Výsledky vyhľadávania - "TEMOZOLOMIDE"

Nanoparticles of silver and titanium can increase temozolomide sensitivity against human glioblastoma: an in vitro study on apoptosis and inflammation.

Autori: Goswami S Verma Y Rana SVS

Zdroj: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2025 Dec; Vol. 398 (12), pp. 17881-17893. Date of Electronic Publication: 2025 Jun 26.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Temozolomide*/pharmacology , Temozolomide*/administration & dosage , Glioblastoma*/drug therapy , Glioblastoma*/pathology , Glioblastoma*/metabolism , Silver*/administration & dosage , Silver*/pharmacology , Titanium*/administration & dosage , Titanium*/pharmacology , Metal Nanoparticles*/administration & dosage , Antineoplastic Agents, Alkylating*/pharmacology , Antineoplastic Agents, Alkylating*/administration & dosage , Brain Neoplasms*/drug therapy , Brain Neoplasms*/pathology , Brain Neoplasms*/metabolism, Humans ; Apoptosis/drug effects ; Cell Line, Tumor ; Inflammation/drug therapy ; Inflammation/metabolism ; DNA Fragmentation/drug effects

Sanggenol L Enhances Temozolomide Drug Sensitivity by Inhibiting Mitophagy and Inducing Apoptosis Through the Regulation of the TRIM16-OPTN Axis in Glioblastoma.

Autori: Chang H Hou J Hu X a ďalší

Zdroj: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Dec; Vol. 12 (45), pp. e02915. Date of Electronic Publication: 2025 Sep 24.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

Výrazy zo slovníka MeSH: Temozolomide*/pharmacology , Temozolomide*/therapeutic use , Glioblastoma*/drug therapy , Glioblastoma*/metabolism , Glioblastoma*/pathology , Glioblastoma*/genetics , Mitophagy*/drug effects , Apoptosis*/drug effects , Ubiquitin-Protein Ligases*/metabolism , Ubiquitin-Protein Ligases*/genetics , Tripartite Motif Proteins*/metabolism , Tripartite Motif Proteins*/genetics , Transcription Factors*/metabolism , Transcription Factors*/genetics , Membrane Transport Proteins*/metabolism , Brain Neoplasms*/drug therapy , Brain Neoplasms*/metabolism , DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/genetics , Cell Cycle Proteins*/metabolism, Humans ; Cell Line, Tumor ; Autophagy/drug effects ; Animals ; Drug Resistance, Neoplasm/drug effects

Effects of temozolomide dosing on outcome in glioblastoma.

Autori: Raghu A Killar S Cohen AL

Zdroj: Journal of neuro-oncology [J Neurooncol] 2025 Nov 19; Vol. 176 (1), pp. 89. Date of Electronic Publication: 2025 Nov 19.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Springer Country of Publication: United States NLM ID: 8309335 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-7373 (Electronic) Linking ISSN: 0167594X NLM ISO Abbreviation: J Neurooncol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Temozolomide*/administration & dosage , Temozolomide*/therapeutic use , Glioblastoma*/drug therapy , Glioblastoma*/mortality , Glioblastoma*/pathology , Antineoplastic Agents, Alkylating*/administration & dosage , Antineoplastic Agents, Alkylating*/therapeutic use , Brain Neoplasms*/drug therapy , Brain Neoplasms*/mortality , Brain Neoplasms*/pathology, Humans ; Male ; Female ; Retrospective Studies ; Middle Aged ; Aged ; Adult ; Survival Rate ; Follow-Up Studies ; Treatment Outcome ; Dose-Response Relationship, Drug

cRGD-Functionalized Nanohybrid Conjugates Codelivering Temozolomide and Rapamycin for Treating Glioblastoma Multiforme: In Vitro and In Vivo Evaluation.

Autori: Singh P Mittal A Chitkara D

Zdroj: Molecular pharmaceutics [Mol Pharm] 2025 Nov 03; Vol. 22 (11), pp. 6539-6551. Date of Electronic Publication: 2025 Oct 23.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE

Výrazy zo slovníka MeSH: Temozolomide*/administration & dosage , Temozolomide*/chemistry , Temozolomide*/pharmacology , Glioblastoma*/drug therapy , Glioblastoma*/pathology , Sirolimus*/administration & dosage , Sirolimus*/chemistry , Sirolimus*/pharmacology , Peptides, Cyclic*/chemistry , Nanoconjugates*/chemistry , Brain Neoplasms*/drug therapy, Animals ; Rats ; Cell Line, Tumor ; Rats, Sprague-Dawley ; Humans ; Apoptosis/drug effects ; Male ; Drug Delivery Systems/methods ; Drug Carriers/chemistry

Amlodipine synergizes with temozolomide against glioma stem cells by modulating MGMT expression through downregulation of the AKT/GSK3β/β-catenin axis.

Autori: Zhang X Li Z Wen P a ďalší

Zdroj: Cellular signalling [Cell Signal] 2025 Nov; Vol. 135, pp. 112012. Date of Electronic Publication: 2025 Jul 21.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3913 (Electronic) Linking ISSN: 08986568 NLM ISO Abbreviation: Cell Signal Subsets: MEDLINE

Výrazy zo slovníka MeSH: Temozolomide*/pharmacology , Temozolomide*/therapeutic use , Amlodipine*/pharmacology , Amlodipine*/therapeutic use , Neoplastic Stem Cells*/drug effects , Neoplastic Stem Cells*/metabolism , Neoplastic Stem Cells*/pathology , DNA Modification Methylases*/metabolism , DNA Modification Methylases*/genetics , Glioma*/drug therapy , Glioma*/pathology , Glioma*/metabolism , DNA Repair Enzymes*/metabolism , DNA Repair Enzymes*/genetics , Tumor Suppressor Proteins*/metabolism , Tumor Suppressor Proteins*/genetics , Brain Neoplasms*/drug therapy , Brain Neoplasms*/pathology , Brain Neoplasms*/metabolism, Animals ; Glycogen Synthase Kinase 3 beta/metabolism ; Humans ; Proto-Oncogene Proteins c-akt/metabolism ; beta Catenin/metabolism ; Cell Line, Tumor ; Mice ; Drug Synergism ; Down-Regulation/drug effects ; Mice, Nude ; Signal Transduction/drug effects ; Apoptosis/drug effects ; Xenograft Model Antitumor Assays ; Mice, Inbred BALB C

HTR1D regulates the PI3K/Akt signaling pathway to impact glioblastoma development and resistance to temozolomide.

Autori: Zhang H Liu Z Cheng J a ďalší

Zdroj: Chemico-biological interactions [Chem Biol Interact] 2025 Nov 01; Vol. 421, pp. 111748. Date of Electronic Publication: 2025 Sep 17.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE

Výrazy zo slovníka MeSH: Temozolomide*/pharmacology , Temozolomide*/therapeutic use , Glioblastoma*/drug therapy , Glioblastoma*/pathology , Glioblastoma*/metabolism , Proto-Oncogene Proteins c-akt*/metabolism , Signal Transduction*/drug effects , Phosphatidylinositol 3-Kinases*/metabolism , Drug Resistance, Neoplasm*/drug effects , Brain Neoplasms*/drug therapy , Brain Neoplasms*/pathology , Brain Neoplasms*/metabolism, Humans ; Cell Line, Tumor ; Animals ; Cell Proliferation/drug effects ; Mice ; Mice, Nude ; Antineoplastic Agents, Alkylating/pharmacology ; Antineoplastic Agents, Alkylating/therapeutic use ; Cell Movement/drug effects

Intranasal delivery of temozolomide and disulfiram in situ gel combined with copper for enhanced glioblastoma therapy.

Autori: Qu Y Zhao J Ma L a ďalší

Zdroj: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2025 Nov; Vol. 255, pp. 114898. Date of Electronic Publication: 2025 Jun 24.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9315133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4367 (Electronic) Linking ISSN: 09277765 NLM ISO Abbreviation: Colloids Surf B Biointerfaces Subsets: MEDLINE

Výrazy zo slovníka MeSH: Disulfiram*/pharmacology , Disulfiram*/chemistry , Disulfiram*/administration & dosage , Glioblastoma*/drug therapy , Glioblastoma*/pathology , Copper*/chemistry , Copper*/pharmacology , Temozolomide*/pharmacology , Temozolomide*/chemistry , Temozolomide*/administration & dosage , Brain Neoplasms*/drug therapy , Brain Neoplasms*/pathology , Antineoplastic Agents, Alkylating*/pharmacology , Antineoplastic Agents, Alkylating*/administration & dosage , Antineoplastic Agents, Alkylating*/chemistry, Humans ; Administration, Intranasal ; Animals ; Mice ; Apoptosis/drug effects ; Hydrogels/chemistry ; Drug Delivery Systems ; Gels/chemistry ; Cell Proliferation/drug effects ; Drug Liberation ; Cell Line, Tumor ; Tumor Microenvironment/drug effects

MicroRNA strand ratio disarray promotes temozolomide resistance in glioblastoma.

Autori: Shen F Wu P Li Z a ďalší

Zdroj: Cellular & molecular biology letters [Cell Mol Biol Lett] 2025 Oct 31; Vol. 30 (1), pp. 130. Date of Electronic Publication: 2025 Oct 31.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: BioMed Central Country of Publication: England NLM ID: 9607427 Publication Model: Electronic Cited Medium: Internet ISSN: 1689-1392 (Electronic) Linking ISSN: 14258153 NLM ISO Abbreviation: Cell Mol Biol Lett Subsets: MEDLINE

Výrazy zo slovníka MeSH: Temozolomide*/pharmacology , Temozolomide*/therapeutic use , MicroRNAs*/genetics , MicroRNAs*/metabolism , Glioblastoma*/genetics , Glioblastoma*/drug therapy , Glioblastoma*/pathology , Drug Resistance, Neoplasm*/genetics , Drug Resistance, Neoplasm*/drug effects , Brain Neoplasms*/genetics , Brain Neoplasms*/drug therapy, Humans ; Cell Line, Tumor ; Histone Deacetylases/metabolism ; Histone Deacetylases/genetics ; Forkhead Transcription Factors/metabolism ; Forkhead Transcription Factors/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Repressor Proteins/metabolism ; Repressor Proteins/genetics ; Antineoplastic Agents, Alkylating/pharmacology

Synergistic increase in anti-cancer stemness activity and pro-apoptotic effects in human glioblastoma cancer stem-like cells by combination treatment with temozolomide and corosolic acid.

Autori: Kao CY Shih HY Hsieh YH a ďalší

Zdroj: International journal of medical sciences [Int J Med Sci] 2025 Oct 20; Vol. 22 (16), pp. 4374-4383. Date of Electronic Publication: 2025 Oct 20 (Print Publication: 2025).

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101213954 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-1907 (Electronic) Linking ISSN: 14491907 NLM ISO Abbreviation: Int J Med Sci Subsets: MEDLINE

Výrazy zo slovníka MeSH: Temozolomide*/pharmacology , Temozolomide*/therapeutic use , Glioblastoma*/drug therapy , Glioblastoma*/pathology , Glioblastoma*/genetics , Neoplastic Stem Cells*/drug effects , Neoplastic Stem Cells*/pathology , Triterpenes*/pharmacology , Triterpenes*/therapeutic use , Brain Neoplasms*/drug therapy , Brain Neoplasms*/pathology , Brain Neoplasms*/genetics , Antineoplastic Combined Chemotherapy Protocols*/pharmacology , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use, Humans ; Apoptosis/drug effects ; Drug Synergism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Movement/drug effects ; Molecular Docking Simulation ; Gene Expression Regulation, Neoplastic/drug effects ; Octamer Transcription Factor-3/metabolism ; AC133 Antigen/metabolism

Preparation and evaluation of temozolomide loaded PLGA nanoparticles for the treatment of glioblastoma multiforme.

Autori: Şahin Ş Kaya-Tilki E Baysal M a ďalší

Zdroj: Scientific reports [Sci Rep] 2025 Oct 16; Vol. 15 (1), pp. 36194. Date of Electronic Publication: 2025 Oct 16.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Výrazy zo slovníka MeSH: Temozolomide*/pharmacology , Temozolomide*/chemistry , Temozolomide*/administration & dosage , Glioblastoma*/drug therapy , Glioblastoma*/metabolism , Glioblastoma*/pathology , Polylactic Acid-Polyglycolic Acid Copolymer*/chemistry , Nanoparticles*/chemistry , Brain Neoplasms*/drug therapy , Brain Neoplasms*/metabolism , Brain Neoplasms*/pathology , Antineoplastic Agents, Alkylating*/administration & dosage , Antineoplastic Agents, Alkylating*/pharmacology , Antineoplastic Agents, Alkylating*/chemistry, Humans ; Animals ; Mice ; Cell Line, Tumor ; NIH 3T3 Cells ; Particle Size ; Reactive Oxygen Species/metabolism ; Drug Liberation ; Drug Carriers/chemistry ; Cell Survival/drug effects

β-Lapachone sensitizes glioblastoma to Temozolomide by inhibiting NF-κB signaling.

Autori: Quan C Liu Y Gao Y a ďalší

Zdroj: Functional & integrative genomics [Funct Integr Genomics] 2025 Dec 03; Vol. 25 (1), pp. 261. Date of Electronic Publication: 2025 Dec 03.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Springer Country of Publication: Germany NLM ID: 100939343 Publication Model: Electronic Cited Medium: Internet ISSN: 1438-7948 (Electronic) Linking ISSN: 1438793X NLM ISO Abbreviation: Funct Integr Genomics Subsets: MEDLINE

Výrazy zo slovníka MeSH: Naphthoquinones*/pharmacology , Temozolomide*/pharmacology , Glioblastoma*/drug therapy , Glioblastoma*/metabolism , Glioblastoma*/pathology , Glioblastoma*/genetics , NF-kappa B*/metabolism , Brain Neoplasms*/drug therapy , Brain Neoplasms*/metabolism , Brain Neoplasms*/pathology, Humans ; Animals ; Signal Transduction/drug effects ; Mice ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Epithelial-Mesenchymal Transition/drug effects ; Drug Synergism ; Xenograft Model Antitumor Assays ; Transcription Factor RelA/metabolism ; Mice, Nude

Chemoradiotherapy with temozolomide vs. radiotherapy alone in patients with IDH wild-type and TERT promoter mutation histological grade 2/3 gliomas: An extension retrospective analysis of a randomized controlled trial.

Autori: Zhang J Wang P Ren Y a ďalší

Zdroj: Cancer [Cancer] 2025 Dec 01; Vol. 131 (23), pp. e70171.

Spôsob vydávania: Journal Article; Randomized Controlled Trial; Comparative Study

Informácie o časopise: Publisher: Wiley Country of Publication: United States NLM ID: 0374236 Publication Model: Print Cited Medium: Internet ISSN: 1097-0142 (Electronic) Linking ISSN: 0008543X NLM ISO Abbreviation: Cancer Subsets: MEDLINE

Výrazy zo slovníka MeSH: Temozolomide*/therapeutic use , Temozolomide*/administration & dosage , Temozolomide*/adverse effects , Telomerase*/genetics , Isocitrate Dehydrogenase*/genetics , Glioma*/genetics , Glioma*/therapy , Glioma*/pathology , Glioma*/mortality , Chemoradiotherapy*/methods , Brain Neoplasms*/genetics , Brain Neoplasms*/therapy , Brain Neoplasms*/pathology , Brain Neoplasms*/mortality, Humans ; Female ; Male ; Middle Aged ; Adult ; Mutation ; Promoter Regions, Genetic ; Retrospective Studies ; Aged ; Neoplasm Grading ; Prospective Studies ; Young Adult

Microbubble-enhanced transcranial focused ultrasound with temozolomide for patients with high-grade glioma (BT008NA): a multicentre, open-label, phase 1/2 trial.

Autori: Woodworth GF Anastasiadis P Ozair A a ďalší

Zdroj: The Lancet. Oncology [Lancet Oncol] 2025 Dec; Vol. 26 (12), pp. 1651-1664.

Spôsob vydávania: Journal Article; Clinical Trial, Phase II; Clinical Trial, Phase I; Multicenter Study

Informácie o časopise: Publisher: Lancet Pub. Group Country of Publication: England NLM ID: 100957246 Publication Model: Print Cited Medium: Internet ISSN: 1474-5488 (Electronic) Linking ISSN: 14702045 NLM ISO Abbreviation: Lancet Oncol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Temozolomide*/administration & dosage , Temozolomide*/adverse effects , Temozolomide*/therapeutic use , Microbubbles*/therapeutic use , Brain Neoplasms*/pathology , Brain Neoplasms*/therapy , Brain Neoplasms*/drug therapy , Brain Neoplasms*/diagnostic imaging , Glioma*/pathology , Glioma*/therapy , Antineoplastic Agents, Alkylating*/administration & dosage , Antineoplastic Agents, Alkylating*/adverse effects, Humans ; Middle Aged ; Male ; Female ; Adult ; Aged ; Young Adult ; Neoplasm Grading ; Adolescent ; Aged, 80 and over

A Validated UPLC-MS/MS Method for Monitoring Temozolomide and Perillyl Alcohol Metabolites in Biological Matrices: Insights From a Preclinical Pharmacokinetic Study.

Autori: Lorenzett AKP Babinski TP Peczek SH a ďalší

Zdroj: Biomedical chromatography : BMC [Biomed Chromatogr] 2025 Dec; Vol. 39 (12), pp. e70253.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Wiley Country of Publication: England NLM ID: 8610241 Publication Model: Print Cited Medium: Internet ISSN: 1099-0801 (Electronic) Linking ISSN: 02693879 NLM ISO Abbreviation: Biomed Chromatogr Subsets: MEDLINE

Výrazy zo slovníka MeSH: Tandem Mass Spectrometry*/methods , Temozolomide*/pharmacokinetics , Temozolomide*/blood , Temozolomide*/analysis , Temozolomide*/chemistry , Temozolomide*/metabolism , Monoterpenes*/pharmacokinetics , Monoterpenes*/blood , Monoterpenes*/chemistry , Monoterpenes*/analysis, Animals ; Rats ; Chromatography, High Pressure Liquid/methods ; Reproducibility of Results ; Rats, Sprague-Dawley ; Male ; Linear Models ; Tissue Distribution ; Limit of Detection ; Liquid Chromatography-Mass Spectrometry

Radiosynthesis and In Vitro Bioevaluation of ^99m Tc-Temozolomide as a Radiotracer for Glioma Imaging.

Autori: Tayal S Sharma S Sati J a ďalší

Zdroj: Cancer biotherapy & radiopharmaceuticals [Cancer Biother Radiopharm] 2025 Dec; Vol. 40 (10), pp. 778-789. Date of Electronic Publication: 2025 Aug 06.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 9605408 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8852 (Electronic) Linking ISSN: 10849785 NLM ISO Abbreviation: Cancer Biother Radiopharm Subsets: MEDLINE

Výrazy zo slovníka MeSH: Glioma*/diagnostic imaging , Glioma*/pathology , Temozolomide* , Radiopharmaceuticals*/chemical synthesis , Radiopharmaceuticals*/pharmacology , Radiopharmaceuticals*/chemistry , Technetium*/chemistry , Brain Neoplasms*/diagnostic imaging , Organotechnetium Compounds*/chemical synthesis, Animals ; Humans ; Cell Line, Tumor ; Rats ; Antineoplastic Agents, Alkylating

Effects of re-challenge with temozolomide in grade 2/3 IDH mutant gliomas at first progression.

Autori: Yogendran LV Kareddy A Abbas SO a ďalší

Zdroj: Journal of neuro-oncology [J Neurooncol] 2025 Dec; Vol. 175 (3), pp. 1147-1154. Date of Electronic Publication: 2025 Aug 20.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Springer Country of Publication: United States NLM ID: 8309335 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7373 (Electronic) Linking ISSN: 0167594X NLM ISO Abbreviation: J Neurooncol Subsets: MEDLINE

Výrazy zo slovníka MeSH: Temozolomide*/therapeutic use , Isocitrate Dehydrogenase*/genetics , Brain Neoplasms*/drug therapy , Brain Neoplasms*/genetics , Brain Neoplasms*/pathology , Antineoplastic Agents, Alkylating*/therapeutic use , Glioma*/drug therapy , Glioma*/genetics , Glioma*/pathology , Mutation*, Humans ; Female ; Male ; Middle Aged ; Adult ; Disease Progression ; Aged ; Neoplasm Grading ; Retrospective Studies ; Follow-Up Studies ; Young Adult ; Prognosis

Self-Assembling Nanoparticles Orchestrate Cuproptosis-Immunotherapy Synergy to Suppress Postoperative Glioma Recurrence.

Autori: Zhang C Hou S Hu B a ďalší

Zdroj: ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2025 Nov 26; Vol. 17 (47), pp. 64322-64339. Date of Electronic Publication: 2025 Nov 14.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-8252 (Electronic) Linking ISSN: 19448244 NLM ISO Abbreviation: ACS Appl Mater Interfaces Subsets: MEDLINE

Výrazy zo slovníka MeSH: Nanoparticles*/chemistry , Copper*/chemistry , Temozolomide*/chemistry , Temozolomide*/pharmacology , Temozolomide*/therapeutic use , Immunotherapy* , Neoplasm Recurrence, Local*/drug therapy , Glioblastoma*/drug therapy , Glioblastoma*/pathology , Glioblastoma*/therapy , Brain Neoplasms*/drug therapy , Brain Neoplasms*/pathology , Brain Neoplasms*/therapy , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use , Glioma*/drug therapy , Glioma*/pathology, Humans ; Animals ; Cell Line, Tumor ; Mice ; Tumor Microenvironment/drug effects

LSTA1-GBM-2A: study protocol for an exploratory phase 2a randomised controlled trial evaluating tumour-homing peptide certepetide with temozolomide in glioblastoma multiforme.

Autori: Truusalu JP Oselin K Lass J a ďalší

Zdroj: BMJ open [BMJ Open] 2025 Nov 13; Vol. 15 (11), pp. e106094. Date of Electronic Publication: 2025 Nov 13.

Spôsob vydávania: Journal Article; Clinical Trial Protocol

Informácie o časopise: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE

Výrazy zo slovníka MeSH: Temozolomide*/therapeutic use , Temozolomide*/administration & dosage , Glioblastoma*/drug therapy , Glioblastoma*/therapy , Brain Neoplasms*/drug therapy , Brain Neoplasms*/therapy , Antineoplastic Agents, Alkylating*/therapeutic use , Antineoplastic Agents, Alkylating*/administration & dosage , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use, Humans ; Double-Blind Method ; Clinical Trials, Phase II as Topic ; Randomized Controlled Trials as Topic ; Male ; Female ; Middle Aged ; Adult

Biodegradable nanofibrous scaffolds enhance standard of care for glioblastoma via localized targeted therapy.

Autori: Woodring RN Graham-Gurysh EG Mendell SE a ďalší

Zdroj: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2025 Nov 10; Vol. 387, pp. 114225. Date of Electronic Publication: 2025 Sep 11.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE

Výrazy zo slovníka MeSH: Glioblastoma*/drug therapy , Glioblastoma*/pathology , Temozolomide*/administration & dosage , Temozolomide*/pharmacokinetics , Temozolomide*/therapeutic use , Brain Neoplasms*/drug therapy , Brain Neoplasms*/pathology , Nanofibers*/chemistry , Nanofibers*/administration & dosage , Erlotinib Hydrochloride*/administration & dosage , Erlotinib Hydrochloride*/pharmacokinetics , Erlotinib Hydrochloride*/therapeutic use , Antineoplastic Agents*/administration & dosage , Antineoplastic Agents*/pharmacokinetics, Animals ; Humans ; Cell Line, Tumor ; Dextrans/chemistry ; Mice ; Standard of Care ; Mice, Nude ; Xenograft Model Antitumor Assays ; Drug Liberation ; Female ; Drug Delivery Systems ; ErbB Receptors/antagonists & inhibitors

Synergistic Cancer Metabolic Therapy via Co-Delivery of 3-Bromopyruvate and Temozolomide with a Supramolecular Shuttle.

Autori: Bellavita R Prisco M Palladino S a ďalší

Zdroj: ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2025 Nov 05; Vol. 17 (44), pp. 60342-60360. Date of Electronic Publication: 2025 Oct 22.

Spôsob vydávania: Journal Article

Informácie o časopise: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-8252 (Electronic) Linking ISSN: 19448244 NLM ISO Abbreviation: ACS Appl Mater Interfaces Subsets: MEDLINE

Výrazy zo slovníka MeSH: Temozolomide*/chemistry , Temozolomide*/pharmacology , Pyruvates*/chemistry , Pyruvates*/pharmacology , Glioblastoma*/drug therapy , Glioblastoma*/metabolism , Glioblastoma*/pathology , Nanofibers*/chemistry , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/pharmacology , Drug Carriers*/chemistry, Humans ; Animals ; Rats ; Cell Line, Tumor ; Mitochondria/metabolism ; Mitochondria/drug effects ; Blood-Brain Barrier/metabolism ; Blood-Brain Barrier/drug effects ; Cell-Penetrating Peptides/chemistry