Silico Screening of Insect Molecules for Identification of Novel Anti-Parasitic Compounds

Autori: Tom L. Gallinger Samuel Y. Aboagye Wiebke Obermann a ďalší

Zdroj: Pharmaceuticals, Vol 15, Iss 119, p 119 (2022)

Predmety: Schistosoma mansoni, thioredoxin glutathione reductase, insect compounds, in silico screening, molecular docking, Medicine, Pharmacy and materia medica, RS1-441

Relation: https://www.mdpi.com/1424-8247/15/2/119; https://doaj.org/toc/1424-8247; https://doaj.org/article/29a5cf11c1a04b6bbf5a32fd2c925484

Dostupnosť: https://doi.org/10.3390/ph15020119
https://doaj.org/article/29a5cf11c1a04b6bbf5a32fd2c925484

Drug resistance in Giardia: Mechanisms and alternative treatments for Giardiasis

Autori: Arguello-Garcia, Raul Leitsch, David Skinner-Adams, Tina a ďalší

Predmety: Microbiology, Veterinary sciences, Medical microbiology, Science & Technology, Life Sciences & Biomedicine, Infectious Diseases, Parasitology, THIOREDOXIN-GLUTATHIONE-REDUCTASE

Relation: Giardia and Giardiasis, Part B; Arguello-Garcia, R; Leitsch, D; Skinner-Adams, T; Guadalupe Ortega-Pierres, M, Drug resistance in Giardia: Mechanisms and alternative treatments for Giardiasis, Giardia and Giardiasis, Part B, 2020, 107, pp. 201-282; https://hdl.handle.net/10072/401609

Dostupnosť: https://hdl.handle.net/10072/401609
https://doi.org/10.1016/bs.apar.2019.11.003

Immunization with Fasciola hepatica thioredoxin glutathione reductase failed to confer protection against fasciolosis in cattle

Autori: Gustavo Salinas Tatiana Basika Gabriela Maggioli a ďalší

Prispievatelia: Gustavo Salinas Tatiana Basika Gabriela Maggioli a ďalší

Zdroj: Veterinary Parasitology. 224:13-19

Predmety: 0301 basic medicine, 2. Zero hunger, Fascioliasis, 0303 health sciences, Thioredoxin glutathione reductase, Cattle Diseases, Fasciola hepatica, Parasite Load, Recombinant Proteins, 3. Good health, 03 medical and health sciences, Adjuvants, Immunologic, [CHIM.OTHE] Chemical Sciences/Other, Multienzyme Complexes, Antigens, Helminth, Animals, Cattle, Immunization, NADH, NADPH Oxidoreductases, Vaccine

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/27270384
https://europepmc.org/abstract/MED/27270384
https://www.sciencedirect.com/science/article/pii/S0304401716301613

On the mechanism and rate of gold incorporation into thiol-dependent flavoreductases

Autori: SACCOCCIA, FULVIO ANGELUCCI, Francesco BOUMIS, Giovanna a ďalší

Zdroj: Journal of Inorganic Biochemistry. 108:105-111

Predmety: 0301 basic medicine, 0303 health sciences, Molecular Structure, Schistosoma mansoni, thioredoxin glutathione reductase, gold–cysteine complex, gold-selenocysteine complex, gold–selenocysteine complex, gold-cysteine complex, auranofin, Protein Structure, Secondary, Selenocysteine, 3. Good health, 03 medical and health sciences, Gold-cysteine complex, Multienzyme Complexes, Auranofin, Gold-selenocysteine complex, Animals, NADH, NADPH Oxidoreductases, Cysteine, Gold, Thioredoxin Glutathione Reductase

Prístupová URL adresa: https://europepmc.org/articles/pmc3396563?pdf=render
https://pubmed.ncbi.nlm.nih.gov/22166353
https://www.sciencedirect.com/science/article/pii/S0162013411003291
https://europepmc.org/articles/PMC3396563
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396563/
https://www.ncbi.nlm.nih.gov/pubmed/22166353
http://www.scopus.com/inward/record.url?eid=2-s2.0-84858451329&partnerID=q2rCbXpz
https://doi.org/10.1016/j.jinorgbio.2011.11.005
https://hdl.handle.net/20.500.14243/244744
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000302205600015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a
https://doi.org/10.1016/j.jinorgbio.2011.11.005
https://hdl.handle.net/11573/434335

Investigation of a potential mechanism for the inhibition of SmTGR by Auranofin and its implications for Plasmodium falciparum inhibition

Autori: CAROLI, ANTONIA SIMEONI, silvia LEPORE, ROSALBA a ďalší

Prispievatelia: CAROLI, ANTONIA SIMEONI, silvia LEPORE, ROSALBA a ďalší

Zdroj: Biochemical and Biophysical Research Communications. 417:576-581

Predmety: 0301 basic medicine, 0303 health sciences, Plasmodium falciparum, Schistosoma mansoni, P. falciparum, Protein Structure, Secondary, 3. Good health, Antimalarials, 03 medical and health sciences, Models, Chemical, Multienzyme Complexes, Auranofin, p. falciparum, thioredoxin glutathione reductase, s. mansoni, auranofin, Animals, NADH, NADPH Oxidoreductases, S. mansoni, Thioredoxin Glutathione Reductase

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/22177949
http://www.sciencedirect.com/science/article/pii/S0006291X1102211X
https://www.ncbi.nlm.nih.gov/pubmed/22177949
https://www.sciencedirect.com/science/article/abs/pii/S0006291X1102211X
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000299491600098&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a
https://doi.org/10.1016/j.bbrc.2011.12.009
https://hdl.handle.net/11573/442706

Mapping the Catalytic Cycle of Schistosoma mansoni Thioredoxin Glutathione Reductase by X-ray Crystallography

Autori: ANGELUCCI, Francesco DIMASTROGIOVANNI, Daniela BOUMIS, Giovanna a ďalší

Zdroj: Journal of Biological Chemistry. 285:32557-32567

Predmety: Models, Molecular, 0301 basic medicine, 0303 health sciences, NADPH reductase, thioredoxin glutathione reductase, electron transfer, flavoproteins, schistosoma mansoni, drug target, x-ray crystallography, Molecular Sequence Data, Thioredoxin glutathione reductase, Electrons, Schistosoma mansoni, Crystallography, X-Ray, Catalysis, Protein Structure, Tertiary, 03 medical and health sciences, Multienzyme Complexes, Animals, Humans, NADH, NADPH Oxidoreductases, Oxidation-Reduction, NADP

Prístupová URL adresa: http://www.jbc.org/content/285/42/32557.full.pdf
https://pubmed.ncbi.nlm.nih.gov/20659890
https://europepmc.org/articles/PMC2952258
http://europepmc.org/abstract/MED/20659890
https://www.sciencedirect.com/science/article/pii/S0021925820473065
https://www4.rcsb.org/structure/2X99
https://www.jbc.org/article/S0021-9258(20)47306-5/fulltext
https://www.cabdirect.org/cabdirect/abstract/20103328720
https://hdl.handle.net/20.500.14243/1687
http://www.jbc.org/content/285/42/32557.long
https://doi.org/10.1074/jbc.M110.141960
https://hdl.handle.net/11573/226243
https://doi.org/10.1074/jbc.m110.141960
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000282683000070&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a
http://www.scopus.com/inward/record.url?eid=2-s2.0-77957793022&partnerID=65&md5=332c6751d06ff74ba9de89eb8ce2f78e
https://doi.org/10.1074/jbc.m110.141960
https://hdl.handle.net/11697/2900

Inhibition of Tapeworm Thioredoxin and Glutathione Pathways by an Oxadiazole N-Oxide Leads to Reduced Mesocestoides vogae Infection Burden in Mice

Autori: Pasquet, Vivian Bisio, Hugo López, Gloria a ďalší

Zdroj: Molecules
Molecules, Vol 20, Iss 7, Pp 11793-11807 (2015)
Volume 20
Issue 7
Pages 11793-11807

Predmety: 0301 basic medicine, Oxadiazoles, Sequence Homology, Amino Acid, Molecular Sequence Data, Mesocestoides, Organic chemistry, thioredoxin reductase, tapeworms, Cestode Infections, oxadiazole N-oxide, Article, 3. Good health, Mice, 03 medical and health sciences, QD241-441, 0302 clinical medicine, Multienzyme Complexes, Animals, Cestoda, NADH, NADPH Oxidoreductases, Amino Acid Sequence, glutathione reductase, thioredoxin glutathione reductase

Popis súboru: application/pdf

Prístupová URL adresa: https://www.mdpi.com/1420-3049/20/7/11793/pdf
https://pubmed.ncbi.nlm.nih.gov/26132905
https://doaj.org/article/4fc610fc698e4047982ef2a7c9a61e40
https://www.mdpi.com/1420-3049/20/7/11793/pdf
https://europepmc.org/article/PMC/PMC6332120
https://core.ac.uk/display/90272937
https://www.ncbi.nlm.nih.gov/pubmed/26132905
https://www.mdpi.com/1420-3049/20/7/11793/html

Macromolecular Bases of Antischistosomal Therapy

Autori: ANGELUCCI, Francesco MIELE, Adriana Erica BOUMIS, Giovanna a ďalší

Zdroj: Current Topics in Medicinal Chemistry. 11:2012-2028

Predmety: Models, Molecular, 0301 basic medicine, Glutathione Peroxidase, 0303 health sciences, acetylcholinesterase, artemisinin, auranofin, crystal structure, cyclophilin a, glutathione peroxidase, medicinal chemistry, neglected tropical disease, oxamniquine, peroxiredoxin, praziquantel, proteases, purine nucleoside phosphorylase, schistosomiasis, thioredoxin glutathione reductase, Molecular Conformation, Peroxiredoxins, Schistosoma mansoni, Crystallography, X-Ray, Praziquantel, 3. Good health, Cyclophilins, 03 medical and health sciences, Purine-Nucleoside Phosphorylase, Multienzyme Complexes, Auranofin, Drug Design, Acetylcholinesterase, Animals, Humans, Schistosomiasis, NADH, NADPH Oxidoreductases, Molecular Targeted Therapy, Enzyme Inhibitors, Peptide Hydrolases

Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/21619508
https://www.eurekaselect.com/openurl/content.php?genre=article&issn=1568-0266&volume=11&issue=16&spage=2012
https://core.ac.uk/display/54387168
https://www.ncbi.nlm.nih.gov/pubmed/21619508
https://benthamscience.com/journal/abstracts.php?journalID=ctmc&articleID=88573
http://www.eurekaselect.com/88573/article

Inhibition of Schistosoma mansoni Thioredoxin-glutathione Reductase by Auranofin

Autori: Frida Pauly Giovanna Boumis Andrea Bellelli a ďalší

Zdroj: Journal of Biological Chemistry. 284:28977-28985

Predmety: Models, Molecular, 0301 basic medicine, 0303 health sciences, Dose-Response Relationship, Drug, Helminth Proteins, Schistosoma mansoni, Crystallography, X-Ray, Catalysis, Protein Structure, Tertiary, 3. Good health, Kinetics, Selenium, 03 medical and health sciences, auranofin, gold complexes, schistosoma mansoni, thioredoxin glutathione reductase, Gene Expression Regulation, Multienzyme Complexes, Antirheumatic Agents, Auranofin, Animals, NADH, NADPH Oxidoreductases, Cysteine, Oxidation-Reduction

Prístupová URL adresa: http://www.jbc.org/content/284/42/28977.full.pdf
https://pubmed.ncbi.nlm.nih.gov/19710012
https://pubmed.ncbi.nlm.nih.gov/19710012/
https://europepmc.org/article/PMC/PMC2781444
https://www.cabdirect.org/cabdirect/abstract/20093282508
https://www.cabdirect.org/abstracts/20093282508.html
https://www.jbc.org/content/284/42/28977.abstract?related-urls=yes;284/42/28977
https://www.sciencedirect.com/science/article/pii/S0021925820382661
https://hdl.handle.net/11697/12574
https://doi.org/10.1074/jbc.m109.020701
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781444/?tool=pubmed

High-throughput screening against thioredoxin glutathione reductase identifies novel inhibitors with potential therapeutic value for schistosomiasis

Autori: Li, Ting Ziniel, Peter He, Pan-qing a ďalší

Predmety: High-throughput screening, Schistosomiasis, Inhibitor, Thioredoxin glutathione reductase

Relation: http://www.idpjournal.com/content/4/1/40

Dostupnosť: http://www.idpjournal.com/content/4/1/40

Selenoprotein TXNRD3 supports male fertility via the redox regulation of spermatogenesis.

Autori: Dou, Qianhui Turanov, Anton A Mariotti, Marco a ďalší

Zdroj: J Biol Chem ; ISSN:1083-351X ; Volume:298 ; Issue:8

Predmety: male fertility, redox regulation, sperm motility, thioredoxin glutathione reductase

Relation: https://doi.org/10.1016/j.jbc.2022.102183; https://pubmed.ncbi.nlm.nih.gov/35753352; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352919/

Dostupnosť: https://doi.org/10.1016/j.jbc.2022.102183
https://pubmed.ncbi.nlm.nih.gov/35753352
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352919/

Redox regulation by TXNRD3 during epididymal maturation underlies capacitation-associated mitochondrial activity and sperm motility in mice.

Autori: Wang, Huafeng Dou, Qianhui Jeong, Kyung Jo a ďalší

Zdroj: J Biol Chem ; ISSN:1083-351X ; Volume:298 ; Issue:7

Predmety: TXNRD3, male fertility, mitochondrial function, redox homeostasis, thioredoxin glutathione reductase, ultrastructure

Relation: https://doi.org/10.1016/j.jbc.2022.102077; https://pubmed.ncbi.nlm.nih.gov/35643315; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218152/

Dostupnosť: https://doi.org/10.1016/j.jbc.2022.102077
https://pubmed.ncbi.nlm.nih.gov/35643315
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218152/

The Enzymatic and Structural Basis for Inhibition of Echinococcus granulosus Thioredoxin Glutathione Reductase by Gold(I)

Autori: Salinas, Gustavo Gao, Wei Wang, Yang a ďalší

Prispievatelia: Salinas, Gustavo Gao, Wei Wang, Yang a ďalší

Zdroj: ISSN: 1523-0864.

Predmety: Echinococcus, flatworm, glutaredoxin, gold, selenocysteine, selenoprotein, thioredoxin glutathione reductase, MESH: Animals, MESH: Binding Sites, MESH: NADH, NADPH Oxidoreductases, MESH: Organogold Compounds, MESH: Protein Binding, MESH: Protein Conformation, MESH: Cysteine, MESH: Echinococcus granulosus, MESH: Enzyme Inhibitors, MESH: Glutaredoxins, MESH: Helminth Proteins, MESH: Models, Molecular, MESH: Multienzyme Complexes, MESH: Mutation, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], [CHIM.ORGA]Chemical Sciences/Organic chemistry

Relation: info:eu-repo/semantics/altIdentifier/pmid/28463568; PUBMED: 28463568; PUBMEDCENTRAL: PMC5678357

Dostupnosť: https://riip.hal.science/pasteur-01882359
https://doi.org/10.1089/ars.2016.6816

A new promising drug against schistosomiasis

Autori: Dissous, Colette Ahier, Arnaud Long, Thavy

Predmety: Thioredoxin Glutathione-Reductase, Mansoni

Relation: orcid:0000-0002-9999-3887

Dostupnosť: https://espace.library.uq.edu.au/view/UQ:621730

Characterization and enzymatic function of thioredoxin glutathione reductase in Orientobilharzia turkestanicum isolated from Xizang.

Autori: Tang W Yue Y Shi B a ďalší

Zdroj: BMC veterinary research [BMC Vet Res] 2025 Aug 18; Vol. 21 (1), pp. 517. Date of Electronic Publication: 2025 Aug 18.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 101249759 Publication Model: Electronic Cited Medium: Internet ISSN: 1746-6148 (Electronic) Linking ISSN: 17466148 NLM ISO Abbreviation: BMC Vet Res Subsets: In Process; MEDLINE